Regulation of levels of specific Sertoli cell mRNAs by vitamin A.

abstract：:Nucleostemin (NS), a member of a family of nucleolar GTP-binding proteins, is highly expressed in proliferating cells such as stem and cancer cells and is involved in the control of cell cycle progression. Both depletion and overexpression of NS result in stabilization of the tumor suppressor p53 protein in vitro. Alt...

journal_title：Developmental biology

authors： Paridaen JT,Janson E,Utami KH,Pereboom TC,Essers PB,van Rooijen C,Zivkovic D,MacInnes AW

更新日期：2011-07-15 00:00:00

abstract：:The universal signal for egg activation at fertilization is a rise in cytoplasmic Ca(2+) with defined spatial and temporal kinetics. Mammalian and amphibian eggs acquire the ability to produce such Ca(2+) signals during a maturation period that precedes fertilization and encompasses resumption of meiosis and progressi...

journal_title：Developmental biology

authors： Machaca K

更新日期：2004-11-01 00:00:00

abstract：:The Hedgehog (Hh) signal transduction pathway plays a central role in the development of invertebrates and vertebrates. While much is known about the pathway, the role of Suppressor of fused (Su(fu)), a component of the pathway's signaling complex has remained enigmatic. Previous studies have linked Su(fu) to the cyto...

journal_title：Developmental biology

authors： Sisson BE,Ziegenhorn SL,Holmgren RA

更新日期：2006-06-01 00:00:00

abstract：:An immunocytochemical study of cholecalcin (28-kDa calcium-binding protein, CaBP, calbindin) was carried out during the development of the rat hippocampus. In normal animals, the protein appeared from Postnatal Day 3 in the granule cells of the dentate gyrus and from Day 5 in the CA1-CA2 pyramidal cells of Ammon's hor...

journal_title：Developmental biology

authors： Rami A,Bréhier A,Thomasset M,Rabié A

更新日期：1987-11-01 00:00:00

abstract：:We have phenotypically and molecularly analyzed the cutlet locus in Drosophila. Homozygous cutlet flies exhibit abnormal development of a subset of adult tissues, including the eye, wing, and ovary. We show that abnormal development of these tissues is due to a defect in normal cell growth. Surprisingly, cell growth i...

journal_title：Developmental biology

authors： Jaffe AB,Jongens TA

更新日期：2001-02-15 00:00:00

abstract：:Retinoic acid (RA) plays a critical role in neural patterning and organogenesis in the vertebrate embryo. Here we characterize a mutant of the zebrafish named giraffe (gir) in which the gene for the RA-degrading enzyme Cyp26a1 is mutated. The gir mutant displayed patterning defects in multiple organs including the com...

journal_title：Developmental biology

authors： Emoto Y,Wada H,Okamoto H,Kudo A,Imai Y

更新日期：2005-02-15 00:00:00

abstract：:Tissue specificity of cell adhesion was directly characterized in a unit cell interaction using a novel laser trapping cell manipulator in combination with a fixed micropipet. We quantified the adhesive specificity of endodermal and ectodermal epithelial cells from Hydra, which are known to sort out within hours after...

journal_title：Developmental biology

authors： Sato-Maeda M,Uchida M,Graner F,Tashiro H

更新日期：1994-03-01 00:00:00

abstract：:The regulation of cell cycle rate is essential for the correct timing of proliferation and differentiation during development. Changes to cell cycle rate can have profound effects on the size, shape and cell types of a developing organ. We previously identified a zebrafish mutant ceylon (cey) that has a severe reducti...

journal_title：Developmental biology

authors： Hutchinson SA,Tooke-Locke E,Wang J,Tsai S,Katz T,Trede NS

更新日期：2012-08-15 00:00:00

abstract：:The monoclonal antibody HNK-1 was used to identify neural crest cells in serial sections of avian embryos to provide a detailed description of the distribution of trunk neural crest cells. The results indicate the presence of three migratory routes in the trunk: (1) a ventral pathway through the anterior sclerotome; (...

journal_title：Developmental biology

authors： Bronner-Fraser M

更新日期：1986-05-01 00:00:00

abstract：:Egfr/Ras signaling promotes vein cell fate specification in the developing Drosophila wing. While the importance of Ras signaling in vein determination has been extensively documented, the mechanisms linking Ras activity to vein differentiation remain unclear. We found that Ras signaling regulates both the levels and ...

journal_title：Developmental biology

authors： O'Keefe DD,Prober DA,Moyle PS,Rickoll WL,Edgar BA

更新日期：2007-11-01 00:00:00

abstract：:Mesenchymal-epithelial interactions are an important source of information for pattern formation during organogenesis. In the developing excretory system, one of the secreted mesenchymal factors thought to play a critical role in patterning the growth and branching of the epithelial ureteric bud is GDNF. We have teste...

journal_title：Developmental biology

authors： Shakya R,Jho EH,Kotka P,Wu Z,Kholodilov N,Burke R,D'Agati V,Costantini F

更新日期：2005-07-01 00:00:00

abstract：:The Foxl1 gene, which encodes a winged helix transcriptional regulator, is expressed in the mesenchymal layer of developing and mature gastrointestinal tract. Foxl1-deficient mice exhibit various defects not only in the epithelial layer of the gastrointestinal tract but also in gut-associated lymphoid tissues. In the ...

journal_title：Developmental biology

authors： Fukuda K,Yoshida H,Sato T,Furumoto TA,Mizutani-Koseki Y,Suzuki Y,Saito Y,Takemori T,Kimura M,Sato H,Taniguchi M,Nishikawa S,Nakayama T,Koseki H

更新日期：2003-03-15 00:00:00

abstract：:The nuclear lamina is an extensive protein network that underlies the inner nuclear envelope. This network includes the LAP2-emerin-MAN1-domain (LEM-D) protein family, proteins that share an association with the chromatin binding protein Barrier-to-autointegration factor (BAF). Loss of individual LEM-D proteins causes...

journal_title：Developmental biology

authors： Barton LJ,Lovander KE,Pinto BS,Geyer PK

更新日期：2016-07-01 00:00:00

abstract：:The arterial pole of the heart is the region where the ventricular myocardium continues as the vascular smooth muscle tunics of the aorta and pulmonary trunk. It has been shown that the arterial pole myocardium derives from the secondary heart field and the smooth muscle tunic of the aorta and pulmonary trunk derives ...

journal_title：Developmental biology

authors： Waldo KL,Hutson MR,Ward CC,Zdanowicz M,Stadt HA,Kumiski D,Abu-Issa R,Kirby ML

更新日期：2005-05-01 00:00:00

abstract：:The interaction of heterologous tissues involves cell adhesion mediated by the extracellular matrix and its receptor integrins. The Drosophila wing disc is an ectodermal invagination that contacts specific tracheal branches at the basolateral cell surface. We show that an alpha subunit of laminin, encoded by wing blis...

journal_title：Developmental biology

authors： Inoue Y,Hayashi S

更新日期：2007-04-01 00:00:00

abstract：:Wnt signaling is essential to many events during organogenesis, including the development of the mammalian lung. The Wnt family member Wnt4 has been shown to be required for the development of kidney, gonads, thymus, mammary and pituitary glands. Here, we show that Wnt4 is critical for proper morphogenesis and growth ...

journal_title：Developmental biology

authors： Caprioli A,Villasenor A,Wylie LA,Braitsch C,Marty-Santos L,Barry D,Karner CM,Fu S,Meadows SM,Carroll TJ,Cleaver O

更新日期：2015-10-15 00:00:00

abstract：:FOG-2 is a multi-zinc finger protein that binds the transcriptional activator GATA4 and modulates GATA4-mediated regulation of target genes during heart development. Our previous work has demonstrated that the Nucleosome Remodeling and Deacetylase (NuRD) complex physically interacts with FOG-2 and is necessary for FOG...

journal_title：Developmental biology

authors： Garnatz AS,Gao Z,Broman M,Martens S,Earley JU,Svensson EC

更新日期：2014-11-01 00:00:00

abstract：:RNA localization is tightly coordinated with RNA stability and translation control. Bicaudal-D (Bic-D), Egalitarian (Egl), microtubules and their motors are part of a Drosophila transport machinery that localizes mRNAs to specific cellular regions during oogenesis and embryogenesis. We identified the Poly(A)-binding p...

journal_title：Developmental biology

authors： Vazquez-Pianzola P,Urlaub H,Suter B

更新日期：2011-09-15 00:00:00

abstract：:Metazoan replication-dependent histone mRNAs accumulate to high levels during S phase as a result of an increase in the rate of histone gene transcription, pre-mRNA processing, and mRNA stability at the G1-S transition. However, relatively little is known about the contribution of these processes to histone expression...

journal_title：Developmental biology

authors： Lanzotti DJ,Kupsco JM,Marzluff WF,Duronio RJ

更新日期：2004-10-01 00:00:00

abstract：:NK-2-class homeobox genes have been identified in a variety of metazoans, from sponges to arthropods and vertebrates, and have been shown to play roles in a variety of cell and tissue specifications. Here we describe the characterization of the NK-2 homolog CnNK-2 from Hydra vulgaris, a freshwater cnidarian. CnNK-2 ex...

journal_title：Developmental biology

authors： Grens A,Gee L,Fisher DA,Bode HR

更新日期：1996-12-15 00:00:00

abstract：:In the nematode Caenorhabditis elegans, the BMP-related growth factor DBL-1 regulates body size and male tail morphogenesis via a conserved receptor/Smad signaling pathway. Smads are transcription factors, but rely on transcription cofactors for appropriate regulation of target genes in response to TGF-beta- and BMP-r...

journal_title：Developmental biology

authors： Liang J,Yu L,Yin J,Savage-Dunn C

更新日期：2007-05-15 00:00:00

abstract：:In this study, we demonstrate the developmental activation, in the zebrafish embryo, of a surveillance mechanism which triggers apoptosis to remove damaged cells. We determine the time course of activation of this mechanism by exposing embryos to camptothecin, an agent which specifically inhibits topoisomerase I withi...

journal_title：Developmental biology

authors： Ikegami R,Hunter P,Yager TD

更新日期：1999-05-15 00:00:00

abstract：:We recently demonstrated a critical role for two-pore channel type 2 (TPC2)-mediated Ca2+ release during the differentiation of slow (skeletal) muscle cells (SMC) in intact zebrafish embryos, via the introduction of a translational-blocking morpholino antisense oligonucleotide (MO). Here, we extend our study and demon...

journal_title：Developmental biology

authors： Kelu JJ,Webb SE,Parrington J,Galione A,Miller AL

更新日期：2017-05-15 00:00:00

abstract：:Drosophila thoracic muscles are comprised of both direct flight muscles (DFMs) and indirect flight muscles (IFMs). The IFMs can be further subdivided into dorsolongitudinal muscles (DLMs) and dorsoventral muscles (DVMs). The correct patterning of each category of muscles requires the coordination of specific executive...

journal_title：Developmental biology

authors： Bernard F,Lalouette A,Gullaud M,Jeantet AY,Cossard R,Zider A,Ferveur JF,Silber J

更新日期：2003-08-15 00:00:00

abstract：:The location and movement of mammalian gut tissue progenitors, prior to the expression of tissue-specific genes, has been unknown, but this knowledge is essential to identify transitions that lead to cell type specification. To address this, we used vital dyes to label exposed anterior endoderm cells of early somite s...

journal_title：Developmental biology

authors： Tremblay KD,Zaret KS

更新日期：2005-04-01 00:00:00

abstract：:During early vertebrate development, members of the transforming growth factor beta (TGFbeta) family play important roles in a variety of processes, including germ layer specification, patterning, cell differentiation, migration, and organogenesis. The activities of TGFbetas need to be tightly controlled to ensure the...

journal_title：Developmental biology

authors： Chang C,Eggen BJ,Weinstein DC,Brivanlou AH

更新日期：2003-03-01 00:00:00

abstract：:A small number of signaling pathways are used repeatedly during organogenesis, and they can have drastically different effects on the same population of cells depending on the embryonic stage. How cellular competence changes over developmental time is not well understood. Here we used Xenopus, mouse, and human pluripo...

journal_title：Developmental biology

authors： Rankin SA,McCracken KW,Luedeke DM,Han L,Wells JM,Shannon JM,Zorn AM

更新日期：2018-02-01 00:00:00

abstract：:Changes in gene regulatory networks are a major engine for creating developmental novelty during evolution. Conversely, regulatory linkages that survive for very long evolutionary periods might be characteristic of ancient and abstract functions of fundamental utility to all metazoans. The proneural genes, which encod...

journal_title：Developmental biology

authors： Rebeiz M,Stone T,Posakony JW

更新日期：2005-05-15 00:00:00

abstract：:The definitive feature of the many thousand cis-regulatory control modules in an animal genome is their information processing capability. These modules are "wired" together in large networks that control major processes such as development; they constitute "genomic computers." Each control module receives multiple in...

journal_title：Developmental biology

authors： Istrail S,De-Leon SB,Davidson EH

更新日期：2007-10-15 00:00:00

abstract：:Concentration of mast-cell precursors in hematopoietic tissues of mouse embryos was evaluated by a limiting dilution method. Cells from yolk sacs, livers, and bodies of (WB x C57BL/6)F1 (hereafter called WBB6F1)- +/+ embryos were injected directly into the skin of adult WBB6F1-W/Wv mice which were genetically depleted...

journal_title：Developmental biology

authors： Sonoda T,Hayashi C,Kitamura Y

更新日期：1983-05-01 00:00:00