CnNK-2, an NK-2 homeobox gene, has a role in patterning the basal end of the axis in hydra.

abstract：:POSH (Plenty of SH3s) has distinct roles as a scaffold for specific c-Jun N-terminal kinase (JNK) signaling modules and as an E3 ubiquitin ligase. The physiological function of POSH remains unclear, however, and its possible involvement in developmental processes motivated the present study wherein the Xenopus ortholo...

journal_title：Developmental biology

authors： Kim GH,Park E,Han JK

更新日期：2005-10-01 00:00:00

abstract：:It is well established that the notochord influences the development of adjacent neural and mesodermal tissue. Involvement of the notochord in the differentiation of the dorsal pancreas has been demonstrated. However, our knowledge of the signals involved in pancreatic development is still incomplete. In order to iden...

journal_title：Developmental biology

authors： Stephan JP,Bald L,Roberts PE,Lee J,Gu Q,Mather JP

更新日期：1999-08-15 00:00:00

abstract：:We present evidence to show that differentiation in wing cells to produce hairs is synchronous over the distal 90% of the wing surface (approximately 28,000 cells). In spite of this synchrony within such a large area a temporal gradient exists between zones (in general anterior to posterior) on the animal surface with...

journal_title：Developmental biology

authors： Mitchell HK,Petersen NS

更新日期：1983-02-01 00:00:00

abstract：:Breaking symmetry in populations of uniform cells, to induce adoption of an alternative cell fate, is an essential developmental mechanism. Similarly, domain and boundary establishment are crucial steps to forming organs during development. Notch signaling is a pathway ideally suited to mediating precise patterning cu...

journal_title：Developmental biology

authors： Sjöqvist M,Andersson ER

更新日期：2019-03-01 00:00:00

abstract：:Large steady electrical currents traverse Drosophila follicles in vitro as well as permeabilized eggs. During the period of main follicle growth (stages 9-11), these currents enter the anterior or nurse cell end of the follicles. This inward current acts like a sodium ion influx with some calcium involvement. During t...

journal_title：Developmental biology

authors： Overall R,Jaffe LF

更新日期：1985-03-01 00:00:00

abstract：:Genome integrity in the developing germ line is strictly required for fecundity. In proliferating somatic cells and in germ cells, there are mitotic checkpoint mechanisms that ensure accurate chromosome segregation and euploidy. There is growing evidence of mitotic cell cycle components that are uniquely required in t...

journal_title：Developmental biology

authors： Czechanski A,Kim H,Byers C,Greenstein I,Stumpff J,Reinholdt LG

更新日期：2015-06-15 00:00:00

abstract：:Planarians are well-known for their exceptional regenerative abilities. This investigation focuses on the involvement of a Y-box protein, defined by the presence of a cold-shock domain, in regeneration-specific processes. Previous studies have shown that developmentally expressed Y-box proteins bind to mRNA molecules ...

journal_title：Developmental biology

authors： Salvetti A,Batistoni R,Deri P,Rossi L,Sommerville J

更新日期：1998-09-15 00:00:00

abstract：:Connective tissue outgrowths of neonatal muscle onto a substratum of bone matrix differentiate into cartilage in response to a bone morphogenetic protein (BMP). The BMP can be separated from bone matrix by extraction with 4 M guanidine hydrochloride (GuHCl) or degraded in situ by endogenous proteolytic enzymes to deac...

journal_title：Developmental biology

authors： Kawamura M,Urist MR

更新日期：1988-12-01 00:00:00

abstract：:Tube formation is a widespread process during organogenesis. Specific cellular behaviors participate in the invagination of epithelial monolayers that form tubes. However, little is known about the evolutionary mechanisms of cell assembly into tubes during development. In Caenorhabditis elegans, the detailed step-to-s...

journal_title：Developmental biology

authors： Kolotuev I,Podbilewicz B

更新日期：2004-02-15 00:00:00

abstract：:Complement components have been implicated in a wide variety of functions including neurogenesis, proliferation, cell migration, differentiation, cancer, and more recently early development and regeneration. Following our initial observations indicating that C3a/C3aR signaling induces chick retina regeneration, we ana...

journal_title：Developmental biology

authors： Grajales-Esquivel E,Luz-Madrigal A,Bierly J,Haynes T,Reis ES,Han Z,Gutierrez C,McKinney Z,Tzekou A,Lambris JD,Tsonis PA,Del Rio-Tsonis K

更新日期：2017-08-01 00:00:00

abstract：:Myoblasts of the L6 rat cell line were grown in Ham's F12 nutrient medium containing 10% fetal calf serum (F12 + FCS). Although the cells were confluent by 6 days in culture, fusion was not observed even if cultures were maintained for 10-14 days. At least 80% of the cells in such confluent unfused cultures were in th...

journal_title：Developmental biology

authors： Pinset C,Whalen RG

更新日期：1984-04-01 00:00:00

abstract：:Superior cervical ganglia of postnatal mice with a targeted disruption of the gene for neurotrophin-3 have 50% fewer neurons than those of wild-type mice. In culture, neurotrophin-3 increases the survival of proliferating sympathetic precursors. Both precursor death (W. ElShamy et al., 1996, Development 122, 491-500) ...

journal_title：Developmental biology

authors： Francis N,Farinas I,Brennan C,Rivas-Plata K,Backus C,Reichardt L,Landis S

更新日期：1999-06-15 00:00:00

abstract：:The proper removal of superfluous neurons through apoptosis and subsequent phagocytosis is essential for normal development of the central nervous system (CNS). During Drosophila embryogenesis, a large number of apoptotic neurons are efficiently engulfed and degraded by phagocytic glia. Here we demonstrate that glial ...

journal_title：Developmental biology

authors： Shklyar B,Sellman Y,Shklover J,Mishnaevski K,Levy-Adam F,Kurant E

更新日期：2014-09-15 00:00:00

abstract：:The origin of resident (noninflammatory) macrophages in vertebrate tissues is still poorly understood. In the zebrafish embryo, we recently described a specific lineage of early macrophages that differentiate in the yolk sac before the onset of blood circulation. We now show that these early macrophages spread in the ...

journal_title：Developmental biology

authors： Herbomel P,Thisse B,Thisse C

更新日期：2001-10-15 00:00:00

abstract：:Oocyte maturation (meiosis reinitiation) in starfish is induced by the natural hormone 1-methyladenine (1-MeAde). Oocytes of Evasterias troschelii contain 0.43 pmole cyclic AMP/mg protein and 0.47 pmole cyclic GMP/mg protein. Upon stimulation by 1-MeAde the oocytes undergo a moderate (10-30%) decrease in their cAMP co...

journal_title：Developmental biology

authors： Meijer L,Zarutskie P

更新日期：1987-06-01 00:00:00

abstract：:We have examined the presence of protein kinase C in oocytes of Chaetopterus pergamentaceus and its role in the initiation of germinal vesicle breakdown (GVBD). First, we demonstrated that the oocytes contain a phospholipid- and calcium-dependent protein kinase, protein kinase C (PKC). Since PKC is the primary intrace...

journal_title：Developmental biology

authors： Eckberg WR,Palazzo RE

更新日期：1992-02-01 00:00:00

abstract：:GATA4, a transcription factor expressed in the proximal small intestine but not in the distal ileum, maintains proximal-distal distinctions by multiple processes involving gene repression, gene activation, and cell fate determination. Friend of GATA (FOG) is an evolutionarily conserved family of cofactors whose member...

journal_title：Developmental biology

authors： Beuling E,Bosse T,aan de Kerk DJ,Piaseckyj CM,Fujiwara Y,Katz SG,Orkin SH,Grand RJ,Krasinski SD

更新日期：2008-10-01 00:00:00

abstract：:Plants often display a high competence for regeneration under stress conditions. Signals produced in response to various types of stress serve as critical triggers for de novo organogenesis, but the identity of these signaling molecules underlying cellular reprogramming are largely unknown. We previously identified an...

journal_title：Developmental biology

authors： Iwase A,Mita K,Favero DS,Mitsuda N,Sasaki R,Kobayshi M,Takebayashi Y,Kojima M,Kusano M,Oikawa A,Sakakibara H,Saito K,Imamura J,Sugimoto K

更新日期：2018-10-01 00:00:00

abstract：:Foxg1 expression is highly restricted to the telencephalon and other head structures in the early embryo. This expression pattern has been exploited to generate conditional knockout mice, based on a widely used Foxg1-Cre knock-in line (Foxg1(tm1(cre)Skm)), in which the Foxg1 coding region was replaced by the Cre gene....

journal_title：Developmental biology

authors： Kawaguchi D,Sahara S,Zembrzycki A,O'Leary DDM

更新日期：2016-04-01 00:00:00

abstract：:Vertebrate pigment cells are derived from neural crest, a tissue that also forms most of the peripheral nervous system and a variety of ectomesenchymal cell types. Formation of pigment cells from multipotential neural crest cells involves a number of common developmental processes. Pigment cells must be specified; the...

journal_title：Developmental biology

authors： Kelsh RN,Schmid B,Eisen JS

更新日期：2000-09-15 00:00:00

abstract：:Hoxa-11 and Hoxd-11 are paralogous genes required for proper development of the vertebral column, the limbs, and the urogenital system. To further explore the functional relationship between these genes, as well as the potential rescue of one function by the other, we have introduced a Hoxd-11-expressing transgene int...

journal_title：Developmental biology

authors： Zákány J,Gérard M,Favier B,Potter SS,Duboule D

更新日期：1996-06-15 00:00:00

abstract：:This first study of the onset of spermatogenesis in the sea urchin, Strongylocentrotus purpuratus, was undertaken using individuals reared in the laboratory. Spermatogenesis commences about 11-12 months after metamorphosis in these animals. Bindin message accumulates in late spermatocytes and early spermatids which li...

journal_title：Developmental biology

authors： Cameron RA,Minor JE,Nishioka D,Britten RJ,Davidson EH

更新日期：1990-11-01 00:00:00

abstract：:Sm and Sm-like proteins are core components of the splicesome but have other functions distinct from pre-mRNA processing. Here, we show that Sm proteins also regulate germ cell specification during early C. elegans embryogenesis. SmE and SmG were required to maintain transcriptional quiescence in embryonic germ cell p...

journal_title：Developmental biology

authors： Barbee SA,Evans TC

更新日期：2006-03-01 00:00:00

abstract：:Optimal maturation of oocytes and successful development of preimplantation embryos is essential for reproduction. We performed DNA microarray analyses of ovarian transcripts and identified glial cell line-derived neurotrophic factor (GDNF) secreted by cumulus, granulosa, and theca cells as an ovarian factor stimulate...

journal_title：Developmental biology

authors： Kawamura K,Ye Y,Kawamura N,Jing L,Groenen P,Gelpke MS,Rauch R,Hsueh AJ,Tanaka T

更新日期：2008-03-01 00:00:00

abstract：:The insect head is composed of several segments. During embryonic development, the segments fuse to form a rigid head capsule where obvious segmental boundaries are lacking. Hence, the assignment of regions of the insect head to specific segments is hampered, especially with respect to dorsal (vertex) and lateral (gen...

journal_title：Developmental biology

authors： Posnien N,Bucher G

更新日期：2010-02-01 00:00:00

abstract：:Runx2-Cbfa1, a Runt transcription factor, plays important roles during skeletal development. It is required for differentiation and function of osteoblasts. In its absence, chondrocyte hypertrophy is severely impaired and there is no vascularization of cartilage templates during skeletal development. These tissue-spec...

journal_title：Developmental biology

authors： Wang W,Wang YG,Reginato AM,Glotzer DJ,Fukai N,Plotkina S,Karsenty G,Olsen BR

更新日期：2004-06-15 00:00:00

abstract：:The unfertilized oocyte contains various granules which serve as storage sites for proteins, the majority which are yolk granules or platelets. Yolk granules are thought to provide the developing embryo with nutrients essential for its survival, while other granules contain proteins such as enzymes and extracellular m...

journal_title：Developmental biology

authors： Reimer CL,Crawford BJ

更新日期：1995-02-01 00:00:00

abstract：:Drosophila thoracic muscles are comprised of both direct flight muscles (DFMs) and indirect flight muscles (IFMs). The IFMs can be further subdivided into dorsolongitudinal muscles (DLMs) and dorsoventral muscles (DVMs). The correct patterning of each category of muscles requires the coordination of specific executive...

journal_title：Developmental biology

authors： Bernard F,Lalouette A,Gullaud M,Jeantet AY,Cossard R,Zider A,Ferveur JF,Silber J

更新日期：2003-08-15 00:00:00

abstract：:The differentiation of three anterior pituitary cell types is regulated by the tissue-specific POU domain factor Pit-1, which is initially expressed on Embryonic Day 13.5-14 in mice. The Pit-1 gene remains continuously, highly expressed in the somatotrope, thyrotrope, and lactotrope cells of the adult. Using the Pit-1...

journal_title：Developmental biology

authors： DiMattia GE,Rhodes SJ,Krones A,Carrière C,O'Connell S,Kalla K,Arias C,Sawchenko P,Rosenfeld MG

更新日期：1997-02-01 00:00:00

abstract：:The GATA family of transcription factors are known to play multiple critical roles in vertebrate developmental processes, including erythropoiesis, endoderm formation and cardiogenesis. There have been no previous demonstrations of a functional role for any GATA family member being associated with musculoskeletal deve...

journal_title：Developmental biology

authors： Alexandrovich A,Qureishi A,Coudert AE,Zhang L,Grigoriadis AE,Shah AM,Brewer AC,Pizzey JA

更新日期：2008-02-15 00:00:00