The Pit-1 gene is regulated by distinct early and late pituitary-specific enhancers.

Abstract:

:The differentiation of three anterior pituitary cell types is regulated by the tissue-specific POU domain factor Pit-1, which is initially expressed on Embryonic Day 13.5-14 in mice. The Pit-1 gene remains continuously, highly expressed in the somatotrope, thyrotrope, and lactotrope cells of the adult. Using the Pit-1-defective Snell dwarf as a genetic background, we demonstrate that the Pit-1 gene utilizes distinct enhancers for initial gene activation and for subsequent autoregulation (required for maintenance of expression) and that Pit-1-dependent activation of the distal enhancer can be mediated in the absence of the early enhancer. These two distinct enhancers provide the basis for temporally specific regulation by discrete pituitary-specific factors, events likely to be prototypic for regulation of other classes of genes encoding transcription factors controlling terminal differentiation.

journal_name

Dev Biol

journal_title

Developmental biology

authors

DiMattia GE,Rhodes SJ,Krones A,Carrière C,O'Connell S,Kalla K,Arias C,Sawchenko P,Rosenfeld MG

doi

10.1006/dbio.1996.8472

subject

Has Abstract

pub_date

1997-02-01 00:00:00

pages

180-90

issue

1

eissn

0012-1606

issn

1095-564X

pii

S0012-1606(96)98472-9

journal_volume

182

pub_type

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