Abstract:
:Hoxa-11 and Hoxd-11 are paralogous genes required for proper development of the vertebral column, the limbs, and the urogenital system. To further explore the functional relationship between these genes, as well as the potential rescue of one function by the other, we have introduced a Hoxd-11-expressing transgene into Hoxa-11/Hoxd-11 mutant genetic backgrounds. A range of phenotypes was observed, with transgenic mice displaying as few as four lumbar vertebrae while double mutant mice had as many as eight. When transgenic, double homozygote mutant animals showed six lumbar vertebrae, instead of the eight usually observed. The phenotypic rescue of these genotypes shows that the Hoxa-11 and Hoxd-11 products are functionally equivalent and that extra doses of Hoxd-11 can rescue Hoxa-11 loss of function.
journal_name
Dev Bioljournal_title
Developmental biologyauthors
Zákány J,Gérard M,Favier B,Potter SS,Duboule Ddoi
10.1006/dbio.1996.0137subject
Has Abstractpub_date
1996-06-15 00:00:00pages
325-8issue
2eissn
0012-1606issn
1095-564Xpii
S0012-1606(96)90137-2journal_volume
176pub_type
杂志文章abstract::The serine/threonine kinase LKB1 is a master kinase that regulates a number of critical events such as cell transformation, polarization, development, stress response, and energy metabolism in metazoa. After multiple unsuccessful attempts of generating Dictyostelium lkb1-null cells, an RNAi-based knockdown approach pr...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2011.10.006
更新日期:2011-12-15 00:00:00
abstract::Development of the craniofacial structures requires the precise differentiation of cranial neural crest cells into osteoblasts or chondrocytes. Here, we explore the epigenetic and non-epigenetic mechanisms that are required for the development of craniofacial chondrocytes. We previously demonstrated that the acetyltra...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2020.05.006
更新日期:2020-08-01 00:00:00
abstract::Recombinant limb buds constructed of an ectodermal jacket containing dissociated anterior wing bud mesoderm cells form limb-like structures lacking anteroposterior polarity. Polarity can be restored by implanting a small piece of polarizing region into the recombinant limb. We used recombinant limbs to study expressio...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1994.1296
更新日期:1994-11-01 00:00:00
abstract::To gain an understanding of the genes and mechanisms that govern morphogenesis and its evolution, we have analyzed mutations that disrupt this process in a simple model structure, the male tail tip of the rhabditid nematode C. elegans. During the evolution of rhabditid male tails, there have been several independent c...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2006.04.472
更新日期:2006-09-01 00:00:00
abstract::Transcription factors are key orchestrators of the emergence of neuronal diversity within the developing spinal cord. As such, the two paralogous proteins Pax3 and Pax7 regulate the specification of progenitor cells within the intermediate neural tube, by defining a neat segregation between those fated to form motor c...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2017.06.014
更新日期:2017-12-01 00:00:00
abstract::Formation of the adenohypophysis in mammalian embryos occurs via an invagination of the oral ectoderm to form Rathke's pouch, which becomes exposed to opposing dorsoventral gradients of signaling proteins governing specification of the different hormone-producing pituitary cell types. One signal promoting pituitary ce...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/s0012-1606(02)00124-0
更新日期:2003-02-01 00:00:00
abstract::Homeotic genes in the Antennapedia Complex of Drosophila specify identity of the posterior head segments; the labial segment requires Sex combs reduced (Scr) for proper development, Deformed (Dfd) specifies maxillary and mandibular identity, and labial is necessary for intercalary segment identity. Although mutations ...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1996.0290
更新日期:1996-11-25 00:00:00
abstract::The ubiquitin-proteasome system is essential for intracellular protein degradation, but there are few studies of this system in the extracellular milieu. Recently, we reported that a 70-kDa sperm receptor, HrVC70, on the vitelline coat is ubiquitinated and then degraded by the sperm proteasome during fertilization of ...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2003.07.016
更新日期:2003-12-01 00:00:00
abstract::The MSP domain is a conserved immunoglobulin-like structure that is important for C. elegans reproduction and human motor neuron survival. C. elegans MSPs are the most abundant proteins in sperm, where they function as intracellular cytoskeletal proteins and secreted hormones. Secreted MSPs bind to multiple receptors ...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2010.03.026
更新日期:2010-06-01 00:00:00
abstract::This investigation provides the first systematic determination of the cellular and molecular progression of vocal fold (VF) epithelium development in a murine model. We define five principal developmental events that constitute the progression from VF initiation in the embryonic anterior foregut tube to fully differen...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2014.12.037
更新日期:2015-03-15 00:00:00
abstract::Three unrelated chromosome 2q14.1-14.2 region translocations caused the split hand/foot limb malformation development in humans by an unknown mechanism. Their etiology was described by the autosomal dominant inheritance with incomplete penetrance genetic model although authors stated, "the understanding of the genotyp...
journal_title:Developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.ydbio.2015.10.013
更新日期:2015-12-01 00:00:00
abstract::The nuclear lamina is an extensive protein network that underlies the inner nuclear envelope. This network includes the LAP2-emerin-MAN1-domain (LEM-D) protein family, proteins that share an association with the chromatin binding protein Barrier-to-autointegration factor (BAF). Loss of individual LEM-D proteins causes...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2016.05.001
更新日期:2016-07-01 00:00:00
abstract::Type II collagen is a major component of cartilage extracellular matrix. Differentiation of mesenchyme into cartilage involves the cessation of type I collagen synthesis and the onset of type II collagen synthesis. Solution hybridization of mRNA isolated from chick limb buds with a cDNA probe to type II collagen mRNA ...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(88)90057-7
更新日期:1988-01-01 00:00:00
abstract::Rho GTPases control signal transduction pathways that link cell surface receptors to a variety of intracellular responses. They are best known as regulators of the actin cytoskeleton, but in addition they control cell polarity, gene expression, microtubule dynamics and vesicular trafficking. Through these diverse func...
journal_title:Developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.ydbio.2003.06.003
更新日期:2004-01-01 00:00:00
abstract::Fertilized eggs of the leech Helobdella triserialis undergo a cytoplasmic reorganization which generates domains of nonyolky cytoplasm, called teloplasm, at the animal and vegetal poles. The segregation of teloplasm to one cell of the eight-cell embryo is responsible for a unique developmental fate of that cell, i.e.,...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(89)90181-4
更新日期:1989-10-01 00:00:00
abstract::This work has identified the enzymes involved in the activation and conjugation of the ubiquitin-like protein NED-8 in Caenorhabditis elegans. A C. elegans conjugating enzyme, UBC-12, is highly specific in its ability to utilize NED-8 as a substrate. Immunostaining shows that NED-8 is conjugated in vivo to a major tar...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.2000.9847
更新日期:2000-10-01 00:00:00
abstract::I report on the synthesis of fibronectin in the developing chick Müllerian duct mesenchymal cells. Before the differentiation of female chick Müllerian duct, the amount of fibronectin in the cells of the right duct is 44% lower than in the left duct. While after differentiation, the amount of fibronectin in the right ...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(90)90047-m
更新日期:1990-07-01 00:00:00
abstract::Although round spermatid injection can be used to create progeny for males who do not produce mature sperm, the rate of successful embryogenesis after such procedures is significantly lower than that for similar procedures using mature spermatozoa. The mechanisms underlying this difference are unknown. In this study, ...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2005.10.026
更新日期:2006-01-01 00:00:00
abstract::Drosophila Polycomb Repressive Complex 2 (PRC2) is a lysine methyltransferase that trimethylates histone H3 lysine 27 (H3K27me3), a modification essential for Polycomb silencing. Mutations in its catalytic subunit, E(Z), that abolish its methyltransferase activity disrupt Polycomb silencing, causing derepression of Po...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2011.12.007
更新日期:2012-04-15 00:00:00
abstract::The location, timing and intensity of Nodal signalling are all critical for proper patterning of the vertebrate embryo. Genetic evidence from mouse and zebrafish indicates that EGF-CFC family members are essential for Nodal ligands to signal. However, the Xenopus EGF-CFC, FRL1, has been implicated in Wnt signalling an...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2006.01.006
更新日期:2006-04-15 00:00:00
abstract::The shoot meristem generates all of the aerial structures of an adult plant. It is organized in three layers which produce the epidermis (L1 layer) and the subepidermal layers (L2 and L3). The origin of adult structures has previously been fate mapped to the primary meristem for L2 and L3 tissues. In this work we cons...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1996.0112
更新日期:1996-05-01 00:00:00
abstract::The human kidneys filter 180 l of blood every day via about 2.5 million glomeruli. The three layers of the glomerular filtration apparatus consist of fenestrated endothelium, specialized extracellular matrix known as the glomerular basement membrane (GBM) and the podocyte foot processes with their modified adherens ju...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2007.10.047
更新日期:2008-01-15 00:00:00
abstract::During early vertebrate development, ANF homeobox genes are expressed in the prospective forebrain. Their regulation is essential for correct morphogenesis and function of the prosencephalon. We identified a 1-kb fragment upstream of the chicken GANF gene sufficient to drive lacZ expression in the endogenous expressio...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2004.01.044
更新日期:2004-05-15 00:00:00
abstract::Genetic interactions regulating intermediate stages of tubulogenesis in the developing kidney have been difficult to define. A systems biology strategy using microarray was combined with in vitro/ex vivo and genetic approaches to identify pathways regulating specific stages of tubulogenesis. Analysis of the progressio...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2012.01.014
更新日期:2012-04-01 00:00:00
abstract::The scalloped and vestigial genes are both required for the formation of the Drosophila wing, and recent studies have indicated that they can function as a heterodimeric complex to regulate the expression of downstream target genes. We have analyzed the consequences of complete loss of scalloped function, ectopic expr...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.2000.9939
更新日期:2000-12-15 00:00:00
abstract::Bone Morphogenetic Proteins (BMPs) have multiple activities in the developing spinal cord: they specify the identity of the dorsal-most neuronal populations and then direct the trajectories of dorsal interneuron (dI) 1 commissural axons. How are these activities decoded by dorsal neurons to result in different cellula...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2012.05.014
更新日期:2012-07-15 00:00:00
abstract::Cadherin-11 (cad-11) is a novel member of the cadherin family of cell adhesion molecules, having recently been identified by means of the polymerase chain reaction. To study the function and expression of this molecule, we cloned mouse, cad-11 cDNA. Transfection of L cells with cDNA led them to acquire a typical cadhe...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1995.1149
更新日期:1995-05-01 00:00:00
abstract::A rapid, gentle technique is described for the isolation of nuclei from sea urchin embryos. Using this technique, we have analyzed the synthesis and accumulation of nonhistone nuclear proteins during sea urchin development by two-dimensional gel electrophoresis. Most nuclear proteins fall into one of three patterns of...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(87)90445-3
更新日期:1987-09-01 00:00:00
abstract::The forkhead genes encode a transcription factor involved in embryogenesis and pattern formation in multicellular organisms. They are mammalian transcriptional regulators that bind DNA as a monomer through their forkhead domain. The Foxf2 (LUN) mRNA is expressed in the mesenchyme directly adjacent to the ectoderm-deri...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/s0012-1606(03)00176-3
更新日期:2003-07-01 00:00:00
abstract::We have cloned a Caenorhabditis elegans homologue of the Drosophila gap gene hunchback (hb) and have designated it hbl-1 (hunchback-like). hbl-1 encodes a predicted 982-amino-acid protein, containing two putative zinc-finger domains similar to those of Drosophila Hunchback. The gene is transcribed embryonically, but u...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1998.9096
更新日期:1999-01-15 00:00:00