The role of HOM-C genes in segmental transformations: reexamination of the Drosophila Sex combs reduced embryonic phenotype.

abstract：:How natural variation in embryo size affects patterning of the Drosophila embryo dorsal-ventral (DV) axis is not known. Here we examined quantitatively the relationship between nuclear distribution of the Dorsal transcription factor, boundary positions for several target genes, and DV axis length. Data were obtained f...

journal_title：Developmental biology

authors： Garcia M,Nahmad M,Reeves GT,Stathopoulos A

更新日期：2013-09-01 00:00:00

abstract：:We have cloned a partial cDNA of chicken glial cell line-derived neurotrophic factor (GDNF) and systematically examined its expression pattern as well as that of GDNF-binding components (GDNF family receptor alpha-1 and 2: GFRalpha-1 and 2) and a common signal transduction receptor (c-ret protooncogene: RET) during ve...

journal_title：Developmental biology

authors： Homma S,Oppenheim RW,Yaginuma H,Kimura S

更新日期：2000-01-01 00:00:00

abstract：:We show that the intermediate filament protein nestin is expressed in myogenic cells and that multiple mechanisms regulate nestin expression at different stages of myogenesis. Cultured embryonic, fetal, and neonatal mouse limb myoblasts initially expressed nestin in the absence of the four muscle regulatory factors (M...

journal_title：Developmental biology

authors： Kachinsky AM,Dominov JA,Miller JB

更新日期：1994-09-01 00:00:00

abstract：:During mouse fertilization the spermatozoon induces a series of low-frequency long-lasting Ca(2+) oscillations. It is generally accepted that these oscillations are due to Ca(2+) release through the inositol 1,4,5-trisphosphate (InsP(3)) receptor. However, InsP(3) microinjection does not mimic sperm-induced Ca(2+) osc...

journal_title：Developmental biology

authors： Jones KT,Nixon VL

更新日期：2000-09-01 00:00:00

abstract：:It has been difficult to examine the role of TGF-ß in post-natal tooth development due to perinatal lethality in many of the signaling deficient mouse models. To address the role of Tgfbr2 in postnatal tooth development, we generated a mouse in which Tgfbr2 was deleted in odontoblast- and bone-producing mesenchyme. Os...

journal_title：Developmental biology

authors： Wang Y,Cox MK,Coricor G,MacDougall M,Serra R

更新日期：2013-10-01 00:00:00

abstract：:Development of the Drosophila embryonic midgut is dependent on a number of genes, including tinman and bagpipe, which are required for formation of the visceral mesoderm, and the homeotic genes and their targets, which act locally in the visceral mesoderm to direct formation of specific midgut constrictions. Here we r...

journal_title：Developmental biology

authors： Cimbora DM,Sakonju S

更新日期：1995-06-01 00:00:00

abstract：:The NCK adaptor proteins are composed entirely of SH3 and SH2 domains and serve as protein interaction bridges for several receptors during signal transduction events. Here we report the molecular and genetic analysis of the Caenorhabditis elegans nck-1 gene. C. elegans nck-1 encodes two isoforms: NCK-1A and a shorter...

journal_title：Developmental biology

authors： Mohamed AM,Chin-Sang ID

更新日期：2011-06-01 00:00:00

abstract：:Morphogenesis of the anterior metatarsal skin (scutate scale region), from 9.5 to 12 days of development, results in the formation of orderly patterned scale ridges. It is after the initial formation of the Definitive Scale Ridge that the characteristic outer and inner epidermal surfaces differentiate. The hard, plate...

journal_title：Developmental biology

authors： Shames RB,Jennings AG,Sawyer RH

更新日期：1991-09-01 00:00:00

abstract：:This investigation provides the first systematic determination of the cellular and molecular progression of vocal fold (VF) epithelium development in a murine model. We define five principal developmental events that constitute the progression from VF initiation in the embryonic anterior foregut tube to fully differen...

journal_title：Developmental biology

authors： Lungova V,Verheyden JM,Herriges J,Sun X,Thibeault SL

更新日期：2015-03-15 00:00:00

abstract：:Chromatin structure plays an important role in the regulation of gene expression. Methylation of lysine residues on histone tails is an epigenetic mark that influences chromatin repression when specifically imparted on lysines 9 and 27 of histone H3, and on lysine 20 of H4. Histone lysines can be mono-, di-, and trime...

journal_title：Developmental biology

authors： Payne C,Braun RE

更新日期：2006-05-15 00:00:00

abstract：:Integrins are expressed on the surface of some vertebrate eggs where they are thought to have a role in fertilization. The objective of this study is to determine if integrins are expressed on sea urchin eggs. The alphaB and betaC subunits were cloned using the homology polymerase chain reaction. Monoclonal and polycl...

journal_title：Developmental biology

authors： Murray G,Reed C,Marsden M,Rise M,Wang D,Burke RD

更新日期：2000-11-15 00:00:00

abstract：:Hox genes encode transcription factors which provide positional information during morphogenesis along the body axis; genetic interaction among Hox genes is thought to be necessary for correct pattern formation. One of the most curious features of the 39 vertebrate Hox genes is that they form four clusters each compos...

journal_title：Developmental biology

authors： Suemori H,Noguchi S

更新日期：2000-04-15 00:00:00

abstract：:Three different null alleles of the myogenic bHLH gene MRF4/herculin/Myf-6 were created recently. The three alleles were similar in design but were surprisingly different in the intensity of their phenotypes, which ranged from complete viability of homozygotes to complete lethality. One possible explanation for these ...

journal_title：Developmental biology

authors： Yoon JK,Olson EN,Arnold HH,Wold BJ

更新日期：1997-08-15 00:00:00

abstract：:The mammalian kidney consists of an array of tubules connected to a ductal system that collectively function to control water/salt balance and to remove waste from the organisms' circulatory system. During mammalian embryogenesis, three kidney structures form within the intermediate mesoderm. The two most anterior str...

journal_title：Developmental biology

authors： Mugford JW,Sipilä P,Kobayashi A,Behringer RR,McMahon AP

更新日期：2008-07-15 00:00:00

abstract：:Cell-cell fusion is a fundamental cellular process that is essential for development as well as fertilization. Myoblast fusion to form multinucleated skeletal muscle myotubes is a well studied, yet incompletely understood example of cell-cell fusion that is essential for formation of contractile skeletal muscle tissue...

journal_title：Developmental biology

authors： Duan R,Gallagher PJ

更新日期：2009-01-15 00:00:00

abstract：:Caudal homeobox genes are found across animals, typically linked to two other homeobox genes in what has been called the ParaHox cluster. These genes have been proposed to pattern the anterior-posterior axis of the endoderm ancestrally, but the expression of Caudal in extant groups is varied and often occurs in other ...

journal_title：Developmental biology

authors： Johnson AB,Lambert JD

更新日期：2021-02-01 00:00:00

abstract：:The Xenopus helix-loop-helix transcription factor Hairy2 is essential for neural crest progenitor survival and maintains cells in a mitotic undifferentiated pre-neural crest state. However, its mode of action remains largely unknown. Here we show that a Hairy2 DNA-binding mutant is unable to promote cell survival and ...

journal_title：Developmental biology

authors： Nichane M,Ren X,Souopgui J,Bellefroid EJ

更新日期：2008-10-15 00:00:00

abstract：:Auxin is implicated throughout plant growth and development. Although the effects of this plant hormone have been recognized for more than a century, it is only in the past two decades that light has been shed on the molecular mechanisms that regulate auxin homeostasis, signaling, transport, crosstalk with other hormo...

journal_title：Developmental biology

authors： Finet C,Jaillais Y

更新日期：2012-09-01 00:00:00

abstract：:The patterns of myosin heavy chain (MyHC) isoform expression in the embryo and in the adult mouse are reasonably well characterized and quite distinct. However, little is known about the transition between these two states, which involves major decreases and increases in the expression of several MyHC genes. In the pr...

journal_title：Developmental biology

authors： Allen DL,Leinwand LA

更新日期：2001-01-15 00:00:00

abstract：:Cis-regulatory modules (CRMs) control spatiotemporal gene expression patterns in embryos. While measurement of quantitative CRM activities has become efficient, measurement of spatial CRM activities still relies on slow, one-by-one methods. To overcome this bottleneck, we have developed a high-throughput method that c...

journal_title：Developmental biology

authors： Guay CL,McQuade ST,Nam J

更新日期：2017-02-15 00:00:00

abstract：:The source of neurite outgrowth in explant cultures of normal adult Apteronotus spinal cord was examined. Explants which contained the central region of spinal cord, including ependyma, showed neurite outgrowth in culture. Explants which did not contain ependyma showed no neurite outgrowth. It is concluded that the ep...

journal_title：Developmental biology

authors： Anderson MJ,Waxman SG,Fong HL

更新日期：1987-02-01 00:00:00

abstract：:We have investigated the sequential changes of acetylcholine receptor (AChR) distribution on identified Xenopus laevis muscle cells in culture before and after innervation. AChRs on muscle cells were stained with tetramethylrhodamine-conjugated alpha-bungarotoxin and the distribution of AChR clusters was examined on a...

journal_title：Developmental biology

authors： Kuromi H,Kidokoro Y

更新日期：1984-05-01 00:00:00

abstract：:AKT signaling is an essential intracellular pathway controlling cell homeostasis, cell proliferation and survival, as well as cell migration and differentiation in adults. Alterations impacting the AKT pathway are involved in many pathological conditions in human disease. Similarly, during development, multiple transm...

journal_title：Developmental biology

authors： Sittewelle M,Monsoro-Burq AH

更新日期：2018-12-01 00:00:00

abstract：:Angiogenesis relies on specialized endothelial tip cells to extend toward guidance cues in order to direct growing blood vessels. Although many of the signaling pathways that control this directional endothelial sprouting are well known, the specific cellular mechanisms that mediate this process remain to be fully elu...

journal_title：Developmental biology

authors： Yang H,Fang L,Zhan R,Hegarty JM,Ren J,Hsiai TK,Gleeson JG,Miller YI,Trejo J,Chi NC

更新日期：2015-08-15 00:00:00

abstract：:The unc-52 gene of Claenorhabditis elegans encodes a homologue of the basement membrane heparan sulfate proteoglycan perlecan. Viable alleles reduce the abundance of UNC-52 in late larval stages and increase the frequency of distal tip cell (DTC) migration defects caused by mutations disrupting the UNC-6/netrin guidan...

journal_title：Developmental biology

authors： Merz DC,Alves G,Kawano T,Zheng H,Culotti JG

更新日期：2003-04-01 00:00:00

abstract：:Two populations of blastomeres become positionally distinct during fourth cleavage in the mouse embryo; the inner cells become enclosed within the embryo and the outer cells form the enclosing layer. The segregation of these two cell populations is important for later development, because it represents the initial ste...

journal_title：Developmental biology

authors： Sutherland AE,Speed TP,Calarco PG

更新日期：1990-01-01 00:00:00

abstract：:Despite undergoing normal development and acquiring normal morphology and motility, mutations in spe-38 or trp-3/spe-41 cause identical phenotypes in Caenorhabditis elegans-mutant sperm fail to fertilize oocytes despite direct contact. SPE-38 is a novel, four-pass transmembrane protein and TRP-3/SPE-41 is a Ca(2+)-per...

journal_title：Developmental biology

authors： Singaravelu G,Chatterjee I,Rahimi S,Druzhinina MK,Kang L,Xu XZ,Singson A

更新日期：2012-05-15 00:00:00

abstract：:We have examined the interfaces between protein and lipid sulfation, the response of progenitor cells to specific growth factors, and developmental lineage progression. The experimental system used is the oligodendrocyte (OL), the cell responsible for myelination of axons in the central nervous system. The ability to ...

journal_title：Developmental biology

authors： Bansal R,Pfeiffer SE

更新日期：1994-04-01 00:00:00

abstract：:Spinal cord regenerative ability is lost with development, but the mechanisms underlying this loss are still poorly understood. In chick embryos, effective regeneration does not occur after E13, when spinal cord injury induces extensive apoptotic response and tissue damage. As initial experiments showed that treatment...

journal_title：Developmental biology

authors： Lange S,Gögel S,Leung KY,Vernay B,Nicholas AP,Causey CP,Thompson PR,Greene ND,Ferretti P

更新日期：2011-07-15 00:00:00

abstract：:The commitment and differentiation of the alveolar type I (AT1) cell lineage is a critical step for the formation of distal lung saccules, which are the primitive alveolar units required for postnatal respiration. How AT1 cells arise from the distal lung epithelial progenitor cells prior to birth and whether this proc...

journal_title：Developmental biology

authors： Wang X,Wang Y,Snitow ME,Stewart KM,Li S,Lu M,Morrisey EE

更新日期：2016-06-15 00:00:00