Abstract：
:Two populations of blastomeres become positionally distinct during fourth cleavage in the mouse embryo; the inner cells become enclosed within the embryo and the outer cells form the enclosing layer. The segregation of these two cell populations is important for later development, because it represents the initial step in the divergence of placental and fetal lineages. The mechanism by which the inner cells become allocated has been thought to involve the oriented division of polarized 8-cell blastomeres, but this has never been examined in the intact embryo. By using the technique of time-lapse cinemicrography, we have been able for the first time to directly examine the division planes of 8-cell blastomeres during fourth cleavage, and find that there are three, rather than two, major division plane orientations; anticlinal (perpendicular to the outer surface of the blastomere), periclinal (parallel to the outer surface of the blastomere), and oblique (at an angle between the other two). The observed frequencies of each type of division plane orientation provide evidence that the inner cells of the morula must derive from oriented division of 8-cell blastomeres, in accordance with the polarization hypothesis. Analysis of fourth cleavage division plane orientation with respect to either lineage or division order reveals that it is not associated with lineage from either the 2- or the 4-cell stage, but has a slight statistical association with fourth cleavage division order. The lack of association between division plane orientation and lineage supports the prediction that packing patterns and intercellular interactions within the 8-cell embryo during compaction play a role in determining fourth cleavage division plane orientation and thus, the positional fate of the daughter 16-cell blastomeres.
journal_name
Dev Bioljournal_title
Developmental biologyauthors
Sutherland AE,Speed TP,Calarco PGdoi
10.1016/0012-1606(90)90003-2subject
Has Abstractpub_date
1990-01-01 00:00:00pages
13-25issue
1eissn
0012-1606issn
1095-564Xpii
0012-1606(90)90003-2journal_volume
137pub_type
杂志文章abstract：:Thyroid hormone deficiency is known to deeply affect cerebellum post-natal development. We present here a detailed analysis of the phenotype of a recently generated mouse model, expressing a dominant-negative TRα1 mutation. Although hormonal level is not affected, the cerebellum of these mice displays profound alterat...
journal_title：Developmental biology
pub_type： 杂志文章
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更新日期：2011-08-15 00:00:00
abstract：:Pulses of ecdysteroids induce dramatic changes in gene expression that direct the early stages of Drosophila metamorphosis. This gene activity is reflected by the appearance of early and late puffs in the salivary gland polytene chromosomes. Curiously, the early puff genes that have been studied to date are induced by...
journal_title：Developmental biology
pub_type： 杂志文章
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更新日期：1995-09-01 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/0012-1606(85)90009-0
更新日期：1985-03-01 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1006/dbio.1995.1015
更新日期：1995-01-01 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章
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journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/0012-1606(92)90108-s
更新日期：1992-10-01 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章
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更新日期：1984-02-01 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/0012-1606(92)90294-q
更新日期：1992-02-01 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章
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更新日期：2005-09-01 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章
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更新日期：2015-09-01 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章
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更新日期：2019-11-01 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章
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更新日期：2013-09-01 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/j.ydbio.2019.07.004
更新日期：2019-11-15 00:00:00
abstract：:The sizes of amino acid pools in growing Xenopus laevis oocytes have been measured. The total free amino acid content per oocyte increases nearly 25-fold during oocyte growth. Together, glutamic acid and aspartic acid account for approximately 59-75% of the total amino acid pool in Xenopus oocytes. On the other hand, ...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/0012-1606(87)90480-5
更新日期：1987-11-01 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/j.ydbio.2006.01.006
更新日期：2006-04-15 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/0012-1606(86)90372-6
更新日期：1986-09-01 00:00:00
abstract：:Myogenesis in the embryo and the adult mammal consists of a highly organized and regulated sequence of cellular processes to form or repair muscle tissue that include cell proliferation, migration, and differentiation. Data from cell culture and in vivo experiments implicate both FGFs and HGF as critical regulators of...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1006/dbio.2001.0416
更新日期：2001-11-01 00:00:00
abstract：:Notch pathway is crucial for stem/progenitor cell maintenance, growth and differentiation in a variety of tissues. Using a transgenic cell ablation approach, we found in our previous study that cells expressing Notch1 are crucial for prostate early development and re-growth. Here, we further define the role of Notch s...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/j.ydbio.2005.11.009
更新日期：2006-02-01 00:00:00
abstract：:Vertebrate morphology has been evolutionarily modified by natural and/or artificial selection. The morphological variation of goldfish is a representative example. In particular, the twin-tail strain of ornamental goldfish shows highly diverged anal and caudal fin morphology: bifurcated anal and caudal fins. Recent mo...
journal_title：Developmental biology
pub_type： 杂志文章,评审
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更新日期：2017-07-15 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章
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更新日期：1983-07-01 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章
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更新日期：1987-06-01 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/j.ydbio.2005.04.032
更新日期：2005-07-15 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章
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更新日期：1995-07-01 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章
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更新日期：2009-12-15 00:00:00
abstract：:Previous study of the development of the levator ani muscle (LA) revealed that the sex difference in muscle fiber number is under the control of testosterone during the perinatal period. In this study, the development of the LA muscle was examined in both sexes to test the hypothesis that testosterone action determine...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1006/dbio.1994.1070
更新日期：1994-03-01 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/j.ydbio.2007.08.029
更新日期：2007-11-15 00:00:00
abstract：:Progression of germ cells through meiosis is regulated by phosphorylation events. We previously showed the key role of cyclin dependent kinases in meiotic divisions of rat spermatocytes co-cultured with Sertoli cells (SC). In the present study, we used the same culture system to address the role of mitogen-activated p...
journal_title：Developmental biology
pub_type： 杂志文章
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更新日期：2008-03-01 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章
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更新日期：2002-07-01 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章
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更新日期：2017-12-15 00:00:00
abstract：:During early vertebrate development, ANF homeobox genes are expressed in the prospective forebrain. Their regulation is essential for correct morphogenesis and function of the prosencephalon. We identified a 1-kb fragment upstream of the chicken GANF gene sufficient to drive lacZ expression in the endogenous expressio...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/j.ydbio.2004.01.044
更新日期：2004-05-15 00:00:00
