UNC-52/perlecan affects gonadal leader cell migrations in C. elegans hermaphrodites through alterations in growth factor signaling.

abstract：:Neural crest cells migrate along two pathways in the trunk: the ventral path, between the neural tube and somite, and the dorsolateral path, between the somite and overlying ectoderm. In avian embryos, ventral migration precedes dorsolateral migration by nearly 24 h, and the onset of dorsolateral migration coincides w...

journal_title：Developmental biology

authors： Reedy MV,Faraco CD,Erickson CA

更新日期：1998-08-15 00:00:00

abstract：:The Rho family of small GTPases has been implicated in many neurological disorders including mental retardation, but whether they are involved in primary microcephaly (microcephalia vera) is unknown. Here, we examine the role of Rac1 in mammalian neural progenitors and forebrain development by a conditional gene-targe...

journal_title：Developmental biology

authors： Chen L,Melendez J,Campbell K,Kuan CY,Zheng Y

更新日期：2009-01-01 00:00:00

abstract：:The epidermis forms a vital barrier composed of stratified keratinocytes and their differentiated products. One of these products, keratin K10, is critical to epidermal integrity, because mutations in k10 lead to abnormal blistering. For the normal expression of k10, differentiation-associated transcription factors C/...

journal_title：Developmental biology

authors： Maytin EV,Lin JC,Krishnamurthy R,Batchvarova N,Ron D,Mitchell PJ,Habener JF

更新日期：1999-12-01 00:00:00

abstract：:Satellite cells, also known as muscle stem cells, are responsible for skeletal muscle growth and repair in mammals. Pax7 and Pax3 transcription factors are established satellite cell markers required for muscle development and regeneration, and there is great interest in identifying additional factors that regulate sa...

journal_title：Developmental biology

authors： Berberoglu MA,Gallagher TL,Morrow ZT,Talbot JC,Hromowyk KJ,Tenente IM,Langenau DM,Amacher SL

更新日期：2017-04-15 00:00:00

abstract：:Plant growth and development are driven by extended phases of irreversible cell expansion generating cells that increase in volume from 10- to 100-fold. Some specialized cell types define cortical sites that reinitiate polarized growth and generate branched cell morphology. This structural specialization of individual...

journal_title：Developmental biology

authors： Li J,Kim T,Szymanski DB

更新日期：2019-07-01 00:00:00

abstract：:In studies initially focused on roles of nonmuscle myosin IIA (NMIIA) in the developing mouse epidermis, we have discovered that a previously described cytokeratin 5 (K5)-Cre gene construct is expressed in early embryo development. Mice carrying floxed alleles of the nonmuscle myosin II heavy chain gene (NMHC IIA(flox...

journal_title：Developmental biology

authors： Crish J,Conti MA,Sakai T,Adelstein RS,Egelhoff TT

更新日期：2013-10-01 00:00:00

abstract：:Islet1 (Isl1) is a LIM homedomain protein that plays a pivotal role in cardiac progenitors of the second heart field. Here, lineage studies with an inducible isl1-cre demonstrated that most Isl1 progenitors have migrated into the heart by E9. Although Isl1 expression is downregulated in most cardiac progenitors as the...

journal_title：Developmental biology

authors： Sun Y,Liang X,Najafi N,Cass M,Lin L,Cai CL,Chen J,Evans SM

更新日期：2007-04-01 00:00:00

abstract：:The molecular and cellular mechanism for clearance of dead neurons was explored in the developing Drosophila optic lobe. During development of the optic lobe, many neural cells die through apoptosis, and corpses are immediately removed in the early pupal stage. Most of the cells that die in the optic lobe are young ne...

journal_title：Developmental biology

authors： Nakano R,Iwamura M,Obikawa A,Togane Y,Hara Y,Fukuhara T,Tomaru M,Takano-Shimizu T,Tsujimura H

更新日期：2019-09-01 00:00:00

abstract：:Growth and Differentiation Factor 1 (GDF-1) has been implicated in left-right patterning of the mouse embryo but has no other known function. Here, we demonstrate a genetic interaction between Gdf1 and Nodal during anterior axis development. Gdf1-/-;Nodal+/- mutants displayed several abnormalities that were not presen...

journal_title：Developmental biology

authors： Andersson O,Reissmann E,Jörnvall H,Ibáñez CF

更新日期：2006-05-15 00:00:00

abstract：:The definitive feature of the many thousand cis-regulatory control modules in an animal genome is their information processing capability. These modules are "wired" together in large networks that control major processes such as development; they constitute "genomic computers." Each control module receives multiple in...

journal_title：Developmental biology

authors： Istrail S,De-Leon SB,Davidson EH

更新日期：2007-10-15 00:00:00

abstract：:Epithelial sheet movement is an essential morphogenetic process during mouse embryonic eyelid closure in which Mitogen-Activated Protein 3 Kinase 1 (MAP3K1) and c-Jun play a critical role. Here we show that MAP3K1 associates with the cytoskeleton, activates Jun N-terminal kinase (JNK) and actin polymerization, and pro...

journal_title：Developmental biology

authors： Meng Q,Mongan M,Wang J,Tang X,Zhang J,Kao W,Xia Y

更新日期：2014-11-01 00:00:00

abstract：:Notch signaling inhibits hair cell differentiation, based on studies on mice deficient in Notch signaling-related genes and its downstream genes. However, the precise mechanisms of this inhibition are unknown because it is difficult to control the timing and duration of the suppression of Notch signaling. Here, we dev...

journal_title：Developmental biology

authors： Takebayashi S,Yamamoto N,Yabe D,Fukuda H,Kojima K,Ito J,Honjo T

更新日期：2007-07-01 00:00:00

abstract：:Myoblasts of the L6 rat cell line were grown in Ham's F12 nutrient medium containing 10% fetal calf serum (F12 + FCS). Although the cells were confluent by 6 days in culture, fusion was not observed even if cultures were maintained for 10-14 days. At least 80% of the cells in such confluent unfused cultures were in th...

journal_title：Developmental biology

authors： Pinset C,Whalen RG

更新日期：1984-04-01 00:00:00

abstract：:Cellular interactions with laminin are important for numerous morphogenetic events. In Xenopus, the first of these is neurulation. The integrin alpha6 subunit mediates an attachment of the cells of the neural plate to the underlying basal lamina. A disruption of this interaction results in embryos that fail to neurula...

journal_title：Developmental biology

authors： Lallier TE,DeSimone DW

更新日期：2000-09-01 00:00:00

abstract：:This investigation provides the first systematic determination of the cellular and molecular progression of vocal fold (VF) epithelium development in a murine model. We define five principal developmental events that constitute the progression from VF initiation in the embryonic anterior foregut tube to fully differen...

journal_title：Developmental biology

authors： Lungova V,Verheyden JM,Herriges J,Sun X,Thibeault SL

更新日期：2015-03-15 00:00:00

abstract：:Most, if not all, endocrine cells seem capable of synthesizing and storing more than one hormone. Such cellular colocalization of hormones can be due either to the presence of two or more specific granules within the cells or to colocalization of the hormones within a single granule. The present study was performed to...

journal_title：Developmental biology

authors： Lukinius A,Ericsson JL,Grimelius L,Korsgren O

更新日期：1992-10-01 00:00:00

abstract：:Individual somatic muscles and heart progenitors are specified at defined positions within the mesodermal layer of Drosophila. The expression of the homeobox gene even-skipped (eve) identifies one specific subset of cells in the dorsal mesoderm, which give rise to particular pericardial cells and dorsal body wall musc...

journal_title：Developmental biology

authors： Knirr S,Frasch M

更新日期：2001-10-01 00:00:00

abstract：:Chicken talpid(3) mutant embryos have a wide range of Hedgehog-signalling related defects and it is now known that the talpid(3) gene product encodes a novel protein essential for Hedgehog signalling which is required for both activator and repressor functions of Gli transcription factors (Davey, M.G., Paton, I.R., Yi...

journal_title：Developmental biology

authors： Davey MG,James J,Paton IR,Burt DW,Tickle C

更新日期：2007-01-01 00:00:00

abstract：:The organizer is an essential signaling center required for axial formation during vertebrate embryonic development. In the basal chordate amphioxus, the dorsal blastopore lip of the gastrula has been proposed to be homologous to the vertebrate organizer. Lefty is one of the first genes to be expressed in the organize...

journal_title：Developmental biology

authors： Zhang H,Chen S,Shang C,Wu X,Wang Y,Li G

更新日期：2019-12-01 00:00:00

abstract：:Prophase-arrested oocytes of Ruditapes philippinarum are triggered to undergo germinal vesicle breakdown under the influence of the neurohormone serotonin (5HT) and then arrest in metaphase 1. Our data show that these oocytes possess a single class of original 5HT receptors. Their binding parameters have been determin...

journal_title：Developmental biology

authors： Gobet I,Durocher Y,Leclerc C,Moreau M,Guerrier P

更新日期：1994-08-01 00:00:00

abstract：:Elastic fibers are produced during fetal and neonatal periods, and by maturity elastin expression has ceased. Fetal bovine hyaline chondrocytes acquired an elastogenic phenotype within 24 hr after isolation from the tissue, even though the tissue does not produce elastic fibers or tropoelastin mRNA in vivo. By multipl...

journal_title：Developmental biology

authors： Lee KA,Pierce RA,Davis EC,Mecham RP,Parks WC

更新日期：1994-05-01 00:00:00

abstract：:Differentiation from a haploid round spermatid to a highly streamlined, motile sperm requires temporal and spatial regulation of the expression of numerous proteins. One form of regulation is the storage of translationally repressed mRNAs. In Drosophila spermatocytes, the transcription of many of these translationally...

journal_title：Developmental biology

authors： Barckmann B,Chen X,Kaiser S,Jayaramaiah-Raja S,Rathke C,Dottermusch-Heidel C,Fuller MT,Renkawitz-Pohl R

更新日期：2013-05-01 00:00:00

abstract：:Despite 30 years of Hox gene study, we have a remarkably limited knowledge of the downstream target genes that Hox transcription factors regulate to confer regional identity. Here, we have used a microarray approach to identify genes that function downstream of a single vertebrate Hox gene, zebrafish hoxb1a. This gene...

journal_title：Developmental biology

authors： Rohrschneider MR,Elsen GE,Prince VE

更新日期：2007-09-15 00:00:00

abstract：:The unfertilized oocyte contains various granules which serve as storage sites for proteins, the majority which are yolk granules or platelets. Yolk granules are thought to provide the developing embryo with nutrients essential for its survival, while other granules contain proteins such as enzymes and extracellular m...

journal_title：Developmental biology

authors： Reimer CL,Crawford BJ

更新日期：1995-02-01 00:00:00

abstract：:In this study, we present evidence that neurogenic cells inhibit the differentiation of cardiogenic cells. When cells of the entire area pellucida at stage 5 were dissociated and reaggregated, the aggregates differentiated into neural tissues and other structures of any germ layer origin, except for heart tissues, des...

journal_title：Developmental biology

authors： Climent S,Sarasa M,Villar JM,Murillo-Ferrol NL

更新日期：1995-09-01 00:00:00

abstract：:This study evaluated Na/K-ATPase alpha 1- and alpha 3-subunit isoform polypeptide expression and localization during bovine preattachment development. Na/K-ATPase cation transport activity from the one-cell to blastocyst stage was also determined by measuring ouabain-sensitive 86Rb+ uptake. Both alpha1- and alpha 3-su...

journal_title：Developmental biology

authors： Betts DH,Barcroft LC,Watson AJ

更新日期：1998-05-01 00:00:00

abstract：:In vertebrates, the Müllerian duct elongates along the Wolffian duct, a mesonephric structure that is required for Müllerian duct formation. Recently, several genes required for initial Müllerian duct formation have been identified. However, the precise mechanism of Müllerian duct elongation remains to be elucidated. ...

journal_title：Developmental biology

authors： Fujino A,Arango NA,Zhan Y,Manganaro TF,Li X,MacLaughlin DT,Donahoe PK

更新日期：2009-01-15 00:00:00

abstract：:Retinoic acid (RA) signaling is required for normal development of multiple organs. However, little is known about how RA influences the initial stages of lung development. Here, we used a combination of genetic, pharmacological and explant culture approaches to address this issue, and to investigate how signaling by ...

journal_title：Developmental biology

authors： Desai TJ,Chen F,Lü J,Qian J,Niederreither K,Dollé P,Chambon P,Cardoso WV

更新日期：2006-03-01 00:00:00

abstract：:This paper reports a preliminary in silico analysis of the sea urchin kinome. The predicted protein kinases in the sea urchin genome were identified, annotated and classified, according to both function and kinase domain taxonomy. The results show that the sea urchin kinome, consisting of 353 protein kinases, is close...

journal_title：Developmental biology

authors： Bradham CA,Foltz KR,Beane WS,Arnone MI,Rizzo F,Coffman JA,Mushegian A,Goel M,Morales J,Geneviere AM,Lapraz F,Robertson AJ,Kelkar H,Loza-Coll M,Townley IK,Raisch M,Roux MM,Lepage T,Gache C,McClay DR,Manning G

更新日期：2006-12-01 00:00:00

abstract：:The Drosophila abnormal wing discs (awd) gene encodes the subunit of a protein that has nucleoside diphosphate kinase (NDP kinase) activity. Null mutations of the awd gene cause lethality after puparium formation. Larvae homozygous for such mutations have small imaginal discs, lymph glands, and brain lobes. Neither th...

journal_title：Developmental biology

authors： Xu J,Liu LZ,Deng XF,Timmons L,Hersperger E,Steeg PS,Veron M,Shearn A

更新日期：1996-08-01 00:00:00