当前位置： SCI文献检索 > DEVELOPMENTAL BIOLOGY期刊下所有文献 > Molecular integration of inductive and mesoderm-intrinsic inputs governs even-skipped enhancer activity in a subset of pericardial and dorsal muscle progenitors.

Molecular integration of inductive and mesoderm-intrinsic inputs governs even-skipped enhancer activity in a subset of pericardial and dorsal muscle progenitors.

Abstract：

:Individual somatic muscles and heart progenitors are specified at defined positions within the mesodermal layer of Drosophila. The expression of the homeobox gene even-skipped (eve) identifies one specific subset of cells in the dorsal mesoderm, which give rise to particular pericardial cells and dorsal body wall muscles. Genetic analysis has shown that the induction of eve in these cells involves the combined activities of genes encoding mesoderm-intrinsic factors, such as Tinman (Tin), and spatially restricted signaling activities that are largely derived from the ectoderm, particularly those encoded by wingless (wg) and decapentaplegic (dpp). Here we show that a Dpp-activated Smad protein, phosphorylated Mad, is colocalized in eve-expressing cells during an extended developmental period. We demonstrate further that a mesodermally active enhancer of eve contains several Smad and Tin binding sites that are essential for enhancer activity in vivo. This enhancer also contains a number of binding sites for the Wg-effector Pangolin (Pan/Lef-1), which are required for full levels of enhancer activity. However, we find that their main function is to prevent ectopic enhancer activity in the dorsal mesoderm. This suggests that, in the absence of Wg signaling, Pan binding serves to abrogate the synergistic activities of Smads and Tin in eve activation while, in cells that receive Wg signals, Pan is converted into a coactivator that promotes eve induction. Together, these data show that the eve enhancer integrates several regulatory pathways via the combinatorial binding of the mesoderm-intrinsic regulator Tin and the effectors of the Dpp and Wg signals.

journal_name

Dev Biol

journal_title

Developmental biology

authors

Knirr S,Frasch M

doi

10.1006/dbio.2001.0397

subject

Has Abstract

pub_date

2001-10-01 00:00:00

pages

13-26

issue

1

eissn

0012-1606

issn

1095-564X

pii

S0012-1606(01)90397-5

journal_volume

238

pub_type

杂志文章

相关文献

DEVELOPMENTAL BIOLOGY文献大全
  • Zebrafish puma mutant decouples pigment pattern and somatic metamorphosis.

    abstract：:The genetic and developmental bases for trait expression and variation in adults are largely unknown. One system in which genes and cell behaviors underlying adult traits can be elucidated is the larval-to-adult transformation of zebrafish, Danio rerio. Metamorphosis in this and many other teleost fishes resembles amp...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/s0012-1606(03)00015-0

    authors： Parichy DM,Turner JM

    更新日期：2003-04-15 00:00:00

  • Nek2B stimulates zygotic centrosome assembly in Xenopus laevis in a kinase-independent manner.

    abstract：:Pronuclear migration and formation of the first mitotic spindle depend upon assembly of a functional zygotic centrosome. For most animals, this involves both paternal and maternal contributions as sperm basal bodies are converted into centrosomes competent for microtubule nucleation through recruitment of egg proteins...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2003.10.001

    authors： Twomey C,Wattam SL,Pillai MR,Rapley J,Baxter JE,Fry AM

    更新日期：2004-01-15 00:00:00

  • Defective proventriculus specifies the ocellar region in the Drosophila head.

    abstract：:A pair of the Drosophila eye-antennal disc gives rise to four distinct organs (eyes, antennae, maxillary palps, and ocelli) and surrounding head cuticle. Developmental processes of this imaginal disc provide an excellent model system to study the mechanism of regional specification and subsequent organogenesis. The do...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2011.06.015

    authors： Yorimitsu T,Kiritooshi N,Nakagoshi H

    更新日期：2011-08-15 00:00:00

  • Continuously growing bipotential and monopotential myogenic, adipogenic, and chondrogenic subclones isolated from the multipotential RCJ 3.1 clonal cell line.

    abstract：:The clonal multipotential RCJ 3.1 cell line, which gives rise to myotubes, adipocytes, chondrocytes, and osteoblasts, contains different progenitor subpopulations. By limiting dilution analysis, of 296 single colonies identified, approximately 20% contained a single recognizable cell type, approximately 10% contained ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(90)90352-j

    authors： Grigoriadis AE,Heersche JN,Aubin JE

    更新日期：1990-12-01 00:00:00

  • Elk3 is essential for the progression from progenitor to definitive neural crest cell.

    abstract：:Elk3/Net/Sap2 (here referred to as Elk3) is an Ets ternary complex transcriptional repressor known for its involvement in angiogenesis during embryonic development. Although Elk3 is expressed in various tissues, additional roles for the protein outside of vasculature development have yet to be reported. Here, we chara...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2012.12.009

    authors： Rogers CD,Phillips JL,Bronner ME

    更新日期：2013-02-15 00:00:00

  • The expression pattern of thyroid hormone response genes in remodeling tadpole tissues defines distinct growth and resorption gene expression programs.

    abstract：:Thyroid hormone (TH) induces dramatic skeletal and tissue remodeling of the anuran head and body at metamorphosis. The expression pattern of TH up-regulated genes has been correlated with tissues that either grow or resorb at metamorphosis. Whereas the expression of the thyroid hormone receptors in Xenopus laevis tadp...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1998.8975

    authors： Berry DL,Rose CS,Remo BF,Brown DD

    更新日期：1998-11-01 00:00:00

  • Normal newt limb regeneration requires matrix metalloproteinase function.

    abstract：:Newts regenerate lost limbs through a complex process involving dedifferentiation, migration, proliferation, and redifferentiation of cells proximal to the amputation plane. To identify the genes controlling these cellular events, we performed a differential display analysis between regenerating and nonregenerating li...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2004.12.003

    authors： Vinarsky V,Atkinson DL,Stevenson TJ,Keating MT,Odelberg SJ

    更新日期：2005-03-01 00:00:00

  • Effects of acidic and basic fibroblast growth factors (aFGF, bFGF) on glial precursor cell proliferation: age dependency and brain region specificity.

    abstract：:Acidic fibroblast growth factor (aFGF) and basic fibroblast growth factor (bFGF) are present in high levels in most areas of the embryonic rodent brain. To begin to understand the role of these growth factors in brain development, the effects of aFGF and bFGF on dissociated cell cultures prepared from embryonic and ne...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(92)90143-5

    authors： Engele J,Bohn MC

    更新日期：1992-08-01 00:00:00

  • Patterning through differential endoreduplication in epithelial organogenesis of the chordate, Oikopleura dioica.

    abstract：:The contributions that control of cell proliferation and cell growth make to developmental regulation of organ and body size remain poorly explored, particularly with respect to endocycles in polyploid tissues. The epithelium of the marine chordate Oikopleura dioica is composed of a fixed number of cells grouped in te...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.2002.0834

    authors： Ganot P,Thompson EM

    更新日期：2002-12-01 00:00:00

  • MOM-5 frizzled regulates the distribution of DSH-2 to control C. elegans asymmetric neuroblast divisions.

    abstract：:Asymmetric cell divisions produce all 302 neurons of the C. elegans hermaphrodite. Here, we describe a role for a C. elegans Dishevelled homolog, DSH-2, in an asymmetric neuroblast division. In dsh-2 mutants, neurons normally descended from the anterior neuroblast daughter of the ABpl/rpppa blast cell were frequently ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2005.05.024

    authors： Hawkins NC,Ellis GC,Bowerman B,Garriga G

    更新日期：2005-08-01 00:00:00

  • Chondroitin sulfate synthase 1 (Chsy1) is required for bone development and digit patterning.

    abstract：:Joint and skeletal development is highly regulated by extracellular matrix (ECM) proteoglycans, of which chondroitin sulfate proteoglycans (CSPGs) are a major class. Despite the requirement of joint CSPGs for skeletal flexibility and structure, relatively little is understood regarding their role in establishing joint...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2012.01.005

    authors： Wilson DG,Phamluong K,Lin WY,Barck K,Carano RA,Diehl L,Peterson AS,Martin F,Solloway MJ

    更新日期：2012-03-15 00:00:00

  • Premeiotic aster as a device to anchor the germinal vesicle to the cell surface of the presumptive animal pole in starfish oocytes.

    abstract：:The germinal vesicle (GV) of starfish oocytes stays just beneath the oocyte cortex at the presumptive animal pole during the long period of oogenesis. We subjected oocytes to a centrifugal force field to detach the GV from the cortex. The association between the cortex and the GV persisted and withstood a small amount...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1999.9577

    authors： Miyazaki A,Kamitsubo E,Nemoto SI

    更新日期：2000-02-15 00:00:00

  • Formation of the insect head involves lateral contribution of the intercalary segment, which depends on Tc-labial function.

    abstract：:The insect head is composed of several segments. During embryonic development, the segments fuse to form a rigid head capsule where obvious segmental boundaries are lacking. Hence, the assignment of regions of the insect head to specific segments is hampered, especially with respect to dorsal (vertex) and lateral (gen...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2009.11.010

    authors： Posnien N,Bucher G

    更新日期：2010-02-01 00:00:00

  • Characterization and localization of a mouse egg cortical granule antigen prior to and following fertilization or egg activation.

    abstract：:Immunological approaches were used to characterize an antigen that is present within the cortical granules of mouse oocytes and eggs. Immunoelectron microscopy shows a specific localization of the antigen to the cortical granules in the cortex of mouse oocytes and eggs. Following in vitro fertilization, the antigen is...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(90)90392-v

    authors： Pierce KE,Siebert MC,Kopf GS,Schultz RM,Calarco PG

    更新日期：1990-10-01 00:00:00

  • Oocyte development in Hydra involves selection from competent precursor cells.

    abstract：:We have investigated oocyte development in Hydra vulgaris, a member of one of the oldest metazoan phyla. We show that oocyte determination involves a mechanism that establishes a subset of precursor interstitial cells competent to differentiate into oocytes. The oocyte is singled out from this subset and the competenc...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.2000.9790

    authors： Miller MA,Technau U,Smith KM,Steele RE

    更新日期：2000-08-15 00:00:00

  • Bmp6 and Bmp7 are required for cushion formation and septation in the developing mouse heart.

    abstract：:The mature heart valves and septa are derived from the cardiac cushions which initially form as local outgrowths of mesenchymal cells within the outflow tract and atrioventricular regions. Endocardial cells respond to signals from the overlying myocardium and undergo an epithelial-to-mesenchymal transformation to inva...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.2001.0284

    authors： Kim RY,Robertson EJ,Solloway MJ

    更新日期：2001-07-15 00:00:00

  • Connexins, E-cadherin, Claudin-7 and β-catenin transiently form junctional nexuses during the post-natal mammary gland development.

    abstract：:Gap junctions are intercellular channels made of connexins (Cxs) that allow direct communication between adjacent cells. Modulation of Cxs has been associated with abnormal development and function of the mammary gland and breast cancer. However, the mechanisms underlying their expression during normal mammary gland a...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2016.06.011

    authors： Dianati E,Poiraud J,Weber-Ouellette A,Plante I

    更新日期：2016-08-01 00:00:00

  • Conservation as well as divergence in Mcidas function underlies the differentiation of multiciliated cells in vertebrates.

    abstract：:Multiciliated cells (MCCs) differentiate hundreds of motile cilia that beat to drive fluid movement over various kinds of epithelia. In Xenopus, mice and human, the coiled-coil containing protein Mcidas (Mci) has been shown to be a key transcriptional regulator of MCC differentiation. We have examined Mci function in ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2020.07.005

    authors： Zhou F,Rayamajhi D,Ravi V,Narasimhan V,Chong YL,Lu H,Venkatesh B,Roy S

    更新日期：2020-09-15 00:00:00

  • Expression of Patella vulgata orthologs of engrailed and dpp-BMP2/4 in adjacent domains during molluscan shell development suggests a conserved compartment boundary mechanism.

    abstract：:The engrailed gene is well known from its role in segmentation and central nervous system development in a variety of species. In molluscs, however, engrailed is involved in shell formation. So far, it seemed that engrailed had been co-opted uniquely for this particular process in molluscs. Here, we show that, in the ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.2002.0653

    authors： Nederbragt AJ,van Loon AE,Dictus WJ

    更新日期：2002-06-15 00:00:00

  • A delayed role for nitric oxide-sensitive guanylate cyclases in a migratory population of embryonic neurons.

    abstract：:Neuronal differentiation requires a coordinated intracellular response to diverse extracellular stimuli, but the role of specific signaling mechanisms in regulating this process is still poorly understood. Soluble guanylate cyclases (sGCs), which can be stimulated by diffusible free radical gasses such as nitric oxide...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1998.9066

    authors： Wright JW,Schwinof KM,Snyder MA,Copenhaver PF

    更新日期：1998-12-01 00:00:00

  • Homeobox-containing genes in teratocarcinoma embryoid bodies: a possible role for Hox-D12 (Hox-4.7) in establishing the extraembryonic endoderm lineage in the mouse.

    abstract：:We wish to identify genes involved in mediating early lineage decisions in the mouse embryo. F9 teratocarcinoma cells treated with retinoic acid (RA) in suspension culture develop into embryoid bodies (EBs) with an outer layer of visceral endoderm. In order to identify genes that are involved in establishing this extr...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1993.1236

    authors： Labosky PA,Weir MP,Grabel LB

    更新日期：1993-09-01 00:00:00

  • FGF-10 plays an essential role in the growth of the fetal prostate.

    abstract：:Induction and branching morphogenesis of the prostate are dependent on androgens, which act via the mesenchyme to induce prostatic epithelial development. One mechanism by which the mesenchyme may regulate the epithelium is through secreted growth factors such as FGF-10. We have examined the male reproductive tract of...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/s0012-1606(03)00250-1

    authors： Donjacour AA,Thomson AA,Cunha GR

    更新日期：2003-09-01 00:00:00

  • Dynamic expression of broad-complex isoforms mediates temporal control of an ecdysteroid target gene at the onset of Drosophila metamorphosis.

    abstract：:Metamorphosis in Drosophila melanogaster is orchestrated by the steroid hormone ecdysone, which triggers a cascade of primary-response transcriptional regulators and secondary effector genes during the third larval instar and prepupal periods of development. The early ecdysone-response Broad-Complex (BR-C) gene, a key...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.2000.9879

    authors： Mugat B,Brodu V,Kejzlarova-Lepesant J,Antoniewski C,Bayer CA,Fristrom JW,Lepesant JA

    更新日期：2000-11-01 00:00:00

  • DCC plays a role in navigation of forebrain axons across the ventral midbrain commissure in embryonic xenopus.

    abstract：:In the developing vertebrate brain, growing axons establish a scaffold of axon tracts connected across the midline via commissures. We have previously identified a population of telencephalic neurons that express NOC-2, a novel glycoform of the neural cell adhesion molecule N-CAM that is involved in axon guidance in t...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1999.9549

    authors： Anderson RB,Cooper HM,Jackson SC,Seaman C,Key B

    更新日期：2000-01-15 00:00:00

  • The planar cell polarity gene strabismus regulates convergence and extension and neural fold closure in Xenopus.

    abstract：:We cloned Xenopus Strabismus (Xstbm), a homologue of the Drosophila planar cell or tissue polarity gene. Xstbm encodes four transmembrane domains in its N-terminal half and a PDZ-binding motif in its C-terminal region, a structure similar to Drosophila and mouse homologues. Xstbm is expressed strongly in the deep cell...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.2002.0673

    authors： Goto T,Keller R

    更新日期：2002-07-01 00:00:00

  • Hoxd and Gli3 interactions modulate digit number in the amniote limb.

    abstract：:During limb development, Sonic hedgehog (SHH) and HOX proteins are considered among the most important factors regulating digit number and identity. SHH signaling prevents the processing of GLI3 into a short form that functions as a strong transcriptional repressor. Gli3 mutant limbs are characterized by a severe poly...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2007.07.023

    authors： Sheth R,Bastida MF,Ros M

    更新日期：2007-10-15 00:00:00

  • Role of epidermal growth factor expression in early mouse embryo lung branching morphogenesis in culture: antisense oligodeoxynucleotide inhibitory strategy.

    abstract：:Epidermal growth factor (EGF) expression and branching morphogenesis were inhibited using a 5' 15-mer antisense oligodeoxynucleotide (ODN) directed against EGF precursor mRNA in embryonic mouse lung in culture under chemically defined, serumless conditions. Antisense EGF ODN resulted in > 90% inhibition of EGF immunor...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1993.1213

    authors： Seth R,Shum L,Wu F,Wuenschell C,Hall FL,Slavkin HC,Warburton D

    更新日期：1993-08-01 00:00:00

  • Sox9 is required for prostate development.

    abstract：:The mammalian prostate arises from the urogenital sinus and few factors have been identified to be important in the early stages of prostate development. In this study we show that the transcription factor Sox9 is expressed in the epithelia of all mouse prostatic lobes from the initial stages of their development. We ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2008.01.030

    authors： Thomsen MK,Butler CM,Shen MM,Swain A

    更新日期：2008-04-15 00:00:00

  • Lineage specific trimethylation of H3 on lysine 4 during C. elegans early embryogenesis.

    abstract：:In many organisms early embryogenesis is characterised by a period refractory to transcription. In Caenorhabditis elegans, the one-cell embryo is transcriptionally inactive, but at around eight-cell stage transcription is activated in the somatic lineage. This model suggests that histone tail modifications associated ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2011.04.010

    authors： Wang S,Fisher K,Poulin GB

    更新日期：2011-07-15 00:00:00

  • A critical role for Cadherin6B in regulating avian neural crest emigration.

    abstract：:Neural crest cells originate in the dorsal neural tube but subsequently undergo an epithelial-to-mesenchymal transition (EMT), delaminate, and migrate to diverse locations in the embryo where they contribute to a variety of derivatives. Cadherins are a family of cell-cell adhesion molecules expressed in a broad range ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2007.09.056

    authors： Coles EG,Taneyhill LA,Bronner-Fraser M

    更新日期：2007-12-15 00:00:00