Role of epidermal growth factor expression in early mouse embryo lung branching morphogenesis in culture: antisense oligodeoxynucleotide inhibitory strategy.

abstract：:The three fibronectin leucine-rich repeat transmembrane (FLRT) proteins contain 10 leucine-rich repeats (LRR), a type III fibronectin (FN) domain, followed by the transmembrane region, and a short cytoplasmic tail. XFLRT3, a Nodal/TGFbeta target, regulates cell adhesion and modulates FGF signalling during Xenopus gast...

journal_title：Developmental biology

authors： Maretto S,Müller PS,Aricescu AR,Cho KW,Bikoff EK,Robertson EJ

更新日期：2008-06-01 00:00:00

abstract：:Hedgehog (Hh) proteins and cAMP-dependent protein kinase A (PKA) generally play opposing roles in developmental patterning events. Humans and mice heterozygous for mutations in the sonic hedgehog (Shh) receptor gene patched-1 (ptc1) have an increased incidence of certain types of cancer, including medulloblastoma (MB)...

journal_title：Developmental biology

authors： Lelievre V,Seksenyan A,Nobuta H,Yong WH,Chhith S,Niewiadomski P,Cohen JR,Dong H,Flores A,Liau LM,Kornblum HI,Scott MP,Waschek JA

更新日期：2008-01-01 00:00:00

abstract：:Thyroid hormone (TH) induces dramatic skeletal and tissue remodeling of the anuran head and body at metamorphosis. The expression pattern of TH up-regulated genes has been correlated with tissues that either grow or resorb at metamorphosis. Whereas the expression of the thyroid hormone receptors in Xenopus laevis tadp...

journal_title：Developmental biology

authors： Berry DL,Rose CS,Remo BF,Brown DD

更新日期：1998-11-01 00:00:00

abstract：:Zygotic gene activation is essential for development beyond the 2-cell stage in the preimplantation mouse embryo. Based on alpha-amanitin-sensitive BrUTP incorporation, transcription initiates in the 1-cell embryo and a major reprogramming of gene expression driven by newly expressed genes is prominently observed duri...

journal_title：Developmental biology

authors： Zeng F,Schultz RM

更新日期：2005-07-01 00:00:00

abstract：:Adult tissue stem cells self-renew and differentiate in a way that exactly meets the biological demand of the dependent tissue. We evaluated spermatogonial stem cell (SSC) activity in the developing rat testis and the quality and accessibility of the stem cell niche in wild type, and two busulfan-treated models of rat...

journal_title：Developmental biology

authors： Ryu BY,Orwig KE,Avarbock MR,Brinster RL

更新日期：2003-11-15 00:00:00

abstract：:Vertebrate hematopoiesis is characterized by two evolutionally conserved phases of development, i.e., primitive hematopoiesis, which is a transient phenomenon in the early embryo, and definitive hematopoiesis, which takes place in the later stages. Beni fuji (bef) was originally isolated as a medaka mutant that has an...

journal_title：Developmental biology

authors： Moriyama A,Inohaya K,Maruyama K,Kudo A

更新日期：2010-09-15 00:00:00

abstract：:Cells that overexpress PKA as a consequence of carrying multiple copies of the gene encoding the catalytic subunit can be induced to sporulate when developing as single cells. A peptide phosphorylated by PKA, termed SDF-1, has recently been shown to stimulate this process (Anjard et al., 1997). Several genes have been...

journal_title：Developmental biology

authors： Anjard C,Zeng C,Loomis WF,Nellen W

更新日期：1998-01-15 00:00:00

abstract：:We report here the identification and characterization of a novel gene, T1 alpha, expressed in high abundance in adult rat lung, fetal lung, and early fetal brain. T1 alpha was identified by a monoclonal antibody previously shown to be specific for an antigen expressed by alveolar epithelial type I cells. The cDNA for...

journal_title：Developmental biology

authors： Rishi AK,Joyce-Brady M,Fisher J,Dobbs LG,Floros J,VanderSpek J,Brody JS,Williams MC

更新日期：1995-01-01 00:00:00

abstract：:In many organisms, like Caenorhabditis elegans and Drosophila melanogaster, establishment of spatial patterns and definition of cell fate are driven by the segregation of determinants in response to spatial cues, as early as oogenesis or fertilization. In these organisms, a family of conserved proteins, the PAR protei...

journal_title：Developmental biology

authors： Vinot S,Le T,Ohno S,Pawson T,Maro B,Louvet-Vallée S

更新日期：2005-06-15 00:00:00

abstract：:We have identified cDNA clones encoding a testis-specific poly(A) polymerase, termed TPAP, a candidate molecule responsible for cytoplasmic polyadenylation of preexisting mRNAs in male haploid germ cells. The TPAP gene was most abundantly expressed coincident with the additional elongation of mRNA poly(A) tails in rou...

journal_title：Developmental biology

authors： Kashiwabara S,Zhuang T,Yamagata K,Noguchi J,Fukamizu A,Baba T

更新日期：2000-12-01 00:00:00

abstract：:Organismal growth and body size are influenced by both genetic and environmental factors. We have utilized the strong molecular genetic techniques available in the nematode Caenorhabditis elegans to identify genetic determinants of body size. In C. elegans, DBL-1, a member of the conserved family of secreted growth fa...

journal_title：Developmental biology

authors： Fernando T,Flibotte S,Xiong S,Yin J,Yzeiraj E,Moerman DG,Meléndez A,Savage-Dunn C

更新日期：2011-04-01 00:00:00

abstract：:Integrins are alphabeta transmembrane receptors that function in key cellular processes, including cell adhesion, differentiation, and extracellular matrix deposition through interactions with extracellular, membrane, and cytoplasmic proteins. We previously identified and cloned a muscle beta1 integrin cytoplasmic bin...

journal_title：Developmental biology

authors： Li J,Rao H,Burkin D,Kaufman SJ,Wu C

更新日期：2003-09-01 00:00:00

abstract：:Arthropods, vertebrates, and annelids all have a segmented body. Our recent discovery of involvement of Notch-signalling in spider segmentation revived the discussion on the origin of segmented body plans and suggests the sharing of a common genetic program in a common ancestor. Here, we analysed the spider homologues...

journal_title：Developmental biology

authors： Schoppmeier M,Damen WG

更新日期：2005-04-01 00:00:00

abstract：:The gastrointestinal (GI) tract of metazoans is lined by a series of regionally distinct epithelia. To maintain structure and function of the GI tract, regionally diversified differentiation of somatic stem cell (SC) lineages is critical. The adult Drosophila midgut provides an accessible model to study SC regulation ...

journal_title：Developmental biology

authors： Li H,Qi Y,Jasper H

更新日期：2016-11-15 00:00:00

abstract：:It has been difficult to examine the role of TGF-ß in post-natal tooth development due to perinatal lethality in many of the signaling deficient mouse models. To address the role of Tgfbr2 in postnatal tooth development, we generated a mouse in which Tgfbr2 was deleted in odontoblast- and bone-producing mesenchyme. Os...

journal_title：Developmental biology

authors： Wang Y,Cox MK,Coricor G,MacDougall M,Serra R

更新日期：2013-10-01 00:00:00

abstract：:The nuclear lamina is an extensive protein network that underlies the inner nuclear envelope. This network includes the LAP2-emerin-MAN1-domain (LEM-D) protein family, proteins that share an association with the chromatin binding protein Barrier-to-autointegration factor (BAF). Loss of individual LEM-D proteins causes...

journal_title：Developmental biology

authors： Barton LJ,Lovander KE,Pinto BS,Geyer PK

更新日期：2016-07-01 00:00:00

abstract：:Individual somatic muscles and heart progenitors are specified at defined positions within the mesodermal layer of Drosophila. The expression of the homeobox gene even-skipped (eve) identifies one specific subset of cells in the dorsal mesoderm, which give rise to particular pericardial cells and dorsal body wall musc...

journal_title：Developmental biology

authors： Knirr S,Frasch M

更新日期：2001-10-01 00:00:00

abstract：:The development of neural crest-derived melanocytes, as well as haematopoietic and germ cells, is affected by mutations of the Kit and Mgf genes, which lead to dominant spotting (W) or steel (Sl) phenotypes. Mgf codes for the ligand of the receptor tyrosine kinase encoded by the Kit locus. KitW-v, a point mutation exe...

journal_title：Developmental biology

authors： Mackenzie MA,Jordan SA,Budd PS,Jackson IJ

更新日期：1997-12-01 00:00:00

abstract：:Endogenous patterns of retinoic acid (RA) signaling in avian cardiac morphogenesis were characterized by localized expression of a key RA-synthetic enzyme, RALDH2, which displayed a biphasic pattern during heart development. RALDH2 immunoreactivity was initially apparent posterior to Hensen's node of stage 5-6 embryos...

journal_title：Developmental biology

authors： Xavier-Neto J,Shapiro MD,Houghton L,Rosenthal N

更新日期：2000-03-01 00:00:00

abstract：:From July 19-24, 2015, 169 clinicians and basic scientists gathered in the vertiginous heights of Snowmass, Colorado (2502 m) for the fourth FASEB summer research conference on the 'Biology of Cilia and Flagella'. Organizers Maureen Barr (Rutgers University), Iain Drummond (Massachusetts General Hospital/Harvard Medic...

journal_title：Developmental biology

authors： Tran PV,Lechtreck KF

更新日期：2016-01-15 00:00:00

abstract：:Alkaline phosphatase (AP) activity is expressed by endodermal cells of ascidian larvae. It was reported previously that the expression of AP activity is resistant to treatment with actinomycin D, a transcription inhibitor that inhibits the appearance of several other tissue-specific molecules and morphological markers...

journal_title：Developmental biology

authors： Kumano G,Nishida H

更新日期：1998-06-15 00:00:00

abstract：:We examined the development of epithelial Na+ conductance in 6- and 7-day post coitus (p.c.) preimplantation rabbit embryos using the whole-cell patch-clamp technique on dissociated rabbit trophectodermal cells and by immunocytochemical localization using a polyclonal antibody directed against subunits of an apical ep...

journal_title：Developmental biology

authors： Robinson DH,Bubien JK,Smith PR,Benos DJ

更新日期：1991-10-01 00:00:00

abstract：:A functional ribosomal protein mRNA, encoding the 60 S subunit protein L1, has been synthesized in vitro using bacteriophage SP6 RNA polymerase. This mRNA directs the synthesis of a product indistinguishable from L1 protein purified from Xenopus ovarian ribosomes. Our results show that L1 synthesis in stage VI oocytes...

journal_title：Developmental biology

authors： Baum EZ,Hyman LE,Wormington WM

更新日期：1988-03-01 00:00:00

abstract：:In Hydra long-range interactions between head, bud, and foot formation take place in addition to short-range interactions which are recognized as induction phenomena, occurring when transplants are placed into an environment of disparate positional value. Here the long-range promotion of foot formation is analyzed. Th...

journal_title：Developmental biology

authors： Müller WA

更新日期：1995-01-01 00:00:00

abstract：:Cadherin-mediated cell-cell interactions are thought to be critical in controlling cell sorting during embryogenesis. Here, we report that chimeric embryos generated with N-cadherin-deficient (N-cadherin(-/-)) embryonic stem cells develop further than embryos completely lacking N-cadherin only when the myocardium cons...

journal_title：Developmental biology

authors： Kostetskii I,Moore R,Kemler R,Radice GL

更新日期：2001-06-01 00:00:00

abstract：:Egg yolk phosvitin is one of the most highly phosphorylated extracellular matrix proteins known in nature with unique physico-chemical properties deemed to be critical during ex-vivo egg embryo development. We have utilized our unique live mouse calvarial bone organ culture models under conditions which dissociates th...

journal_title：Developmental biology

authors： Liu J,Czernick D,Lin SC,Alasmari A,Serge D,Salih E

更新日期：2013-09-01 00:00:00

abstract：:Primary sensory olfactory neurons reside in a neuroepithelium lining the nasal cavity and project topographically onto the surface of the olfactory bulb, a rostral extension of the telencephalon. Galectin-1, a bivalent galactose-binding vertebrate lectin, is expressed in the developing rodent olfactory system. In the ...

journal_title：Developmental biology

authors： Puche AC,Poirier F,Hair M,Bartlett PF,Key B

更新日期：1996-10-10 00:00:00

abstract：:In previous studies we found that two glycoproteins of 220 and 180 kDa account for 80-90% of the material dissolved from the vitelline coat (VC) of Unio elongatulus egg (Focarelli and Rosati, 1993). The two glycoproteins were purified by electroelution and used to raise the corresponding polyclonal antibodies. Immunof...

journal_title：Developmental biology

authors： Focarelli R,Rosati F

更新日期：1995-10-01 00:00:00

abstract：:Nerve and muscle development was studied in paralysé mutant mice. The mutant phenotype is first recognizable 6-7 days after birth (PN 6-PN 7) as cessation of muscle growth and weakness and incoordination of movement. Mutant animals die between 2 and 3 weeks of age. Muscle fibers from paralysé mutants had a unimodal di...

journal_title：Developmental biology

authors： Blondet B,Duxson MJ,Harris AJ,Melki J,Guénet JL,Pinçon-Raymond M,Rieger F

更新日期：1989-03-01 00:00:00

abstract：:Differentiation from a haploid round spermatid to a highly streamlined, motile sperm requires temporal and spatial regulation of the expression of numerous proteins. One form of regulation is the storage of translationally repressed mRNAs. In Drosophila spermatocytes, the transcription of many of these translationally...

journal_title：Developmental biology

authors： Barckmann B,Chen X,Kaiser S,Jayaramaiah-Raja S,Rathke C,Dottermusch-Heidel C,Fuller MT,Renkawitz-Pohl R

更新日期：2013-05-01 00:00:00