Suppressor of Hairless and Presenilin phenotypes imply involvement of canonical Notch-signalling in segmentation of the spider Cupiennius salei.

abstract：:We have phenotypically and molecularly analyzed the cutlet locus in Drosophila. Homozygous cutlet flies exhibit abnormal development of a subset of adult tissues, including the eye, wing, and ovary. We show that abnormal development of these tissues is due to a defect in normal cell growth. Surprisingly, cell growth i...

journal_title：Developmental biology

authors： Jaffe AB,Jongens TA

更新日期：2001-02-15 00:00:00

abstract：:Eggs have developed their own strategies for early development. Amphibian, teleost fish, and ascidian eggs show cortical rotation and an accompanying structure, a cortical parallel microtubule (MT) array, during the one-cell embryonic stage. Cortical rotation is thought to relocate maternal deposits to a certain compa...

journal_title：Developmental biology

authors： Nishikata T,Goto T,Yagi H,Ishii H

更新日期：2019-04-15 00:00:00

abstract：:The location and movement of mammalian gut tissue progenitors, prior to the expression of tissue-specific genes, has been unknown, but this knowledge is essential to identify transitions that lead to cell type specification. To address this, we used vital dyes to label exposed anterior endoderm cells of early somite s...

journal_title：Developmental biology

authors： Tremblay KD,Zaret KS

更新日期：2005-04-01 00:00:00

abstract：:The transcription factors, GATA4, 5 and 6, recognize the same DNA sequence and are all expressed in the developing myocardium. However, knockout studies in the mouse have indicated that none of them are absolutely required for the specification of the myocardium. Here we present evidence for redundancy in this family ...

journal_title：Developmental biology

authors： Peterkin T,Gibson A,Patient R

更新日期：2007-11-15 00:00:00

abstract：:Retinal ganglion cells (RGCs) are the first cell type to differentiate during retinal histogenesis. It has been postulated that specified RGCs subsequently influence the number and fate of the remaining progenitors to produce the rest of the retinal cell types. However, several genetic knockout models have argued agai...

journal_title：Developmental biology

authors： Moshiri A,Gonzalez E,Tagawa K,Maeda H,Wang M,Frishman LJ,Wang SW

更新日期：2008-04-15 00:00:00

abstract：:The Drosophila melanogaster ventral nerve cord derives from neural progenitor cells called neuroblasts. Individual neuroblasts have unique gene expression profiles and give rise to distinct clones of neurons and glia. The specification of neuroblast identity provides a cell intrinsic mechanism which ultimately results...

journal_title：Developmental biology

authors： Buescher M,Tio M,Tear G,Overton PM,Brook WJ,Chia W

更新日期：2006-04-15 00:00:00

abstract：:The Endo16 gene codes for an RGD-containing calcium-binding protein that is found on the basal surfaces and in the extracellular matrix of cells of the invaginating archenteron during sea urchin gastrulation. Previously, we have shown that Endo16 is a single copy gene and we have determined the coding sequence and ana...

journal_title：Developmental biology

authors： Godin RE,Urry LA,Ernst SG

更新日期：1996-10-10 00:00:00

abstract：:Stimulation of epithelial cell cycling by the neuropeptide head activator was analyzed in Hydra magnipapillata and compared with the action of head activator on bud formation and tentacle formation during head regeneration. The results obtained indicate that head activator treatment stimulates epithelial cell division...

journal_title：Developmental biology

authors： Hobmayer B,Holstein TW,David CN

更新日期：1997-03-01 00:00:00

abstract：:Formation of the adenohypophysis in mammalian embryos occurs via an invagination of the oral ectoderm to form Rathke's pouch, which becomes exposed to opposing dorsoventral gradients of signaling proteins governing specification of the different hormone-producing pituitary cell types. One signal promoting pituitary ce...

journal_title：Developmental biology

authors： Herzog W,Zeng X,Lele Z,Sonntag C,Ting JW,Chang CY,Hammerschmidt M

更新日期：2003-02-01 00:00:00

abstract：:An abundant phosphoprotein with an apparent molecular mass of 65 kDa (p65) has been identified that is enriched in developing new macronuclei (or anlagen) isolated from the holotrichous ciliate, Tetrahymena thermophila. During early stages of macronuclear development, p65 is actively synthesized and deposited into you...

journal_title：Developmental biology

authors： Madireddi MT,Davis MC,Allis CD

更新日期：1994-10-01 00:00:00

abstract：:In mammals, two spatially and temporally distinct waves of fiber cell differentiation are crucial steps for normal lens development. In between these phases, an anterior growth zone forms in which progenitor cells migrate circumferentially, terminally exit the cell cycle and initiate differentiation at the lens equato...

journal_title：Developmental biology

authors： Le TT,Conley KW,Brown NL

更新日期：2009-04-01 00:00:00

abstract：:The dysgenetic lens (dyl) mouse mutant has mutations in Foxe3, which inactivate DNA binding by the encoded forkhead transcription factor. Here we confirm, by targeted inactivation, that Foxe3 mutations are responsible for the dyl phenotype, which include loss of lens epithelium; a small, cataractic lens; and failure o...

journal_title：Developmental biology

authors： Blixt A,Landgren H,Johansson BR,Carlsson P

更新日期：2007-02-01 00:00:00

abstract：:To examine the relationship between growth hormone (GH) and insulin-like growth factor 1 (IGF1) in controlling postnatal growth, we performed a comparative analysis of dwarfing phenotypes manifested in mouse mutants lacking GH receptor, IGF1, or both. This genetic study has provided conclusive evidence demonstrating t...

journal_title：Developmental biology

authors： Lupu F,Terwilliger JD,Lee K,Segre GV,Efstratiadis A

更新日期：2001-01-01 00:00:00

abstract：:Using DiI fluorescent dextrans, we have created fate maps of the neural plate and early neural tube describing the extent of progenitor cell dispersal and the spatial origin of morphologically distinct neuronal cell types along the dorsoventral axis of the developing chick spinal cord. Nonuniform dispersal and mixing ...

journal_title：Developmental biology

authors： Erskine L,Patel K,Clarke JD

更新日期：1998-07-01 00:00:00

abstract：:Cell polarity is thought to be required for the efficient production of nascent blastocoele fluid, which begins at the 16-cell stage of mouse preimplantation development. In this study the 4-cell/16-cell blastomere heterokaryon was used to test the hypothesis that solute transport across the apical membrane domain ind...

journal_title：Developmental biology

authors： Wiley LM,Obasaju MF

更新日期：1989-06-01 00:00:00

abstract：:When a posterior fragment of the chick's marginal zone (PM) was exchanged with equal sized lateral marginal zone fragment (LM), of the same blastoderm, its capacity to initiate an ectopic primitive streak (PS) was found to be both size and stage dependent. Good correlation was demonstrated between the areas of PM frag...

journal_title：Developmental biology

authors： Eyal-Giladi H,Khaner O

更新日期：1989-07-01 00:00:00

abstract：:Vertebrate hematopoiesis is characterized by two evolutionally conserved phases of development, i.e., primitive hematopoiesis, which is a transient phenomenon in the early embryo, and definitive hematopoiesis, which takes place in the later stages. Beni fuji (bef) was originally isolated as a medaka mutant that has an...

journal_title：Developmental biology

authors： Moriyama A,Inohaya K,Maruyama K,Kudo A

更新日期：2010-09-15 00:00:00

abstract：:Planarians are well-known for their exceptional regenerative abilities. This investigation focuses on the involvement of a Y-box protein, defined by the presence of a cold-shock domain, in regeneration-specific processes. Previous studies have shown that developmentally expressed Y-box proteins bind to mRNA molecules ...

journal_title：Developmental biology

authors： Salvetti A,Batistoni R,Deri P,Rossi L,Sommerville J

更新日期：1998-09-15 00:00:00

abstract：:This work has identified the enzymes involved in the activation and conjugation of the ubiquitin-like protein NED-8 in Caenorhabditis elegans. A C. elegans conjugating enzyme, UBC-12, is highly specific in its ability to utilize NED-8 as a substrate. Immunostaining shows that NED-8 is conjugated in vivo to a major tar...

journal_title：Developmental biology

authors： Jones D,Candido EP

更新日期：2000-10-01 00:00:00

abstract：:We have tested the role of proteoglycans in the development of feather pattern by culturing 7-day-old embryonic chick skins on medium containing para-nitrophenyl-beta-D-xyloside (2 mM). Xylosides compete with core proteins of proteoglycans by acting as exogenous acceptors for the synthesis of glycosaminoglycans leadin...

journal_title：Developmental biology

authors： Goetinck PF,Carlone DL

更新日期：1988-05-01 00:00:00

abstract：:We have cloned a partial cDNA of chicken glial cell line-derived neurotrophic factor (GDNF) and systematically examined its expression pattern as well as that of GDNF-binding components (GDNF family receptor alpha-1 and 2: GFRalpha-1 and 2) and a common signal transduction receptor (c-ret protooncogene: RET) during ve...

journal_title：Developmental biology

authors： Homma S,Oppenheim RW,Yaginuma H,Kimura S

更新日期：2000-01-01 00:00:00

abstract：:Adhesive extracellular matrix (ECM) molecules appear to play roles in the migration of neural crest cells, and may also provide cues for differentiation of these cells into a variety of phenotypes. We are studying the influences of specific ECM components on crest differentiation at the levels of both individual cells...

journal_title：Developmental biology

authors： Rogers SL,Bernard L,Weston JA

更新日期：1990-09-01 00:00:00

abstract：:Eight series of mouse chimeras were produced by aggregating 8-cell embryos that differed at the Gpi-1s locus, encoding glucose phosphate isomerase (GPI-1). Chimeric blastocysts (Gpi-1sa/Gpi-1sa <--> Gpi-1sb/Gpi-1sb) were transferred to pseudopregnant females, which produced only GPI-1C enzyme. Quantitative electrophor...

journal_title：Developmental biology

authors： West JD,Flockhart JH,Keighren M

更新日期：1995-03-01 00:00:00

abstract：:In previous studies we found that two glycoproteins of 220 and 180 kDa account for 80-90% of the material dissolved from the vitelline coat (VC) of Unio elongatulus egg (Focarelli and Rosati, 1993). The two glycoproteins were purified by electroelution and used to raise the corresponding polyclonal antibodies. Immunof...

journal_title：Developmental biology

authors： Focarelli R,Rosati F

更新日期：1995-10-01 00:00:00

abstract：:We have identified a cellular efflux pump, RhT, with the properties of an MDR transporter-a type of ATP-binding cassette transporter whose substrates include small hydrophobic molecules. RhT transports rhodamine 123 (Rh123) and is inhibited by low temperature, energy poisons, and several MDR transport inhibitors, such...

journal_title：Developmental biology

authors： Good JR,Kuspa A

更新日期：2000-04-01 00:00:00

abstract：:Hedgehog (Hh) proteins are secreted molecules that play an essential role in development and tumorigenesis. In Drosophila cultured cells, phosphorylation of the kinesin-like Costal2 (Cos2) protein at Ser572 is triggered by the kinase fused (Fu) upon Hh pathway activation. Here, we validate the first phospho-antibody f...

journal_title：Developmental biology

authors： Raisin S,Ruel L,Ranieri N,Staccini-Lavenant L,Thérond PP

更新日期：2010-08-01 00:00:00

abstract：:The morphology of skeletal tissues formed in each of the branchial arches of higher vertebrates is unique. In addition to these structures, which are derived from the neural crest, the crest-derived connective tissues and mesodermal muscles also form different patterns in each of the branchial arches. The objective of...

journal_title：Developmental biology

authors： Noden DM

更新日期：1983-03-01 00:00:00

abstract：:This paper reports a preliminary in silico analysis of the sea urchin kinome. The predicted protein kinases in the sea urchin genome were identified, annotated and classified, according to both function and kinase domain taxonomy. The results show that the sea urchin kinome, consisting of 353 protein kinases, is close...

journal_title：Developmental biology

authors： Bradham CA,Foltz KR,Beane WS,Arnone MI,Rizzo F,Coffman JA,Mushegian A,Goel M,Morales J,Geneviere AM,Lapraz F,Robertson AJ,Kelkar H,Loza-Coll M,Townley IK,Raisch M,Roux MM,Lepage T,Gache C,McClay DR,Manning G

更新日期：2006-12-01 00:00:00

abstract：:The formation of endocardial endothelium in quail embryos was investigated using in vivo and in vitro systems. Based on the expression of an quail endothelial marker, QH-1, the initial emergence of endothelial precursor cells in the embryo occurs at stage 7+ (two somites) in the posterior parts of the bilateral heart ...

journal_title：Developmental biology

authors： Sugi Y,Markwald RR

更新日期：1996-04-10 00:00:00

abstract：:Caenorhabditis elegans embryonic elongation depends on both epidermal and muscle cells. The hemidesmosome-like junctions, commonly called fibrous organelles (FOs), that attach the epidermis to the extracellular matrix ensure muscle anchoring to the cuticular exoskeleton and play an essential role during elongation. To...

journal_title：Developmental biology

authors： Hetherington S,Gally C,Fritz JA,Polanowska J,Reboul J,Schwab Y,Zahreddine H,Behm C,Labouesse M

更新日期：2011-02-15 00:00:00