Abstract：
:Stimulation of epithelial cell cycling by the neuropeptide head activator was analyzed in Hydra magnipapillata and compared with the action of head activator on bud formation and tentacle formation during head regeneration. The results obtained indicate that head activator treatment stimulates epithelial cell division and induces the formation of more tentacle-specific epithelial cells. The number of additional epithelial cells which undergo mitosis during head activator treatment accounts for the increased number of epithelial cells present in the regenerated tentacles. Therefore, the head activator stimulation of tentacle formation can be explained by the mitogenic action of head activator on tentacle cell precursors. To analyze stimulation of bud formation by head activator, polyps of different developmental age were tested under conditions of long-term treatment, and effects on bud formation were compared with effects on epithelial cell proliferation. Head activator treatment strongly stimulated bud formation, but had no detectable effect on epithelial cell numbers. Bud formation occurs at smaller polyp size as a result of head activator treatment, indicating that head activator significantly interferes with the patterning system in hydra.
journal_name
Dev Bioljournal_title
Developmental biologyauthors
Hobmayer B,Holstein TW,David CNdoi
10.1006/dbio.1996.8491subject
Has Abstractpub_date
1997-03-01 00:00:00pages
1-8issue
1eissn
0012-1606issn
1095-564Xpii
S0012-1606(96)98491-2journal_volume
183pub_type
杂志文章abstract：:The kidney of the Gpc3-/ mouse, a novel model of human renal dysplasia, is characterized by selective degeneration of medullary collecting ducts preceded by enhanced cell proliferation and overgrowth during branching morphogenesis. Here, we identify cellular and molecular mechanisms underlying this renal dysplasia. Gl...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1006/dbio.2000.0127
更新日期：2001-03-01 00:00:00
abstract：:Notch signaling inhibits hair cell differentiation, based on studies on mice deficient in Notch signaling-related genes and its downstream genes. However, the precise mechanisms of this inhibition are unknown because it is difficult to control the timing and duration of the suppression of Notch signaling. Here, we dev...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/j.ydbio.2007.04.035
更新日期：2007-07-01 00:00:00
abstract：:Elastic fibers are produced during fetal and neonatal periods, and by maturity elastin expression has ceased. Fetal bovine hyaline chondrocytes acquired an elastogenic phenotype within 24 hr after isolation from the tissue, even though the tissue does not produce elastic fibers or tropoelastin mRNA in vivo. By multipl...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1006/dbio.1994.1140
更新日期：1994-05-01 00:00:00
abstract：:Inverse gradients of transcriptional repressors antagonize the transcriptional effector response to morphogens. However, the role of such inverse regulation might not manifest solely from lack of repressors. Sonic hedgehog (Shh) patterns the forebrain by being expressed ventrally; however, absence of antagonizing Gli3...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/j.ydbio.2019.03.011
更新日期：2019-06-01 00:00:00
abstract：:The polypeptide labeling patterns of somatic cells, gonidia (asexual reproductive cells), embryos, and juvenile spheroids of Volvox carteri cultures synchronized by a light/dark cycle were studied as a function of developmental stage and incubation condition. Specimens were exposed to 35SO=4 for 1-hr periods at select...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/0012-1606(83)90186-0
更新日期：1983-04-01 00:00:00
abstract：:Zygotic Wnt signaling has been shown to be involved in dorsoventral mesodermal patterning in Xenopus embryos, but how it regulates different myogenic gene expression in the lateral mesodermal domains is not clear. Here, we use transient exposure of embryos or explants to lithium, which mimics Wnt/beta-catenin signalin...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1006/dbio.2002.0633
更新日期：2002-05-01 00:00:00
abstract：:The Drosophila brain is tracheated by the cerebral trachea, a branch of the first segmental trachea of the embryo. During larval stages the cerebral trachea splits into several main (primary) branches that grow around the neuropile, forming a perineuropilar tracheal plexus (PNP) at the neuropile surface. Five primary ...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/j.ydbio.2006.09.022
更新日期：2007-02-01 00:00:00
abstract：:In the developing vertebrate brain, growing axons establish a scaffold of axon tracts connected across the midline via commissures. We have previously identified a population of telencephalic neurons that express NOC-2, a novel glycoform of the neural cell adhesion molecule N-CAM that is involved in axon guidance in t...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1006/dbio.1999.9549
更新日期：2000-01-15 00:00:00
abstract：:A glycoprotein from the liver, which shares epitopes with chorion (egg envelope or zona pellucida) glycoproteins, is present only in the spawning female fish, Oryzias latipes, under natural conditions. This spawning female-specific (SF) substance is distinct from vitellogenin but closely resembles a major glycoprotein...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/0012-1606(89)90301-1
更新日期：1989-05-01 00:00:00
abstract：:Retinoic acid (RA) affects the response of many cells to growth factors, including the bone morphogenetic proteins (BMPs). The BMPs are members of the TGF-beta, family of growth factors, originally identified by their bone-inducing activities. Their widespread expression suggests many roles other than that in osteogen...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1006/dbio.1996.0275
更新日期：1996-11-01 00:00:00
abstract：:The colonial tunicate Botrylloides leachi can regenerate functional adults from minute vasculature fragments, in a poorly understood phenomenon termed Whole Body Regeneration (WBR). Using Piwi expression (Bl-Piwi), blood cell labeling and electron microscopy, we show that WBR develops through activation, mobilization ...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/j.ydbio.2010.05.500
更新日期：2010-09-01 00:00:00
abstract：:Characterization of the molecular pathways controlling differentiation and proliferation in mammalian hair follicles is central to our understanding of the regulation of normal hair growth, the basis of hereditary hair loss diseases, and the origin of follicle-based tumors. We demonstrate that the proto-oncogene Wnt3,...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1006/dbio.1998.9140
更新日期：1999-03-01 00:00:00
abstract：:This study describes the temporal pattern of posterior positional identity in mouse limb bud cells. To do this wedges of tissue from the posterior edge of mouse limb buds at various stages (limb stages: Wanek et al., 1989b. J. Exp. Zool. 249, 41-49) were grafted to the anterior edge of a host chick embryo wing bud. Gr...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/0012-1606(91)90306-n
更新日期：1991-10-01 00:00:00
abstract：:Coordinated contraction of the heart is essential for survival and is regulated by the cardiac conduction system. Contraction of ventricular myocytes is controlled by the terminal part of the conduction system known as the Purkinje fiber network. Lineage analyses in chickens and mice have established that the Purkinje...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/j.ydbio.2014.07.008
更新日期：2014-09-15 00:00:00
abstract：:Metamorphosis involves the destruction of larval, the formation of adult and the transformation of larval into adult tissues. In this study, we demonstrate the role of the Drosophila nuclear proteins EAST and Chromator in tissue destruction and remodeling. To better understand the function of east, we performed a yeas...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/j.ydbio.2007.05.001
更新日期：2007-07-15 00:00:00
abstract：:The distribution of microtubules and microtubule organizing centers in the events leading up to the establishment of the first asymmetric cleavage furrow in nematode embryos was followed using indirect immunofluorescence of antibodies to tubulin. Oocytes arrest in meiotic prophase then undergo two meiotic reduction di...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/0012-1606(84)90117-9
更新日期：1984-01-01 00:00:00
abstract：:Zygotes and embryos of the fucoid brown alga Pelvetia compressa undergo a series of asymmetric cleavages. We are interested in the developmental role of these cleavages and the mechanism controlling their alignment. To assess the importance of division plane alignment, the orientation of the first asymmetric division ...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1006/dbio.1997.8832
更新日期：1998-02-15 00:00:00
abstract：:It has been posited that animal development evolved from pre-existing mechanisms for regulating cell differentiation in the single celled and colonial ancestors of animals. Although the progenitors of animals cannot be studied directly, insights into their cell biology may be gleaned from comparisons between animals a...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/j.ydbio.2011.06.003
更新日期：2011-09-01 00:00:00
abstract：:A gene regulatory network (GRN) controls the process by which the endomesoderm of the sea urchin embryo is specified. In this GRN, the program of gene expression unique to the skeletogenic micromere lineage is set in train by activation of the pmar1 gene. Through a double repression system, this gene is responsible fo...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/j.ydbio.2004.07.008
更新日期：2004-10-15 00:00:00
abstract：:The growing pollen tubes of tomato and tobacco were exposed to electrical fields and the effect on the direction of growth was measured. They responded by turning toward the positive electrode (anode) and gave a detectable response in fields as small as 0.1 mV/tube diameter. The sites of germination of tobacco pollen ...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/0012-1606(89)90266-2
更新日期：1989-12-01 00:00:00
abstract：:Breaking symmetry in populations of uniform cells, to induce adoption of an alternative cell fate, is an essential developmental mechanism. Similarly, domain and boundary establishment are crucial steps to forming organs during development. Notch signaling is a pathway ideally suited to mediating precise patterning cu...
journal_title：Developmental biology
pub_type： 杂志文章,评审
doi：10.1016/j.ydbio.2017.09.032
更新日期：2019-03-01 00:00:00
abstract：:To investigate the spatiotemporal dynamics of skin pattern formation, we developed a simple method for artificially disarranging the placement of all three pigment cell types in the body trunk of zebrafish (Danio rerio). We generated transgenic fish with melanophores that ectopically expressed a variant of channelrhod...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/j.ydbio.2018.12.019
更新日期：2020-04-01 00:00:00
abstract：:Mammalian CYPHER (Oracle, KIA0613), a member of the PDZ-LIM family of proteins (Enigma/LMP-1, ENH, ZASP/Cypher, RIL, ALP, and CLP-36), has been associated with cardiac and muscular myopathies. Targeted deletion of Cypher in mice is neonatal lethal possibly caused by myopathies. To further investigate the role of cyphe...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/j.ydbio.2006.07.032
更新日期：2006-11-15 00:00:00
abstract：:Cell signaling pathways, such as Wnt, Hedgehog (Hh), Notch, and Hippo, are essential for embryogenesis, organogenesis, and tissue homeostasis. In this study, we analyzed 415 genes involved in these pathways in the allotetraploid frog, Xenopus laevis. Most genes are retained in two subgenomes called L and S (193 homeol...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/j.ydbio.2016.12.006
更新日期：2017-06-15 00:00:00
abstract：:Selected stages of the developing chicken cornea have been examined for type VI collagen, employing monoclonal antibodies specific for this molecule. By immunofluorescence, the molecule is not detectable in 5 1/2 day corneas, a time at which the epithelial-derived, acellular primary stroma is the only corneal matrix p...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/0012-1606(86)90013-8
更新日期：1986-12-01 00:00:00
abstract：:Oligodendrocyte precursor cells (OPCs) can be differentiated in culture into either oligodendrocytes or type-2 astrocytes (2As), depending on the culture conditions. Whereas oligodendrocyte development can occur in the absence of inducing signals, 2A development apparently cannot. Fetal calf serum (FCS) and bone morph...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/j.ydbio.2003.11.013
更新日期：2004-03-01 00:00:00
abstract：:Acute myeloid leukemia (AML) is a complex malignancy with poor prognosis. Several genetic lesions can lead to the disease. One of these corresponds to the NUP98-HOXA9 (NA9) translocation that fuses sequences encoding the N-terminal part of NUP98 to those encoding the DNA-binding domain of HOXA9. Despite several studie...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/j.ydbio.2016.11.003
更新日期：2017-01-01 00:00:00
abstract：:Vimentin expression in the lens is striking due to the reported mesenchymal preference of vimentin and the epithelial origin of the lens. The amount of chicken vimentin mRNA levels determined by Northern blot analysis increased 3-fold from 7 to 14 days of embryonic lens development and then decreased 10-fold at 16 day...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/0012-1606(90)90278-q
更新日期：1990-05-01 00:00:00
abstract：:Sex in the nematode Caenorhabditis elegans is normally determined by the X chromosome to autosome (X:A) ratio, with XX hermaphrodites and XO males. Previous work has shown that a set of at least four autosomal genes (her-1, tra-2, tra-3, and tra-1) is signaled by the X:A ratio and appears to act in a regulatory pathwa...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/0012-1606(84)90077-0
更新日期：1984-11-01 00:00:00
abstract：:Type II collagen is a major component of hyaline cartilage, and has been suggested to be causally involved in promoting chondrogenesis during embryonic development. In the present study we have performed an immunohistochemical analysis of the distribution of type II collagen during several early stages of embryonic ch...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/s0012-1606(89)80026-0
更新日期：1989-02-01 00:00:00
