Multiple roles of Notch signaling in cochlear development.

Abstract:

:Notch signaling inhibits hair cell differentiation, based on studies on mice deficient in Notch signaling-related genes and its downstream genes. However, the precise mechanisms of this inhibition are unknown because it is difficult to control the timing and duration of the suppression of Notch signaling. Here, we developed a novel in vitro culture and analysis method for mouse fetal cochleae and examined the roles of Notch signaling by its reversible inhibition through the use of Notch signaling inhibitors of gamma-secretase and TNF-alpha-converting enzyme. Notch inhibition with Notch signaling inhibitor treatment increases the number of cochlear hair cells, as observed in gene deletion experiments. We elucidated that this increase is regulated by the dichotomy between hair cells and supporting cells from common progenitors. We also propose other roles of Notch signaling in cochlear development. First, Notch signaling arrests the cell cycle of the cochlear epithelium containing putative hair cells and supporting cell progenitors because Notch inhibition with inhibitor treatment increases the number of 5-bromo-2'-deoxyuridine (BrdU)-positive cells that can differentiate into hair cells or supporting cells. Second, Notch signaling is required for the induction of Prox1-positive supporting cells. Third, Notch signaling is required for the maintenance of supporting cells.

journal_name

Dev Biol

journal_title

Developmental biology

authors

Takebayashi S,Yamamoto N,Yabe D,Fukuda H,Kojima K,Ito J,Honjo T

doi

10.1016/j.ydbio.2007.04.035

subject

Has Abstract

pub_date

2007-07-01 00:00:00

pages

165-78

issue

1

eissn

0012-1606

issn

1095-564X

pii

S0012-1606(07)00858-5

journal_volume

307

pub_type

杂志文章
  • Xenopus Teashirt1 regulates posterior identity in brain and cranial neural crest.

    abstract::We have isolated two related Xenopus homologues of the homeotic zinc finger protein Teashirt1 (Tsh1), XTsh1a and XTsh1b. While Drosophila teashirt specifies trunk identity in the fly, the developmental relevance of vertebrate Tsh homologues is unknown. XTsh1a/b are expressed in prospective trunk CNS throughout early n...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2006.06.041

    authors: Koebernick K,Kashef J,Pieler T,Wedlich D

    更新日期:2006-10-01 00:00:00

  • Temporal separation of the migration of distinct myogenic precursor populations into the developing chick wing bud.

    abstract::The developing chick limb bud contains several stage-specific populations of muscle colony-forming (MCF) cells. The cell lineage relationships of these populations are not completely understood, but previous studies have suggested that there may be at least two myogenic precursor populations present in the limb bud. T...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/0012-1606(84)90237-9

    authors: Seed J,Hauschka SD

    更新日期:1984-12-01 00:00:00

  • Patterns of maternal messenger RNA accumulation and adenylation during oogenesis in Urechis caupo.

    abstract::We have investigated the accumulation and adenylation of the maternal mRNA during oogenesis in the oocytes of the marine worm Urechis caupo. The analysis, using in vitro translation and cDNA probes to assay for specific mRNAs, demonstrates that different maternal mRNAs accumulate with different patterns during oogenes...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/0012-1606(86)90347-7

    authors: Rosenthal ET,Wilt FH

    更新日期:1986-09-01 00:00:00

  • Coordinate and noncoordinate regulation of synaptic vesicle protein genes during embryonic development.

    abstract::Because the formation of a mature nerve terminal requires the accumulation of large quantities of synaptic vesicles, the expression of synaptic vesicle proteins would be expected to correlate with synaptogenesis. However, previous studies have provided conflicting evidence on this point. We have examined the developme...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1006/dbio.1993.1244

    authors: Lou X,Bixby JL

    更新日期:1993-09-01 00:00:00

  • Selective chromatid segregation mechanism proposed for the human split hand/foot malformation development by chromosome 2 translocations: A perspective.

    abstract::Three unrelated chromosome 2q14.1-14.2 region translocations caused the split hand/foot limb malformation development in humans by an unknown mechanism. Their etiology was described by the autosomal dominant inheritance with incomplete penetrance genetic model although authors stated, "the understanding of the genotyp...

    journal_title:Developmental biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.ydbio.2015.10.013

    authors: Klar AJ

    更新日期:2015-12-01 00:00:00

  • Inhibition of RHO-ROCK signaling enhances ICM and suppresses TE characteristics through activation of Hippo signaling in the mouse blastocyst.

    abstract::Specification of the trophectoderm (TE) and inner cell mass (ICM) lineages in the mouse blastocyst correlates with cell position, as TE derives from outer cells whereas ICM from inner cells. Differences in position are reflected by cell polarization and Hippo signaling. Only in outer cells, the apical-basal cell polar...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2014.06.023

    authors: Kono K,Tamashiro DA,Alarcon VB

    更新日期:2014-10-01 00:00:00

  • Expression of a cell adhesion molecule, neuropilin, in the developing chick nervous system.

    abstract::Neuropilin (previously known as the A5 protein) is a membrane protein identified in Xenopus and is presumed to be involved in the target recognition of the optic nerve fibers. We have isolated cDNAs encoding the chick homologue of neuropilin, using the Xenopus neuropilin cDNA as a hybridization probe. The predicted am...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1006/dbio.1995.1208

    authors: Takagi S,Kasuya Y,Shimizu M,Matsuura T,Tsuboi M,Kawakami A,Fujisawa H

    更新日期:1995-07-01 00:00:00

  • Separate elements in the 3' untranslated region of the mouse protamine 1 mRNA regulate translational repression and activation during murine spermatogenesis.

    abstract::The mouse protamine mRNAs, Prm-1 and Prm-2, are translationally repressed for several days during male germ cell differentiation. The translational delay of mouse Prm-1 mRNA has previously been shown to be dependent upon cis-acting elements that reside in the last 62 nucleotides of the Prm-1 3' untranslated region (3'...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1006/dbio.1997.8705

    authors: Fajardo MA,Haugen HS,Clegg CH,Braun RE

    更新日期:1997-11-01 00:00:00

  • The Ciona myogenic regulatory factor functions as a typical MRF but possesses a novel N-terminus that is essential for activity.

    abstract::Electroporation-based assays were used to test whether the myogenic regulatory factor (MRF) of Ciona intestinalis (CiMRF) interferes with endogenous developmental programs, and to evaluate the importance of its unusual N-terminus for muscle development. We found that CiMRF suppresses both notochord and endoderm develo...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2018.10.010

    authors: Ratcliffe LE,Asiedu EK,Pickett CJ,Warburton MA,Izzi SA,Meedel TH

    更新日期:2019-04-15 00:00:00

  • Ameiotic, a gene that controls meiotic chromosome and cytoskeletal behavior in maize.

    abstract::Microtubule organization during the novel cell division of ameiotic microsporocytes was examined using indirect immunofluorescence microscopy. A recessive mutation of the maize gene Ameiotic causes the replacement of meiosis I with a synchronized mitotic division (Palmer, R. G. (1971). Chromosoma 35, 233-246). All ide...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/0012-1606(92)90063-m

    authors: Staiger CJ,Cande WZ

    更新日期:1992-11-01 00:00:00

  • Drosophila Cyclin J is a mitotically stable Cdk1 partner without essential functions.

    abstract::Cyclin J is a cyclin family member that appears to have evolved before the metazoan radiation. Its evolutionary conservation argues for an important role but functional characterizations of Cyclin J have remained very limited. In Drosophila, Cyclin J is expressed only in females. Using transgenic Drosophila lines expr...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2009.06.042

    authors: Althoff F,Viktorinová I,Kastl J,Lehner CF

    更新日期:2009-09-15 00:00:00

  • Competition for factors and cellular resources as a principle of pattern formation in Hydra. II. Assistance of foot formation by heads and buds and a new model of pattern control.

    abstract::In Hydra long-range interactions between head, bud, and foot formation take place in addition to short-range interactions which are recognized as induction phenomena, occurring when transplants are placed into an environment of disparate positional value. Here the long-range promotion of foot formation is analyzed. Th...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1006/dbio.1995.1015

    authors: Müller WA

    更新日期:1995-01-01 00:00:00

  • Characterization of a sperm factor for egg activation at fertilization of the newt Cynops pyrrhogaster.

    abstract::Eggs of the newt, Cynops pyrrhogaster, arrested at the second meiotic metaphase are activated by sperm at fertilization and then complete meiosis to initiate development. We highly purified a sperm factor for egg activation from a sperm extract with several chromatographies. The purified fraction containing only a 45 ...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2007.04.019

    authors: Harada Y,Matsumoto T,Hirahara S,Nakashima A,Ueno S,Oda S,Miyazaki S,Iwao Y

    更新日期:2007-06-15 00:00:00

  • Developmental expression of the sea urchin egg receptor for sperm.

    abstract::Little is known about the biochemical changes underlying the morphological differentiation of the sea urchin egg during oogenesis. Because of this and the essential role of gamete recognition in fertilization, we studied the developmental expression of the recently identified egg surface receptor for sperm during ooge...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1006/dbio.1994.1233

    authors: Ohlendieck K,Partin JS,Stears RL,Lennarz WJ

    更新日期:1994-09-01 00:00:00

  • Osteogenic cell lineage analysis is facilitated by organ cultures of embryonic chick periosteum.

    abstract::Monoclonal antibodies against the surface of embryonic osteogenic cells (SB-1, SB-2, SB-3, and SB-5) have been used to characterize the sequence of transitions involved in the osteogenic cell lineage. In the present study, immunohistochemical analyses of the expression of osteogenic cell surface antigens in organ cult...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/0012-1606(90)90388-y

    authors: Bruder SP,Caplan AI

    更新日期:1990-10-01 00:00:00

  • Neural crest induction by the canonical Wnt pathway can be dissociated from anterior-posterior neural patterning in Xenopus.

    abstract::While Wnt signaling is known to be involved in early steps of neural crest development, the mechanism remains unclear. Because Wnt signaling is able to posteriorize anterior neural tissues, neural crest induction by Wnts has been proposed to be an indirect consequence of posteriorization of neural tissues rather than ...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2004.12.016

    authors: Wu J,Yang J,Klein PS

    更新日期:2005-03-01 00:00:00

  • Epithelial sheet movement requires the cooperation of c-Jun and MAP3K1.

    abstract::Epithelial sheet movement is an essential morphogenetic process during mouse embryonic eyelid closure in which Mitogen-Activated Protein 3 Kinase 1 (MAP3K1) and c-Jun play a critical role. Here we show that MAP3K1 associates with the cytoskeleton, activates Jun N-terminal kinase (JNK) and actin polymerization, and pro...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2014.09.001

    authors: Meng Q,Mongan M,Wang J,Tang X,Zhang J,Kao W,Xia Y

    更新日期:2014-11-01 00:00:00

  • Zebrafish cone-rod (crx) homeobox gene promotes retinogenesis.

    abstract::The mammalian Cone-rod homeobox (Crx) gene is a divergent member of the Otx gene family known to be involved in differentiation and survival of retinal photoreceptors and photoentrainment of circadian rhythms. Zebrafish have two genes in the Otx5/crx orthology class, and we previously showed that crx can transactivate...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2004.01.037

    authors: Shen YC,Raymond PA

    更新日期:2004-05-01 00:00:00

  • Choroideremia gene product affects trophoblast development and vascularization in mouse extra-embryonic tissues.

    abstract::Choroideremia (CHM) is a hereditary eye disease caused by mutations in the X-linked CHM gene. Disruption of the Chm gene in mice resulted in prenatal death of Chm-/Y males and Chm-/Chm+ females that had inherited the mutation from their mothers. Male chimeras and Chm+/Chm- females with paternal transmission of the mut...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2004.04.016

    authors: Shi W,van den Hurk JA,Alamo-Bethencourt V,Mayer W,Winkens HJ,Ropers HH,Cremers FP,Fundele R

    更新日期:2004-08-01 00:00:00

  • Protein tyrosine phosphatase PTP1 negatively regulates Dictyostelium STATa and is required for proper cell-type proportioning.

    abstract::The protein tyrosine phosphatase PTP1, which mediates reversible phosphorylation on tyrosine, has been shown to play an important regulatory role during Dictyostelium development. Mutants lacking PTP1 develop more rapidly than normal, while strains that overexpress PTP1 display aberrant morphology. However, the signal...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1006/dbio.2001.0171

    authors: Early A,Gamper M,Moniakis J,Kim E,Hunter T,Williams JG,Firtel RA

    更新日期:2001-04-01 00:00:00

  • Tube formation by complex cellular processes in Ciona intestinalis notochord.

    abstract::In the course of embryogenesis multicellular structures and organs are assembled from constituent cells. One structural component common to many organs is the tube, which consists most simply of a luminal space surrounded by a single layer of epithelial cells. The notochord of ascidian Ciona forms a tube consisting of...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2009.03.015

    authors: Dong B,Horie T,Denker E,Kusakabe T,Tsuda M,Smith WC,Jiang D

    更新日期:2009-06-15 00:00:00

  • A dual epimorphic and compensatory mode of heart regeneration in zebrafish.

    abstract::Zebrafish heart regeneration relies on the capacity of cardiomyocytes to proliferate upon injury. To understand the principles of this process after cryoinjury-induced myocardial infarction, we established a spatio-temporal map of mitotic cardiomyocytes and their differentiation dynamics. Immunodetection of phosphohis...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2014.12.002

    authors: Sallin P,de Preux Charles AS,Duruz V,Pfefferli C,Jaźwińska A

    更新日期:2015-03-01 00:00:00

  • Formation of the dorsal root ganglia in the avian embryo: segmental origin and migratory behavior of neural crest progenitor cells.

    abstract::The segmental origin and migratory pattern of neural crest cells at the trunk level of avian embryos was studied, with special emphasis on the formation of the dorsal root ganglia (DRG) which organize in the anterior half of each somite. Neural crest cells were visualized using the quail-chick marker and HNK-1 immunof...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/0012-1606(87)90236-3

    authors: Teillet MA,Kalcheim C,Le Douarin NM

    更新日期:1987-04-01 00:00:00

  • Defective development of the embryonic liver in N-myc-deficient mice.

    abstract::The mechanisms involved in the formation and the differentiation of the liver remain unclear despite extensive studies. To investigate these events in mouse hepatic development, we have taken advantage of the N-myc mutant mouse line which exhibits abnormal liver development. N-myc mutant embryos die between 11.5 and 1...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1006/dbio.1997.8823

    authors: Giroux S,Charron J

    更新日期:1998-03-01 00:00:00

  • Expression of type II iodothyronine deiodinase marks the time that a tissue responds to thyroid hormone-induced metamorphosis in Xenopus laevis.

    abstract::The thyroid gland synthesizes thyroxine (T4), which passes through the larval tadpole's circulatory system. The enzyme type II iodothyronine deiodinase (D2) converts thyroxine (T4) to the active hormone 3,5,3'-triiodothyronine (T3) in peripheral tissues. An early response to thyroid hormone (TH) in the Xenopus laevis ...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2003.10.005

    authors: Cai L,Brown DD

    更新日期:2004-02-01 00:00:00

  • Reverse engineering liver buds through self-driven condensation and organization towards medical application.

    abstract::The self-organizing tissue-based approach coupled with induced pluripotent stem (iPS) cell technology is evolving as a promising field for designing organoids in culture and is expected to achieve valuable practical outcomes in regenerative medicine and drug development. Organoids show properties of functional organs ...

    journal_title:Developmental biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.ydbio.2016.06.036

    authors: Shinozawa T,Yoshikawa HY,Takebe T

    更新日期:2016-12-15 00:00:00

  • Sulfated glycosaminoglycan deposition and processing at the basal epithelial surface in branching and beta-D-xyloside-inhibited embryonic salivary glands.

    abstract::We investigated whether the inhibition of proteoglycan synthesis and salivary branching morphogenesis by beta-D-xyloside was related to the deposition and processing of newly synthesized glycosaminoglycans at the basal epithelial surface that correlates with normal branching activity. Forty eight-hour cultures of cont...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/0012-1606(85)90358-6

    authors: Spooner BS,Bassett K,Stokes B

    更新日期:1985-05-01 00:00:00

  • Role of RB1 in human embryonic stem cell-derived retinal organoids.

    abstract::Three-dimensional (3D) organoid models derived from human pluripotent stem cells provide a platform for studying human development and understanding disease mechanisms. Most studies that examine biallelic inactivation of the cell cycle regulator Retinoblastoma 1 (RB1) and the link to retinoblastoma is in mice, however...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2020.03.011

    authors: Zheng C,Schneider JW,Hsieh J

    更新日期:2020-06-15 00:00:00

  • Increased sensitivity and clustering of elementary Ca2+ release events during oocyte maturation.

    abstract::The universal signal for egg activation at fertilization is a rise in cytoplasmic Ca(2+) with defined spatial and temporal kinetics. Mammalian and amphibian eggs acquire the ability to produce such Ca(2+) signals during a maturation period that precedes fertilization and encompasses resumption of meiosis and progressi...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2004.08.004

    authors: Machaca K

    更新日期:2004-11-01 00:00:00

  • Fusion of fibroblasts with differentiated and nondifferentiated leukemia cells resulting in blockage of DNA synthesis.

    abstract::We have investigated the regulation of DNA synthesis in the heterokaryons of HL60 human myelomonocytic leukemia cells and NIH3T3 mouse fibroblasts to examine if the differentiated leukemia cells contained a replication inhibiting activity. Cell fusions were performed either by exposing a suspension of mixed cells to a...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/0012-1606(91)90417-2

    authors: Prudovsky IA,Tsong TY

    更新日期:1991-04-01 00:00:00