Do as I say, Not(ch) as I do: Lateral control of cell fate.

abstract：:Cell proliferation, growth and survival are three different basic processes which converge at determining a fundamental property -the size of an organism. Scalloped (Sd) is the first characterised transcriptional partner to Yorkie (Yki), the downstream effector of the Hippo pathway which is a highly potential and evol...

journal_title：Developmental biology

authors： Rohith BN,Shyamala BV

更新日期：2017-12-15 00:00:00

abstract：:Results of numerous experiments indicate that the transient rise in intracellular Ca2+ following sperm-egg fusion is essential for the subsequent events that constitute egg activation. Some events of egg activation, e.g., cortical granule exocytosis, however, appear more sensitive to intracellular Ca2+ than other even...

journal_title：Developmental biology

authors： Xu Z,Lefevre L,Ducibella T,Schultz RM,Kopf GS

更新日期：1996-12-15 00:00:00

abstract：:The CRISPR/Cas9 system is a rapid, simple, and often extremely efficient gene editing method. This method has been used in a variety of organisms and cell types over the past several years. However, using this technology for generating gene-edited animals involves a number of obstacles. One such obstacle is mosaicism,...

journal_title：Developmental biology

authors： Mehravar M,Shirazi A,Nazari M,Banan M

更新日期：2019-01-15 00:00:00

abstract：:In the present study, we have investigated the role of tyrosine kinase activity during early retinal development in Xenopus laevis. The protein tyrosine kinase (PTK) inhibitors lavendustin A and genistein were used to determine the possible role of tyrosine kinase activity during retinal development in vivo and in vit...

journal_title：Developmental biology

authors： Li M,Babenko NA,Sakaguchi DS

更新日期：2004-02-01 00:00:00

abstract：:Pioneer axons in insect legs are experimentally accessible model systems for the molecular identification and cellular localization of guidance cues regulating the path of axon growth. A detailed study of the Fe2 pioneer axons in the legs of the cockroach was performed to examine the diversity of guidance mechanisms. ...

journal_title：Developmental biology

authors： Rajan I,Denburg JL

更新日期：1997-10-15 00:00:00

abstract：:Retinoic acid (RA) affects the response of many cells to growth factors, including the bone morphogenetic proteins (BMPs). The BMPs are members of the TGF-beta, family of growth factors, originally identified by their bone-inducing activities. Their widespread expression suggests many roles other than that in osteogen...

journal_title：Developmental biology

authors： Glozak MA,Rogers MB

更新日期：1996-11-01 00:00:00

abstract：:We have examined the interfaces between protein and lipid sulfation, the response of progenitor cells to specific growth factors, and developmental lineage progression. The experimental system used is the oligodendrocyte (OL), the cell responsible for myelination of axons in the central nervous system. The ability to ...

journal_title：Developmental biology

authors： Bansal R,Pfeiffer SE

更新日期：1994-04-01 00:00:00

abstract：:Epithelial sheet movement is an essential morphogenetic process during mouse embryonic eyelid closure in which Mitogen-Activated Protein 3 Kinase 1 (MAP3K1) and c-Jun play a critical role. Here we show that MAP3K1 associates with the cytoskeleton, activates Jun N-terminal kinase (JNK) and actin polymerization, and pro...

journal_title：Developmental biology

authors： Meng Q,Mongan M,Wang J,Tang X,Zhang J,Kao W,Xia Y

更新日期：2014-11-01 00:00:00

abstract：:Lens growth involves the proliferation of epithelial cells, followed by their migration to the equator region and differentiation into secondary fiber cells. It is widely accepted that fibroblast growth factor (FGF) signaling is required for the differentiation of lens epithelial cells into crystallin-rich fibers, but...

journal_title：Developmental biology

authors： Song X,Sato Y,Felemban A,Ito A,Hossain M,Ochiai H,Yamamoto T,Sekiguchi K,Tanaka H,Ohta K

更新日期：2012-08-01 00:00:00

abstract：:Biomineralization, the biologically controlled formation of mineral deposits, is of widespread importance in biology, medicine, and engineering. Mineralized structures are found in most metazoan phyla and often have supportive, protective, or feeding functions. Among deuterostomes, only echinoderms and vertebrates pro...

journal_title：Developmental biology

authors： Livingston BT,Killian CE,Wilt F,Cameron A,Landrum MJ,Ermolaeva O,Sapojnikov V,Maglott DR,Buchanan AM,Ettensohn CA

更新日期：2006-12-01 00:00:00

abstract：:During the development of locomotion circuits it is essential that motoneurons with distinct subtype identities select the correct trajectories and target muscles. In vertebrates, the generation of motoneurons and myelinating glia depends on Olig2, one of the five Olig family bHLH transcription factors. We investigate...

journal_title：Developmental biology

authors： Oyallon J,Apitz H,Miguel-Aliaga I,Timofeev K,Ferreira L,Salecker I

更新日期：2012-09-15 00:00:00

abstract：:Integrins are alphabeta transmembrane receptors that function in key cellular processes, including cell adhesion, differentiation, and extracellular matrix deposition through interactions with extracellular, membrane, and cytoplasmic proteins. We previously identified and cloned a muscle beta1 integrin cytoplasmic bin...

journal_title：Developmental biology

authors： Li J,Rao H,Burkin D,Kaufman SJ,Wu C

更新日期：2003-09-01 00:00:00

abstract：:The relationship between ascorbic acid concentration and cellular transport mechanisms was studied in chicken embryos (Gallus gallus domesticus). Unincubated (Day 0) fertile eggs did not contain detectable levels of ascorbic acid as assayed by high performance liquid chromatography with electrochemical detection. Howe...

journal_title：Developmental biology

authors： Wilson JX

更新日期：1990-06-01 00:00:00

abstract：:Regulation of gene expression during early embryonic development in the rabbit was investigated by quantitative assay of firefly luciferase activity obtained by microinjection of three plasmid constructs using the regulatory region of polyomavirus promoter (PrPyV) with two different enhancer sequences (wild type or mu...

journal_title：Developmental biology

authors： Christians E,Rao VH,Renard JP

更新日期：1994-07-01 00:00:00

abstract：:The segmental origin and migratory pattern of neural crest cells at the trunk level of avian embryos was studied, with special emphasis on the formation of the dorsal root ganglia (DRG) which organize in the anterior half of each somite. Neural crest cells were visualized using the quail-chick marker and HNK-1 immunof...

journal_title：Developmental biology

authors： Teillet MA,Kalcheim C,Le Douarin NM

更新日期：1987-04-01 00:00:00

abstract：:We have used amphibian gastrulation as a model system to study the action of the extracellular matrix (ECM) glycoprotein tenascin on mesodermal cell migration. Tenascin function was assayed in vitro during spreading of isolated cells from the dorsal marginal zone (DMZ) and during cell migration from DMZ explants. Plas...

journal_title：Developmental biology

authors： Riou JF,Shi DL,Chiquet M,Boucaut JC

更新日期：1990-02-01 00:00:00

abstract：:Wnt-11/Xfz7 signaling plays a major role in the regulation of convergent extension movements affecting the dorsal marginal zone (DMZ) of gastrulating Xenopus embryos. In order to provide data concerning the molecular targets of Wnt-11/Xfz7 signals, we have analyzed the regulation of the Rho GTPase Cdc42 by Wnt-11. In ...

journal_title：Developmental biology

authors： Penzo-Mendèz A,Umbhauer M,Djiane A,Boucaut JC,Riou JF

更新日期：2003-05-15 00:00:00

abstract：:Cellular interactions with laminin are important for numerous morphogenetic events. In Xenopus, the first of these is neurulation. The integrin alpha6 subunit mediates an attachment of the cells of the neural plate to the underlying basal lamina. A disruption of this interaction results in embryos that fail to neurula...

journal_title：Developmental biology

authors： Lallier TE,DeSimone DW

更新日期：2000-09-01 00:00:00

abstract：:Zygotes and embryos of the fucoid brown alga Pelvetia compressa undergo a series of asymmetric cleavages. We are interested in the developmental role of these cleavages and the mechanism controlling their alignment. To assess the importance of division plane alignment, the orientation of the first asymmetric division ...

journal_title：Developmental biology

authors： Bisgrove SR,Kropf DL

更新日期：1998-02-15 00:00:00

abstract：:Among the derivatives of the cephalic neural crest is the ectomesenchyme which subsequently constitutes most of the craniofacial skeleton. There is evidence to suggest that the skeletogenic fate of the hindbrain neural crest is specified before emigration from the neural tube and that Antennapedia class Hox genes are ...

journal_title：Developmental biology

authors： Hunt P,Ferretti P,Krumlauf R,Thorogood P

更新日期：1995-04-01 00:00:00

abstract：:The vertebrate intestinal epithelium is renewed continuously from stem cells at the base of the crypt in mammals or base of the fold in fish over the life of the organism. As stem cells divide, newly formed epithelial cells make an initial choice between a secretory or enterocyte fate. This choice has previously been ...

journal_title：Developmental biology

authors： Roach G,Heath Wallace R,Cameron A,Emrah Ozel R,Hongay CF,Baral R,Andreescu S,Wallace KN

更新日期：2013-04-15 00:00:00

abstract：:We have cloned a member of the fork head/HNF-3 family of transcription factors from the nematode Caenorhabditis elegans. Within the predicted DNA binding domain, this gene, called Ce-fkh-1, is 75-78% identical to the Drosophila fork head and rat liver HNF-3 alpha, beta, and gamma genes. Ce-fkh-1 mRNA is highly enriche...

journal_title：Developmental biology

authors： Azzaria M,Goszczynski B,Chung MA,Kalb JM,McGhee JD

更新日期：1996-09-15 00:00:00

abstract：:Developing cardiac myocytes divide a limited number of times before they stop and terminally differentiate, but the mechanism that stops their division is unknown. To help study the stopping mechanism, we defined conditions under which embryonic rat cardiac myocytes cultured in serum-free medium proliferate and exit t...

journal_title：Developmental biology

authors： Burton PB,Raff MC,Kerr P,Yacoub MH,Barton PJ

更新日期：1999-12-15 00:00:00

abstract：:We have cloned a partial cDNA of chicken glial cell line-derived neurotrophic factor (GDNF) and systematically examined its expression pattern as well as that of GDNF-binding components (GDNF family receptor alpha-1 and 2: GFRalpha-1 and 2) and a common signal transduction receptor (c-ret protooncogene: RET) during ve...

journal_title：Developmental biology

authors： Homma S,Oppenheim RW,Yaginuma H,Kimura S

更新日期：2000-01-01 00:00:00

abstract：:The mechanisms involved in the formation and the differentiation of the liver remain unclear despite extensive studies. To investigate these events in mouse hepatic development, we have taken advantage of the N-myc mutant mouse line which exhibits abnormal liver development. N-myc mutant embryos die between 11.5 and 1...

journal_title：Developmental biology

authors： Giroux S,Charron J

更新日期：1998-03-01 00:00:00

abstract：:Expression of the c-abl proto-oncogene in the mouse testis is characterized by the production of a unique 4.7-kb transcript present in germ cells that have entered the haploid phase of spermatogenesis. A similar developmental stage specificity of expression is observed for a member of the 70-kDa heat-shock protein (hs...

journal_title：Developmental biology

authors： Zakeri ZF,Ponzetto C,Wolgemuth DJ

更新日期：1988-02-01 00:00:00

abstract：:Cardiomyocyte differentiation overall has been analyzed in vivo and in vitro at the molecular level by homologous recombination, gene mutation studies, and by transgenics; however, the roles of many signal transduction mechanisms that drive this differentiation process are still not fully understood. One set of signal...

journal_title：Developmental biology

authors： Zhou X,Quann E,Gallicano GI

更新日期：2003-03-15 00:00:00

abstract：:A genetically complex mutant, two-faced (tfd), which causes the production of extra eye and antennal tissue on the dorsal head cuticle, has been analyzed for connectivity to and projection patterns in the central brain of nerves derived from these extra structures. It has been found that the extra antennal nerves freq...

journal_title：Developmental biology

authors： Lipshitz HD,Kankel DR

更新日期：1985-01-01 00:00:00

abstract：:Alkaline phosphatase (AP) activity is expressed in the endodermal cell lineage of ascidian embryos beginning at gastrulation. AP expression is resistant to levels of actinomycin D which completely suppress the appearance of other tissue-specific enzyme and morphological markers including acetylcholinesterase (AchE), a...

journal_title：Developmental biology

authors： Bates WR,Jeffery WR

更新日期：1987-02-01 00:00:00

abstract：:We have examined the roles of cell lineage and interactions in the determination of individual identified neurons in the grasshopper embryo by selective ablations of individual cells and/or their neighbors at successive stages following their birth. The neurons in the grasshopper central nervous system (CNS) are produ...

journal_title：Developmental biology

authors： Kuwada JY,Goodman CS

更新日期：1985-07-01 00:00:00