Abstract:
:A genetically complex mutant, two-faced (tfd), which causes the production of extra eye and antennal tissue on the dorsal head cuticle, has been analyzed for connectivity to and projection patterns in the central brain of nerves derived from these extra structures. It has been found that the extra antennal nerves frequently connect to and achieve normal projections in the brain, whereas no convincing connectivity between the nerves from the extra eye tissue and the brain, has been found. This suggests that the mechanisms by which the nerves derived from normal eyes and antennae achieve central connections may differ.
journal_name
Dev Bioljournal_title
Developmental biologyauthors
Lipshitz HD,Kankel DRdoi
10.1016/0012-1606(85)90370-7subject
Has Abstractpub_date
1985-01-01 00:00:00pages
1-12issue
1eissn
0012-1606issn
1095-564Xpii
0012-1606(85)90370-7journal_volume
107pub_type
杂志文章abstract::We investigated whether the inhibition of proteoglycan synthesis and salivary branching morphogenesis by beta-D-xyloside was related to the deposition and processing of newly synthesized glycosaminoglycans at the basal epithelial surface that correlates with normal branching activity. Forty eight-hour cultures of cont...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(85)90358-6
更新日期:1985-05-01 00:00:00
abstract::The PITX1 transcription factor is expressed during hindlimb development, where it plays a critical role in directing hindlimb growth and the specification of hindlimb morphology. While it is known that PITX1 regulates hindlimb formation, in part, through activation of the Tbx4 gene, other transcriptional targets remai...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2017.12.013
更新日期:2018-02-01 00:00:00
abstract::Metamorphosis in Drosophila results from a hierarchy of ecdysone-induced gene expression initiated at the end of the third larval instar. A now classical model of this hierarchy was proposed based on observations of the activity of polytene chromosome "puffs" which distinguished "early" puffs as those directly induced...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1999.9358
更新日期:1999-09-01 00:00:00
abstract::We previously demonstrated that male mice deficient in the soluble adenylyl cyclase (sAC) are sterile and produce spermatozoa with deficits in progressive motility and are unable to fertilize zona-intact eggs. Here, analyses of sAC(-/-) spermatozoa provide additional insights into the functions linked to cAMP signalin...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2006.05.038
更新日期:2006-08-15 00:00:00
abstract::Previous experiments in which vitamin A has been administered to developing or regenerating limbs have shown that different limb axes are affected. In regenerating axolotl limbs, serial reduplications in the proximodistal axis are produced. In the developing chick limb bud, mirror-imaged reduplications in the anteropo...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(83)90370-6
更新日期:1983-08-01 00:00:00
abstract::Gastrulation in Xenopus laevis transforms a ball of undifferentiated cells into a well-organized elongated embryo with a distinct body axis, as a result of extensive cell rearrangements and movements. Since cell adhesion is thought to play an important role during tissue morphogenesis, we investigated the potential ro...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1995.1288
更新日期:1995-10-01 00:00:00
abstract::The formation of primary mesenchyme cells in euechinoid sea urchin embryos involves the transformation of 32 epithelial cells into mesenchymal cells in a process referred to as ingression. The mechanism that drives this epithelial-mesenchymal transformation has yet to be identified. Previous studies (J. R. Gibbins, L....
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/s0012-1606(89)80058-2
更新日期:1989-01-01 00:00:00
abstract::In this study, we demonstrate the developmental activation, in the zebrafish embryo, of a surveillance mechanism which triggers apoptosis to remove damaged cells. We determine the time course of activation of this mechanism by exposing embryos to camptothecin, an agent which specifically inhibits topoisomerase I withi...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1999.9243
更新日期:1999-05-15 00:00:00
abstract::Transcription factors are key orchestrators of the emergence of neuronal diversity within the developing spinal cord. As such, the two paralogous proteins Pax3 and Pax7 regulate the specification of progenitor cells within the intermediate neural tube, by defining a neat segregation between those fated to form motor c...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2017.06.014
更新日期:2017-12-01 00:00:00
abstract::COUP-TFII (also known as Nr2f2), a member of the nuclear orphan receptor superfamily, is expressed in several regions of the central nervous system (CNS), including the ventral thalamus, hypothalamus, midbrain, pons, and spinal cord. To address the function of COUP-TFII in the CNS, we generated conditional COUP-TFII k...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2008.11.001
更新日期:2009-02-15 00:00:00
abstract::The germinal vesicle (GV) of starfish oocytes stays just beneath the oocyte cortex at the presumptive animal pole during the long period of oogenesis. We subjected oocytes to a centrifugal force field to detach the GV from the cortex. The association between the cortex and the GV persisted and withstood a small amount...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1999.9577
更新日期:2000-02-15 00:00:00
abstract:FOREWORD:The neural crest has been the main object of my investigations during my career in science, up to now. It is a fascinating topic for an embryologist because of its two unique characteristics: its large degree of multipotency and the fact that its development involves a phase during which its component cells mi...
journal_title:Developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.ydbio.2018.07.019
更新日期:2018-12-01 00:00:00
abstract::In Xenopus, the hatching and cement glands form at important boundaries in the head. We have examined induction of these glands in order to see the basis for this ectodermal patterning. Ectoderm can be induced to form hatching and cement glands by dorsal mesoderm and by the neural plate. Because the neural plate is su...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1993.1183
更新日期:1993-07-01 00:00:00
abstract::Transcription factors (TFs) can regulate different sets of genes to determine specific cell types by means of combinatorial codes. We previously identified closely-spaced TF binding motifs located 8.2-8.5 kb 5' to the ATG of the murine Pou4f3 gene, a gene required for late hair cell (HC) differentiation and survival. ...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2012.09.002
更新日期:2012-12-01 00:00:00
abstract::The level of early histone mRNA in Strongylocentrotus purpuratus changes abruptly at 6 hr of development, increasing an average of 10-fold by 9-10.5 hr and then decreasing over 2-fold by 13.5-15 hr. These changes occur when the late embryonic mRNA is still a very minor component of histone gene transcription. The exac...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(83)90340-8
更新日期:1983-07-01 00:00:00
abstract::Three-dimensional (3D) organoid models derived from human pluripotent stem cells provide a platform for studying human development and understanding disease mechanisms. Most studies that examine biallelic inactivation of the cell cycle regulator Retinoblastoma 1 (RB1) and the link to retinoblastoma is in mice, however...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2020.03.011
更新日期:2020-06-15 00:00:00
abstract::We have analyzed several aspects of the development of flies carrying mutations at the Glued locus. Optic lobe abnormalities in individuals heterozygous for the original Glued allele were previously shown to result from an action of this mutation in the retinula cells. We have estimated when the functioning of this ge...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(83)90256-7
更新日期:1983-09-01 00:00:00
abstract::The ancestral state of animal gastrulation and its bearing for our understanding of bilaterian evolution still is one of the most controversially discussed topics in the field of evolutionary and developmental biology. One hypothesis, the so-called amphistomy scenario, suggests the presence of a slit-like blastopore i...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2017.04.014
更新日期:2017-07-01 00:00:00
abstract::The cardiac neural crest contains ectomesenchymal and neural anlagen that are necessary for normal heart development. It is not known whether other regions of the neural crest are capable of supporting normal heart development. In the experiments reported herein, quail donor embryos provided cardiac, trunk, or mesence...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(89)90112-7
更新日期:1989-08-01 00:00:00
abstract::Notch signaling is involved in a large range of developmental processes, and has been functionally implicated in body plan segmentation in two of the three diverse segmented taxa, the vertebrates and arthropods. Here we investigate expression of Notch, Delta, and hes gene homologues during larval and juvenile developm...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2008.04.015
更新日期:2008-08-01 00:00:00
abstract::The regulation of early embryonic development in the amphibian Xenopus laevis depends largely upon translational and post-translational regulatory mechanisms to direct the complex cytodifferentiations that take place during early cleavage and blastula formation. The cell cycle dependence of protein synthesis was exami...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(91)90460-k
更新日期:1991-07-01 00:00:00
abstract::Neurons of the dorsal hindbrain and spinal cord are central in receiving, processing and relaying sensory perception and participate in the coordination of sensory-motor output. Numerous cellular and molecular mechanisms that underlie neuronal development in both regions of the nervous system are shared. We discuss he...
journal_title:Developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.ydbio.2016.10.008
更新日期:2017-12-01 00:00:00
abstract::Mf1, which encodes a winged-helix/forkhead transcription factor, is the murine homolog of human FKHL7, mutated in individuals with autosomal dominant inherited dysgenesis of the anterior segment of the eye (Axenfeld-Reiger anomaly). Mouse embryos homozygous for null mutations in Mf1 (Mf1(lacZ) and Mf1(ch)) show severe...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1999.9314
更新日期:1999-07-15 00:00:00
abstract::Retinoic acid (RA) signaling is required for normal development of multiple organs. However, little is known about how RA influences the initial stages of lung development. Here, we used a combination of genetic, pharmacological and explant culture approaches to address this issue, and to investigate how signaling by ...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2005.10.045
更新日期:2006-03-01 00:00:00
abstract::Cis-regulatory modules (CRMs) control spatiotemporal gene expression patterns in embryos. While measurement of quantitative CRM activities has become efficient, measurement of spatial CRM activities still relies on slow, one-by-one methods. To overcome this bottleneck, we have developed a high-throughput method that c...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2017.01.010
更新日期:2017-02-15 00:00:00
abstract::Asymmetric cell divisions produce all 302 neurons of the C. elegans hermaphrodite. Here, we describe a role for a C. elegans Dishevelled homolog, DSH-2, in an asymmetric neuroblast division. In dsh-2 mutants, neurons normally descended from the anterior neuroblast daughter of the ABpl/rpppa blast cell were frequently ...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2005.05.024
更新日期:2005-08-01 00:00:00
abstract::We have identified a cellular efflux pump, RhT, with the properties of an MDR transporter-a type of ATP-binding cassette transporter whose substrates include small hydrophobic molecules. RhT transports rhodamine 123 (Rh123) and is inhibited by low temperature, energy poisons, and several MDR transport inhibitors, such...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.2000.9611
更新日期:2000-04-01 00:00:00
abstract::Caenorhabditis elegans PEB-1 is a novel DNA-binding protein expressed in most pharyngeal cell types and outside the pharynx in the hypodermis, hindgut, and vulva. Previous RNAi analyses indicated that PEB-1 is required for normal morphology of these tissues and growth; however, the peb-1 null phenotype was unknown. He...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2004.08.040
更新日期:2004-12-15 00:00:00
abstract::Cloning and sequencing of Tripneustes gratilla genomic DNA and cDNA encoding a developmentally regulated, embryonic messenger RNA, referred to as Tg616, revealed an actin-encoding gene orthologous to the CyI actin gene described from Strongylocentrotus purpuratus. Tg616 and SpCyI share: (1) 150 nucleotides of highly c...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1994.1239
更新日期:1994-09-01 00:00:00
abstract::In Xenopus laevis, the capacity to regenerate a new lens from the outer cornea gradually decreases between stages 50 and 58, is almost negligible during the metamorphic climax, and disappears after metamorphosis. The factors responsible for lens transdifferentiation of the outer cornea are produced by the neural retin...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1997.8598
更新日期:1997-07-01 00:00:00