Abstract：
:Notch signaling is involved in a large range of developmental processes, and has been functionally implicated in body plan segmentation in two of the three diverse segmented taxa, the vertebrates and arthropods. Here we investigate expression of Notch, Delta, and hes gene homologues during larval and juvenile development in the polychaete annelid Capitella sp. I., a member of the third group of segmented animals. During larval stages, CapI-Notch, CapI-Delta, CapI-hes2, and CapI-hes3 transcripts are initially detected in broad ectodermal domains in future segments as well as in the brain and foregut; later, CapI-Notch, CapI-Delta, and CapI-hes2 transcripts are detected in the presumptive chaetal sacs. In contrast, CapI-hes1 has a segmentally reiterated pattern in a restricted region of the mesoderm in each presumptive segment. CapI-Notch, CapI-Delta, CapI-hes2, and CapI-hes3 and CapI-hes1 are all expressed in the terminal growth zone that generates post-metamorphic segments, however, CapI-hes1 has a non-overlapping complementary expression pattern to that of CapI-Notch and CapI-Delta. CapI-Delta and CapI-Notch transcripts are localized to already formed segments, with posterior boundaries that correlate with the posterior boundary of the nascent segment, while CapI-hes1 lies posterior to CapI-Notch and CapI-Delta. The localization of CapI-Notch, CapI-Delta, and CapI-hes transcripts correlate with areas of rapid cell proliferation in Capitella, which include the brain, foregut, and terminal growth zone.
journal_name
Dev Bioljournal_title
Developmental biologyauthors
Thamm K,Seaver ECdoi
10.1016/j.ydbio.2008.04.015subject
Has Abstractpub_date
2008-08-01 00:00:00pages
304-18issue
1eissn
0012-1606issn
1095-564Xpii
S0012-1606(08)00275-3journal_volume
320pub_type
杂志文章abstract：:Myotendinous junctions (MTJs) are specialized sites at the surface of muscle fibers where force is transmitted between muscle and tendon. Morphogenesis of MTJs in the latter half of embryonic chick development is characterized by formation of basement membrane, appearance of subsarcolemmal densities, association of my...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1006/dbio.1994.1161
更新日期：1994-06-01 00:00:00
abstract：:Cyclic protein-2 (CP-2) is secreted in vitro in substantial amounts by mature rat Sertoli cells in intact Stage VI and Stage VII seminiferous tubules. This stage-dependent secretion has led us to postulate that the biosynthesis of this molecule is stimulated by germ cells at a specific state of development. In order t...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/0012-1606(88)90412-5
更新日期：1988-11-01 00:00:00
abstract：:Monoclonal antibodies against the surface of embryonic osteogenic cells (SB-1, SB-2, SB-3, and SB-5) have been used to characterize the sequence of transitions involved in the osteogenic cell lineage. In the present study, immunohistochemical analyses of the expression of osteogenic cell surface antigens in organ cult...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/0012-1606(90)90388-y
更新日期：1990-10-01 00:00:00
abstract：:We have compared insulin binding by heart cells at 7 and 14 days of development. Species specificity, optimum pH, temperature relationships, and time to equilibrium for binding of insulin were the same in both 7 and 14-day systems. Curvilinear Scatchard plots for chicken insulin binding were demonstrated. Binding affi...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/0012-1606(81)90410-3
更新日期：1981-06-01 00:00:00
abstract：:The tadpole-type larva of Ciona has emerged as an intriguing model system for the study of neurodevelopment. The Ciona intestinalis connectome has been recently mapped, revealing the smallest central nervous system (CNS) known in any chordate, with only 177 neurons. This minimal CNS is highly reminiscent of larger CNS...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/j.ydbio.2018.09.023
更新日期：2019-04-15 00:00:00
abstract：:Sensory placodes are unique columnar epithelia with neurogenic potential that develop in the vertebrate head ectoderm next to the neural tube. They contribute to the paired sensory organs and the cranial sensory ganglia generating a wide variety of cell types ranging from lens fibres to sensory receptor cells and neur...
journal_title：Developmental biology
pub_type： 杂志文章,评审
doi：10.1016/j.ydbio.2004.08.037
更新日期：2004-12-01 00:00:00
abstract：:The Ca2+ oscillations initiated by the fertilizing sperm (but terminating concomitant with pronucleus formation) apparently ensure that the events constituting egg activation occur in the correct temporal order; early events (e.g., cortical granule exocytosis) require fewer oscillations than later events (e.g., recrui...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/j.ydbio.2006.08.041
更新日期：2006-12-15 00:00:00
abstract：:Among the derivatives of the cephalic neural crest is the ectomesenchyme which subsequently constitutes most of the craniofacial skeleton. There is evidence to suggest that the skeletogenic fate of the hindbrain neural crest is specified before emigration from the neural tube and that Antennapedia class Hox genes are ...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1006/dbio.1995.1104
更新日期：1995-04-01 00:00:00
abstract：:As the germ band shortens in Drosophila melanogaster embryos, cell shape changes cause segments to narrow anteroposteriorly and to lengthen dorsoventrally. One of the genes required for this retraction process is the hindsight (hnt) gene. hnt encodes a nuclear Zinc-finger protein that is expressed in the extraembryoni...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1006/dbio.1999.9409
更新日期：1999-10-01 00:00:00
abstract：:A functional ribosomal protein mRNA, encoding the 60 S subunit protein L1, has been synthesized in vitro using bacteriophage SP6 RNA polymerase. This mRNA directs the synthesis of a product indistinguishable from L1 protein purified from Xenopus ovarian ribosomes. Our results show that L1 synthesis in stage VI oocytes...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/0012-1606(88)90247-3
更新日期：1988-03-01 00:00:00
abstract：:At gastrulation in the sea urchin embryo dramatic cell adhesion changes contribute to primary mesenchyme cell ingression movements and to cell rearrangements during archenteron invagination. At ingression, quantitative adhesion assays demonstrated previously that primary mesenchyme cells (PMCs) change their affinity f...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1006/dbio.1998.9165
更新日期：1999-03-01 00:00:00
abstract：:Hedgehog (Hh) signaling is thought to occur in primary cilia, but the molecular basis of Gli2 and Gli3 activation by Hh signaling in cilia is unknown. Similarly, how ciliary gene mutations result in reduced Gli3 processing that generates a repressor is also not clear. Here we show that Hh signaling inhibits Gli2 and G...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/j.ydbio.2017.06.035
更新日期：2017-09-01 00:00:00
abstract：:Krox-20, originally identified as a member of "immediate-early" genes, plays a crucial role in the formation of two specific segments in the hindbrain during early development of the vertebrate nervous system. Here we cloned a genomic sequence of Xenopus Krox-20 (XKrox-20) and studied functions of a promoter element i...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/j.ydbio.2004.08.051
更新日期：2005-01-15 00:00:00
abstract：:Following their birth in olfactory placode, luteinizing hormone-releasing hormone (LHRH)-containing neurons migrate across the developing cribriform plate and form a dispersed population in the mammalian basal forebrain. The present study reveals the colocalization of unique glycoconjugate antigens (detected with mono...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1006/dbio.1993.1045
更新日期：1993-02-01 00:00:00
abstract：:Lineage specification of multipotent progenitor cells is governed by a balance of lineage-affiliated transcription factors, such as GATA1 and PU.1, which regulate the choice between erythroid and myelomonocytic fates. But how ratios of lineage-determining transcription factors stabilize progenitor cells and resolve th...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/j.ydbio.2007.02.036
更新日期：2007-05-15 00:00:00
abstract：:Planarians are well-known for their exceptional regenerative abilities. This investigation focuses on the involvement of a Y-box protein, defined by the presence of a cold-shock domain, in regeneration-specific processes. Previous studies have shown that developmentally expressed Y-box proteins bind to mRNA molecules ...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1006/dbio.1998.8996
更新日期：1998-09-15 00:00:00
abstract：:GDF11, a new member of the TGF-beta gene superfamily, regulates anterior/posterior patterning in the axial skeleton during mouse embryogenesis. Gdf11 null mice display skeletal abnormalities that appear to represent anterior homeotic transformations of vertebrae consistent with high levels of Gdf11 expression in...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1006/dbio.2000.9981
更新日期：2001-01-15 00:00:00
abstract：:Crest-derived glomus cells of the carotid body (CB) are O(2)-sensitive chemoreceptors, which resemble sympathoadrenal (SA) chromaffin cells. In this study, we tested whether perinatal rat glomus cells are sensitive to basic fibroblast growth factor (bFGF) in vitro and whether their sensitivity is regulated by oxygen. ...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1006/dbio.1997.8539
更新日期：1997-04-15 00:00:00
abstract：:A gene regulatory network (GRN) controls the process by which the endomesoderm of the sea urchin embryo is specified. In this GRN, the program of gene expression unique to the skeletogenic micromere lineage is set in train by activation of the pmar1 gene. Through a double repression system, this gene is responsible fo...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/j.ydbio.2004.07.008
更新日期：2004-10-15 00:00:00
abstract：:The Drosophila boule gene is expressed exclusively in the male germline and encodes an RNA binding protein closely related to the mammalian fertility factors encoded by the DAZ (Deleted in Azoospermia) and DAZL (DAZ-like) genes. Mutation of boule blocks both meiotic divisions. Differentiation nonetheless continues, re...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1006/dbio.1998.9098
更新日期：1998-12-15 00:00:00
abstract：:Dictyostelium discoideum amoebas display colonial multicellularity where starving amoebas aggregate to form migrating slugs and fruiting bodies consisting of spores and three supporting cell types. To resolve the cell signalling mechanism that control sporulation, we use insertional mutagenesis of amoebas transformed ...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/j.ydbio.2019.04.017
更新日期：2019-08-15 00:00:00
abstract：:Successful fertilization requires that sperm are activated prior to contacting an oocyte. In C. elegans, this activation process, called spermiogenesis, transforms round immobile spermatids into motile, fertilization-competent spermatozoa. We describe the phenotypic and genetic characterization of spe-43, a new compon...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/j.ydbio.2018.02.013
更新日期：2018-04-15 00:00:00
abstract：:Tie1 is a receptor tyrosine kinase expressed in endothelial cells, where it modulates Angiopoietin/Tie2 signaling. Previous studies have shown that mouse Tie1 mutants exhibit severe cardiovascular defects; however, much remains to be learned about the role of Tie1, especially during cardiac development. To further und...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/j.ydbio.2020.09.008
更新日期：2021-01-01 00:00:00
abstract：:A monoclonal antibody, Mab 8A2, that recognizes a novel set of gangliosides was produced by immunizing a mouse with Embryonic Day 14 chick optic nerve. Immunohistochemical studies of the developing chick retina revealed a complex pattern of Mab 8A2 immunoreactivity. Initially, staining is concentrated in the optic fib...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/0012-1606(91)90221-n
更新日期：1991-05-01 00:00:00
abstract：:During early development, GATA factors have been shown to be important for key events of coronary vasculogenesis, including formation of the epicardium. Myocardial GATA factors are required for coronary vascular (CV) formation; however, the role of epicardial localized GATAs in this process has not been addressed. The...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/j.ydbio.2013.12.033
更新日期：2014-02-01 00:00:00
abstract：:Primary sensory olfactory neurons reside in a neuroepithelium lining the nasal cavity and project topographically onto the surface of the olfactory bulb, a rostral extension of the telencephalon. Galectin-1, a bivalent galactose-binding vertebrate lectin, is expressed in the developing rodent olfactory system. In the ...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1006/dbio.1996.0257
更新日期：1996-10-10 00:00:00
abstract：:The neural crest is a transient and multipotent cell population arising at the edge of the neural plate in vertebrates. Recent findings highlight that neural crest patterning is initiated during gastrulation, i.e. earlier than classically described, in a progenitor domain named the neural border. This chapter reviews ...
journal_title：Developmental biology
pub_type： 杂志文章,评审
doi：10.1016/j.ydbio.2012.01.013
更新日期：2012-06-01 00:00:00
abstract：:The differentiation of three anterior pituitary cell types is regulated by the tissue-specific POU domain factor Pit-1, which is initially expressed on Embryonic Day 13.5-14 in mice. The Pit-1 gene remains continuously, highly expressed in the somatotrope, thyrotrope, and lactotrope cells of the adult. Using the Pit-1...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1006/dbio.1996.8472
更新日期：1997-02-01 00:00:00
abstract：:Islet1 (Isl1) is a LIM homedomain protein that plays a pivotal role in cardiac progenitors of the second heart field. Here, lineage studies with an inducible isl1-cre demonstrated that most Isl1 progenitors have migrated into the heart by E9. Although Isl1 expression is downregulated in most cardiac progenitors as the...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/j.ydbio.2006.12.048
更新日期：2007-04-01 00:00:00
abstract：:The lethal(3)discs overgrown (dco) locus of Drosophila melanogaster, located on the third chromosome at cytogenetic position 100A5,6-100B1,2, is necessary for normal development and growth control in the imaginal discs of the larva. Three recessive lethal alleles (dco2, dco3, and dco18) in heteroallelic combinations a...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/0012-1606(90)90090-6
更新日期：1990-08-01 00:00:00
