Studies of the developing chick retina using monoclonal antibody 8A2 that recognizes a novel set of gangliosides.

abstract：:The epidermis forms a vital barrier composed of stratified keratinocytes and their differentiated products. One of these products, keratin K10, is critical to epidermal integrity, because mutations in k10 lead to abnormal blistering. For the normal expression of k10, differentiation-associated transcription factors C/...

journal_title：Developmental biology

authors： Maytin EV,Lin JC,Krishnamurthy R,Batchvarova N,Ron D,Mitchell PJ,Habener JF

更新日期：1999-12-01 00:00:00

abstract：:Extensive elongation of lens fiber cells is a central feature of lens morphogenesis. Our study investigates the role of N-cadherin junctions in this process in vivo. We investigate both the molecular players involved in N-cadherin junctional maturation and the subsequent function of these junctions as epicenters for t...

journal_title：Developmental biology

authors： Leonard M,Zhang L,Zhai N,Cader A,Chan Y,Nowak RB,Fowler VM,Menko AS

更新日期：2011-01-15 00:00:00

abstract：:The basic helix-loop-helix transcription factor Twist1 plays an essential role in mesenchymal cell populations during embryonic development and in pathological disease. Remodeling of the cardiac outflow tract (OFT) into the functionally separate aortic arch and pulmonary trunk is dependent upon the dynamic, coordinate...

journal_title：Developmental biology

authors： Vincentz JW,Barnes RM,Rodgers R,Firulli BA,Conway SJ,Firulli AB

更新日期：2008-08-01 00:00:00

abstract：:The HCO3(-) anion activates sperm motility, an important early step in capacitation, by increasing flagellar beat frequency through a pathway that requires the atypical adenylyl cyclase SACY and the sperm-specific C alpha2 catalytic subunit of PKA. Here we show that the accelerating action of HCO3(-) also requires the...

journal_title：Developmental biology

authors： Carlson AE,Hille B,Babcock DF

更新日期：2007-12-01 00:00:00

abstract：:The Ca2+ oscillations initiated by the fertilizing sperm (but terminating concomitant with pronucleus formation) apparently ensure that the events constituting egg activation occur in the correct temporal order; early events (e.g., cortical granule exocytosis) require fewer oscillations than later events (e.g., recrui...

journal_title：Developmental biology

authors： Ozil JP,Banrezes B,Tóth S,Pan H,Schultz RM

更新日期：2006-12-15 00:00:00

abstract：:Three-dimensional (3D) organoid models derived from human pluripotent stem cells provide a platform for studying human development and understanding disease mechanisms. Most studies that examine biallelic inactivation of the cell cycle regulator Retinoblastoma 1 (RB1) and the link to retinoblastoma is in mice, however...

journal_title：Developmental biology

authors： Zheng C,Schneider JW,Hsieh J

更新日期：2020-06-15 00:00:00

abstract：:The ubiquitin ligase Smurf1 can target a handful of signaling proteins for ubiquitin-mediated proteasomal destruction or functional modification, including TGF-beta receptors, Smads, transcription factors, RhoA and MEKK2. Smurf1 was initially implicated in BMP pathway regulation in embryonic development, but its poten...

journal_title：Developmental biology

authors： Alexandrova EM,Thomsen GH

更新日期：2006-11-15 00:00:00

abstract：:Ca2+-sensitive microelectrodes were used to study changes in cytoplasmic free calcium during progesterone-induced meiotic maturation in Xenopus laevis oocytes. In contrast to previous reports, no changes were detected during the maturation process, although a large activation pulse of Ca2+ was seen when in vitro matur...

journal_title：Developmental biology

authors： Robinson KR

更新日期：1985-06-01 00:00:00

abstract：:The left-right body axis is coordinately aligned with the orthogonal dorsoventral and anterioposterior body axes. The developmental mechanisms that regulate axis coordination are unknown. Here it is shown that the cardiac left-right orientation in zebrafish (Danio rerio) is randomized in notochord-defective no tail an...

journal_title：Developmental biology

authors： Danos MC,Yost HJ

更新日期：1996-07-10 00:00:00

abstract：:It has been suggested that the mesonephros has a role in normal limb development. This hypothesis was directly tested by removing the mesonephros adjacent to the presumptive limb region of stage 12-18 chick embryos using microsurgery or laser ablation. The experimental manipulation resulted in reduced limb outgrowth o...

journal_title：Developmental biology

authors： Geduspan JS,Solursh M

更新日期：1992-05-01 00:00:00

abstract：:The ability to express exogenous reporter genes in intact, externally developing embryos, such as Xenopus, is a powerful tool for characterizing the activity of cis-regulatory gene elements during development. Although methods exist for generating transgenic Xenopus lines, more simplified methods for use with F0 anima...

journal_title：Developmental biology

authors： Wang C,Szaro BG

更新日期：2015-02-01 00:00:00

abstract：:Collapsin-1 is a secreted glycoprotein that inhibits the extension of specific growth cones in vitro. It has been hypothesized to serve as a repulsive guidance cue for extending growth cones in vivo. Here we report the distribution of collapsin-1 message as demonstrated by in situ hybridization using digoxigenin-label...

journal_title：Developmental biology

authors： Shepherd I,Luo Y,Raper JA,Chang S

更新日期：1996-01-10 00:00:00

abstract：:Neurons of the dorsal hindbrain and spinal cord are central in receiving, processing and relaying sensory perception and participate in the coordination of sensory-motor output. Numerous cellular and molecular mechanisms that underlie neuronal development in both regions of the nervous system are shared. We discuss he...

journal_title：Developmental biology

authors： Hernandez-Miranda LR,Müller T,Birchmeier C

更新日期：2017-12-01 00:00:00

abstract：:Crest-derived glomus cells of the carotid body (CB) are O(2)-sensitive chemoreceptors, which resemble sympathoadrenal (SA) chromaffin cells. In this study, we tested whether perinatal rat glomus cells are sensitive to basic fibroblast growth factor (bFGF) in vitro and whether their sensitivity is regulated by oxygen. ...

journal_title：Developmental biology

authors： Nurse CA,Vollmer C

更新日期：1997-04-15 00:00:00

abstract：:We report the patterns of migration of Sertoli cells plated on specific substrata, and the influences of testicular peritubular cells on these processes. Data presented indicate that while peritubular cells readily spread when explanted onto Type I collagen, Sertoli cells do not. A delay of 4 to 6 days occurs after Se...

journal_title：Developmental biology

authors： Tung PS,Fritz IB

更新日期：1986-01-01 00:00:00

abstract：:The relationship between ascorbic acid concentration and cellular transport mechanisms was studied in chicken embryos (Gallus gallus domesticus). Unincubated (Day 0) fertile eggs did not contain detectable levels of ascorbic acid as assayed by high performance liquid chromatography with electrochemical detection. Howe...

journal_title：Developmental biology

authors： Wilson JX

更新日期：1990-06-01 00:00:00

abstract：:The facial primordia in the chick embryo begin as rounded swellings that surround the primitive mouth and these grow out to form the beak. The control of proximodistal outgrowth is not well understood but may involve similar mechanisms to the limb bud. In order to test this hypothesis, combinations were made between e...

journal_title：Developmental biology

authors： Richman JM,Tickle C

更新日期：1992-12-01 00:00:00

abstract：:The chick spinal cord can regenerate following injury until advanced developmental stages. It is conceivable that changes in stem/progenitor cell plasticity contribute to the loss of this capacity, which occurs around E13. We investigated the contribution of proliferation, phenotypic changes in radial glia progenitors...

journal_title：Developmental biology

authors： Whalley K,Gögel S,Lange S,Ferretti P

更新日期：2009-08-15 00:00:00

abstract：:This manuscript reports on the limb malformations and axial skeleton alterations found in legless fetuses and their heterozygote and wild-type littermates transplacentally exposed to all-trans-retinoic acid via a single intraperitoneal injection on Day 7, 8, 9, 9.5, 10, 10.5, or 11 of gestation. The most surprising as...

journal_title：Developmental biology

authors： Scott WJ,Collins MD,Ernst AN,Supp DM,Potter SS

更新日期：1994-07-01 00:00:00

abstract：:Murine ovarian folliculogenesis commences after birth involving oocyte growth, somatic cell differentiation and structural remodeling of follicle stromal boundaries. The extracellular metalloproteinase ADAMTS-1 has activity against proteoglycans and collagen and is produced by the granulosa cells of ovarian follicles....

journal_title：Developmental biology

authors： Brown HM,Dunning KR,Robker RL,Pritchard M,Russell DL

更新日期：2006-12-15 00:00:00

abstract：:Understanding the regulatory circuitry controlling myogenesis is critical to understanding developmental mechanisms and developmentally-derived diseases. We analyzed the transcriptional regulation of a Drosophila myogenic repressor gene, Holes in muscles (Him). Previously, Him was shown to inhibit Myocyte enhancer fac...

journal_title：Developmental biology

authors： Elwell JA,Lovato TL,Adams MM,Baca EM,Lee T,Cripps RM

更新日期：2015-04-15 00:00:00

abstract：:The midbrain-hindbrain boundary (MHB) acts as a local organizer in the development of the CNS in vertebrates. Previously, we identified an MHB-specific bHLH-WRPW transcriptional repressor gene, Xenopus Hes-related 1 (XHR1), which is initially expressed in the presumptive MHB (pre-MHB) region at the early gastrula stag...

journal_title：Developmental biology

authors： Takada H,Hattori D,Kitayama A,Ueno N,Taira M

更新日期：2005-07-01 00:00:00

abstract：:We have phenotypically and molecularly analyzed the cutlet locus in Drosophila. Homozygous cutlet flies exhibit abnormal development of a subset of adult tissues, including the eye, wing, and ovary. We show that abnormal development of these tissues is due to a defect in normal cell growth. Surprisingly, cell growth i...

journal_title：Developmental biology

authors： Jaffe AB,Jongens TA

更新日期：2001-02-15 00:00:00

abstract：:teashirt (tsh) encodes a zinc-finger protein that is thought to be part of a network that contributes to regionalization of the Drosophila embryo and establishes the domains of Hox protein function. tsh and the Hox gene Sex combs reduced (Scr) are essential to establish the identity of the first thoracic segment. We u...

journal_title：Developmental biology

authors： Taghli-Lamallem O,Gallet A,Leroy F,Malapert P,Vola C,Kerridge S,Fasano L

更新日期：2007-07-01 00:00:00

abstract：:Mammalian sperm must acquire their fertilizing ability after a series of biochemical modifications in the female reproductive tract collectively called capacitation to undergo acrosomal exocytosis, a process that is essential for fertilization. Actin dynamics play a central role in controlling the process of exocytosi...

journal_title：Developmental biology

authors： Romarowski A,Battistone MA,La Spina FA,Puga Molina Ldel C,Luque GM,Vitale AM,Cuasnicu PS,Visconti PE,Krapf D,Buffone MG

更新日期：2015-09-15 00:00:00

abstract：:Cell surface and cytoplasmic polarity is exhibited by the blastomeres of mouse preimplantation embryos following compaction at the 8-cell stage of cleavage. It has been hypothesized that cytoplasmic polarity is initiated by plasma membrane functions of polar blastomeres that are absent from apolar blastomeres. To test...

journal_title：Developmental biology

authors： Wiley LM,Obasaju MF

更新日期：1988-11-01 00:00:00

abstract：:The morphology of skeletal tissues formed in each of the branchial arches of higher vertebrates is unique. In addition to these structures, which are derived from the neural crest, the crest-derived connective tissues and mesodermal muscles also form different patterns in each of the branchial arches. The objective of...

journal_title：Developmental biology

authors： Noden DM

更新日期：1983-03-01 00:00:00

abstract：:The Drosophila melanogaster ventral nerve cord derives from neural progenitor cells called neuroblasts. Individual neuroblasts have unique gene expression profiles and give rise to distinct clones of neurons and glia. The specification of neuroblast identity provides a cell intrinsic mechanism which ultimately results...

journal_title：Developmental biology

authors： Buescher M,Tio M,Tear G,Overton PM,Brook WJ,Chia W

更新日期：2006-04-15 00:00:00

abstract：:Mutations in the Pax6 gene disrupt telencephalic development, resulting in a thin cortical plate, expansion of proliferative layers, and the absence of the olfactory bulb. The primary defect in the neuronal cell population of the developing cerebral cortex was analysed by using mouse chimeras containing a mixture of w...

journal_title：Developmental biology

authors： Talamillo A,Quinn JC,Collinson JM,Caric D,Price DJ,West JD,Hill RE

更新日期：2003-03-01 00:00:00

abstract：:Gastrulation in Xenopus laevis transforms a ball of undifferentiated cells into a well-organized elongated embryo with a distinct body axis, as a result of extensive cell rearrangements and movements. Since cell adhesion is thought to play an important role during tissue morphogenesis, we investigated the potential ro...

journal_title：Developmental biology

authors： Lee CH,Gumbiner BM

更新日期：1995-10-01 00:00:00