spe-43 is required for sperm activation in C. elegans.

abstract：:Acidic fibroblast growth factor (aFGF) and basic fibroblast growth factor (bFGF) are present in high levels in most areas of the embryonic rodent brain. To begin to understand the role of these growth factors in brain development, the effects of aFGF and bFGF on dissociated cell cultures prepared from embryonic and ne...

journal_title：Developmental biology

authors： Engele J,Bohn MC

更新日期：1992-08-01 00:00:00

abstract：:Rapidly growing human teratocarcinoma cells (Tera-2) can be induced to differentiate into quiescent, nontumorigenic cells expressing neuronal markers. To more closely mimic the in vivo conditions for tumor growth, we grew Tera-2 cells in three-dimensional collagen gel cultures. The undifferentiated cells proliferated ...

journal_title：Developmental biology

authors： Alanko T,Tienari J,Lehtonen E,Saksela O

更新日期：1994-01-01 00:00:00

abstract：:Thrombospondin type 1 repeat (TSR) superfamily members regulate diverse biological activities ranging from cell motility to inhibition of angiogenesis. In this study, we verified that mouse protein O-fucosyltransferase-2 (POFUT2) specifically adds O-fucose to TSRs. Using two Pofut2 gene-trap lines, we demonstrated tha...

journal_title：Developmental biology

authors： Du J,Takeuchi H,Leonhard-Melief C,Shroyer KR,Dlugosz M,Haltiwanger RS,Holdener BC

更新日期：2010-10-01 00:00:00

abstract：:Fertilization-related sperm mitochondrial movement occurs at a rate comparable to other actin-myosin-driven movements and is inhibited by cytochalasin B and N-ethyl maleimide in Ascidia ceratodes sperm. F-actin was demonstrated in the tails and mitochondria using NBD-phallacidin fluorescence. Both actin and myosin wer...

journal_title：Developmental biology

authors： Lambert CC,Lambert G

更新日期：1984-12-01 00:00:00

abstract：:Characterization of the molecular pathways controlling differentiation and proliferation in mammalian hair follicles is central to our understanding of the regulation of normal hair growth, the basis of hereditary hair loss diseases, and the origin of follicle-based tumors. We demonstrate that the proto-oncogene Wnt3,...

journal_title：Developmental biology

authors： Millar SE,Willert K,Salinas PC,Roelink H,Nusse R,Sussman DJ,Barsh GS

更新日期：1999-03-01 00:00:00

abstract：:A cell surface protein (3B11) is differentially expressed in the embryonic labial segment of Manduca as two circular monolayers of epithelial cells invaginate and segregate from surrounding epithelial cells. The cells that invaginate and preferentially express 3B11 represent the presumptive prothoracic glands. These c...

journal_title：Developmental biology

authors： Chen CL,Lampe DJ,Robertson HM,Nardi JB

更新日期：1997-01-01 00:00:00

abstract：:The GATA family of transcription factors are known to play multiple critical roles in vertebrate developmental processes, including erythropoiesis, endoderm formation and cardiogenesis. There have been no previous demonstrations of a functional role for any GATA family member being associated with musculoskeletal deve...

journal_title：Developmental biology

authors： Alexandrovich A,Qureishi A,Coudert AE,Zhang L,Grigoriadis AE,Shah AM,Brewer AC,Pizzey JA

更新日期：2008-02-15 00:00:00

abstract：:A new monoclonal antibody, specific to an epitope in the carboxyl terminus of the Drosophila collagen IV molecule (basement membrane collagen) was identified. The distributions of collagen IV, laminin, and an additional extracellular molecule, the 2G2 antigen (2G2-Ag), were followed immunocytochemically during early w...

journal_title：Developmental biology

authors： Murray MA,Fessler LI,Palka J

更新日期：1995-03-01 00:00:00

abstract：:The vertebrate liver and heart arise from adjacent cell layers in the anterior lateral (AL) endoderm and mesoderm of late gastrula embryos, and the earliest stages of liver and heart development are interrelated through reciprocal tissue interactions. Although classical embryological studies performed several decades ...

journal_title：Developmental biology

authors： Zhang W,Yatskievych TA,Baker RK,Antin PB

更新日期：2004-04-15 00:00:00

abstract：:Larvae homozygous for the recessive lethal allele without children(rgl) (woc(rgl)) fail to pupariate. Application of exogenous 20-hydroxyecdysone elicits puparium formation and pupation. Ecdysteroid titer measurements on mutant larvae show an endocrine deficiency in the brain-ring gland complex, which normally synthes...

journal_title：Developmental biology

authors： Wismar J,Habtemichael N,Warren JT,Dai JD,Gilbert LI,Gateff E

更新日期：2000-10-01 00:00:00

abstract：:During early vertebrate development, ANF homeobox genes are expressed in the prospective forebrain. Their regulation is essential for correct morphogenesis and function of the prosencephalon. We identified a 1-kb fragment upstream of the chicken GANF gene sufficient to drive lacZ expression in the endogenous expressio...

journal_title：Developmental biology

authors： Spieler D,Bäumer N,Stebler J,Köprunner M,Reichman-Fried M,Teichmann U,Raz E,Kessel M,Wittler L

更新日期：2004-05-15 00:00:00

abstract：:ragged seedling2 (rgd2) is a novel, recessive mutation affecting lateral organ development in maize. The mutant phenotype of homozygous rgd2-R leaves is variable. Mild leaf phenotypes have a reduced midrib and may be moderately narrow and furcated; severe Rgd2-R(-) leaves are filamentous or even radial. Despite their ...

journal_title：Developmental biology

authors： Henderson DC,Muehlbauer GJ,Scanlon MJ

更新日期：2005-06-15 00:00:00

abstract：:Two 80- to 100-kb chromosomal replicons containing clustered chorion genes amplify in the ovarian follicle cells during the final 22 hr of Drosophila oogenesis. We have studied the relationship between amplification and transcription within one of these domains, located at 7E10-7F3,4 on the X chromosome. A tandem clus...

journal_title：Developmental biology

authors： Parks S,Wakimoto B,Spradling A

更新日期：1986-09-01 00:00:00

abstract：:The developing chick limb bud contains several stage-specific populations of muscle colony-forming (MCF) cells. The cell lineage relationships of these populations are not completely understood, but previous studies have suggested that there may be at least two myogenic precursor populations present in the limb bud. T...

journal_title：Developmental biology

authors： Seed J,Hauschka SD

更新日期：1984-12-01 00:00:00

abstract：:The protein tyrosine phosphatase PTP1, which mediates reversible phosphorylation on tyrosine, has been shown to play an important regulatory role during Dictyostelium development. Mutants lacking PTP1 develop more rapidly than normal, while strains that overexpress PTP1 display aberrant morphology. However, the signal...

journal_title：Developmental biology

authors： Early A,Gamper M,Moniakis J,Kim E,Hunter T,Williams JG,Firtel RA

更新日期：2001-04-01 00:00:00

abstract：:During the process of gastrulation in the sea urchin embryo, the vegetal plate invaginates to form the archenteron, a long narrow tube that extends across the blastocoel. Rearrangement of cells within the archenteron is thought to be a key component of the process of archenteron elongation. While these cell rearrangem...

journal_title：Developmental biology

authors： Ingersoll EP,Ettensohn CA

更新日期：1994-06-01 00:00:00

abstract：:Hedgehog (Hh) signaling is thought to occur in primary cilia, but the molecular basis of Gli2 and Gli3 activation by Hh signaling in cilia is unknown. Similarly, how ciliary gene mutations result in reduced Gli3 processing that generates a repressor is also not clear. Here we show that Hh signaling inhibits Gli2 and G...

journal_title：Developmental biology

authors： Li J,Wang C,Wu C,Cao T,Xu G,Meng Q,Wang B

更新日期：2017-09-01 00:00:00

abstract：:The Hedgehog (Hh) and Notch signal transduction pathways control a variety of developmental processes including cell fate choice, differentiation, proliferation, patterning and boundary formation. Because many components of these pathways are conserved, it was predicted and confirmed that pathway components are largel...

journal_title：Developmental biology

authors： Walton KD,Croce JC,Glenn TD,Wu SY,McClay DR

更新日期：2006-12-01 00:00:00

abstract：:Biologists have long recognized that dramatic bending of a cell sheet may be driven by even modest shrinking of the apical sides of cells. Cell shape changes and tissue movements like these are at the core of many of the morphogenetic movements that shape animal form during development, driving processes such as gastr...

journal_title：Developmental biology

authors： Sawyer JM,Harrell JR,Shemer G,Sullivan-Brown J,Roh-Johnson M,Goldstein B

更新日期：2010-05-01 00:00:00

abstract：:Three unrelated chromosome 2q14.1-14.2 region translocations caused the split hand/foot limb malformation development in humans by an unknown mechanism. Their etiology was described by the autosomal dominant inheritance with incomplete penetrance genetic model although authors stated, "the understanding of the genotyp...

journal_title：Developmental biology

authors： Klar AJ

更新日期：2015-12-01 00:00:00

abstract：:Ammonium transporter C (AmtC) is one of three transporters in Dictyostelium that have been proposed to regulate entry and exit of ammonia in a cell type dependent manner and to mediate ammonia signaling. Previous work demonstrated that disruption of the amtC gene results in a slugger phenotype in which the cells remai...

journal_title：Developmental biology

authors： Kirsten JH,Xiong Y,Dunbar AJ,Rai M,Singleton CK

更新日期：2005-11-01 00:00:00

abstract：:VegT is an essential maternal regulator of germ layer specification in Xenopus. The localization of VegT mRNA to the vegetal cortex of the oocyte during oogenesis ensures its inheritance by vegetal and not animal cells, and directs the differentiation of vegetal cells into endoderm. Similarly localized mRNAs, Vg1 and ...

journal_title：Developmental biology

authors： Heasman J,Wessely O,Langland R,Craig EJ,Kessler DS

更新日期：2001-12-15 00:00:00

abstract：:PDGFB is a growth factor which is vital for the completion of normal prenatal development. In this study, we report the phenotypic analysis of placentas from mouse conceptuses that lack a functional PDGFB or PDGFRbeta gene. Placentas of both types of mutant exhibit changes in the labyrinthine layer, including dilated ...

journal_title：Developmental biology

authors： Ohlsson R,Falck P,Hellström M,Lindahl P,Boström H,Franklin G,Ahrlund-Richter L,Pollard J,Soriano P,Betsholtz C

更新日期：1999-08-01 00:00:00

abstract：:Sine Oculis (So), the founding member of the SIX family of homeobox transcription factors, binds to sequence specific DNA elements and regulates transcription of downstream target genes. It does so, in part, through the formation of distinct biochemical complexes with Eyes Absent (Eya) and Groucho (Gro). While these c...

journal_title：Developmental biology

authors： Anderson AM,Weasner BP,Weasner BM,Kumar JP

更新日期：2014-06-15 00:00:00

abstract：:Drosophila melanogaster mature oocytes in ovaries are arrested at metaphase I of meiosis. Eggs that have reached the uterus have released this arrest. It was not known where in the female reproductive tract egg activation occurs and what triggers it. We investigated when and where the egg is activated in Drosophila in...

journal_title：Developmental biology

authors： Heifetz Y,Yu J,Wolfner MF

更新日期：2001-06-15 00:00:00

abstract：:Although round spermatid injection can be used to create progeny for males who do not produce mature sperm, the rate of successful embryogenesis after such procedures is significantly lower than that for similar procedures using mature spermatozoa. The mechanisms underlying this difference are unknown. In this study, ...

journal_title：Developmental biology

authors： Kishigami S,Van Thuan N,Hikichi T,Ohta H,Wakayama S,Mizutani E,Wakayama T

更新日期：2006-01-01 00:00:00

abstract：:In the full grown oocyte of Xenopus laevis, a sodium permeability can be induced by depolarization to positive potential with current injection. Voltage-clamp analysis has shown that depolarization causes a long-lasting modification of the membrane during which voltage-gated sodium channels become functional. In the p...

journal_title：Developmental biology

authors： Baud C

更新日期：1983-10-01 00:00:00

abstract：:The gastrointestinal (GI) tract of metazoans is lined by a series of regionally distinct epithelia. To maintain structure and function of the GI tract, regionally diversified differentiation of somatic stem cell (SC) lineages is critical. The adult Drosophila midgut provides an accessible model to study SC regulation ...

journal_title：Developmental biology

authors： Li H,Qi Y,Jasper H

更新日期：2016-11-15 00:00:00

abstract：:Retinoic acid (RA) signaling is required for normal development of multiple organs. However, little is known about how RA influences the initial stages of lung development. Here, we used a combination of genetic, pharmacological and explant culture approaches to address this issue, and to investigate how signaling by ...

journal_title：Developmental biology

authors： Desai TJ,Chen F,Lü J,Qian J,Niederreither K,Dollé P,Chambon P,Cardoso WV

更新日期：2006-03-01 00:00:00

abstract：:The gene nhr-6 encodes the Caenorhabditis elegans ortholog of the NR4A nuclear receptor. We determined the biological functions of NHR-6 through the isolation and characterization of a deletion allele of nhr-6, lg6001. We demonstrate that nhr-6 has an essential role in the development of the C. elegans somatic gonad. ...

journal_title：Developmental biology

authors： Gissendanner CR,Kelley K,Nguyen TQ,Hoener MC,Sluder AE,Maina CV

更新日期：2008-01-15 00:00:00