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The dorsal spinal cord and hindbrain: From developmental mechanisms to functional circuits.

Abstract：

:Neurons of the dorsal hindbrain and spinal cord are central in receiving, processing and relaying sensory perception and participate in the coordination of sensory-motor output. Numerous cellular and molecular mechanisms that underlie neuronal development in both regions of the nervous system are shared. We discuss here the mechanisms that generate neuronal diversity in the dorsal spinal cord and hindbrain, and emphasize similarities in patterning and neuronal specification. Insight into the developmental mechanisms has provided tools that can help to assign functions to small subpopulations of neurons. Hence, novel information on how mechanosensory or pain sensation is encoded under normal and neuropathic conditions has already emerged. Such studies show that the complex neuronal circuits that control perception of somatosensory and viscerosensory stimuli are becoming amenable to investigations.

journal_name

Dev Biol

journal_title

Developmental biology

authors

Hernandez-Miranda LR,Müller T,Birchmeier C

doi

10.1016/j.ydbio.2016.10.008

subject

Has Abstract

pub_date

2017-12-01 00:00:00

pages

34-42

issue

1

eissn

0012-1606

issn

1095-564X

pii

S0012-1606(16)30462-6

journal_volume

432

pub_type

杂志文章,评审

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