PITX1 promotes chondrogenesis and myogenesis in mouse hindlimbs through conserved regulatory targets.

abstract：:Morphogenesis of the Drosophila tracheal system relies on different signalling pathways that have distinct roles in specifying both the migration of the tracheal cells and the particular morphological features of the primary branches. The current view is that the tracheal cells are initially specified as an equivalent...

journal_title：Developmental biology

authors： Franch-Marro X,Casanova J

更新日期：2002-10-15 00:00:00

abstract：:An important developmental question concerns whether neurotransmitter phenotype is an inherent property of neurons or is influenced by target tissues. This issue can be addressed in the avian ciliary ganglion (CG) which contains two cholinergic populations, ciliary and choroid neurons, that differentially express the ...

journal_title：Developmental biology

authors： Darland DC,Nishi R

更新日期：1998-10-15 00:00:00

abstract：:Previous studies have shown that cultured Schwann cells secrete platelet-derived growth factor (PDGF) and express PDGF receptors which transmit a mitogenic response particularly when their levels are upregulated by elevation of intracellular cAMP. In this study the expression of PDGF and PDGF alpha- and beta-receptors...

journal_title：Developmental biology

authors： Eccleston PA,Funa K,Heldin CH

更新日期：1993-02-01 00:00:00

abstract：:Unidirectional blue light directs the rhizoid-thallus axis in the apolar zygotes of Fucus and Pelvetia. Here, it is shown that blue light (but not red light) increased cyclic GMP levels of Pelvetia zygotes by about a factor of 2. When the increase in cyclic GMP was blocked by a guanylyl cyclase inhibitor, photopolariz...

journal_title：Developmental biology

authors： Robinson KR,Miller BJ

更新日期：1997-07-01 00:00:00

abstract：:The individual blastomeres of the preimplantation mouse embryo become polarized during the 8-cell stage. Microvilli become restricted to the free surface of the embryo and this region of the membrane shows increased labeling with FITC-Con A and trinitrobenzenesulfonate (TNBS). Previous studies have shown that this pol...

journal_title：Developmental biology

authors： Adler RR,Ziomek CA

更新日期：1986-04-01 00:00:00

abstract：:Recent results have demonstrated the occurrence of mRNA cap methylation in the sea urchin embryo following fertilization. It has been suggested that this methylation event is responsible for the translational activation of maternal histone mRNAs in these embryos. We have used aphidicolin, an effective inhibitor of bot...

journal_title：Developmental biology

authors： Showman RM,Leaf DS,Anstrom JA,Raff RA

更新日期：1987-05-01 00:00:00

abstract：:Vulval epithelial tubes invaginate through concerted cell migration, ring formation, stacking of rings and intra-ring cell fusion in the nematodes Caenorhabditis elegans, Oscheius tipulae and Pristionchus pacificus. The number of rings forming the invaginations is invariantly seven, six, and eight, respectively. We hy...

journal_title：Developmental biology

authors： Kolotuev I,Podbilewicz B

更新日期：2008-01-01 00:00:00

abstract：:A glycoprotein from the liver, which shares epitopes with chorion (egg envelope or zona pellucida) glycoproteins, is present only in the spawning female fish, Oryzias latipes, under natural conditions. This spawning female-specific (SF) substance is distinct from vitellogenin but closely resembles a major glycoprotein...

journal_title：Developmental biology

authors： Hamazaki TS,Nagahama Y,Iuchi I,Yamagami K

更新日期：1989-05-01 00:00:00

abstract：:The relative sizes of the various structures in Hydra attenuata were compared over a broad range of animal sizes to determine in detail the ability to regulate proportions during regeneration. The three components of the head, namely hypostome, tentacles, and tentacle zone from which the tentacles emerge, the body col...

journal_title：Developmental biology

authors： Bode PM,Bode HR

更新日期：1984-06-01 00:00:00

abstract：:Sulfs are secreted sulfatases that catalyse removal of sulfate from Heparan Sulfate Proteoglycans (HSPGs) in the extracellular space. These enzymes are well known to regulate a number of crucial signalling pathways during development. In this study, we report that DSulfatase-1 (DSulf1), the unique Drosophila Sulf prot...

journal_title：Developmental biology

authors： Wojcinski A,Nakato H,Soula C,Glise B

更新日期：2011-10-01 00:00:00

abstract：:The corepressor SMRT acts on a range of transcription factors, including the retinoid and thyroid hormone nuclear receptors. The carboxy-terminal region of SMRT contains CoRNR box motifs that mediate these interactions. We have shown, in Xenopus, that SMRT can exist as isoforms containing either two or three CoRNR box...

journal_title：Developmental biology

authors： Malartre M,Short S,Sharpe C

更新日期：2006-04-15 00:00:00

abstract：:The epithelial-mesenchymal transition of cardiac endothelium is a critical developmental event in the formation of valvular and septal anlagen. We have demonstrated previously that this event can be mimicked in culture by treating atrioventricular canal (AV) endothelium with EDTA-soluble proteins extracted from embryo...

journal_title：Developmental biology

authors： Mjaatvedt CH,Krug EL,Markwald RR

更新日期：1991-06-01 00:00:00

abstract：:In the absence of maternal expression of the pecanex gene, the embryo develops severe hyperneuralization similar to that characteristic of Notch mutant embryos. We have extended a previous molecular analysis of the chromosomal interval that encompasses pecanex by using additional deficiencies to localize the locus on ...

journal_title：Developmental biology

authors： LaBonne SG,Sunitha I,Mahowald AP

更新日期：1989-11-01 00:00:00

abstract：:Cortical granules of eggs contain a population of heterogeneous proteins that are sequestered selectively within the cortical granule during oogenesis and that participate in the block to polyspermy during the fertilization reaction. To begin to understand the targeting mechanism of proteins to this organelle, we have...

journal_title：Developmental biology

authors： Wessel GM

更新日期：1995-01-01 00:00:00

abstract：:In Xenopus laevis, the capacity to regenerate a new lens from the outer cornea gradually decreases between stages 50 and 58, is almost negligible during the metamorphic climax, and disappears after metamorphosis. The factors responsible for lens transdifferentiation of the outer cornea are produced by the neural retin...

journal_title：Developmental biology

authors： Filoni S,Bernardini S,Cannata SM,D'Alessio A

更新日期：1997-07-01 00:00:00

abstract：:Spermatogenesis is initiated by the interaction of germ cells and somatic cells in seminiferous tubules. We used cDNA microarrays and representational difference analysis to identify genes that are expressed in the testis of the jsd/jsd mutant mouse, which contains only type A spermatogonial germ cells and Sertoli cel...

journal_title：Developmental biology

authors： Tanaka K,Tamura H,Tanaka H,Katoh M,Futamata Y,Seki N,Nishimune Y,Hara T

更新日期：2002-06-15 00:00:00

abstract：:The sensory neurons of the Drosophila wing differentiate during the initial stages of metamorphosis, appearing in the imaginal wing disc as it everts and flattens. These identifiable neurons arise in a stereotyped sequence, and lay down a specific pattern of axon bundles which travel proximally to the CNS. In several ...

journal_title：Developmental biology

authors： Blair SS,Palka J

更新日期：1985-04-01 00:00:00

abstract：:A protein complex consisting of Mago Nashi and Tsunagi/Y14 is required to establish the major body axes and for the localization of primordial germ cell determinants during Drosophila melanogaster oogenesis. The Mago Nashi:Tsunagi/Y14 heterodimer also serves as the core of the exon junction complex (EJC), a multiprote...

journal_title：Developmental biology

authors： Parma DH,Bennett PE Jr,Boswell RE

更新日期：2007-08-15 00:00:00

abstract：:Lineage diversification in the vertebrate neural crest may occur via instructive signals acting on pluripotent cells, and/or via early specification of subpopulations towards particular lineages. Mesencephalic neural crest cells normally form cholinergic parasympathetic neurons in the ciliary ganglion, while trunk neu...

journal_title：Developmental biology

authors： Lee VM,Bronner-Fraser M,Baker CV

更新日期：2005-02-01 00:00:00

abstract：:An organism's genome sequence serves as a blueprint for the proteins and regulatory RNAs essential for cellular function. The genome also harbors cis-acting non-coding sequences that control gene expression and are essential to coordinate regulatory programs during embryonic development. However, the genome sequence i...

journal_title：Developmental biology

authors： Aday AW,Zhu LJ,Lakshmanan A,Wang J,Lawson ND

更新日期：2011-09-15 00:00:00

abstract：:During mouse fertilization the spermatozoon induces a series of low-frequency long-lasting Ca(2+) oscillations. It is generally accepted that these oscillations are due to Ca(2+) release through the inositol 1,4,5-trisphosphate (InsP(3)) receptor. However, InsP(3) microinjection does not mimic sperm-induced Ca(2+) osc...

journal_title：Developmental biology

authors： Jones KT,Nixon VL

更新日期：2000-09-01 00:00:00

abstract：:Hedgehog (Hh) proteins are secreted molecules that play an essential role in development and tumorigenesis. In Drosophila cultured cells, phosphorylation of the kinesin-like Costal2 (Cos2) protein at Ser572 is triggered by the kinase fused (Fu) upon Hh pathway activation. Here, we validate the first phospho-antibody f...

journal_title：Developmental biology

authors： Raisin S,Ruel L,Ranieri N,Staccini-Lavenant L,Thérond PP

更新日期：2010-08-01 00:00:00

abstract：:Congenital bony syngnathia, a rare but severe human birth defect, is characterized by bony fusion of the mandible to the maxilla. However, the genetic mechanisms underlying this birth defect are poorly understood, largely due to limitation of available animal models. Here we present evidence that transgenic expression...

journal_title：Developmental biology

authors： He F,Hu X,Xiong W,Li L,Lin L,Shen B,Yang L,Gu S,Zhang Y,Chen Y

更新日期：2014-07-15 00:00:00

abstract：:Zygote arrest (Zar) proteins are crucial for early embryonic development, but their molecular mechanism of action is unknown. The Translational Control Sequence (TCS) in the 3' untranslated region (UTR) of the maternal mRNA, Wee1, mediates translational repression in immature Xenopus oocytes and translational activati...

journal_title：Developmental biology

authors： Charlesworth A,Yamamoto TM,Cook JM,Silva KD,Kotter CV,Carter GS,Holt JW,Lavender HF,MacNicol AM,Ying Wang Y,Wilczynska A

更新日期：2012-09-15 00:00:00

abstract：:Autoradiography has been used to confirm and to extend previous microspectrophotometric studies (Doerder and DeBault, 1975) on the timing of DNA synthesis during conjugation in Tetrahymena thermophila. The majority of DNA synthesis occurs at the expected periods preceding gamete formation and the two postzygotic divis...

journal_title：Developmental biology

authors： Allis CD,Colavito-Shepanski M,Gorovsky MA

更新日期：1987-12-01 00:00:00

abstract：:Tyrosinase is the rate-limiting enzyme for the production of melanin pigmentation. In the mouse and other animals, homozygous null mutations in the Tyrosinase gene (Tyr) result in the absence of pigmentation, i.e. albinism. Here we used the CRISPR/Cas9 system to generate mono- and bi-allelic null mutations in the Tyr ...

journal_title：Developmental biology

authors： Yen ST,Zhang M,Deng JM,Usman SJ,Smith CN,Parker-Thornburg J,Swinton PG,Martin JF,Behringer RR

更新日期：2014-09-01 00:00:00

abstract：:We investigated the potential role of rostral-caudal and dorsal-ventral subdivisions of the early rostral brain by relating these subdivisions to the early patterning of neuron cell bodies and their axon projections. The earliest neurons were mapped using the lipophilic axon tracers diI and diO on embryos fixed on emb...

journal_title：Developmental biology

authors： Mastick GS,Easter SS Jr

更新日期：1996-01-10 00:00:00

abstract：:Although local epithelial-mesenchymal tissue interactions which are presumably mediated by extracellular matrix molecules are important regulators of tooth morphogenesis and differentiation, our studies have indicated that these developmental processes also depend on circulating molecules. The iron-carrying serum prot...

journal_title：Developmental biology

authors： Partanen AM,Ekblom P,Thesleff I

更新日期：1985-09-01 00:00:00

abstract：:The uterus undergoes a series of dramatic changes in response to an implanting conceptus that, in some mammalian species, includes differentiation of the endometrial stroma into decidual tissue. This process, called decidualization, can be induced artificially in rodents indicating that the conceptus may not be essent...

journal_title：Developmental biology

authors： Bany BM,Cross JC

更新日期：2006-06-15 00:00:00

abstract：:Two populations of blastomeres become positionally distinct during fourth cleavage in the mouse embryo; the inner cells become enclosed within the embryo and the outer cells form the enclosing layer. The segregation of these two cell populations is important for later development, because it represents the initial ste...

journal_title：Developmental biology

authors： Sutherland AE,Speed TP,Calarco PG

更新日期：1990-01-01 00:00:00