当前位置： SCI文献检索 > DEVELOPMENTAL BIOLOGY期刊下所有文献 > Molecular genetics of pecanex, a maternal-effect neurogenic locus of Drosophila melanogaster that potentially encodes a large transmembrane protein.

Molecular genetics of pecanex, a maternal-effect neurogenic locus of Drosophila melanogaster that potentially encodes a large transmembrane protein.

Abstract：

:In the absence of maternal expression of the pecanex gene, the embryo develops severe hyperneuralization similar to that characteristic of Notch mutant embryos. We have extended a previous molecular analysis of the chromosomal interval that encompasses pecanex by using additional deficiencies to localize the locus on the molecular map. RNA blot analysis shows that the locus encodes a rare 9-kb transcript as well as minor transcripts of 3.7 and 2.3 kb. The temporal expression of these transcripts is appropriate for a neurogenic locus. Phenocopies of the mutant phenotype have been produced following microinjection of antisense RNA corresponding to a portion of the pecanex transcripts. Conceptual translation of a partial coding sequence compiled from cDNA and genomic clones indicates that the pecanex locus potentially encodes a large, membrane-spanning protein.

journal_name

Dev Biol

journal_title

Developmental biology

authors

LaBonne SG,Sunitha I,Mahowald AP

doi

10.1016/0012-1606(89)90127-9

subject

Has Abstract

pub_date

1989-11-01 00:00:00

pages

1-16

issue

1

eissn

0012-1606

issn

1095-564X

pii

0012-1606(89)90127-9

journal_volume

136

pub_type

杂志文章

相关文献

DEVELOPMENTAL BIOLOGY文献大全
  • MGL-1 on AIY neurons translates starvation to reproductive plasticity via neuropeptide signaling in Caenorhabditis elegans.

    abstract：:Reproductive plasticity is the ability of an animal to modulate its reproductive functions in response to environmental changes. For example, Caenorhabditis elegans, a free-living nematode, can adjust the onsets of oogenesis and embryogenesis under harsh environmental conditions, including starvation. However, the mol...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2017.08.014

    authors： Jeong H,Paik YK

    更新日期：2017-10-01 00:00:00

  • The survival of chick retinal ganglion cells in response to brain-derived neurotrophic factor depends on their embryonic age.

    abstract：:The survival effects of brain-derived neurotrophic factor (BDNF) on the ganglion cells of the chick retina were studied in vitro at different embryonic ages. We found these effects to be strongly age-dependent: at E5, when the first ganglion cell axons have crossed the optic chiasm, but not yet reached the tectum, gan...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(89)90256-x

    authors： Rodriguez-Tébar A,Jeffrey PL,Thoenen H,Barde YA

    更新日期：1989-12-01 00:00:00

  • Dorsoventral patterning by the Chordin-BMP pathway: a unified model from a pattern-formation perspective for Drosophila, vertebrates, sea urchins and Nematostella.

    abstract：:Conserved from Cnidarians to vertebrates, the dorsoventral (DV) axis is patterned by the Chordin-BMP pathway. However, the functions of the pathway's components are very different in different phyla. By modeling it is shown that many observations can be integrated by the assumption that BMP, acting as an inhibitory co...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2015.05.025

    authors： Meinhardt H

    更新日期：2015-09-01 00:00:00

  • Confocal and video imaging of cytoskeleton dynamics in the leech zygote.

    abstract：:Ooplasmic segregation in the late interphase zygote of the leech Theromyzon trizonare is accomplished by reorganization of an ectoplasmic cytoskeleton formed by polar rings and meridional bands. The dynamic properties of this cytoskeleton were explored by time-lapse confocal and video microscopy. Cytoskeleton assembly...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2004.03.023

    authors： Fernández J,Toro J,Ubilla A

    更新日期：2004-07-01 00:00:00

  • Keratin 9 is a component of the perinuclear ring of the manchette of rat spermatids.

    abstract：:Previous work in our laboratory has shown that a 62- to 64-kDa protein was a major component of the perinuclear ring of manchettes fractionated from rat spermatids. Mass spectrometry analysis of this protein indicated the presence of a glycine-rich domain homologous to human keratin 9 (K9). Several antibodies to K9, r...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.2000.9911

    authors： Mochida K,Rivkin E,Gil M,Kierszenbaum AL

    更新日期：2000-11-15 00:00:00

  • Genetic interactions of eyes absent, twin of eyeless and orthodenticle regulate sine oculis expression during ocellar development in Drosophila.

    abstract：:The homeobox gene sine oculis (so) is required for the development of the entire visual system in Drosophila, which includes the compound eyes, the ocelli, the optic lobe of the brain and the Bolwig's organ. During ocelli development, so expression labels, together with eyes absent (eya), the emergence of the ocellar ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2010.05.494

    authors： Blanco J,Pauli T,Seimiya M,Udolph G,Gehring WJ

    更新日期：2010-08-15 00:00:00

  • Evaluation of the contributions of ADAMs 9, 12, 15, 17, and 19 to heart development and ectodomain shedding of neuregulins beta1 and beta2.

    abstract：:Defects in heart development are the most common congenital abnormalities in humans, providing a strong incentive to learn more about the underlying causes. Previous studies have implicated the metalloprotease-disintegrins ADAMs (a disintegrin and metalloprotease) 17 and 19 as well as heparin binding EGF-like growth f...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2005.05.004

    authors： Horiuchi K,Zhou HM,Kelly K,Manova K,Blobel CP

    更新日期：2005-07-15 00:00:00

  • The roles of an ephrin and a semaphorin in patterning cell-cell contacts in C. elegans sensory organ development.

    abstract：:Ephrins and semaphorins regulate a wide variety of developmental processes, including axon guidance and cell migration. We have studied the roles of the ephrin EFN-4 and the semaphorin MAB-20 in patterning cell-cell contacts among the cells that give rise to the ray sensory organs of Caenorhabditis elegans. In wild-ty...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/s0012-1606(02)00129-x

    authors： Hahn AC,Emmons SW

    更新日期：2003-04-15 00:00:00

  • Synthesis and distribution of carbohydrate chains in cleavage-stage mouse embryos carrying the t12 lethal mutation.

    abstract：:Carbohydrate chains on the t12 mutant embryos were analyzed. No abnormalities of the synthesis of the carbohydrate chains were observed in the t12 homozygotes until the late morula stage, when radiolabeled carbohydrate chains were analyzed by Sephadex G-50 column chromatography. Furthermore, polarization of the Con A ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(88)90309-0

    authors： Iwakura Y,Nozaki M

    更新日期：1988-08-01 00:00:00

  • An ancient transcriptional regulatory linkage.

    abstract：:Changes in gene regulatory networks are a major engine for creating developmental novelty during evolution. Conversely, regulatory linkages that survive for very long evolutionary periods might be characteristic of ancient and abstract functions of fundamental utility to all metazoans. The proneural genes, which encod...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2005.03.004

    authors： Rebeiz M,Stone T,Posakony JW

    更新日期：2005-05-15 00:00:00

  • Modeling DNA sequence-based cis-regulatory gene networks.

    abstract：:Gene network analysis requires computationally based models which represent the functional architecture of regulatory interactions, and which provide directly testable predictions. The type of model that is useful is constrained by the particular features of developmentally active cis-regulatory systems. These systems...

    journal_title：Developmental biology

    pub_type： 杂志文章,评审

    doi：10.1006/dbio.2002.0617

    authors： Bolouri H,Davidson EH

    更新日期：2002-06-01 00:00:00

  • Pax6 is essential for the generation of late-born retinal neurons and for inhibition of photoreceptor-fate during late stages of retinogenesis.

    abstract：:In the developing retina, as in other regions of the CNS, neural progenitors give rise to individual cell types during discrete temporal windows. Pax6 is expressed in retinal progenitor cells (RPCs) throughout the course of retinogenesis, and has been shown to be required during early retinogenesis for generation of m...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2017.09.030

    authors： Remez LA,Onishi A,Menuchin-Lasowski Y,Biran A,Blackshaw S,Wahlin KJ,Zack DJ,Ashery-Padan R

    更新日期：2017-12-01 00:00:00

  • Continuously growing bipotential and monopotential myogenic, adipogenic, and chondrogenic subclones isolated from the multipotential RCJ 3.1 clonal cell line.

    abstract：:The clonal multipotential RCJ 3.1 cell line, which gives rise to myotubes, adipocytes, chondrocytes, and osteoblasts, contains different progenitor subpopulations. By limiting dilution analysis, of 296 single colonies identified, approximately 20% contained a single recognizable cell type, approximately 10% contained ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(90)90352-j

    authors： Grigoriadis AE,Heersche JN,Aubin JE

    更新日期：1990-12-01 00:00:00

  • An octamer element is required for the expression of the alpha H2B histone gene during the early development of the sea urchin.

    abstract：:Early (alpha) histone genes are one of several histone gene families in the sea urchin genome. They are expressed at high levels in blastula-stage embryos and are inactivated by the early gastrula stage. By microinjecting mutant early H2B genes into sea urchin zygotes and monitoring their transcriptional activity in b...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(92)90248-f

    authors： Bell J,Char BR,Maxson R

    更新日期：1992-04-01 00:00:00

  • Cellular heterogeneity during vertebrate skeletal muscle development.

    abstract：:Although skeletal muscles appear superficially alike at different anatomical locations, in reality there is considerably more diversity than previously anticipated. Heterogeneity is not only restricted to completely developed fibers, but is clearly apparent during development at the molecular, cellular and anatomical ...

    journal_title：Developmental biology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ydbio.2007.06.006

    authors： Biressi S,Molinaro M,Cossu G

    更新日期：2007-08-15 00:00:00

  • The representation of heart development in the gene ontology.

    abstract：:An understanding of heart development is critical in any systems biology approach to cardiovascular disease. The interpretation of data generated from high-throughput technologies (such as microarray and proteomics) is also essential to this approach. However, characterizing the role of genes in the processes underlyi...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2011.03.011

    authors： Khodiyar VK,Hill DP,Howe D,Berardini TZ,Tweedie S,Talmud PJ,Breckenridge R,Bhattarcharya S,Riley P,Scambler P,Lovering RC

    更新日期：2011-06-01 00:00:00

  • Dissecting Drosophila embryonic brain development using photoactivated gene expression.

    abstract：:The Drosophila brain is generated by a complex series of morphogenetic movements. To better understand brain development and to provide a guide for experimental manipulation of brain progenitors, we created a fate map using photoactivated gene expression to mark cells originating within specific mitotic domains and ti...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/s0012-1606(03)00220-3

    authors： Robertson K,Mergliano J,Minden JS

    更新日期：2003-08-01 00:00:00

  • Stage-specific increase in cell surface galactosyltransferase activity during spermatogenesis in mice bearing t alleles.

    abstract：:Mouse sperm surface galactosyltransferase (GalTase) mediates fertilization by binding to its appropriate glycoconjugate substrate in the egg zona pellucida. GalTase is present throughout all stages of spermatogenesis, during which time it redistributes within the plasma membrane from a uniform, diffuse distribution on...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(88)90072-3

    authors： Scully NF,Shur BD

    更新日期：1988-01-01 00:00:00

  • The oncofetal gene Pem specifies a divergent paired class homeodomain.

    abstract：:The polypeptide sequence predicted from the Pem oncofetal gene cDNA contains a homeodomain most closely related to the paired class. Pem, paired class member orthodenticle, and the bicoid maternal gene product homeodomains all have lysine residues at a recognition helix position implicated in DNA-binding specificity. ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(91)90467-h

    authors： Rayle RE

    更新日期：1991-07-01 00:00:00

  • An ECM-bound, PDGF-like growth factor and a TGF-alpha-like growth factor are required for gastrulation and spiculogenesis in the Lytechinus embryo.

    abstract：:Growth factors and the extracellular matrix have been shown to fulfill vital developmental roles in many embryonic systems. Our hypothesis is that a developmental role played by the extracellular matrix in sea urchins may be the binding of a PDGF-like growth factor to promote signaling activity. We report here that an...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1995.8059

    authors： Govindarajan V,Ramachandran RK,George JM,Shakes DC,Tomlinson CR

    更新日期：1995-12-01 00:00:00

  • Cell lineage conversion in the sea urchin embryo.

    abstract：:The mesoderm of the sea urchin embryo conventionally is divided into two populations of cells; the primary mesenchyme cells (PMCs), which produce the larval skeleton, and the secondary mesenchyme cells (SMCs), which differentiate into a variety of cell types but do not participate in skeletogenesis. In this study we e...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(88)90220-5

    authors： Ettensohn CA,McClay DR

    更新日期：1988-02-01 00:00:00

  • Huntingtin interacting proteins 14 and 14-like are required for chorioallantoic fusion during early placental development.

    abstract：:Huntington disease (HD) is an adult-onset neurodegenerative disease characterized by motor, cognitive, and psychiatric symptoms that is caused by a CAG expansion in the HTT gene. Palmitoylation is the addition of saturated fatty acids to proteins by DHHC palmitoylacyl transferases. HTT is palmitoylated by huntingtin i...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2014.11.018

    authors： Sanders SS,Hou J,Sutton LM,Garside VC,Mui KK,Singaraja RR,Hayden MR,Hoodless PA

    更新日期：2015-01-15 00:00:00

  • An organizing role for the TGF-β signaling pathway in axes formation of the annelid Capitella teleta.

    abstract：:Embryonic organizers are signaling centers that coordinate developmental events within an embryo. Localized to either an individual cell or group of cells, embryonic organizing activity induces the specification of other cells in the embryo and can influence formation of body axes. In the spiralian Capitella teleta, p...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2018.01.004

    authors： Lanza AR,Seaver EC

    更新日期：2018-03-01 00:00:00

  • Keratin 10 gene expression during differentiation of mouse epidermis requires transcription factors C/EBP and AP-2.

    abstract：:The epidermis forms a vital barrier composed of stratified keratinocytes and their differentiated products. One of these products, keratin K10, is critical to epidermal integrity, because mutations in k10 lead to abnormal blistering. For the normal expression of k10, differentiation-associated transcription factors C/...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1999.9460

    authors： Maytin EV,Lin JC,Krishnamurthy R,Batchvarova N,Ron D,Mitchell PJ,Habener JF

    更新日期：1999-12-01 00:00:00

  • Elk3 is essential for the progression from progenitor to definitive neural crest cell.

    abstract：:Elk3/Net/Sap2 (here referred to as Elk3) is an Ets ternary complex transcriptional repressor known for its involvement in angiogenesis during embryonic development. Although Elk3 is expressed in various tissues, additional roles for the protein outside of vasculature development have yet to be reported. Here, we chara...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2012.12.009

    authors： Rogers CD,Phillips JL,Bronner ME

    更新日期：2013-02-15 00:00:00

  • Multiple roles of the eyes absent gene in Drosophila.

    abstract：:The eyes absent (eya) gene plays an essential role in the events that lead to formation of the Drosophila eye; without expression of eya in retinal progenitor cells, they undergo programmed cell death just prior to the morphogenetic furrow, leading to an eyeless or reduced eye phenotype. The eya gene has recently been...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1997.8845

    authors： Bonini NM,Leiserson WM,Benzer S

    更新日期：1998-04-01 00:00:00

  • The insulator protein Suppressor of Hairy wing is required for proper ring canal development during oogenesis in Drosophila.

    abstract：:Chromatin insulators orchestrate gene transcription during embryo development and cell differentiation by stabilizing interactions between distant genomic sites. Mutations in genes encoding insulator proteins are generally lethal, making in vivo functional analyses of insulator proteins difficult. In Drosophila, howev...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2015.03.024

    authors： Hsu SJ,Plata MP,Ernest B,Asgarifar S,Labrador M

    更新日期：2015-07-01 00:00:00

  • Neuronal determination during embryonic development of the grasshopper nervous system.

    abstract：:We have examined the roles of cell lineage and interactions in the determination of individual identified neurons in the grasshopper embryo by selective ablations of individual cells and/or their neighbors at successive stages following their birth. The neurons in the grasshopper central nervous system (CNS) are produ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(85)90069-7

    authors： Kuwada JY,Goodman CS

    更新日期：1985-07-01 00:00:00

  • The extracellular matrix dimension of skeletal muscle development.

    abstract：:Cells anchor to substrates by binding to extracellular matrix (ECM). In addition to this anchoring function however, cell-ECM binding is a mechanism for cells to sense their surroundings and to communicate and coordinate behaviour amongst themselves. Several ECM molecules and their receptors play essential roles in mu...

    journal_title：Developmental biology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ydbio.2011.03.015

    authors： Thorsteinsdóttir S,Deries M,Cachaço AS,Bajanca F

    更新日期：2011-06-15 00:00:00

  • Substratum effects on cell dispersal, morphology, and differentiation in cultures of avian neural crest cells.

    abstract：:Adhesive extracellular matrix (ECM) molecules appear to play roles in the migration of neural crest cells, and may also provide cues for differentiation of these cells into a variety of phenotypes. We are studying the influences of specific ECM components on crest differentiation at the levels of both individual cells...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(90)90112-v

    authors： Rogers SL,Bernard L,Weston JA

    更新日期：1990-09-01 00:00:00