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Stage-specific increase in cell surface galactosyltransferase activity during spermatogenesis in mice bearing t alleles.

Abstract：

:Mouse sperm surface galactosyltransferase (GalTase) mediates fertilization by binding to its appropriate glycoconjugate substrate in the egg zona pellucida. GalTase is present throughout all stages of spermatogenesis, during which time it redistributes within the plasma membrane from a uniform, diffuse distribution on primary spermatocytes to a restricted domain overlying the dorsal surface of the acrosome. Previously, we have shown that GalTase activity is elevated on transmission-distorting t-bearing sperm populations, relative to normal sperm, and in this paper, we define the stage when surface GalTase activity becomes elevated during t spermatogenesis. GalTase specific activity is equal between normal and t-bearing primary spermatocytes, but following meiosis, surface GalTase activity becomes elevated nearly fourfold on t-bearing round spermatids. The increased GalTase activity on t-bearing spermatids is not due to decreased hydrolysis of the GalTase substrates, and is appropriately localized over the acrosomal region, even on misshapen sperm heads occasionally seen in t-sperm populations. These studies define the stage when a specific biochemical defect associated with mutant alleles of the T/t complex first becomes detectable. The t factors that elevate GalTase activity on round spermatids may be similar to previously identified t-specific testicular proteins that are maximally expressed at the same developmental stage, and which map to the same portion of the T/t complex.

journal_name

Dev Biol

journal_title

Developmental biology

authors

Scully NF,Shur BD

doi

10.1016/0012-1606(88)90072-3

subject

Has Abstract

pub_date

1988-01-01 00:00:00

pages

195-9

issue

1

eissn

0012-1606

issn

1095-564X

pii

0012-1606(88)90072-3

journal_volume

125

pub_type

杂志文章

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