How cells dedifferentiate: a lesson from plants.

abstract：:It has long been hypothesized that in fishes the contents of cortical granules are involved in the hardening of egg envelope following fertilization. We previously purified the egg envelope hardening initiation factor from the exudates released from activated medaka (Oryzias latipes) eggs and tentatively termed this p...

journal_title：Developmental biology

authors： Shibata Y,Iwamatsu T,Suzuki N,Young G,Naruse K,Nagahama Y,Yoshikuni M

更新日期：2012-12-15 00:00:00

abstract：:Specification of the trophectoderm (TE) and inner cell mass (ICM) lineages in the mouse blastocyst correlates with cell position, as TE derives from outer cells whereas ICM from inner cells. Differences in position are reflected by cell polarization and Hippo signaling. Only in outer cells, the apical-basal cell polar...

journal_title：Developmental biology

authors： Kono K,Tamashiro DA,Alarcon VB

更新日期：2014-10-01 00:00:00

abstract：:Much progress has been made in elucidating the molecular networks required for specifying retinal cells, including photoreceptors, but the downstream mechanisms that maintain identity and regulate differentiation remain poorly understood. Here, we report that the transcription factor Glass has a dual role in establish...

journal_title：Developmental biology

authors： Liang X,Mahato S,Hemmerich C,Zelhof AC

更新日期：2016-06-01 00:00:00

abstract：:Lineage specification of multipotent progenitor cells is governed by a balance of lineage-affiliated transcription factors, such as GATA1 and PU.1, which regulate the choice between erythroid and myelomonocytic fates. But how ratios of lineage-determining transcription factors stabilize progenitor cells and resolve th...

journal_title：Developmental biology

authors： Huang S,Guo YP,May G,Enver T

更新日期：2007-05-15 00:00:00

abstract：:During development of the vertebrate visual system, retinal ganglion cell (RGC) axons follow a precise path toward their midbrain targets. Although much is known about the cues that direct RGC axons once they have left the optic disc, less is known about the guidance of axons at earlier stages, when RGCs first send ou...

journal_title：Developmental biology

authors： Ohta K,Tannahill D,Yoshida K,Johnson AR,Cook GM,Keynes RJ

更新日期：1999-07-01 00:00:00

abstract：:The GRAM domain was found in glucosyltransferases, myotubularins and other membrane-associated proteins. So far, functions for majority of these proteins are yet to be uncovered. In order to address the evolutionary and functional significance of this family members, we have performed a comprehensive investigation on ...

journal_title：Developmental biology

authors： Jiang SY,Ramamoorthy R,Ramachandran S

更新日期：2008-02-15 00:00:00

abstract：:The ubiquitin-proteasome system is essential for intracellular protein degradation, but there are few studies of this system in the extracellular milieu. Recently, we reported that a 70-kDa sperm receptor, HrVC70, on the vitelline coat is ubiquitinated and then degraded by the sperm proteasome during fertilization of ...

journal_title：Developmental biology

authors： Sakai N,Sawada H,Yokosawa H

更新日期：2003-12-01 00:00:00

abstract：:Cyclin J is a cyclin family member that appears to have evolved before the metazoan radiation. Its evolutionary conservation argues for an important role but functional characterizations of Cyclin J have remained very limited. In Drosophila, Cyclin J is expressed only in females. Using transgenic Drosophila lines expr...

journal_title：Developmental biology

authors： Althoff F,Viktorinová I,Kastl J,Lehner CF

更新日期：2009-09-15 00:00:00

abstract：:The mechanism by which pluripotent progenitors give rise to distinct classes of mature neurons in vertebrates is not well understood. To address this issue we undertook a genetic screen for mutations which affect the commitment and differentiation of catecholaminergic (CA) [dopaminergic (DA), noradrenergic (NA), and a...

journal_title：Developmental biology

authors： Guo S,Wilson SW,Cooke S,Chitnis AB,Driever W,Rosenthal A

更新日期：1999-04-15 00:00:00

abstract：:We have used an in vitro model to investigate the relationship between cell proliferation, cell maturation, and intercellular junctional changes that are seen during normal liver development. Chick liver fragments of embryonic stages 21, 28, and 39 were grown in organ culture in Medium 199 with 10% bovine serum albumi...

journal_title：Developmental biology

authors： Meyer RA,Overton J

更新日期：1983-09-01 00:00:00

abstract：:The subdivision of the developing field by region-specific expression of genes encoding transcription factors is an essential step during appendage development in arthropod and vertebrates. In Drosophila leg development, the distal-most region (pretarsus) is specified by the expression of homeobox genes, aristaless an...

journal_title：Developmental biology

authors： Kojima T,Tsuji T,Saigo K

更新日期：2005-03-15 00:00:00

abstract：:A fusion gene construct containing the bacterial chloramphenicol acetyltransferase (CAT) gene under the control of CyIIIa actin gene regulatory sequences was injected into unfertilized eggs of the urchin Strongylocentrotus purpuratus, and early pluteus stage embryos that developed from these eggs were fixed and sectio...

journal_title：Developmental biology

authors： Hough-Evans BR,Franks RR,Cameron RA,Britten RJ,Davidson EH

更新日期：1987-06-01 00:00:00

abstract：:An abundant phosphoprotein with an apparent molecular mass of 65 kDa (p65) has been identified that is enriched in developing new macronuclei (or anlagen) isolated from the holotrichous ciliate, Tetrahymena thermophila. During early stages of macronuclear development, p65 is actively synthesized and deposited into you...

journal_title：Developmental biology

authors： Madireddi MT,Davis MC,Allis CD

更新日期：1994-10-01 00:00:00

abstract：:In Hydra long-range interactions between head, bud, and foot formation take place in addition to short-range interactions which are recognized as induction phenomena, occurring when transplants are placed into an environment of disparate positional value. Here the long-range promotion of foot formation is analyzed. Th...

journal_title：Developmental biology

authors： Müller WA

更新日期：1995-01-01 00:00:00

abstract：:Oct-4 is the earliest expressed gene known to encode a transcription factor which is developmentally regulated during mammalian embryogenesis. In order to understand the role of Oct-4 in early murine embryogenesis, we carried out an analysis of the temporal and spatial pattern of protein expression. We report the pres...

journal_title：Developmental biology

authors： Palmieri SL,Peter W,Hess H,Schöler HR

更新日期：1994-11-01 00:00:00

abstract：:Pericytes heterogeneity is based on their morphology, distribution, and markers. It is well known that pericytes from different organs may have distinct embryonic sources. Yamazaki et al. (2017) using several transgenic mouse model reveal by cell-lineage tracing that pericytes are even more heterogeneous than previous...

journal_title：Developmental biology

authors： Dias Moura Prazeres PH,Sena IFG,Borges IDT,de Azevedo PO,Andreotti JP,de Paiva AE,de Almeida VM,de Paula Guerra DA,Pinheiro Dos Santos GS,Mintz A,Delbono O,Birbrair A

更新日期：2017-07-01 00:00:00

abstract：UNLABELLED:Notch signaling plays an acknowledged role in bile-duct development, but its involvement in cholangiocyte-fate determination remains incompletely understood. We investigated the effects of early Notch2 deletion in Notch2(fl/fl)/Alfp-Cre(tg/-) ("Notch2-cKO") and Notch2(fl/fl)/Alfp-Cre(-/-) ("control") mice. F...

journal_title：Developmental biology

authors： Falix FA,Weeda VB,Labruyere WT,Poncy A,de Waart DR,Hakvoort TB,Lemaigre F,Gaemers IC,Aronson DC,Lamers WH

更新日期：2014-12-15 00:00:00

abstract：:Microtubule organization during the novel cell division of ameiotic microsporocytes was examined using indirect immunofluorescence microscopy. A recessive mutation of the maize gene Ameiotic causes the replacement of meiosis I with a synchronized mitotic division (Palmer, R. G. (1971). Chromosoma 35, 233-246). All ide...

journal_title：Developmental biology

authors： Staiger CJ,Cande WZ

更新日期：1992-11-01 00:00:00

abstract：:In Xenopus, the hatching and cement glands form at important boundaries in the head. We have examined induction of these glands in order to see the basis for this ectodermal patterning. Ectoderm can be induced to form hatching and cement glands by dorsal mesoderm and by the neural plate. Because the neural plate is su...

journal_title：Developmental biology

authors： Drysdale TA,Elinson RP

更新日期：1993-07-01 00:00:00

abstract：:These studies examined the potential for reorganization and differentiation of dissociated 18-day fetal rat intestine. Cultures of trypsin-dissociated fetal intestine were maintained in vitro for 1 week on a three-dimensional matrix, then transplanted into syngeneic hosts. When harvested after 4 weeks, these transplan...

journal_title：Developmental biology

authors： Montgomery RK,Zinman HM,Smith BT

更新日期：1983-11-01 00:00:00

abstract：:Previous studies have established that embryonal carcinoma (EC) cells produce several different growth factors, but express few, if any, receptors for epidermal growth factor, platelet-derived growth factor, or transforming growth factor type-beta. In this study, the production and utilization of fibroblast growth fac...

journal_title：Developmental biology

authors： Rizzino A,Kuszynski C,Ruff E,Tiesman J

更新日期：1988-09-01 00:00:00

abstract：:Embryonic development involves a series of cell adhesive interactions that provide mechanical and instructive information required for morphogenesis. The ADAMs family of membrane-anchored proteins, containing a disintegrin and metalloprotease domain, is well suited for participating in such developmental events. They ...

journal_title：Developmental biology

authors： Alfandari D,Wolfsberg TG,White JM,DeSimone DW

更新日期：1997-02-15 00:00:00

abstract：:Notch signaling is involved in a large range of developmental processes, and has been functionally implicated in body plan segmentation in two of the three diverse segmented taxa, the vertebrates and arthropods. Here we investigate expression of Notch, Delta, and hes gene homologues during larval and juvenile developm...

journal_title：Developmental biology

authors： Thamm K,Seaver EC

更新日期：2008-08-01 00:00:00

abstract：:The survival effects of brain-derived neurotrophic factor (BDNF) on the ganglion cells of the chick retina were studied in vitro at different embryonic ages. We found these effects to be strongly age-dependent: at E5, when the first ganglion cell axons have crossed the optic chiasm, but not yet reached the tectum, gan...

journal_title：Developmental biology

authors： Rodriguez-Tébar A,Jeffrey PL,Thoenen H,Barde YA

更新日期：1989-12-01 00:00:00

abstract：:There has been a resurgence of interest in comparative embryology. It is now important to be able to compare gene expression in different species at similar developmental stages. One phenomenon which may make it difficult to compare embryos in this way is heterochrony--a change in developmental timing during evolution...

journal_title：Developmental biology

authors： Richardson MK

更新日期：1995-12-01 00:00:00

abstract：:Oocyte maturation (meiosis reinitiation) in starfish is induced by the natural hormone 1-methyladenine (1-MeAde). Oocytes of Evasterias troschelii contain 0.43 pmole cyclic AMP/mg protein and 0.47 pmole cyclic GMP/mg protein. Upon stimulation by 1-MeAde the oocytes undergo a moderate (10-30%) decrease in their cAMP co...

journal_title：Developmental biology

authors： Meijer L,Zarutskie P

更新日期：1987-06-01 00:00:00

abstract：:Septins are guanosine triphosphate-binding proteins that are evolutionally conserved in all eukaryotes other than plants. They function as multimeric complexes that interact with membrane lipids, actomyosin, and microtubules. Based on these interactions, septins play essential roles in the morphogenesis and physiologi...

journal_title：Developmental biology

authors： Torii H,Yoshida A,Katsuno T,Nakagawa T,Ito J,Omori K,Kinoshita M,Yamamoto N

更新日期：2016-11-15 00:00:00

abstract：:TGF-beta (TGFβ) family mediated Smad signaling is involved in mesoderm and endoderm specifications, left-right asymmetry formation and neural tube development. The TGFβ1/2/3 and Activin/Nodal signal transduction cascades culminate with activation of SMAD2 and/or SMAD3 transcription factors and their overactivation are...

journal_title：Developmental biology

authors： Casari A,Schiavone M,Facchinello N,Vettori A,Meyer D,Tiso N,Moro E,Argenton F

更新日期：2014-12-01 00:00:00

abstract：:FoxC, FoxF, FoxL1 and FoxQ1 genes have been shown to be clustered in some animal genomes, with mesendodermal expression hypothesised as a selective force maintaining cluster integrity. Hypotheses are, however, constrained by a lack of data from the Lophotrochozoa. Here we characterise members of the FoxC, FoxF, FoxL1 ...

journal_title：Developmental biology

authors： Shimeld SM,Boyle MJ,Brunet T,Luke GN,Seaver EC

更新日期：2010-04-15 00:00:00

abstract：:Caveolin-1 (Cav-1) is the principal component of plasma membrane caveolae that negatively regulates a number of cellular signaling events including canonical Wnt signaling. Activation of the Wnt/beta-catenin pathway is essential for dorsal organizer formation and specification in early vertebrate embryos, but it remai...

journal_title：Developmental biology

authors： Mo S,Wang L,Li Q,Li J,Li Y,Thannickal VJ,Cui Z

更新日期：2010-08-01 00:00:00