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Pericytes are heterogeneous in their origin within the same tissue.

Abstract：

:Pericytes heterogeneity is based on their morphology, distribution, and markers. It is well known that pericytes from different organs may have distinct embryonic sources. Yamazaki et al. (2017) using several transgenic mouse model reveal by cell-lineage tracing that pericytes are even more heterogeneous than previously appreciated. This study shows that pericytes from within the same tissue may be heterogeneous in their origin. Remarkably, a subpopulation of embryonic dermal pericytes derives from the hematopoietic lineage, an unexpected source. Reconstructing the lineage of pericytes is central to understanding development, and also for the diagnosis and treatment of diseases in which pericytes play important roles.

journal_name

Dev Biol

journal_title

Developmental biology

authors

Dias Moura Prazeres PH,Sena IFG,Borges IDT,de Azevedo PO,Andreotti JP,de Paiva AE,de Almeida VM,de Paula Guerra DA,Pinheiro Dos Santos GS,Mintz A,Delbono O,Birbrair A

doi

10.1016/j.ydbio.2017.05.001

subject

Has Abstract

pub_date

2017-07-01 00:00:00

pages

6-11

issue

1

eissn

0012-1606

issn

1095-564X

pii

S0012-1606(17)30233-6

journal_volume

427

pub_type

杂志文章

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