Abstract:
:In the deuterostomes and ecdysozoans that have been studied (e.g. chordates and insects), neural fate specification relies on signaling from surrounding cells. However, very little is known about mechanisms of neural specification in the third major bilaterian clade, spiralians. Using blastomere isolation in the annelid Capitella teleta, a spiralian, we studied to what extent extrinsic versus intrinsic signals are involved in early neural specification of the brain and ventral nerve cord. For the first time in any bilaterian, we found that brain neural ectoderm is autonomously specified. This occurs in the daughters of first-quartet micromeres, which also generate anterior neural ectoderm in other spiralians. In contrast, isolation of the animal cap, including the 2d micromere, which makes the trunk ectoderm and ventral nerve cord, blocked ventral nerve cord formation. When the animal cap was isolated with the 2D macromere, the resulting partial larvae had a ventral nerve cord. These data suggest that extrinsic signals from second-quartet macromeres or their daughters, which form mesoderm and endoderm, are required for nerve cord specification in C. teleta and that the 2D macromere or its daughters are sufficient to provide the inductive signal. We propose that autonomous specification of anterior neural ectoderm evolved in spiralians in order to enable them to quickly respond to environmental cues encountered by swimming larvae in the water column. In contrast, a variety of signaling pathways could have been co-opted to conditionally specify the nerve cord. This flexibility of nerve cord development may be linked to the large diversity of trunk nervous systems present in Spiralia.
journal_name
Dev Bioljournal_title
Developmental biologyauthors
Carrillo-Baltodano AM,Meyer NPdoi
10.1016/j.ydbio.2017.09.022subject
Has Abstractpub_date
2017-11-15 00:00:00pages
134-144issue
2eissn
0012-1606issn
1095-564Xpii
S0012-1606(17)30493-1journal_volume
431pub_type
杂志文章abstract::The formation of endocardial endothelium in quail embryos was investigated using in vivo and in vitro systems. Based on the expression of an quail endothelial marker, QH-1, the initial emergence of endothelial precursor cells in the embryo occurs at stage 7+ (two somites) in the posterior parts of the bilateral heart ...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1996.0096
更新日期:1996-04-10 00:00:00
abstract::Interstitial cell migration was characterized in Hydra vulgaris (formerly H. attenuata) and the effects of axial position and tissue injury on migration were investigated. Migrating cells were labeled with the thymidine analog, bromodeoxyuridine, and grafted into unlabeled host polyps. Alternatively, cells were labele...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(90)90177-k
更新日期:1990-03-01 00:00:00
abstract::During endochondral ossification, the differentiation of proliferating into hypertrophic chondrocytes is a key step determining the pace of bone formation and the future length of the skeletal elements. A variety of transcription factors are expressed at the onset of hypertrophy coordinating the expression of differen...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2019.09.012
更新日期:2020-01-01 00:00:00
abstract::The Xenopus helix-loop-helix transcription factor Hairy2 is essential for neural crest progenitor survival and maintains cells in a mitotic undifferentiated pre-neural crest state. However, its mode of action remains largely unknown. Here we show that a Hairy2 DNA-binding mutant is unable to promote cell survival and ...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2008.07.026
更新日期:2008-10-15 00:00:00
abstract::The t haplotypes are variant forms of the proximal portion of chromosome 17 in the mouse. The t haplotypes alter spermatogenesis and many also contain lethal factors. Although the lethal factors vary between t haplotypes, all t haplotypes have the same effect on sperm, that of altering sperm function in fertilization....
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1993.1002
更新日期:1993-01-01 00:00:00
abstract::An antiserum (anti-H2) directed at the second helix of the helix-loop-helix (HLH) protein MyoD1 reacts with a protein expressed during avian cardiac myocyte differentiation. Indirect immunohistochemical whole mount staining with anti-H2 detected a protein expressed in stage 11 hearts, but not in hearts of older embryo...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1993.1088
更新日期:1993-04-01 00:00:00
abstract::Intestinal tract development is a coordinated process involving signaling among the progenitors and developing cells from all three germ layers. Development of endoderm-derived intestinal epithelium has been shown to depend on epigenetic modifications, but whether that is also the case for intestinal tract cell types ...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2019.08.002
更新日期:2019-11-15 00:00:00
abstract::The mab-21 gene was first identified because of its requirement for ray identity specification in Caenorhabditis elegans. It is now known to constitute a family of genes that are highly conserved from vertebrates to invertebrates, and two homologues Mab21l1 and Mab21l2 have been identified in many species. Here we des...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2004.07.016
更新日期:2004-10-15 00:00:00
abstract::FgfrL1, which interacts with Fgf ligands and heparin, is a member of the fibroblast growth factor receptor (Fgfr) family. FgfrL1-deficient mice show two significant alterations when compared to wildtype mice: They die at birth due to a malformed diaphragm and they lack metanephric kidneys. Utilizing gene arrays, qPCR ...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2014.08.016
更新日期:2014-10-15 00:00:00
abstract::When a posterior fragment of the chick's marginal zone (PM) was exchanged with equal sized lateral marginal zone fragment (LM), of the same blastoderm, its capacity to initiate an ectopic primitive streak (PS) was found to be both size and stage dependent. Good correlation was demonstrated between the areas of PM frag...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(89)90091-2
更新日期:1989-07-01 00:00:00
abstract::Epidermal growth factor (EGF) expression and branching morphogenesis were inhibited using a 5' 15-mer antisense oligodeoxynucleotide (ODN) directed against EGF precursor mRNA in embryonic mouse lung in culture under chemically defined, serumless conditions. Antisense EGF ODN resulted in > 90% inhibition of EGF immunor...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1993.1213
更新日期:1993-08-01 00:00:00
abstract::We defined the cellular mechanisms for genesis, migration, and differentiation of the initial population of olfactory bulb (OB) interneurons. This cohort of early generated cells, many of which become postmitotic on embryonic day (E) 14.5, differentiates into a wide range of mature OB interneurons by postnatal day (P)...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2006.05.009
更新日期:2006-09-15 00:00:00
abstract::Sensory placodes are unique columnar epithelia with neurogenic potential that develop in the vertebrate head ectoderm next to the neural tube. They contribute to the paired sensory organs and the cranial sensory ganglia generating a wide variety of cell types ranging from lens fibres to sensory receptor cells and neur...
journal_title:Developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.ydbio.2004.08.037
更新日期:2004-12-01 00:00:00
abstract::We have tested the role of proteoglycans in the development of feather pattern by culturing 7-day-old embryonic chick skins on medium containing para-nitrophenyl-beta-D-xyloside (2 mM). Xylosides compete with core proteins of proteoglycans by acting as exogenous acceptors for the synthesis of glycosaminoglycans leadin...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(88)90199-6
更新日期:1988-05-01 00:00:00
abstract::Complement components have been implicated in a wide variety of functions including neurogenesis, proliferation, cell migration, differentiation, cancer, and more recently early development and regeneration. Following our initial observations indicating that C3a/C3aR signaling induces chick retina regeneration, we ana...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2017.05.019
更新日期:2017-08-01 00:00:00
abstract::Gene network analysis requires computationally based models which represent the functional architecture of regulatory interactions, and which provide directly testable predictions. The type of model that is useful is constrained by the particular features of developmentally active cis-regulatory systems. These systems...
journal_title:Developmental biology
pub_type: 杂志文章,评审
doi:10.1006/dbio.2002.0617
更新日期:2002-06-01 00:00:00
abstract::Proliferating intestinal stem cells (ISCs) generate all cell types of the Drosophila midgut, including enterocytes, endocrine cells, and gland cells (e.g., copper cells), throughout the lifetime of the animal. Among the signaling mechanisms controlling the balance between ISC self-renewal and the production of differe...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2016.06.018
更新日期:2016-08-15 00:00:00
abstract::The three fibronectin leucine-rich repeat transmembrane (FLRT) proteins contain 10 leucine-rich repeats (LRR), a type III fibronectin (FN) domain, followed by the transmembrane region, and a short cytoplasmic tail. XFLRT3, a Nodal/TGFbeta target, regulates cell adhesion and modulates FGF signalling during Xenopus gast...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2008.03.021
更新日期:2008-06-01 00:00:00
abstract::During early heart development the expression pattern of N-cadherin, a calcium-dependent cell adhesion molecule, suggests its involvement in morphoregulation and the stabilization of cardiomyocyte differentiation. N-cadherin's adhesive activity is dependent upon its interaction with the intracellular catenins. An asso...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1997.8570
更新日期:1997-05-15 00:00:00
abstract::In Xenopus gastrulation, the involuting mesodermal and non-involuting ectodermal cells remain separated from each other, undergoing convergent extension. Here, we show that Eph-ephrin signaling is crucial for the tissue separation and convergence during gastrulation. The loss of EphA4 function results in aberrant gast...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2010.12.012
更新日期:2011-02-15 00:00:00
abstract::Long non-coding RNAs (lncRNAs) have been recently recognized as a major class of regulators in mammalian systems. LncRNAs function by diverse and heterogeneous mechanisms in gene regulation, and are key contributors to development, neurological disorders, and cancer. This emerging importance of lncRNAs, along with rec...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2013.01.035
更新日期:2013-04-15 00:00:00
abstract::Establishment and maintenance of functional stem cells is critical for organ development and tissue homeostasis. Little is known about the mechanisms underlying stem establishment during organogenesis. Drosophila testes are among the most thoroughly characterized systems for studying stem cell behavior, with germline ...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2012.09.009
更新日期:2012-12-01 00:00:00
abstract::Polychaete annelids and arthropods are both segmented protostome invertebrates. To investigate whether the segmented body plan of these two phyla share a common molecular ground pattern, we report the developmental expression of orthologues of the arthropod segment polarity genes engrailed (en), hedgehog (hh), and win...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2005.10.025
更新日期:2006-01-01 00:00:00
abstract::Members of the fibroblast growth factor (FGF) family of peptide growth factors are widely expressed in the germ layer derivatives during gastrulation and early organogenesis of the mouse. We have investigated the effect of administering recombinant FGF-4 in the late-primitive streak stage embryo to test if the pattern...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.2000.9663
更新日期:2000-05-01 00:00:00
abstract::Mutations in the Bone Morphogenetic Protein (BMP) pathway are associated with a range of defects in skeletal formation. Genetic analysis of BMP signaling requirements is complicated by the presence of three partially redundant BMPs that are required for multiple stages of limb development. We generated an inducible al...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2014.07.003
更新日期:2014-09-15 00:00:00
abstract::CHARGE syndrome is caused by spontaneous loss-of-function mutations to the ATP-dependant chromatin remodeller chromodomain-helicase-DNA-binding protein 7 (CHD7). It is characterised by a distinct pattern of congenital anomalies, including cardiovascular malformations. Disruption to the neural crest lineage has previou...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2015.06.017
更新日期:2015-09-01 00:00:00
abstract::Alterations in cAMP concentrations have been implicated in developmentally regulated gene expression in Dictyostelium. Using a variety of culture conditions to control the metabolism of cAMP during cytodifferentiation, I have examined the role of the cyclic nucleotide in development. Conditions which allow intracellul...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(87)90342-3
更新日期:1987-07-01 00:00:00
abstract::Plants often display a high competence for regeneration under stress conditions. Signals produced in response to various types of stress serve as critical triggers for de novo organogenesis, but the identity of these signaling molecules underlying cellular reprogramming are largely unknown. We previously identified an...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2018.07.006
更新日期:2018-10-01 00:00:00
abstract::We have studied the differentiation of the oocyte vitelline coat (VC) and jelly coat (JC) of the starfish, Astropecten aurantiacus. The precursor material of both envelopes is secreted by the oocyte while the follicle cells do not appear to participate in the secretory process. The first indication of differentiation ...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(83)90296-8
更新日期:1983-10-01 00:00:00
abstract::Wnt-4, a member of the Wnt family of secreted signaling molecules, is essential for nephrogenesis, but its expression in the presumptive medulla suggests additional developmental roles in kidney organogenesis. We demonstrate here that Wnt-4 signaling plays also a role in the determination of the fate of smooth muscle ...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2006.02.019
更新日期:2006-05-15 00:00:00