Wnt-4 signaling is involved in the control of smooth muscle cell fate via Bmp-4 in the medullary stroma of the developing kidney.

Abstract:

:Wnt-4, a member of the Wnt family of secreted signaling molecules, is essential for nephrogenesis, but its expression in the presumptive medulla suggests additional developmental roles in kidney organogenesis. We demonstrate here that Wnt-4 signaling plays also a role in the determination of the fate of smooth muscle cells in the medullary stroma of the developing kidney, as a differentiation marker, smooth muscle alpha-actin (alpha-SMA), is markedly reduced in the absence of its signaling. Wnt-4 probably performs this function by activating the Bmp-4 gene encoding a known differentiation factor for smooth muscle cells, since Bmp-4 gene expression was lost in the absence of Wnt-4 while Wnt-4 signaling led to a rescue of Bmp-4 expression and induction of alpha-SMA-positive cells in vitro. Recombinant Bmp-4 similarly rescued the differentiation of alpha-SMA-expressing cells in cultured Wnt-4-deficient embryonic kidney. The lack of smooth muscle cell differentiation leads to an associated deficiency in the pericytes around the developing vessels of the Wnt-4-deficient kidney and apparently leads to a secondary defect in the maturation of the kidney vessels. Thus, besides being critical for regulating mesenchymal to epithelial transformation in the cortical region in nephrogenesis, Wnt-4 signaling regulates the fate of smooth muscle cells in the developing medullary region.

journal_name

Dev Biol

journal_title

Developmental biology

authors

Itäranta P,Chi L,Seppänen T,Niku M,Tuukkanen J,Peltoketo H,Vainio S

doi

10.1016/j.ydbio.2006.02.019

subject

Has Abstract

pub_date

2006-05-15 00:00:00

pages

473-83

issue

2

eissn

0012-1606

issn

1095-564X

pii

S0012-1606(06)00116-3

journal_volume

293

pub_type

杂志文章
  • Regulation of broad by the Notch pathway affects timing of follicle cell development.

    abstract::During Drosophila oogenesis, activation of Notch signaling in the follicular epithelium (FE) around stage 6 of oogenesis is essential for entry into the endocycle and a series of other changes such as cell differentiation and migration of subsets of the follicle cells. Notch induces the expression of zinc finger prote...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2014.04.024

    authors: Jia D,Tamori Y,Pyrowolakis G,Deng WM

    更新日期:2014-08-01 00:00:00

  • SpGCF1, a sea urchin embryo DNA-binding protein, exists as five nested variants encoded by a single mRNA.

    abstract::Several Strongylocentrotus purpuratus gene cis-regulatory regions contain asymmetric C4 sequences which are core elements of target sites for a specific DNA-protein interaction. Blastula stage nuclear extract contains five proteins which specifically bind to these target sites, resulting in a characteristic pattern of...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1006/dbio.1995.1181

    authors: Zeller RW,Coffman JA,Harrington MG,Britten RJ,Davidson EH

    更新日期:1995-06-01 00:00:00

  • Patterning of the third pharyngeal pouch into thymus/parathyroid by Six and Eya1.

    abstract::Previous studies have suggested a role of the homeodomain Six family proteins in patterning the developing vertebrate head that involves appropriate segmentation of three tissue layers, the endoderm, the paraxial mesoderm and the neural crest cells; however, the developmental programs and mechanisms by which the Six g...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2005.12.015

    authors: Zou D,Silvius D,Davenport J,Grifone R,Maire P,Xu PX

    更新日期:2006-05-15 00:00:00

  • Genetic interactions of eyes absent, twin of eyeless and orthodenticle regulate sine oculis expression during ocellar development in Drosophila.

    abstract::The homeobox gene sine oculis (so) is required for the development of the entire visual system in Drosophila, which includes the compound eyes, the ocelli, the optic lobe of the brain and the Bolwig's organ. During ocelli development, so expression labels, together with eyes absent (eya), the emergence of the ocellar ...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2010.05.494

    authors: Blanco J,Pauli T,Seimiya M,Udolph G,Gehring WJ

    更新日期:2010-08-15 00:00:00

  • Gap junction formation between cultured embryonic lens cells is inhibited by antibody to N-cadherin.

    abstract::Intercellular communication mediated by gap junctions is important for tissue homeostasis in the avascular lens, and extensive areas of gap junctions form between fiber cells during fiber cell differentiation and lens development. We examined the role of the calcium-dependent cell adhesion molecule, N-cadherin, in the...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1006/dbio.1996.0237

    authors: Frenzel EM,Johnson RG

    更新日期:1996-10-10 00:00:00

  • The union of somatic gonad precursors and primordial germ cells during Caenorhabditis elegans embryogenesis.

    abstract::Somatic gonadal niche cells control the survival, differentiation, and proliferation of germline stem cells. The establishment of this niche-stem cell relationship is critical, and yet the precursors to these two cell types are often born at a distance from one another. The simple Caenorhabditis elegans gonadal primor...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2013.03.019

    authors: Rohrschneider MR,Nance J

    更新日期:2013-07-15 00:00:00

  • The zinc finger homeodomain-2 gene of Drosophila controls Notch targets and regulates apoptosis in the tarsal segments.

    abstract::The development of the Drosophila leg is a good model to study processes of pattern formation, cell death and segmentation. Such processes require the coordinate activity of different genes and signaling pathways that progressively subdivide the leg territory into smaller domains. One of the main pathways needed for l...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2013.10.011

    authors: Guarner A,Manjón C,Edwards K,Steller H,Suzanne M,Sánchez-Herrero E

    更新日期:2014-01-15 00:00:00

  • Single-cell analysis of regulatory gene expression in quiescent and activated mouse skeletal muscle satellite cells.

    abstract::Repair and regeneration of adult skeletal muscle are mediated by satellite cells. In healthy muscle these rare mononucleate muscle precursor cells are mitotically quiescent. Upon muscle injury or degeneration, members of this self-renewing pool are activated to proliferate and then differentiate. Here we analyzed in s...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1006/dbio.1997.8721

    authors: Cornelison DD,Wold BJ

    更新日期:1997-11-15 00:00:00

  • Downregulation of Notch mediates the seamless transition of individual Drosophila neuroepithelial progenitors into optic medullar neuroblasts during prolonged G1.

    abstract::The first step in the development of the Drosophila optic medullar primordia is the expansion of symmetrically dividing neuroepithelial cells (NEs); this step is then followed by the appearance of asymmetrically dividing neuroblasts (NBs). However, the mechanisms responsible for the change from NEs to NBs remain uncle...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2010.12.044

    authors: Orihara-Ono M,Toriya M,Nakao K,Okano H

    更新日期:2011-03-01 00:00:00

  • Non-neuronal cell conditioned medium stimulates peptidergic expression in sympathetic and sensory neurons in vitro.

    abstract::Regulation of peptide neurotransmitter metabolism was examined in dissociated cell cultures of neonatal rat sympathetic and sensory ganglia. Previous studies have shown that pineal gland conditioned medium (PCM) influences substance P (SP) and somatostatin (SS) metabolism in sympathetic neurons in vitro. The present s...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/0012-1606(84)90061-7

    authors: Kessler JA

    更新日期:1984-11-01 00:00:00

  • Nuclear and chromatin reorganization in the MHC-Oct3/4 locus at developmental phases of embryonic stem cell differentiation.

    abstract::Epigenetic gene control is involved in mechanisms of development. Little is known about the cooperation of nuclear and chromatin events in programmed differentiation from mouse embryonic stem cells (ESC). To address this, Oct3/4-positive ESC and differentiated progenies, Sox1-positive neural precursor cells (NPC) and ...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2006.04.450

    authors: Aoto T,Saitoh N,Ichimura T,Niwa H,Nakao M

    更新日期:2006-10-15 00:00:00

  • Cyclin A associates with the fusome during germline cyst formation in the Drosophila ovary.

    abstract::Regulated changes in the cell cycle underlie many aspects of growth and differentiation. Prior to meiosis, germ cell cycles in many organisms become accelerated, synchronized, and modified to lack cytokinesis. These changes cause cysts of interconnected germ cells to form that typically contain 2(n) cells. In Drosophi...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1006/dbio.1999.9570

    authors: Lilly MA,de Cuevas M,Spradling AC

    更新日期:2000-02-01 00:00:00

  • Functional genomics identifies neural stem cell sub-type expression profiles and genes regulating neuroblast homeostasis.

    abstract::The Drosophila larval central brain contains about 10,000 differentiated neurons and 200 scattered neural progenitors (neuroblasts), which can be further subdivided into ~95 type I neuroblasts and eight type II neuroblasts per brain lobe. Only type II neuroblasts generate self-renewing intermediate neural progenitors ...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2011.10.020

    authors: Carney TD,Miller MR,Robinson KJ,Bayraktar OA,Osterhout JA,Doe CQ

    更新日期:2012-01-01 00:00:00

  • Prostate development requires Sonic hedgehog expressed by the urogenital sinus epithelium.

    abstract::The prostate gland develops from the urogenital sinus by a testosterone-dependent process of ductal morphogenesis. Sonic hedgehog (Shh) is expressed in the urogenital sinus epithelium and the time course of expression coincides with the formation of the main prostatic ducts. Expression is most abundant in the lumen of...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1006/dbio.1999.9229

    authors: Podlasek CA,Barnett DH,Clemens JQ,Bak PM,Bushman W

    更新日期:1999-05-01 00:00:00

  • Expression patterns of Hoxb genes in the Xenopus embryo suggest roles in anteroposterior specification of the hindbrain and in dorsoventral patterning of the mesoderm.

    abstract::Hox genes are thought to participate in patterning the anteroposterior (a-p) axis during vertebrate embryogenesis. In this investigation, the spatial expression of six Hoxb genes was analyzed in early embryos of Xenopus laevis by in situ hybridization. Hoxb gene expression was first detected in late gastrulae/early ne...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1006/dbio.1994.1330

    authors: Godsave S,Dekker EJ,Holling T,Pannese M,Boncinelli E,Durston A

    更新日期:1994-12-01 00:00:00

  • MEMO1 drives cranial endochondral ossification and palatogenesis.

    abstract::The cranial base is a component of the neurocranium and has a central role in the structural integration of the face, brain and vertebral column. Consequently, alteration in the shape of the human cranial base has been intimately linked with primate evolution and defective development is associated with numerous human...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2015.12.024

    authors: Van Otterloo E,Feng W,Jones KL,Hynes NE,Clouthier DE,Niswander L,Williams T

    更新日期:2016-07-15 00:00:00

  • Unique and redundant functions of C. elegans HP1 proteins in post-embryonic development.

    abstract::HP1 proteins are essential components of heterochromatin and contribute to the transcriptional repression of euchromatic genes. Although most species contain more than one HP1 family member which differ in their chromosomal distribution, it is not known to what extent the activity of these different family members is ...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2006.06.039

    authors: Schott S,Coustham V,Simonet T,Bedet C,Palladino F

    更新日期:2006-10-01 00:00:00

  • Coordination of skeletal muscle gene expression occurs late in mammalian development.

    abstract::The acquisition of specialized skeletal muscle fiber phenotypes during development is investigated by systematic measurement of the accumulation of 21 contractile protein mRNAs during hindlimb development in the rat and the human. During early myotube formation in both species there is no coordination of expression of...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/0012-1606(91)90457-e

    authors: Sutherland CJ,Elsom VL,Gordon ML,Dunwoodie SL,Hardeman EC

    更新日期:1991-07-01 00:00:00

  • Cis regulatory requirements for vulval cell-specific expression of the Caenorhabditis elegans fibroblast growth factor gene egl-17.

    abstract::The Caenorhabditis elegans EGL-17/FGF protein is involved in the gonadal signaling that guides the migrations of sex myoblasts (SMs). egl-17::GFP reporter constructs are expressed dynamically in vulval cell lineages. Expression in the primary vulval cells is correlated with the precise positioning of SMs. We have inve...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/s0012-1606(03)00033-2

    authors: Cui M,Han M

    更新日期:2003-05-01 00:00:00

  • A mutation in the E(Z) methyltransferase that increases trimethylation of histone H3 lysine 27 and causes inappropriate silencing of active Polycomb target genes.

    abstract::Drosophila Polycomb Repressive Complex 2 (PRC2) is a lysine methyltransferase that trimethylates histone H3 lysine 27 (H3K27me3), a modification essential for Polycomb silencing. Mutations in its catalytic subunit, E(Z), that abolish its methyltransferase activity disrupt Polycomb silencing, causing derepression of Po...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2011.12.007

    authors: Stepanik VA,Harte PJ

    更新日期:2012-04-15 00:00:00

  • Cellular heterogeneity during vertebrate skeletal muscle development.

    abstract::Although skeletal muscles appear superficially alike at different anatomical locations, in reality there is considerably more diversity than previously anticipated. Heterogeneity is not only restricted to completely developed fibers, but is clearly apparent during development at the molecular, cellular and anatomical ...

    journal_title:Developmental biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.ydbio.2007.06.006

    authors: Biressi S,Molinaro M,Cossu G

    更新日期:2007-08-15 00:00:00

  • MSP hormonal control of the oocyte MAP kinase cascade and reactive oxygen species signaling.

    abstract::The MSP domain is a conserved immunoglobulin-like structure that is important for C. elegans reproduction and human motor neuron survival. C. elegans MSPs are the most abundant proteins in sperm, where they function as intracellular cytoskeletal proteins and secreted hormones. Secreted MSPs bind to multiple receptors ...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2010.03.026

    authors: Yang Y,Han SM,Miller MA

    更新日期:2010-06-01 00:00:00

  • Pax3- and Pax7-mediated Dbx1 regulation orchestrates the patterning of intermediate spinal interneurons.

    abstract::Transcription factors are key orchestrators of the emergence of neuronal diversity within the developing spinal cord. As such, the two paralogous proteins Pax3 and Pax7 regulate the specification of progenitor cells within the intermediate neural tube, by defining a neat segregation between those fated to form motor c...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2017.06.014

    authors: Gard C,Gonzalez Curto G,Frarma YE,Chollet E,Duval N,Auzié V,Auradé F,Vigier L,Relaix F,Pierani A,Causeret F,Ribes V

    更新日期:2017-12-01 00:00:00

  • Notch signaling regulates endocrine cell specification in the zebrafish anterior pituitary.

    abstract::The vertebrate pituitary gland is a key endocrine control organ that contains six distinct hormone secreting cell types. In this study, we analyzed the role of direct cell-to-cell Delta-Notch signaling in zebrafish anterior pituitary cell type specification. We demonstrate that initial formation of the anterior pituit...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2008.04.019

    authors: Dutta S,Dietrich JE,Westerfield M,Varga ZM

    更新日期:2008-07-15 00:00:00

  • The muscle integrin binding protein (MIBP) interacts with alpha7beta1 integrin and regulates cell adhesion and laminin matrix deposition.

    abstract::Integrins are alphabeta transmembrane receptors that function in key cellular processes, including cell adhesion, differentiation, and extracellular matrix deposition through interactions with extracellular, membrane, and cytoplasmic proteins. We previously identified and cloned a muscle beta1 integrin cytoplasmic bin...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/s0012-1606(03)00304-x

    authors: Li J,Rao H,Burkin D,Kaufman SJ,Wu C

    更新日期:2003-09-01 00:00:00

  • Different MRF4 knockout alleles differentially disrupt Myf-5 expression: cis-regulatory interactions at the MRF4/Myf-5 locus.

    abstract::Three different null alleles of the myogenic bHLH gene MRF4/herculin/Myf-6 were created recently. The three alleles were similar in design but were surprisingly different in the intensity of their phenotypes, which ranged from complete viability of homozygotes to complete lethality. One possible explanation for these ...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1006/dbio.1997.8670

    authors: Yoon JK,Olson EN,Arnold HH,Wold BJ

    更新日期:1997-08-15 00:00:00

  • Regulated expression of homeobox genes Msx-1 and Msx-2 in mouse mammary gland development suggests a role in hormone action and epithelial-stromal interactions.

    abstract::The murine homeobox genes Msx-1 and Msx-2 are related to the Drosophila msh gene and are expressed in a variety of tissues during mouse embryogenesis. We now report the developmentally regulated expression of Msx-1 and Msx-2 in the mouse mammary gland and show that their expression patterns point toward significant fu...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1006/dbio.1996.0168

    authors: Friedmann Y,Daniel CW

    更新日期:1996-07-10 00:00:00

  • Alkaline phosphatase expression in ascidian egg fragments and andromerogons.

    abstract::Alkaline phosphatase (AP) activity is expressed in the endodermal cell lineage of ascidian embryos beginning at gastrulation. AP expression is resistant to levels of actinomycin D which completely suppress the appearance of other tissue-specific enzyme and morphological markers including acetylcholinesterase (AchE), a...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/0012-1606(87)90043-1

    authors: Bates WR,Jeffery WR

    更新日期:1987-02-01 00:00:00

  • Purkinje cell lineage and the topographic organization of the cerebellar cortex: a view from X inactivation mosaics.

    abstract::We utilized a strain of mice, derived from a radiation mutagenesis experiment and carrying an activity-attenuated allele of the X-linked enzyme glucose-6-phosphate dehydrogenase (G6PD), to analyze the development of the cell lineage leading to cerebellar Purkinje neurons. Due to random X inactivation during early embr...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1006/dbio.1996.0083

    authors: Baader SL,Schilling ML,Rosengarten B,Pretsch W,Teutsch HF,Oberdick J,Schilling K

    更新日期:1996-03-15 00:00:00

  • Eif3ba regulates cranial neural crest development by modulating p53 in zebrafish.

    abstract::Congenital diseases caused by abnormal development of the cranial neural crest usually present craniofacial malformations and heart defects while the precise mechanism is not fully understood. Here, we show that the zebrafish eif3ba mutant caused by pseudo-typed retrovirus insertion exhibited a similar phenotype due t...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2013.06.009

    authors: Xia Z,Tong X,Liang F,Zhang Y,Kuok C,Zhang Y,Liu X,Zhu Z,Lin S,Zhang B

    更新日期:2013-09-01 00:00:00