Wnt-4 signaling is involved in the control of smooth muscle cell fate via Bmp-4 in the medullary stroma of the developing kidney.

abstract：UNLABELLED:Notch signaling plays an acknowledged role in bile-duct development, but its involvement in cholangiocyte-fate determination remains incompletely understood. We investigated the effects of early Notch2 deletion in Notch2(fl/fl)/Alfp-Cre(tg/-) ("Notch2-cKO") and Notch2(fl/fl)/Alfp-Cre(-/-) ("control") mice. F...

journal_title：Developmental biology

authors： Falix FA,Weeda VB,Labruyere WT,Poncy A,de Waart DR,Hakvoort TB,Lemaigre F,Gaemers IC,Aronson DC,Lamers WH

更新日期：2014-12-15 00:00:00

abstract：:The mammalian Cul4 genes, Cul4A and Cul4B, encode the scaffold components of the cullin-based E3 ubiquitin ligases. The two Cul4 genes are functionally redundant. Recent study indicated that mice expressing a truncated CUL4A that fails to interact with its functional partner ROC1 exhibit no developmental phenotype. We...

journal_title：Developmental biology

authors： Kopanja D,Roy N,Stoyanova T,Hess RA,Bagchi S,Raychaudhuri P

更新日期：2011-04-15 00:00:00

abstract：:The uterus undergoes a series of dramatic changes in response to an implanting conceptus that, in some mammalian species, includes differentiation of the endometrial stroma into decidual tissue. This process, called decidualization, can be induced artificially in rodents indicating that the conceptus may not be essent...

journal_title：Developmental biology

authors： Bany BM,Cross JC

更新日期：2006-06-15 00:00:00

abstract：:Notch signaling inhibits hair cell differentiation, based on studies on mice deficient in Notch signaling-related genes and its downstream genes. However, the precise mechanisms of this inhibition are unknown because it is difficult to control the timing and duration of the suppression of Notch signaling. Here, we dev...

journal_title：Developmental biology

authors： Takebayashi S,Yamamoto N,Yabe D,Fukuda H,Kojima K,Ito J,Honjo T

更新日期：2007-07-01 00:00:00

abstract：:A complex regulatory cascade is required for normal cardiac development, and many aspects of this network are conserved from Drosophila to mammals. In Drosophila, the seven-up (svp) gene, an ortholog of the vertebrate chick ovalbumin upstream promoter transcription factors (COUP-TFI and II), is initially activated in ...

journal_title：Developmental biology

authors： Ryan KM,Hendren JD,Helander LA,Cripps RM

更新日期：2007-02-15 00:00:00

abstract：:A mammalian embryo experiences the first cell segregation at the blastocyst stage, in which cells giving form to the embryo are sorted into two lineages; trophectoderm (TE) and inner cell mass (ICM). This first cell segregation process is governed by cell position-dependent Hippo signaling, which is a phosphorylation ...

journal_title：Developmental biology

authors： Yamamura S,Goda N,Akizawa H,Kohri N,Balboula AZ,Kobayashi K,Bai H,Takahashi M,Kawahara M

更新日期：2020-12-01 00:00:00

abstract：:Cranial nerves VII, IX and X provide both gustatory (taste) and non-gustatory (touch, pain, temperature) innervation to the oral cavity of vertebrates. Gustatory neurons innervate taste buds and project centrally to the rostral nucleus of the solitary tract (NTS), whereas neurons providing general epithelial innervati...

journal_title：Developmental biology

authors： Harlow DE,Barlow LA

更新日期：2007-10-15 00:00:00

abstract：:Type II collagen is a major component of hyaline cartilage, and has been suggested to be causally involved in promoting chondrogenesis during embryonic development. In the present study we have performed an immunohistochemical analysis of the distribution of type II collagen during several early stages of embryonic ch...

journal_title：Developmental biology

authors： Kosher RA,Solursh M

更新日期：1989-02-01 00:00:00

abstract：:Zygotic Wnt signaling has been shown to be involved in dorsoventral mesodermal patterning in Xenopus embryos, but how it regulates different myogenic gene expression in the lateral mesodermal domains is not clear. Here, we use transient exposure of embryos or explants to lithium, which mimics Wnt/beta-catenin signalin...

journal_title：Developmental biology

authors： Shi DL,Bourdelas A,Umbhauer M,Boucaut JC

更新日期：2002-05-01 00:00:00

abstract：:Vertebrate Cdx genes encode homeodomain transcription factors related to caudal in Drosophila. The murine Cdx homologues Cdx1, Cdx2 and Cdx4 play important roles in anterior-posterior patterning of the embryonic axis and the intestine, as well as axial elongation. While our understanding of the ontogenic programs requ...

journal_title：Developmental biology

authors： Grainger S,Lam J,Savory JG,Mears AJ,Rijli FM,Lohnes D

更新日期：2012-01-01 00:00:00

abstract：:During endochondral bone formation, vascular invasion initiates the replacement of avascular cartilage by bone. We demonstrate herein that the cartilage-specific overexpression of VEGF-A(164) in mice results in the hypervascularization of soft connective tissues away from cartilage. Unexpectedly, perichondrial tissue ...

journal_title：Developmental biology

authors： Takimoto A,Nishizaki Y,Hiraki Y,Shukunami C

更新日期：2009-08-15 00:00:00

abstract：:The myogenic basic helix-loop-helix transcription factor myogenin plays an essential role in the differentiation of skeletal muscle and, secondarily, in rib and sternum formation during mouse development. However, virtually nothing is known about the quantitative requirements for myogenin in these processes. Here, we ...

journal_title：Developmental biology

authors： Vivian JL,Gan L,Olson EN,Klein WH

更新日期：1999-04-01 00:00:00

abstract：:The development of the reproductive system in Caenorhabditis elegans is a well-established model system for patterning and organogenesis. We report the characterization of the cog-1 gene, mutations in which cause novel phenotypes in late patterning in vulval lineages, establishment of the vulva-uterine connection, dev...

journal_title：Developmental biology

authors： Palmer RE,Inoue T,Sherwood DR,Jiang LI,Sternberg PW

更新日期：2002-12-15 00:00:00

abstract：:Heparan sulfate proteoglycans (HSPGs) regulate a number of major developmental processes, but their roles in synovial joint formation remain unknown. Here we created conditional mouse embryo mutants lacking Ext1 in developing joints by mating Ext1(f/f) and Gdf5-Cre mice. Ext1 encodes a subunit of the Ext1/Ext2 Golgi-a...

journal_title：Developmental biology

authors： Mundy C,Yasuda T,Kinumatsu T,Yamaguchi Y,Iwamoto M,Enomoto-Iwamoto M,Koyama E,Pacifici M

更新日期：2011-03-01 00:00:00

abstract：:Choriogenesis (eggshell formation) within the silkmoth Antheraea polyphemus proceeds in parallel for the two major subpopulations of follicle cells, diverging only during the very late period when aeropyle crown surface structures form in one region but not in the other. Correlated with their appearance is the synthes...

journal_title：Developmental biology

authors： Regier JC,Cole C,Leclerc RF

更新日期：1993-11-01 00:00:00

abstract：:The arterial pole of the heart is the region where the ventricular myocardium continues as the vascular smooth muscle tunics of the aorta and pulmonary trunk. It has been shown that the arterial pole myocardium derives from the secondary heart field and the smooth muscle tunic of the aorta and pulmonary trunk derives ...

journal_title：Developmental biology

authors： Waldo KL,Hutson MR,Ward CC,Zdanowicz M,Stadt HA,Kumiski D,Abu-Issa R,Kirby ML

更新日期：2005-05-01 00:00:00

abstract：:Recent results have demonstrated the occurrence of mRNA cap methylation in the sea urchin embryo following fertilization. It has been suggested that this methylation event is responsible for the translational activation of maternal histone mRNAs in these embryos. We have used aphidicolin, an effective inhibitor of bot...

journal_title：Developmental biology

authors： Showman RM,Leaf DS,Anstrom JA,Raff RA

更新日期：1987-05-01 00:00:00

abstract：:Pulses of ecdysteroids induce dramatic changes in gene expression that direct the early stages of Drosophila metamorphosis. This gene activity is reflected by the appearance of early and late puffs in the salivary gland polytene chromosomes. Curiously, the early puff genes that have been studied to date are induced by...

journal_title：Developmental biology

authors： Baehrecke EH,Thummel CS

更新日期：1995-09-01 00:00:00

abstract：:Large steady electrical currents traverse Drosophila follicles in vitro as well as permeabilized eggs. During the period of main follicle growth (stages 9-11), these currents enter the anterior or nurse cell end of the follicles. This inward current acts like a sodium ion influx with some calcium involvement. During t...

journal_title：Developmental biology

authors： Overall R,Jaffe LF

更新日期：1985-03-01 00:00:00

abstract：:The origin of resident (noninflammatory) macrophages in vertebrate tissues is still poorly understood. In the zebrafish embryo, we recently described a specific lineage of early macrophages that differentiate in the yolk sac before the onset of blood circulation. We now show that these early macrophages spread in the ...

journal_title：Developmental biology

authors： Herbomel P,Thisse B,Thisse C

更新日期：2001-10-15 00:00:00

abstract：:Chordin is the prototype of a group of cysteine-rich domain-containing proteins that bind and modulate signaling of various TGFbeta-like ligands. Chordin-like 1 and 2 (CHL1 and 2) are two members of this group that have been described in human, mouse, and chick. However, in vivo roles for CHL1 and 2 in early developme...

journal_title：Developmental biology

authors： Branam AM,Hoffman GG,Pelegri F,Greenspan DS

更新日期：2010-05-15 00:00:00

abstract：:We describe the identification, biochemical characterisation, and mutation of a novel mouse gene: Sp5. Sp5 encodes a protein having a C-terminal C(2)H(2) zinc finger domain closely related to that of the transcription factor Sp1. In vitro, DNA binding studies show that it binds to the GC box, a DNA motif present in th...

journal_title：Developmental biology

authors： Harrison SM,Houzelstein D,Dunwoodie SL,Beddington RS

更新日期：2000-11-15 00:00:00

abstract：:Continuous communication between cells is necessary for development of any multicellular organism and depends on the recognition of secreted signals. A wide range of molecules including proteins, peptides, amino acids, nucleic acids, steroids and polylketides are used as intercellular signals in plants and animals. Th...

journal_title：Developmental biology

authors： Loomis WF

更新日期：2014-07-01 00:00:00

abstract：:Actin dynamics are necessary at multiple steps in the formation of multinucleated muscle cells. BAR domain proteins can regulate actin dynamics in several cell types, but have been little studied in skeletal muscle. Here, we identify novel functions for the N-BAR domain protein, Bridging integrator 3 (Bin3), during my...

journal_title：Developmental biology

authors： Simionescu-Bankston A,Leoni G,Wang Y,Pham PP,Ramalingam A,DuHadaway JB,Faundez V,Nusrat A,Prendergast GC,Pavlath GK

更新日期：2013-10-01 00:00:00

abstract：:Integrin α5-null embryos die in mid-gestation from severe defects in cardiovascular morphogenesis, which stem from defective development of the neural crest, heart and vasculature. To investigate the role of integrin α5β1 in cardiovascular development, we used the Mesp1(Cre) knock-in strain of mice to ablate integrin ...

journal_title：Developmental biology

authors： Liang D,Wang X,Mittal A,Dhiman S,Hou SY,Degenhardt K,Astrof S

更新日期：2014-11-15 00:00:00

abstract：:The role of angiotensin II (Ang II) in the early embryonic development of the heart has not been examined. We have used RT-PCR to identify mRNA for angiotensinogen, angiotensin-converting enzyme, and the Ang II AT1 and AT2 receptors in embryonic day 10.25 Sprague-Dawley rats, and have used confocal microscopy to local...

journal_title：Developmental biology

authors： Price RL,Carver W,Simpson DG,Fu L,Zhao J,Borg TK,Terracio L

更新日期：1997-12-15 00:00:00

abstract：:This study reports a morphological, skeletal, and molecular characterization of the supernumerary limbs induced by systemic administration of all-trans retinoic acid to egg-cylinder stage mouse embryos. As initially described by Rutledge et al. (Proc. Natl. Acad. Sci. USA 91, 5436, 1994), we have found that oral admin...

journal_title：Developmental biology

authors： Niederreither K,Ward SJ,Dollé P,Chambon P

更新日期：1996-06-15 00:00:00

abstract：:Neural crest cells have broad migratory and differentiative ability that differs according to their axial level of origin. However, their transient nature has limited understanding of their stem cell and self-renewal properties. While an in vitro culture method has made it possible to maintain cranial neural crest cel...

journal_title：Developmental biology

authors： Mohlin S,Kunttas E,Persson CU,Abdel-Haq R,Castillo A,Murko C,Bronner ME,Kerosuo L

更新日期：2019-03-15 00:00:00

abstract：:To examine whether the extracellular matrix (ECM) plays a role in mediating interactions between the apical ectodermal ridge (AER) and the subjacent mesoderm in the chick wing bud, we used immunohistochemistry to locate the following tissue components during wing morphogenesis: types I and IV collagens, fibronectin, t...

journal_title：Developmental biology

authors： Critchlow MA,Hinchliffe JR

更新日期：1994-05-01 00:00:00

abstract：:The aim of this study was to evaluate the role segmentation plays in the determination of neuronal identity in the hindbrain. We focused on two specific sets of hindbrain neurons, namely, the vestibulospinal and vestibulo-ocular neurons, which comprise distinct groups that can be identified and distinguished by virtue...

journal_title：Developmental biology

authors： Díaz C,Puelles L,Marín F,Glover JC

更新日期：1998-10-01 00:00:00