Making sense of Dlx1 antisense RNA.

abstract：:In Drosophila, wing hairs are aligned in a distally oriented, parallel array. The frizzled pathway determines proximal-distal cell polarity in the wing; however, in frizzled pathway mutants, wing hairs remain parallel. How wing hairs align has not been determined. We have demonstrated a novel role for the septate junc...

journal_title：Developmental biology

authors： Venema DR,Zeev-Ben-Mordehai T,Auld VJ

更新日期：2004-11-15 00:00:00

abstract：:Growth factor signaling regulates tissue-tissue interactions to control organogenesis and tissue homeostasis. Specifically, transforming growth factor beta (TGFβ) signaling plays a crucial role in the development of cranial neural crest (CNC) cell-derived bone, and loss of Tgfbr2 in CNC cells results in craniofacial s...

journal_title：Developmental biology

authors： Ho TV,Iwata J,Ho HA,Grimes WC,Park S,Sanchez-Lara PA,Chai Y

更新日期：2015-04-15 00:00:00

abstract：:Chick embryonic heart cell isolates and monolayer cultures were prepared from atria and ventricles at selected stages of cardiac development. The cardiac myocytes were assayed for myosin heavy chain (MHC) content using monoclonal antibodies (McAbs) specific in the heart for atrial (B-1), ventricular (ALD-19), or condu...

journal_title：Developmental biology

authors： Zadeh BJ,González-Sánchez A,Fischman DA,Bader DM

更新日期：1986-05-01 00:00:00

abstract：:Nociceptive neurons innervate the skin with complex dendritic arbors that respond to pain-evoking stimuli such as harsh mechanical force or extreme temperatures. Here we describe the structure and development of a model nociceptor, the PVD neuron of C. elegans, and identify transcription factors that control morphogen...

journal_title：Developmental biology

authors： Smith CJ,Watson JD,Spencer WC,O'Brien T,Cha B,Albeg A,Treinin M,Miller DM 3rd

更新日期：2010-09-01 00:00:00

abstract：:cAMP chemoattractant receptors on the surface of Dictyostelium discoideum cells are visualized by means of immunocytochemistry. Receptor antigen is virtually absent from growing cells and begins to accumulate after about 6 hr of starvation, concomitant with the increase in surface cAMP binding activity. In aggregating...

journal_title：Developmental biology

authors： Wang M,Van Haastert PJ,Devreotes PN,Schaap P

更新日期：1988-07-01 00:00:00

abstract：:The eukaryotic initiation translation factor eIF6 is a highly conserved, essential protein implicated in translation. eIF6 is regulated in vivo by extracellular signals, such as IGF signaling (for a review see Miluzio et al., 2009). In Xenopus, eif6 over-expression causes a delay in eye development (De Marco et al., 2...

journal_title：Developmental biology

authors： De Marco N,Tussellino M,Carotenuto R,Ronca R,Rizzolio S,Biffo S,Campanella C

更新日期：2017-07-01 00:00:00

abstract：:The lethal(3)discs overgrown (dco) locus of Drosophila melanogaster, located on the third chromosome at cytogenetic position 100A5,6-100B1,2, is necessary for normal development and growth control in the imaginal discs of the larva. Three recessive lethal alleles (dco2, dco3, and dco18) in heteroallelic combinations a...

journal_title：Developmental biology

authors： Jursnich VA,Fraser SE,Held LI Jr,Ryerse J,Bryant PJ

更新日期：1990-08-01 00:00:00

abstract：:The oblique muscle layer in the leech body wall is built upon the processes of a unique identified embryonic cell, the Comb- or C-cell. Each C-cell is composed of a spindle-shaped soma that projects approximately 70 parallel processes through the developing body wall at an angle oblique to the long axis. The morphogen...

journal_title：Developmental biology

authors： Jellies J,Kristan WB Jr

更新日期：1991-11-01 00:00:00

abstract：:The evolution of canalized traits is a central question in evolutionary biology. Natural variation in highly conserved traits can provide clues about their evolutionary potential. Here we investigate natural variation in a conserved trait-even-skipped (eve) expression at the cellular blastoderm stage of embryonic deve...

journal_title：Developmental biology

authors： Jiang P,Ludwig MZ,Kreitman M,Reinitz J

更新日期：2015-09-01 00:00:00

abstract：:The role of the wound epithelium in amphibian limb regeneration is not understood. We showed previously that monoclonal antibody (mAb) WE3 stains the wound epithelium but not skin epidermis, suggesting that the WE3 antigen may be a marker for, or be important in, the function of the wound epithelium. In the present st...

journal_title：Developmental biology

authors： Goldhamer DJ,Tomlinson BL,Tassava RA

更新日期：1989-10-01 00:00:00

abstract：:To identify guanine nucleotide binding proteins (G-proteins) in sea urchin eggs and to investigate their role in signal transduction at fertilization, we used cholera toxin (CTX) and pertussis toxin (PTX), which catalyze the specific ADP-ribosylation of G-proteins. Cell surface complex, consisting of plasma membranes ...

journal_title：Developmental biology

authors： Turner PR,Jaffe LA,Primakoff P

更新日期：1987-04-01 00:00:00

abstract：:Spore germination is a defined developmental process that marks a critical point in the life cycle of Dictyostelium discoideum. Upon germination the environmental conditions must be conducive to cell growth to ensure survival of emerged amoebae. However, the signal transduction pathways controlling the various aspects...

journal_title：Developmental biology

authors： Zinda MJ,Singleton CK

更新日期：1998-04-15 00:00:00

abstract：:Proper calcium channel and insulin signaling are essential for normal brain development. Leaner mice with a mutation in the P/Q-type voltage-gated calcium channel, Cacna1a, develop cerebellar atrophy and mutations in the homologous human gene are associated with increased migraine and seizure tendency. Similarly, abno...

journal_title：Developmental biology

authors： Estevez AO,Cowie RH,Gardner KL,Estevez M

更新日期：2006-10-01 00:00:00

abstract：:Mf1, which encodes a winged-helix/forkhead transcription factor, is the murine homolog of human FKHL7, mutated in individuals with autosomal dominant inherited dysgenesis of the anterior segment of the eye (Axenfeld-Reiger anomaly). Mouse embryos homozygous for null mutations in Mf1 (Mf1(lacZ) and Mf1(ch)) show severe...

journal_title：Developmental biology

authors： Kidson SH,Kume T,Deng K,Winfrey V,Hogan BL

更新日期：1999-07-15 00:00:00

abstract：:The interaction of heterologous tissues involves cell adhesion mediated by the extracellular matrix and its receptor integrins. The Drosophila wing disc is an ectodermal invagination that contacts specific tracheal branches at the basolateral cell surface. We show that an alpha subunit of laminin, encoded by wing blis...

journal_title：Developmental biology

authors： Inoue Y,Hayashi S

更新日期：2007-04-01 00:00:00

abstract：:The pattern of innervation in 13 chicken hindlimb muscles was studied at various stages of development in order to examine the mechanisms which regulate its formation. The pattern of innervation was visualized by examining the distribution of fiber types within each muscle. It was found that the fiber type which a myo...

journal_title：Developmental biology

authors： McLennan IS

更新日期：1983-05-01 00:00:00

abstract：:Bone morphogenetic protein-4 (BMP-4) induces epidermis and represses neural fate in Xenopus ectoderm. Our previous findings implicate p42 Erk MAP kinase (MAPK) in the response to neural induction. We have examined the effects of BMP-4 on MAPK activity in gastrula ectoderm. Expression of a dominant negative BMP-4 recep...

journal_title：Developmental biology

authors： Goswami M,Uzgare AR,Sater AK

更新日期：2001-08-15 00:00:00

abstract：:The remarkable regenerative capacity displayed by plants and various vertebrates, such as amphibians, is largely based on the capability of somatic cells to undergo dedifferentiation. In this process, mature cells reverse their state of differentiation and acquire pluripotentiality--a process preceding not only reentr...

journal_title：Developmental biology

authors： Grafi G

更新日期：2004-04-01 00:00:00

abstract：:We have investigated the regulation of DNA synthesis in the heterokaryons of HL60 human myelomonocytic leukemia cells and NIH3T3 mouse fibroblasts to examine if the differentiated leukemia cells contained a replication inhibiting activity. Cell fusions were performed either by exposing a suspension of mixed cells to a...

journal_title：Developmental biology

authors： Prudovsky IA,Tsong TY

更新日期：1991-04-01 00:00:00

abstract：:The nervous system development of the sea cucumber Stichopus japonicus was investigated to explore the development of the bilateral larval nervous system into the pentaradial adult form typical of echinoderms. The first nerve cells were detected in the apical region of epidermis in the late gastrula. In the auriculari...

journal_title：Developmental biology

authors： Nakano H,Murabe N,Amemiya S,Nakajima Y

更新日期：2006-04-01 00:00:00

abstract：:Differences are demonstrated in the chondrogenic potential of cells derived from the distal and proximal halves of chick wing buds from as early as stage 23, prior to the appearance of overt cartilage differentiation. In high cell density cultures, cells obtained from the distal portions of stage 23 or 24 limb buds ar...

journal_title：Developmental biology

authors： Swalla BJ,Owens EM,Linsenmayer TF,Solursh M

更新日期：1983-05-01 00:00:00

abstract：:The levels of al-1 and al-2 transcripts change dramatically in response to light and development during the formation of Neurospora crassa asexual spores (conidia). al-1 and al-2 mRNAs accumulate throughout conidiation irrespective of lighting conditions initially at low levels. As conidiation proceeds, two increases ...

journal_title：Developmental biology

authors： Li C,Schmidhauser TJ

更新日期：1995-05-01 00:00:00

abstract：:teashirt (tsh) encodes a zinc-finger protein that is thought to be part of a network that contributes to regionalization of the Drosophila embryo and establishes the domains of Hox protein function. tsh and the Hox gene Sex combs reduced (Scr) are essential to establish the identity of the first thoracic segment. We u...

journal_title：Developmental biology

authors： Taghli-Lamallem O,Gallet A,Leroy F,Malapert P,Vola C,Kerridge S,Fasano L

更新日期：2007-07-01 00:00:00

abstract：:Developmental patterning and growth of the vertebrate digestive and respiratory tracts requires interactions between the epithelial endoderm and adjacent mesoderm. The esophagus is a specialized structure that connects the digestive and respiratory systems and its normal development is critical for both. Shh signaling...

journal_title：Developmental biology

authors： Korzh S,Winata CL,Zheng W,Yang S,Yin A,Ingham P,Korzh V,Gong Z

更新日期：2011-11-15 00:00:00

abstract：:Spontaneous germ cell death is a common cellular process in the mammalian testis, although the function of this process during spermatogenesis is unclear. An investigation was undertaken to determine whether p53 serves as a mechanism in germ cell quality control by causing spontaneous germ cell death. Using an annexin...

journal_title：Developmental biology

authors： Yin Y,Stahl BC,DeWolf WC,Morgentaler A

更新日期：1998-12-01 00:00:00

abstract：:Monoclonal antibodies (mAbs), electrophoresis, immunoblotting, and immunohistochemistry were used to determine the molecular properties of cardiac myosin heavy chain (MHC) isoforms and the regions of the developing chicken heart in which they were expressed. Adult atria expressed three electrophoretically distinct MHC...

journal_title：Developmental biology

authors： Evans D,Miller JB,Stockdale FE

更新日期：1988-06-01 00:00:00

abstract：:To examine the relationship between growth hormone (GH) and insulin-like growth factor 1 (IGF1) in controlling postnatal growth, we performed a comparative analysis of dwarfing phenotypes manifested in mouse mutants lacking GH receptor, IGF1, or both. This genetic study has provided conclusive evidence demonstrating t...

journal_title：Developmental biology

authors： Lupu F,Terwilliger JD,Lee K,Segre GV,Efstratiadis A

更新日期：2001-01-01 00:00:00

abstract：:Named for its assembly near exon-exon junctions during pre-mRNA splicing, the exon junction complex (EJC) regulates multiple aspects of RNA biochemistry, including export of spliced mRNAs from the nucleus and translation. Transcriptome analyses have revealed broad EJC occupancy of spliced metazoan transcripts, yet inh...

journal_title：Developmental biology

authors： Kimball C,Powers K,Dustin J,Poirier V,Pellettieri J

更新日期：2020-01-01 00:00:00

abstract：:Results of numerous experiments indicate that the transient rise in intracellular Ca2+ following sperm-egg fusion is essential for the subsequent events that constitute egg activation. Some events of egg activation, e.g., cortical granule exocytosis, however, appear more sensitive to intracellular Ca2+ than other even...

journal_title：Developmental biology

authors： Xu Z,Lefevre L,Ducibella T,Schultz RM,Kopf GS

更新日期：1996-12-15 00:00:00

abstract：:The ectoderm of early Xenopus gastrula is competent to become induced to neural tissue, but dorsal ectoderm is more neural competent than ventral ectoderm. It is a tenable, but as yet untested possibility that the higher neural competence of dorsal gastrula ectoderm is dependent on the presence of the dorsal mesoderm....

journal_title：Developmental biology

authors： Otte AP,Moon RT

更新日期：1992-07-01 00:00:00