当前位置： SCI文献检索 > DEVELOPMENTAL BIOLOGY期刊下所有文献 > The involvement of Eph-Ephrin signaling in tissue separation and convergence during Xenopus gastrulation movements.

The involvement of Eph-Ephrin signaling in tissue separation and convergence during Xenopus gastrulation movements.

Abstract：

:In Xenopus gastrulation, the involuting mesodermal and non-involuting ectodermal cells remain separated from each other, undergoing convergent extension. Here, we show that Eph-ephrin signaling is crucial for the tissue separation and convergence during gastrulation. The loss of EphA4 function results in aberrant gastrulation movements, which are due to selective inhibition of tissue constriction and separation. At the cellular levels, knockdown of EphA4 impairs polarization and migratory activity of gastrulating cells but not specification of their fates. Importantly, rescue experiments demonstrate that EphA4 controls tissue separation via RhoA GTPase in parallel to Fz7 and PAPC signaling. In addition, we show that EphA4 and its putative ligand, ephrin-A1 are expressed in a complementary manner in the involuting mesodermal and non-involuting ectodermal layers of early gastrulae, respectively. Depletion of ephrin-A1 also abrogates tissue separation behaviors. Therefore, these results suggest that Eph receptor and its ephrin ligand might mediate repulsive interaction for tissue separation and convergence during early Xenopus gastrulation movements.

journal_name

Dev Biol

journal_title

Developmental biology

authors

Park EC,Cho GS,Kim GH,Choi SC,Han JK

doi

10.1016/j.ydbio.2010.12.012

subject

Has Abstract

pub_date

2011-02-15 00:00:00

pages

441-50

issue

2

eissn

0012-1606

issn

1095-564X

pii

S0012-1606(10)01253-4

journal_volume

350

pub_type

杂志文章

相关文献

DEVELOPMENTAL BIOLOGY文献大全
  • Genome-wide network of regulatory genes for construction of a chordate embryo.

    abstract：:Animal development is controlled by gene regulation networks that are composed of sequence-specific transcription factors (TF) and cell signaling molecules (ST). Although housekeeping genes have been reported to show clustering in the animal genomes, whether the genes comprising a given regulatory network are physical...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2008.01.009

    authors： Shoguchi E,Hamaguchi M,Satoh N

    更新日期：2008-04-15 00:00:00

  • Protein deiminases: new players in the developmentally regulated loss of neural regenerative ability.

    abstract：:Spinal cord regenerative ability is lost with development, but the mechanisms underlying this loss are still poorly understood. In chick embryos, effective regeneration does not occur after E13, when spinal cord injury induces extensive apoptotic response and tissue damage. As initial experiments showed that treatment...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2011.04.015

    authors： Lange S,Gögel S,Leung KY,Vernay B,Nicholas AP,Causey CP,Thompson PR,Greene ND,Ferretti P

    更新日期：2011-07-15 00:00:00

  • Transient apical polarization of Gliotactin and Coracle is required for parallel alignment of wing hairs in Drosophila.

    abstract：:In Drosophila, wing hairs are aligned in a distally oriented, parallel array. The frizzled pathway determines proximal-distal cell polarity in the wing; however, in frizzled pathway mutants, wing hairs remain parallel. How wing hairs align has not been determined. We have demonstrated a novel role for the septate junc...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2004.07.040

    authors： Venema DR,Zeev-Ben-Mordehai T,Auld VJ

    更新日期：2004-11-15 00:00:00

  • Serendipity delta, a Drosophila zinc finger protein present in embryonic nuclei at the onset of zygotic gene transcription.

    abstract：:Serendipity delta (sry delta) is a member of a set of Drosophila zinc finger protein genes showing maximal transcription during oogenesis. By using transformant lines, we monitored the zygotic expression of the sry delta gene and characterized some biochemical properties of a sry delta/beta-galactosidase fusion protei...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(89)90272-8

    authors： Payre F,Yanicostas C,Vincent A

    更新日期：1989-12-01 00:00:00

  • Genetic and molecular analysis of fs(1)h, a maternal effect homeotic gene in Drosophila.

    abstract：:Mutations at the Drosophila melanogaster locus female sterile (1) homeotic (fs(1)h) result in segmental abnormalities including missing organs and homeotic transformations in the progeny of mutant mothers. Homeotic transformations are enhanced when the zygotes carry one of several third chromosome mutations, specifica...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(86)90392-1

    authors： Digan ME,Haynes SR,Mozer BA,Dawid IB,Forquignon F,Gans M

    更新日期：1986-03-01 00:00:00

  • A Caenorhabditis elegans homologue of hunchback is required for late stages of development but not early embryonic patterning.

    abstract：:We have cloned a Caenorhabditis elegans homologue of the Drosophila gap gene hunchback (hb) and have designated it hbl-1 (hunchback-like). hbl-1 encodes a predicted 982-amino-acid protein, containing two putative zinc-finger domains similar to those of Drosophila Hunchback. The gene is transcribed embryonically, but u...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1998.9096

    authors： Fay DS,Stanley HM,Han M,Wood WB

    更新日期：1999-01-15 00:00:00

  • Changing of the cell division axes drives vulva evolution in nematodes.

    abstract：:Vulval epithelial tubes invaginate through concerted cell migration, ring formation, stacking of rings and intra-ring cell fusion in the nematodes Caenorhabditis elegans, Oscheius tipulae and Pristionchus pacificus. The number of rings forming the invaginations is invariantly seven, six, and eight, respectively. We hy...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2007.10.010

    authors： Kolotuev I,Podbilewicz B

    更新日期：2008-01-01 00:00:00

  • Primary oocyte transcriptional activation of aqp1ab by the nuclear progestin receptor determines the pelagic egg phenotype of marine teleosts.

    abstract：:In marine teleosts, the aqp1ab water channel plays a vital role in the development of the pelagic egg phenotype. However, the developmental control of aqp1ab activation during oogenesis remains to be established. Here, we report the isolation of the 5'-flanking region of the teleost gilthead seabream aqp1ab gene, in w...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2013.03.001

    authors： Zapater C,Chauvigné F,Tingaud-Sequeira A,Finn RN,Cerdà J

    更新日期：2013-05-15 00:00:00

  • The proprioceptive and contractile systems in Drosophila are both patterned by the EGR family transcription factor Stripe.

    abstract：:Coordinated locomotion of Drosophila larvae depends on accurate patterning and stable attachment to the cuticle of both muscles and proprioceptors (chordotonal organs). Unlike muscle spindles in mammals, the fly chordotonal organs are not embedded in the body-wall muscles. Yet, the contractile system (muscles and tend...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2009.11.022

    authors： Klein Y,Halachmi N,Egoz-Matia N,Toder M,Salzberg A

    更新日期：2010-01-15 00:00:00

  • MAPK/ERK activity is required for the successful progression of mitosis in sea urchin embryos.

    abstract：:Using sea urchin embryos, we demonstrate that the MEK/MAPK/ERK cascade is essential for the proper progression of the cell cycle. Activation of a limited fraction of MAPK/ERK is required between S-phase and M-phase. Neither DNA replication nor CDK1 activation are impacted by the inhibition of this small active MAPK/ER...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2016.11.018

    authors： Mulner-Lorillon O,Chassé H,Morales J,Bellé R,Cormier P

    更新日期：2017-01-15 00:00:00

  • Repression of gene expression at the beginning of mouse development.

    abstract：:The transition from maternal to zygotic gene expression in the mouse occurs in the 2-cell embryo. Previous studies in which DNA was injected into 2-cell embryos revealed that transcription promoters and origins of DNA replication are strongly repressed in cleavage stage embryos unless linked to an embryo-responsive en...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1995.1160

    authors： Henery CC,Miranda M,Wiekowski M,Wilmut I,DePamphilis ML

    更新日期：1995-06-01 00:00:00

  • Opposite effects of FGF and BMP-4 on embryonic blood formation: roles of PV.1 and GATA-2.

    abstract：:In adult vertebrates, fibroblast growth factor (FGF) synergizes with many hematopoietic cytokines to stimulate the proliferation of hematopoietic progenitors. In vertebrate development, the FGF signaling pathway is important in the formation of some derivatives of ventroposterior mesoderm. However, the function of FGF...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1999.9205

    authors： Xu RH,Ault KT,Kim J,Park MJ,Hwang YS,Peng Y,Sredni D,Kung Hf

    更新日期：1999-04-15 00:00:00

  • Mitogen-activated protein kinases, adherens junction dynamics, and spermatogenesis: a review of recent data.

    abstract：:Mitogen-activated protein kinases (MAPKs) are important regulators of many cellular processes. In mammalian testes, these kinases are involved in controlling cell division, differentiation, survival and death, and are therefore critical to spermatogenesis. Recent studies have also illustrated their involvement in junc...

    journal_title：Developmental biology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ydbio.2005.08.001

    authors： Wong CH,Cheng CY

    更新日期：2005-10-01 00:00:00

  • In vitro penetration of hamster oocyte-cumulus complexes using physiological numbers of sperm.

    abstract：:We have compared the ability of uncapacitated, capacitated acrosome intact, and acrosome-reacted hamster sperm to penetrate the cumulus and corona radiata of fresh hamster oocyte-cumulus complexes (OCC) in vitro. This was done using physiological numbers (1-20) of sperm so that cumulus and corona radiata cells did not...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(87)90348-4

    authors： Corselli J,Talbot P

    更新日期：1987-07-01 00:00:00

  • Completion of Meiosis I of preovulatory oocytes and facilitation of preimplantation embryo development by glial cell line-derived neurotrophic factor.

    abstract：:Optimal maturation of oocytes and successful development of preimplantation embryos is essential for reproduction. We performed DNA microarray analyses of ovarian transcripts and identified glial cell line-derived neurotrophic factor (GDNF) secreted by cumulus, granulosa, and theca cells as an ovarian factor stimulate...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2007.12.029

    authors： Kawamura K,Ye Y,Kawamura N,Jing L,Groenen P,Gelpke MS,Rauch R,Hsueh AJ,Tanaka T

    更新日期：2008-03-01 00:00:00

  • Mosaicism in CRISPR/Cas9-mediated genome editing.

    abstract：:The CRISPR/Cas9 system is a rapid, simple, and often extremely efficient gene editing method. This method has been used in a variety of organisms and cell types over the past several years. However, using this technology for generating gene-edited animals involves a number of obstacles. One such obstacle is mosaicism,...

    journal_title：Developmental biology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ydbio.2018.10.008

    authors： Mehravar M,Shirazi A,Nazari M,Banan M

    更新日期：2019-01-15 00:00:00

  • CDX4 and retinoic acid interact to position the hindbrain-spinal cord transition.

    abstract：:The sub-division of the posterior-most territory of the neural plate results in the formation of two distinct neural structures, the hindbrain and the spinal cord. Although many of the molecular signals regulating the development of these individual structures have been elucidated, the mechanisms involved in delineati...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2015.12.025

    authors： Chang J,Skromne I,Ho RK

    更新日期：2016-02-15 00:00:00

  • Sequential programs of retinoic acid synthesis in the myocardial and epicardial layers of the developing avian heart.

    abstract：:Endogenous patterns of retinoic acid (RA) signaling in avian cardiac morphogenesis were characterized by localized expression of a key RA-synthetic enzyme, RALDH2, which displayed a biphasic pattern during heart development. RALDH2 immunoreactivity was initially apparent posterior to Hensen's node of stage 5-6 embryos...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1999.9588

    authors： Xavier-Neto J,Shapiro MD,Houghton L,Rosenthal N

    更新日期：2000-03-01 00:00:00

  • An octamer element is required for the expression of the alpha H2B histone gene during the early development of the sea urchin.

    abstract：:Early (alpha) histone genes are one of several histone gene families in the sea urchin genome. They are expressed at high levels in blastula-stage embryos and are inactivated by the early gastrula stage. By microinjecting mutant early H2B genes into sea urchin zygotes and monitoring their transcriptional activity in b...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(92)90248-f

    authors： Bell J,Char BR,Maxson R

    更新日期：1992-04-01 00:00:00

  • Dynamic expression of Lrp2 pathway members reveals progressive epithelial differentiation of primitive endoderm in mouse blastocyst.

    abstract：:Mesenchyme to epithelium transitions are crucial to embryonic development. The early mouse embryo offers an excellent model to study epithelium formation as during the first three days of development two epithelia are formed, the trophectoderm (TE) and the primitive endoderm (PrE). We have previously shown that PrE ce...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2007.10.048

    authors： Gerbe F,Cox B,Rossant J,Chazaud C

    更新日期：2008-01-15 00:00:00

  • Germ cell-Sertoli cell interactions: analysis of the biosynthesis and secretion of cyclic protein-2.

    abstract：:Cyclic protein-2 (CP-2) is secreted in vitro in substantial amounts by mature rat Sertoli cells in intact Stage VI and Stage VII seminiferous tubules. This stage-dependent secretion has led us to postulate that the biosynthesis of this molecule is stimulated by germ cells at a specific state of development. In order t...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(88)90412-5

    authors： Wright WW

    更新日期：1988-11-01 00:00:00

  • Identification of a proliferating marginal zone of retinal progenitors in postnatal chickens.

    abstract：:In warm-blooded vertebrates it is generally accepted that after early stages of development new neurons are not added to the retina. Contrary to this belief, we show here that hatched chickens have a zone of proliferating cells at the peripheral margin of the retina, similar to that of fish and amphibians. We found th...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.2000.9640

    authors： Fischer AJ,Reh TA

    更新日期：2000-04-15 00:00:00

  • Zonula adherens formation in Caenorhabditis elegans requires dlg-1, the homologue of the Drosophila gene discs large.

    abstract：:The correct assembly of junction components, such as E-cadherin and beta-catenin, into the zonula adherens is fundamental for the function of epithelia, both in flies and in vertebrates. In C. elegans, however, the cadherin-catenin system is not essential for general adhesion, raising the question as to the genetic ba...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.2000.0113

    authors： Bossinger O,Klebes A,Segbert C,Theres C,Knust E

    更新日期：2001-02-01 00:00:00

  • The effect of agrin and laminin on acetylcholine receptor dynamics in vitro.

    abstract：:Using optical imaging assays, we investigated the dynamics of acetylcholine receptors (AChRs) at laminin-associated clusters on cultured myotubes in the absence or presence of the nerve-derived clustering factor, agrin. Using fluorescence recovery after photobleaching (FRAP) on fluorescent bungarotoxin-labeled recepto...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2005.09.041

    authors： Bruneau EG,Macpherson PC,Goldman D,Hume RI,Akaaboune M

    更新日期：2005-12-01 00:00:00

  • The development of the pattern of innervation in chicken hindlimb muscles: evidence for specification of nerve-muscle connections.

    abstract：:The pattern of innervation in 13 chicken hindlimb muscles was studied at various stages of development in order to examine the mechanisms which regulate its formation. The pattern of innervation was visualized by examining the distribution of fiber types within each muscle. It was found that the fiber type which a myo...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(83)90080-5

    authors： McLennan IS

    更新日期：1983-05-01 00:00:00

  • The patterns on chondrogenesis of cells from facial primordia of chick embryos in micromass culture.

    abstract：:Chondrogenesis of mesenchymal cells from the frontonasal mass, mandibles and maxillae of stage-24 chick embryos has been investigated in micromass (high-density) cultures. Distinct differences in the amount and pattern of cartilage differentiation are found. In cultures of frontonasal mass cells, a central sheet of ca...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(86)90349-0

    authors： Wedden SE,Lewin-Smith MR,Tickle C

    更新日期：1986-09-01 00:00:00

  • Neurogenesis in the water flea Daphnia magna (Crustacea, Branchiopoda) suggests different mechanisms of neuroblast formation in insects and crustaceans.

    abstract：:Within euarthropods, the morphological and molecular mechanisms of early nervous system development have been analysed in insects and several representatives of chelicerates and myriapods, while data on crustaceans are fragmentary. Neural stem cells (neuroblasts) generate the nervous system in insects and in higher cr...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2011.05.662

    authors： Ungerer P,Eriksson BJ,Stollewerk A

    更新日期：2011-09-01 00:00:00

  • Ca2+ oscillatory pattern in fertilized mouse eggs affects gene expression and development to term.

    abstract：:The Ca2+ oscillations initiated by the fertilizing sperm (but terminating concomitant with pronucleus formation) apparently ensure that the events constituting egg activation occur in the correct temporal order; early events (e.g., cortical granule exocytosis) require fewer oscillations than later events (e.g., recrui...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2006.08.041

    authors： Ozil JP,Banrezes B,Tóth S,Pan H,Schultz RM

    更新日期：2006-12-15 00:00:00

  • Pax8 and Pax2 are specifically required at different steps of Xenopus pronephros development.

    abstract：:The respective role of Pax2 and Pax8 in early kidney development in vertebrates is poorly understood. In this report, we have studied the roles of Pax8 and Pax2 in Xenopus pronephros development using a loss-of-function approach. Our results highlight a differential requirement of these two transcription factors for p...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2014.10.022

    authors： Buisson I,Le Bouffant R,Futel M,Riou JF,Umbhauer M

    更新日期：2015-01-15 00:00:00

  • Near complete loss of retinal ganglion cells in the math5/brn3b double knockout elicits severe reductions of other cell types during retinal development.

    abstract：:Retinal ganglion cells (RGCs) are the first cell type to differentiate during retinal histogenesis. It has been postulated that specified RGCs subsequently influence the number and fate of the remaining progenitors to produce the rest of the retinal cell types. However, several genetic knockout models have argued agai...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2008.01.015

    authors： Moshiri A,Gonzalez E,Tagawa K,Maeda H,Wang M,Frishman LJ,Wang SW

    更新日期：2008-04-15 00:00:00