Abstract:
:Serendipity delta (sry delta) is a member of a set of Drosophila zinc finger protein genes showing maximal transcription during oogenesis. By using transformant lines, we monitored the zygotic expression of the sry delta gene and characterized some biochemical properties of a sry delta/beta-galactosidase fusion protein-containing fingers. Further analysis made use of anti-sry delta specific antibodies. During oogenesis, while sry delta mRNAs transcribed by nurse cells are transferred to the oocyte starting in stage 10, translation into protein occurs in the ooplasm starting in stage 12. The maternally inherited protein concentrates in embryonic nuclei during early cleavages, prior to the onset of zygotic transcription. At the blastoderm stage, the sry delta protein is localized in all somatic nuclei. Later in embryogenesis and up to the adult stage, the zygotic protein is present in nuclei of transcriptionally active cells (both somatic and germ line). These data are consistent with the sry delta protein being a transcription factor, with a role in zygotic activation of general cellular functions.
journal_name
Dev Bioljournal_title
Developmental biologyauthors
Payre F,Yanicostas C,Vincent Adoi
10.1016/0012-1606(89)90272-8subject
Has Abstractpub_date
1989-12-01 00:00:00pages
469-80issue
2eissn
0012-1606issn
1095-564Xpii
0012-1606(89)90272-8journal_volume
136pub_type
杂志文章abstract::A rapid, gentle technique is described for the isolation of nuclei from sea urchin embryos. Using this technique, we have analyzed the synthesis and accumulation of nonhistone nuclear proteins during sea urchin development by two-dimensional gel electrophoresis. Most nuclear proteins fall into one of three patterns of...
journal_title:Developmental biology
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pub_type: 杂志文章,评审
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journal_title:Developmental biology
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journal_title:Developmental biology
pub_type: 杂志文章
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