Cul4A is essential for spermatogenesis and male fertility.

abstract：:Notch signaling has a fundamental role in stem cell maintenance and in cell fate choice in the intestine of different species. Canonically, Notch signaling represses the expression of transcription factors of the achaete-scute like (ASCL) or atonal related protein (ARP) families. Identifying the ARP/ASCL genes express...

journal_title：Developmental biology

authors： Flasse LC,Stern DG,Pirson JL,Manfroid I,Peers B,Voz ML

更新日期：2013-04-15 00:00:00

abstract：:Early mammalian embryogenesis is controlled by mechanisms governing the balance between pluripotency and differentiation. The expression of early lineage-specific genes can vary significantly between species, with implications for developmental control and stem cell derivation. However, the mechanisms involved in patt...

journal_title：Developmental biology

authors： Niakan KK,Eggan K

更新日期：2013-03-01 00:00:00

abstract：:These studies examined the potential for reorganization and differentiation of dissociated 18-day fetal rat intestine. Cultures of trypsin-dissociated fetal intestine were maintained in vitro for 1 week on a three-dimensional matrix, then transplanted into syngeneic hosts. When harvested after 4 weeks, these transplan...

journal_title：Developmental biology

authors： Montgomery RK,Zinman HM,Smith BT

更新日期：1983-11-01 00:00:00

abstract：:Recently, it has been suggested that a mouse sperm-associated protein with properties similar to the inhibitory guanine nucleotide-binding regulatory protein Gi plays an intermediary role in the zona pellucida-induced acrosome reaction (Endo, Y., Lee, M. A., and Kopf, G. S. 1987. Dev. Biol. 119, 210-216). In the prese...

journal_title：Developmental biology

authors： Endo Y,Lee MA,Kopf GS

更新日期：1988-09-01 00:00:00

abstract：:John W. Saunders, Jr. made seminal discoveries unveiling how chick embryos develop their limbs. He discovered the apical ectodermal ridge (AER), the zone of polarizing activity (ZPA), and the domains of interdigital cell death within the developing limb and determined their function through experimental analysis. Thes...

journal_title：Developmental biology

authors： Young JJ,Tabin CJ

更新日期：2017-09-15 00:00:00

abstract：:VegT is an essential maternal regulator of germ layer specification in Xenopus. The localization of VegT mRNA to the vegetal cortex of the oocyte during oogenesis ensures its inheritance by vegetal and not animal cells, and directs the differentiation of vegetal cells into endoderm. Similarly localized mRNAs, Vg1 and ...

journal_title：Developmental biology

authors： Heasman J,Wessely O,Langland R,Craig EJ,Kessler DS

更新日期：2001-12-15 00:00:00

abstract：:Climate change is multi-faceted, and includes changing concentrations of greenhouse gases in the atmosphere, rising temperatures, changes in precipitation patterns, and increasing frequency of extreme weather events. Here, we focus on the effects of rising atmospheric CO2 concentrations, rising temperature, and drough...

journal_title：Developmental biology

authors： Gray SB,Brady SM

更新日期：2016-11-01 00:00:00

abstract：:Thyroid hormone deficiency is known to deeply affect cerebellum post-natal development. We present here a detailed analysis of the phenotype of a recently generated mouse model, expressing a dominant-negative TRα1 mutation. Although hormonal level is not affected, the cerebellum of these mice displays profound alterat...

journal_title：Developmental biology

authors： Fauquier T,Romero E,Picou F,Chatonnet F,Nguyen XN,Quignodon L,Flamant F

更新日期：2011-08-15 00:00:00

abstract：:Planarians are well-known for their exceptional regenerative abilities. This investigation focuses on the involvement of a Y-box protein, defined by the presence of a cold-shock domain, in regeneration-specific processes. Previous studies have shown that developmentally expressed Y-box proteins bind to mRNA molecules ...

journal_title：Developmental biology

authors： Salvetti A,Batistoni R,Deri P,Rossi L,Sommerville J

更新日期：1998-09-15 00:00:00

abstract：:Tabby is a mouse mutant characterized by deficient development of the ectodermal organs: teeth, hair, and a subset of glands. Ectodysplasin, the protein encoded by the Tabby gene, was recently identified as a novel TNF-like transmembrane protein but little is known about its function. We have examined the Tabby tooth ...

journal_title：Developmental biology

authors： Pispa J,Jung HS,Jernvall J,Kettunen P,Mustonen T,Tabata MJ,Kere J,Thesleff I

更新日期：1999-12-15 00:00:00

abstract：:Interleukin-6 is a member of a class of hormone-like molecules termed cytokines. The actions of IL-6 are highly pleiotropic. In adults IL-6 functions as a major mediator of inflammatory responses as well as inducing the synthesis of acute phase proteins by the liver following infection or injury. Based on in vitro and...

journal_title：Developmental biology

authors： Lee FD

更新日期：1992-06-01 00:00:00

abstract：:Missense mutations in the MYH3 gene encoding myosin heavy chain-embryonic (MyHC-embryonic) have been reported to cause two skeletal muscle contracture syndromes, Freeman Sheldon Syndrome (FSS) and Sheldon Hall Syndrome (SHS). Two residues in MyHC-embryonic that are most frequently mutated, leading to FSS, R672 and T17...

journal_title：Developmental biology

authors： Das S,Kumar P,Verma A,Maiti TK,Mathew SJ

更新日期：2019-05-15 00:00:00

abstract：:Experiments in which the developing gut of avian embryos was back-transplanted to permit the bowel to interact with the developing neural tube were undertaken. Segments of intestine from 4-day quail embryos were implanted between the somites and neural tubes of chick embryos of 7 to 24 somites. The spinal cord respond...

journal_title：Developmental biology

authors： Rothman TP,Gershon MD,Fontaine-Pérus JC,Chanconie M,Le Douarin NM

更新日期：1987-12-01 00:00:00

abstract：:Successful fertilization requires that sperm are activated prior to contacting an oocyte. In C. elegans, this activation process, called spermiogenesis, transforms round immobile spermatids into motile, fertilization-competent spermatozoa. We describe the phenotypic and genetic characterization of spe-43, a new compon...

journal_title：Developmental biology

authors： Krauchunas AR,Mendez E,Ni JZ,Druzhinina M,Mulia A,Parry J,Gu SG,Stanfield GM,Singson A

更新日期：2018-04-15 00:00:00

abstract：:The zebrafish hedgehog (hh) family members tiggy-winkle hedgehog (twhh) and sonic hedgehog (shh) are involved in patterning the ventral CNS and proximal eye. Using a dominant negative protein kinase A regulatory subunit mutant, we show that these hh activities are mediated by protein kinase A. The effects of dominant ...

journal_title：Developmental biology

authors： Ungar AR,Moon RT

更新日期：1996-08-25 00:00:00

abstract：:Several genomic clones were isolated from a Drosophila library screened with cDNA prepared from abundant adult female mRNA. Cytoplasmic dot hybridizations have shown that the genes in all of these clones are expressed only in posteclosion (stages 8-14) follicles. One set of overlapping clones (lambda 20, lambda 28, an...

journal_title：Developmental biology

authors： Higgins MJ,Walker VK,Holden JA,White BN

更新日期：1984-09-01 00:00:00

abstract：:nautilus (nau), one member of the myogenic regulatory family of bHLH-encoding genes, is expressed in a subset of muscle precursors and differentiated fibers in the Drosophila embryo. To elucidate the role of nautilus in myogenesis, we have misexpressed it using the GAL4-targeted system. We find that ectopic expression...

journal_title：Developmental biology

authors： Keller CA,Erickson MS,Abmayr SM

更新日期：1997-01-15 00:00:00

abstract：:Genetic interactions regulating intermediate stages of tubulogenesis in the developing kidney have been difficult to define. A systems biology strategy using microarray was combined with in vitro/ex vivo and genetic approaches to identify pathways regulating specific stages of tubulogenesis. Analysis of the progressio...

journal_title：Developmental biology

authors： Gallegos TF,Kouznetsova V,Kudlicka K,Sweeney DE,Bush KT,Willert K,Farquhar MG,Nigam SK

更新日期：2012-04-01 00:00:00

abstract：:The location and distribution of neural crest-derived Schwann cells during development of the peripheral nerves of chick forelimbs were examined using chick-quail chimeras. Neural crest cells were labeled by transplantation of the dorsal part of the neural tube from a quail donor to a chick host at levels of the neura...

journal_title：Developmental biology

authors： Carpenter EM,Hollyday M

更新日期：1992-03-01 00:00:00

abstract：:During development of the central nervous system (CNS), commissural axons grow toward the ventral midline. After crossing the floor plate, they abruptly change their trajectory from the circumferential to the longitudinal axis. The contacts between the commissural axons and the floor plate cells are involved in this a...

journal_title：Developmental biology

authors： Okabe N,Shimizu K,Ozaki-Kuroda K,Nakanishi H,Morimoto K,Takeuchi M,Katsumaru H,Murakami F,Takai Y

更新日期：2004-09-15 00:00:00

abstract：:Sensory perception of light is mediated by specialized Photoreceptor neurons (PRs) in the eye. During development all PRs are genetically determined to express a specific Rhodopsin (Rh) gene and genes mediating a functional phototransduction pathway. While the genetic and molecular mechanisms of PR development is well...

journal_title：Developmental biology

authors： Mishra AK,Bargmann BOR,Tsachaki M,Fritsch C,Sprecher SG

更新日期：2016-02-15 00:00:00

abstract：:The transcription factors, GATA4, 5 and 6, recognize the same DNA sequence and are all expressed in the developing myocardium. However, knockout studies in the mouse have indicated that none of them are absolutely required for the specification of the myocardium. Here we present evidence for redundancy in this family ...

journal_title：Developmental biology

authors： Peterkin T,Gibson A,Patient R

更新日期：2007-11-15 00:00:00

abstract：:The universal signal for egg activation at fertilization is a rise in cytoplasmic Ca(2+) with defined spatial and temporal kinetics. Mammalian and amphibian eggs acquire the ability to produce such Ca(2+) signals during a maturation period that precedes fertilization and encompasses resumption of meiosis and progressi...

journal_title：Developmental biology

authors： Machaca K

更新日期：2004-11-01 00:00:00

abstract：:We report periodic movements during erection of Dictyostelium discoideum (Dd) sorocarps. Our observations lead to the working hypothesis that Dd sorocarp erection occurs by two superimposed processes: one periodic, with a modal period of 6 1/2 min, and one continuous. We tentatively identify the periodic process with ...

journal_title：Developmental biology

authors： Durston AJ,Cohen MH,Drage DJ,Potel MJ,Robertson A,Wonio D

更新日期：1976-09-01 00:00:00

abstract：:Extraocular muscles (EOM) represent a unique muscle group that controls eye movements and originates from head mesoderm, while the more typically studied body and limb muscles are somite-derived. Aiming to investigate myogenic progenitors (satellite cells) in EOM versus limb and diaphragm of adult mice, we have been u...

journal_title：Developmental biology

authors： Stuelsatz P,Shearer A,Yablonka-Reuveni Z

更新日期：2014-01-15 00:00:00

abstract：:Salivary gland formation in the Drosophila embryo is dependent on the homeotic gene Sex combs reduced (Scr). When Scr function is missing, salivary glands do not form, and when SCR is expressed everywhere in the embryo, salivary glands form in new places. Scr is normally expressed in all the cells that form the saliva...

journal_title：Developmental biology

authors： Henderson KD,Andrew DJ

更新日期：2000-01-15 00:00:00

abstract：:Symplastic spermatids (sys) male mice are sterile due to a recessive mutation that causes defective adhesion between spermatids and Sertoli cells within the seminiferous epithelium. We show that the mutation in sys mice involves a deletion of 1.24 Mb of chromosome 14. Comparative genomic analysis suggests that this re...

journal_title：Developmental biology

authors： Obholz KL,Akopyan A,Waymire KG,MacGregor GR

更新日期：2006-10-15 00:00:00

abstract：:During development, cells craft an impressive array of actin-based structures, mediating events as diverse as cytokinesis, apical constriction, and cell migration. One challenge is to determine how cells regulate actin assembly and disassembly to carry out these cell behaviors. During Drosophila oogenesis diverse cell...

journal_title：Developmental biology

authors： Gates J,Nowotarski SH,Yin H,Mahaffey JP,Bridges T,Herrera C,Homem CC,Janody F,Montell DJ,Peifer M

更新日期：2009-09-01 00:00:00

abstract：:TGF-beta (TGFβ) family mediated Smad signaling is involved in mesoderm and endoderm specifications, left-right asymmetry formation and neural tube development. The TGFβ1/2/3 and Activin/Nodal signal transduction cascades culminate with activation of SMAD2 and/or SMAD3 transcription factors and their overactivation are...

journal_title：Developmental biology

authors： Casari A,Schiavone M,Facchinello N,Vettori A,Meyer D,Tiso N,Moro E,Argenton F

更新日期：2014-12-01 00:00:00

abstract：:The cytoplasmic factor responsible for chromosome condensation was introduced into mouse zygotes at different times after fertilization by fusion of the zygotes with metaphase I oocytes. In 72% of heterokaryons obtained after fusion of early zygotes (14-18 hr post-human chorionic gonadotrophin (HCG) with oocytes, the ...

journal_title：Developmental biology

authors： Bałakier H,Masui Y

更新日期：1986-09-01 00:00:00