A protein kinase A and Wnt-dependent network regulating an intermediate stage in epithelial tubulogenesis during kidney development.

abstract：:The 3' penultimate exon (exon 18) of transcripts from the muscle myosin heavy chain (MHC) gene of Drosophila melanogaster is excluded from mRNAs of embryonic and larval muscle, while it is included in mRNAs of adult thoracic muscles. By transforming organisms with the MHC gene 5' end, linked in-frame to the MHC gene 3...

journal_title：Developmental biology

authors： Hess NK,Bernstein SI

更新日期：1991-08-01 00:00:00

abstract：:Mutations that inactivate either merlin (mer) or expanded (ex) result in increased cell growth and proliferation in Drosophila. Both Mer and Ex are members of the Band 4.1 protein superfamily, and, based on analyses of mer ex double mutants, they are proposed to function together in at least a partially redundant mann...

journal_title：Developmental biology

authors： Pellock BJ,Buff E,White K,Hariharan IK

更新日期：2007-04-01 00:00:00

abstract：:The developmental events of sporulation and fruiting body formation in the prokaryote Myxococcus xanthus are preceded by a stage of massive cell death. Two phenotypically complementable strains of M. xanthus defective in developmental lysis were identified from a group of conditional sporulation mutants. Mixture of th...

journal_title：Developmental biology

authors： Janssen GR,Dworkin M

更新日期：1985-11-01 00:00:00

abstract：:Zygotic Wnt signaling has been shown to be involved in dorsoventral mesodermal patterning in Xenopus embryos, but how it regulates different myogenic gene expression in the lateral mesodermal domains is not clear. Here, we use transient exposure of embryos or explants to lithium, which mimics Wnt/beta-catenin signalin...

journal_title：Developmental biology

authors： Shi DL,Bourdelas A,Umbhauer M,Boucaut JC

更新日期：2002-05-01 00:00:00

abstract：:To examine whether the 200-kDa neurofilament protein (200K NFP) is involved in mechanically stabilizing axons, we studied the developmental appearance of immunoreactivity to nonphosphorylated and phosphorylated 200K NFP at the neuromuscular junction. Polyinnervated rat muscle fibers become singly innervated during the...

journal_title：Developmental biology

authors： Donahue SP,Wood JG,English AW

更新日期：1988-11-01 00:00:00

abstract：:In the spawned Xenopus egg, germ plasm is found as cytoplasmic islands spread over a wide cortical region of the vegetal pole. However, by the blastula stage, the same material is found concentrated into a few large blastomeres at the floor of the blastocoel. Components of the germ plasm can be specifically labeled wi...

journal_title：Developmental biology

authors： Savage RM,Danilchik MV

更新日期：1993-06-01 00:00:00

abstract：:In adult vertebrates, fibroblast growth factor (FGF) synergizes with many hematopoietic cytokines to stimulate the proliferation of hematopoietic progenitors. In vertebrate development, the FGF signaling pathway is important in the formation of some derivatives of ventroposterior mesoderm. However, the function of FGF...

journal_title：Developmental biology

authors： Xu RH,Ault KT,Kim J,Park MJ,Hwang YS,Peng Y,Sredni D,Kung Hf

更新日期：1999-04-15 00:00:00

abstract：:The ubiquitin ligase Smurf1 can target a handful of signaling proteins for ubiquitin-mediated proteasomal destruction or functional modification, including TGF-beta receptors, Smads, transcription factors, RhoA and MEKK2. Smurf1 was initially implicated in BMP pathway regulation in embryonic development, but its poten...

journal_title：Developmental biology

authors： Alexandrova EM,Thomsen GH

更新日期：2006-11-15 00:00:00

abstract：:The accumulation of total RNA transcripts of 18 late embryo-abundant (Lea) gene families, each encoding two closely related Lea mRNAs, was measured in cotyledon total RNA during embryogenesis and germination of Gossypium hirsutum L. by RNA dot hybridization. Transcript abundance of the three storage protein families w...

journal_title：Developmental biology

authors： Galau GA,Bijaisoradat N,Hughes DW

更新日期：1987-09-01 00:00:00

abstract：:The role of retrograde signaling between target cells and their presynaptic partners during early cell-cell interactions was examined in cell culture. Using time-lapse video microscopy and fura-2 calcium analysis, we followed contacts between presynaptic neurites of Helisoma motoneurons and muscle fibers dissociated f...

journal_title：Developmental biology

authors： Zoran MJ,Funte LR,Kater SB,Haydon PG

更新日期：1993-07-01 00:00:00

abstract：:Thoracic sensory neurons in bullfrog tadpoles can be induced to form connections typical of brachial sensory neurons by transplanting thoracic ganglia to the branchial level at stages when some thoracic sensory neurons already have formed connections. In order to find out how many postmitotic sensory neurons survive t...

journal_title：Developmental biology

authors： Smith CL

更新日期：1990-12-01 00:00:00

abstract：:Concentration of mast-cell precursors in hematopoietic tissues of mouse embryos was evaluated by a limiting dilution method. Cells from yolk sacs, livers, and bodies of (WB x C57BL/6)F1 (hereafter called WBB6F1)- +/+ embryos were injected directly into the skin of adult WBB6F1-W/Wv mice which were genetically depleted...

journal_title：Developmental biology

authors： Sonoda T,Hayashi C,Kitamura Y

更新日期：1983-05-01 00:00:00

abstract：:A genetically complex mutant, two-faced (tfd), which causes the production of extra eye and antennal tissue on the dorsal head cuticle, has been analyzed for connectivity to and projection patterns in the central brain of nerves derived from these extra structures. It has been found that the extra antennal nerves freq...

journal_title：Developmental biology

authors： Lipshitz HD,Kankel DR

更新日期：1985-01-01 00:00:00

abstract：:Embryonic kidney development begins with the outgrowth of the ureteric bud (UB) from the Wolffian duct (WD) into the adjacent metanephric mesenchyme (MM). Both a GDNF-dependent and GDNF-independent (Maeshima et al., 2007) pathway have been identified. In vivo and in vitro, the GDNF-dependent pathway is inhibited by BM...

journal_title：Developmental biology

authors： Tee JB,Choi Y,Shah MM,Dnyanmote A,Sweeney DE,Gallegos TF,Johkura K,Ito C,Bush KT,Nigam SK

更新日期：2010-11-15 00:00:00

abstract：:In Xenopus laevis, the capacity to regenerate a new lens from the outer cornea gradually decreases between stages 50 and 58, is almost negligible during the metamorphic climax, and disappears after metamorphosis. The factors responsible for lens transdifferentiation of the outer cornea are produced by the neural retin...

journal_title：Developmental biology

authors： Filoni S,Bernardini S,Cannata SM,D'Alessio A

更新日期：1997-07-01 00:00:00

abstract：:A complex regulatory cascade is required for normal cardiac development, and many aspects of this network are conserved from Drosophila to mammals. In Drosophila, the seven-up (svp) gene, an ortholog of the vertebrate chick ovalbumin upstream promoter transcription factors (COUP-TFI and II), is initially activated in ...

journal_title：Developmental biology

authors： Ryan KM,Hendren JD,Helander LA,Cripps RM

更新日期：2007-02-15 00:00:00

abstract：:The zebrafish T-box transcription factors spadetail (spt) and the brachyury ortholog no tail (ntl) are together essential for posterior mesoderm formation. In addition to being functionally redundant, spt and ntl also genetically interact with zygotic mutant alleles of one-eyed pinhead (Zoep), leading to synergistic m...

journal_title：Developmental biology

authors： Griffin KJ,Kimelman D

更新日期：2003-12-15 00:00:00

abstract：:Notch signaling is involved in a large range of developmental processes, and has been functionally implicated in body plan segmentation in two of the three diverse segmented taxa, the vertebrates and arthropods. Here we investigate expression of Notch, Delta, and hes gene homologues during larval and juvenile developm...

journal_title：Developmental biology

authors： Thamm K,Seaver EC

更新日期：2008-08-01 00:00:00

abstract：:beta-Catenin was originally identified biochemically as a protein that binds E-cadherin in cultured cells and that interaction was later shown to be essential for cadherin function. Independently, armadillo, the beta-catenin homolog in Drosophila melanogaster, was identified as a segment polarity gene necessary for th...

journal_title：Developmental biology

authors： Miller JR,McClay DR

更新日期：1997-12-15 00:00:00

abstract：:DSL (Delta, Serrate, Lag-2) ligands activate Notch signaling and thereby regulate the differentiation of many different cell types during development. We have isolated a novel Serrate-like gene, Jagged2, whose amino acid sequence and expression pattern during rat embryogenesis suggest that it functions as a ligand for...

journal_title：Developmental biology

authors： Shawber C,Boulter J,Lindsell CE,Weinmaster G

更新日期：1996-11-25 00:00:00

abstract：:Full-grown Xenopus oocytes, Stage VI (1200-1300 microns), undergo meiotic maturation when exposed to progesterone. Smaller stage IV (800 microns) and stage V (1000 microns) oocytes remain in prophase arrest when exposed to this steroid. The larger stage VI oocytes undergo an intracellular alkalization from 7.2 to 7.6,...

journal_title：Developmental biology

authors： Wasserman WJ,Houle JG,Samuel D

更新日期：1984-10-01 00:00:00

abstract：:The large ampullate glands of the orb-web spider, Nephila clavipes provide massive amounts of fibroin throughout the lifetime of the adult female. We have developed methods to culture the glands and manipulate their biosynthetic activity. This has allowed us to monitor a series of molecular events that precede silk pr...

journal_title：Developmental biology

authors： Candelas GC,Arroyo G,Carrasco C,Dompenciel R

更新日期：1990-07-01 00:00:00

abstract：:Cells that overexpress PKA as a consequence of carrying multiple copies of the gene encoding the catalytic subunit can be induced to sporulate when developing as single cells. A peptide phosphorylated by PKA, termed SDF-1, has recently been shown to stimulate this process (Anjard et al., 1997). Several genes have been...

journal_title：Developmental biology

authors： Anjard C,Zeng C,Loomis WF,Nellen W

更新日期：1998-01-15 00:00:00

abstract：:The Rho family of small GTPases has been implicated in many neurological disorders including mental retardation, but whether they are involved in primary microcephaly (microcephalia vera) is unknown. Here, we examine the role of Rac1 in mammalian neural progenitors and forebrain development by a conditional gene-targe...

journal_title：Developmental biology

authors： Chen L,Melendez J,Campbell K,Kuan CY,Zheng Y

更新日期：2009-01-01 00:00:00

abstract：:The molecular and cellular mechanism for clearance of dead neurons was explored in the developing Drosophila optic lobe. During development of the optic lobe, many neural cells die through apoptosis, and corpses are immediately removed in the early pupal stage. Most of the cells that die in the optic lobe are young ne...

journal_title：Developmental biology

authors： Nakano R,Iwamura M,Obikawa A,Togane Y,Hara Y,Fukuhara T,Tomaru M,Takano-Shimizu T,Tsujimura H

更新日期：2019-09-01 00:00:00

abstract：:Using an in vitro model of rat epiphyseal chondrocyte differentiation in which cells are maintained in a three-dimensional cell pellet, we show that exogenous TGF-beta 1 reversibly prevents terminal differentiation of epiphyseal chondrocytes into hypertrophic cells. Through maintenance of gene expression for the carti...

journal_title：Developmental biology

authors： Ballock RT,Heydemann A,Wakefield LM,Flanders KC,Roberts AB,Sporn MB

更新日期：1993-08-01 00:00:00

abstract：:The protein content of various size follicles was measured in Fundulus heteroclitus and indicated four phases of increase relative to follicle volume: Phases I (previtellogenic; estimated to be less than 0.01 mg/mm3), II (vitellogenic; 0.20 mg/mm3), III (early maturation; 0.03 mg/mm3), and IV (late maturation; 0 mg/mm...

journal_title：Developmental biology

authors： Wallace RA,Selman K

更新日期：1985-08-01 00:00:00

abstract：:Spermatogonia are adult germline stem cells that can both self-renew and differentiate into spermatocytes. Little is known about factors necessary for spermatogonial differentiation. We identified a novel germ-cell-specific transcription factor that we named Sohlh1 (testis and ovary expressed basic helix-loop-helix (b...

journal_title：Developmental biology

authors： Ballow D,Meistrich ML,Matzuk M,Rajkovic A

更新日期：2006-06-01 00:00:00

abstract：:Lineage diversification in the vertebrate neural crest may occur via instructive signals acting on pluripotent cells, and/or via early specification of subpopulations towards particular lineages. Mesencephalic neural crest cells normally form cholinergic parasympathetic neurons in the ciliary ganglion, while trunk neu...

journal_title：Developmental biology

authors： Lee VM,Bronner-Fraser M,Baker CV

更新日期：2005-02-01 00:00:00

abstract：:The differentiation of three anterior pituitary cell types is regulated by the tissue-specific POU domain factor Pit-1, which is initially expressed on Embryonic Day 13.5-14 in mice. The Pit-1 gene remains continuously, highly expressed in the somatotrope, thyrotrope, and lactotrope cells of the adult. Using the Pit-1...

journal_title：Developmental biology

authors： DiMattia GE,Rhodes SJ,Krones A,Carrière C,O'Connell S,Kalla K,Arias C,Sawchenko P,Rosenfeld MG

更新日期：1997-02-01 00:00:00