TGF-beta 1 prevents hypertrophy of epiphyseal chondrocytes: regulation of gene expression for cartilage matrix proteins and metalloproteases.

abstract：:The early mouse embryo undertakes two types of cell division: symmetric that gives rise to the trophectoderm and then placenta or asymmetric that gives rise to inner cells that generate the embryo proper. Although cell division orientation is important, the mechanism regulating it has remained unclear. Here, we identi...

journal_title：Developmental biology

authors： Ajduk A,Biswas Shivhare S,Zernicka-Goetz M

更新日期：2014-08-15 00:00:00

abstract：:Specific binding of spermatozoa to the zona pellucida that surrounds mammalian eggs is a key step in the fertilization process. However, the sperm proteins that recognise zona pellucida receptors remain contentious despite longstanding research efforts to identify them. Here we present evidence that proacrosin, a tiss...

journal_title：Developmental biology

authors： Gaboriau D,Howes EA,Clark J,Jones R

更新日期：2007-06-15 00:00:00

abstract：:A series of chimeras was generated by injecting single normal, parthenogenetic, or androgenetic blastomeres carrying transgenic markers under the zona pellucida of nontransgenic eight-cell embryos. These chimeras were cultured to the blastocyst stage and sectioned, and the transgenic component was detected by in situ ...

journal_title：Developmental biology

authors： Thomson JA,Solter D

更新日期：1989-02-01 00:00:00

abstract：:We investigated the potential role of rostral-caudal and dorsal-ventral subdivisions of the early rostral brain by relating these subdivisions to the early patterning of neuron cell bodies and their axon projections. The earliest neurons were mapped using the lipophilic axon tracers diI and diO on embryos fixed on emb...

journal_title：Developmental biology

authors： Mastick GS,Easter SS Jr

更新日期：1996-01-10 00:00:00

abstract：:The C-X-C motif ligand 14 (CXCL14) is a recently discovered chemokine that is highly conserved in vertebrates and expressed in various embryonic and adult tissues. CXCL14 signaling has been implicated to function as an antiangiogenic and anticancer agent in adults. However, its function during development is unknown. ...

journal_title：Developmental biology

authors： Ojeda AF,Munjaal RP,Lwigale PY

更新日期：2017-03-01 00:00:00

abstract：:During primary neurogenesis in Xenopus, a cascade of helix--loop--helix (HLH) transcription factors regulates neuronal determination and differentiation. While XNeuroD functions at a late step in this cascade to regulate neuronal differentiation, the factors that carry out terminal differentiation are still unknown. W...

journal_title：Developmental biology

authors： Pozzoli O,Bosetti A,Croci L,Consalez GG,Vetter ML

更新日期：2001-05-15 00:00:00

abstract：:During mammalian spermiogenesis transitional proteins and protamines replace histones on the DNA as the chromatin condenses. While previous studies suggested that histone genes are inactive postmeiotically, we have shown both by steady-state RNA analysis and nuclear run-off transcription assays that histone 2b (H2b) t...

journal_title：Developmental biology

authors： Moss SB,Challoner PB,Groudine M

更新日期：1989-05-01 00:00:00

abstract：:The morphology of skeletal tissues formed in each of the branchial arches of higher vertebrates is unique. In addition to these structures, which are derived from the neural crest, the crest-derived connective tissues and mesodermal muscles also form different patterns in each of the branchial arches. The objective of...

journal_title：Developmental biology

authors： Noden DM

更新日期：1983-03-01 00:00:00

abstract：:Lineage specification of multipotent progenitor cells is governed by a balance of lineage-affiliated transcription factors, such as GATA1 and PU.1, which regulate the choice between erythroid and myelomonocytic fates. But how ratios of lineage-determining transcription factors stabilize progenitor cells and resolve th...

journal_title：Developmental biology

authors： Huang S,Guo YP,May G,Enver T

更新日期：2007-05-15 00:00:00

abstract：:Sm and Sm-like proteins are core components of the splicesome but have other functions distinct from pre-mRNA processing. Here, we show that Sm proteins also regulate germ cell specification during early C. elegans embryogenesis. SmE and SmG were required to maintain transcriptional quiescence in embryonic germ cell p...

journal_title：Developmental biology

authors： Barbee SA,Evans TC

更新日期：2006-03-01 00:00:00

abstract：:Cadherin-11 (cad-11) is a novel member of the cadherin family of cell adhesion molecules, having recently been identified by means of the polymerase chain reaction. To study the function and expression of this molecule, we cloned mouse, cad-11 cDNA. Transfection of L cells with cDNA led them to acquire a typical cadhe...

journal_title：Developmental biology

authors： Kimura Y,Matsunami H,Inoue T,Shimamura K,Uchida N,Ueno T,Miyazaki T,Takeichi M

更新日期：1995-05-01 00:00:00

abstract：:We recently discovered that in rat spermatids, kinesin light chain KLC3 can associate with outer dense fibers, major sperm tail components, and accumulates in the sperm midpiece. Here, we show that mitochondria isolated from rat-elongating spermatids have bound KLC3. Immunoelectron microscopy indicates that the associ...

journal_title：Developmental biology

authors： Zhang Y,Oko R,van der Hoorn FA

更新日期：2004-11-01 00:00:00

abstract：:Malfunctions of motile cilia cause a variety of developmental defects and diseases in humans and animal model organisms. Defects include impaired mucociliary clearance of the airways, sperm immotility, hydrocephalus and organ laterality. Here, we characterize the evolutionary conserved Cfap43 gene by loss-of-function ...

journal_title：Developmental biology

authors： Rachev E,Schuster-Gossler K,Fuhl F,Ott T,Tveriakhina L,Beckers A,Hegermann J,Boldt K,Mai M,Kremmer E,Ueffing M,Blum M,Gossler A

更新日期：2020-03-15 00:00:00

abstract：:A gene regulatory network (GRN) controls the process by which the endomesoderm of the sea urchin embryo is specified. In this GRN, the program of gene expression unique to the skeletogenic micromere lineage is set in train by activation of the pmar1 gene. Through a double repression system, this gene is responsible fo...

journal_title：Developmental biology

authors： Revilla-i-Domingo R,Minokawa T,Davidson EH

更新日期：2004-10-15 00:00:00

abstract：:Nanos is a translational regulator required for the survival and maintenance of primordial germ cells during embryogenesis. Three nanos homologs are present in the genome of the sea urchin Strongylocentrotus purpuratus (Sp), and each nanos mRNA accumulates specifically in the small micromere (sMic) lineage. We found t...

journal_title：Developmental biology

authors： Oulhen N,Yoshida T,Yajima M,Song JL,Sakuma T,Sakamoto N,Yamamoto T,Wessel GM

更新日期：2013-05-01 00:00:00

abstract：:The distribution and ontogeny of four neuropeptides in developing chick lumbosacral sensory and sympathetic ganglia were studied using immunohistochemical techniques. Antibodies to two of these peptides, substance P (SP) and calcitonin gene-related peptide (CGRP), stained small neurons in the medial part of the dorsal...

journal_title：Developmental biology

authors： New HV,Mudge AW

更新日期：1986-08-01 00:00:00

abstract：:Extraocular muscles (EOM) represent a unique muscle group that controls eye movements and originates from head mesoderm, while the more typically studied body and limb muscles are somite-derived. Aiming to investigate myogenic progenitors (satellite cells) in EOM versus limb and diaphragm of adult mice, we have been u...

journal_title：Developmental biology

authors： Stuelsatz P,Shearer A,Yablonka-Reuveni Z

更新日期：2014-01-15 00:00:00

abstract：:Developmental pattern formation allows cells within a tissue or organ to coordinate their development and establish cell types in relationship to one another. To better characterize the developmental patterning events within one organ, the C. elegans hindgut, we have analyzed the expression pattern of several genes us...

journal_title：Developmental biology

authors： Sewell ST,Zhang G,Uttam A,Chamberlin HM

更新日期：2003-10-01 00:00:00

abstract：:The universal signal for egg activation at fertilization is a rise in cytoplasmic Ca(2+) with defined spatial and temporal kinetics. Mammalian and amphibian eggs acquire the ability to produce such Ca(2+) signals during a maturation period that precedes fertilization and encompasses resumption of meiosis and progressi...

journal_title：Developmental biology

authors： Machaca K

更新日期：2004-11-01 00:00:00

abstract：:Mammalian eggs remain arrested at metaphase of the second meiotic division (metII) for an indeterminate time before fertilization. During this period, which can last several hours, the continued attachment of sister chromatids is thought to be achieved by inhibition of the protease separase. Separase is known to be in...

journal_title：Developmental biology

authors： Nabti I,Reis A,Levasseur M,Stemmann O,Jones KT

更新日期：2008-09-15 00:00:00

abstract：:Previous studies suggest that sensory innervation of muscles is patterned by motor innervation. Muscle afferent projections mirror motor projections after various experimental manipulations and muscle afferents fail to project to muscle in the absence of motoneurons. It is not known, however, whether muscle afferents ...

journal_title：Developmental biology

authors： Wang G,Scott SA

更新日期：1997-06-01 00:00:00

abstract：:Acquisition of limb-forming ability by discrete regions of the lateral plate of the chick embryo is thought to depend on a signaling cascade moving sequentially from the area of Hensen's node to the somitic mesoderm, the intermediate mesoderm, and then to the prospective limb-forming regions of the lateral plate (Step...

journal_title：Developmental biology

authors： Dealy CN

更新日期：1997-08-15 00:00:00

abstract：:During animal fertilizations, each oocyte or egg must produce a proper intracellular calcium signal for development to proceed normally. As a supplement to recent synopses of fertilization-induced calcium responses in mammals, this paper reviews the spatiotemporal properties of calcium signaling during fertilization a...

journal_title：Developmental biology

authors： Stricker SA

更新日期：1999-07-15 00:00:00

abstract：:During vesicular transport between the endoplasmic reticulum and the Golgi, members of the TMED/p24 protein family form hetero-oligomeric complexes that facilitate protein-cargo recognition as well as vesicle budding. In addition, they regulate each other's level of expression. Despite analyses of TMED/p24 protein dis...

journal_title：Developmental biology

authors： Jerome-Majewska LA,Achkar T,Luo L,Lupu F,Lacy E

更新日期：2010-05-01 00:00:00

abstract：:The germinal vesicle (GV) of starfish oocytes contains a factor which is required to drive the cytoplasmic cycle of the meiotic division. Biochemical investigation of this factor has been difficult due to the small quantities of obtainable GV materials. To overcome this, we have developed a mass-isolation procedure fo...

journal_title：Developmental biology

authors： Nemoto S,Yamamoto K,Hashimoto N

更新日期：1992-06-01 00:00:00

abstract：:The respective role of Pax2 and Pax8 in early kidney development in vertebrates is poorly understood. In this report, we have studied the roles of Pax8 and Pax2 in Xenopus pronephros development using a loss-of-function approach. Our results highlight a differential requirement of these two transcription factors for p...

journal_title：Developmental biology

authors： Buisson I,Le Bouffant R,Futel M,Riou JF,Umbhauer M

更新日期：2015-01-15 00:00:00

abstract：:The nuclear lamina is an extensive protein network that underlies the inner nuclear envelope. This network includes the LAP2-emerin-MAN1-domain (LEM-D) protein family, proteins that share an association with the chromatin binding protein Barrier-to-autointegration factor (BAF). Loss of individual LEM-D proteins causes...

journal_title：Developmental biology

authors： Barton LJ,Lovander KE,Pinto BS,Geyer PK

更新日期：2016-07-01 00:00:00

abstract：:The ability of Xenopus oocytes to undergo insulin- or insulin-like growth factor 1-induced meiotic maturation develops during oogenesis, with cells 1.0 mm in diameter or larger responding in a size-dependent manner. Since insulin-induced oocyte maturation was shown previously to be p21 ras-dependent, experiments were ...

journal_title：Developmental biology

authors： Davis D,Sadler SE

更新日期：1992-01-01 00:00:00

abstract：:In order to further our understanding of the biological role of desmin, the muscle-specific intermediate filament protein, a null mutation in the desmin gene was introduced into the germ line of mice. Despite the complete lack of desmin, these mice developed and reproduced. Since we show that skeletal, cardiac, and sm...

journal_title：Developmental biology

authors： Li Z,Colucci-Guyon E,Pinçon-Raymond M,Mericskay M,Pournin S,Paulin D,Babinet C

更新日期：1996-05-01 00:00:00

abstract：:Embryonic kidney development begins with the outgrowth of the ureteric bud (UB) from the Wolffian duct (WD) into the adjacent metanephric mesenchyme (MM). Both a GDNF-dependent and GDNF-independent (Maeshima et al., 2007) pathway have been identified. In vivo and in vitro, the GDNF-dependent pathway is inhibited by BM...

journal_title：Developmental biology

authors： Tee JB,Choi Y,Shah MM,Dnyanmote A,Sweeney DE,Gallegos TF,Johkura K,Ito C,Bush KT,Nigam SK

更新日期：2010-11-15 00:00:00