Chimeras between parthenogenetic or androgenetic blastomeres and normal embryos: allocation to the inner cell mass and trophectoderm.

Abstract:

:A series of chimeras was generated by injecting single normal, parthenogenetic, or androgenetic blastomeres carrying transgenic markers under the zona pellucida of nontransgenic eight-cell embryos. These chimeras were cultured to the blastocyst stage and sectioned, and the transgenic component was detected by in situ hybridization. No statistically significant difference was found among the normal, parthenogenetic, and androgenetic chimeras in the number of chimeric blastocysts with a transgenic contribution to the inner cell mass (ICM), the trophectoderm, or both the ICM and trophectoderm. Since androgenetic and parthenogenetic cells were present in chimeras at a high frequency in both the ICM and trophectoderm at the blastocyst stage, but not in similar chimeras at late gastrulation, these cells must not respond normally to developmental signals subsequent to blastocyst formation and prior to late gastrulation.

journal_name

Dev Biol

journal_title

Developmental biology

authors

Thomson JA,Solter D

doi

10.1016/s0012-1606(89)80028-4

subject

Has Abstract

pub_date

1989-02-01 00:00:00

pages

580-3

issue

2

eissn

0012-1606

issn

1095-564X

pii

S0012-1606(89)80028-4

journal_volume

131

pub_type

杂志文章
  • Localization of antigenic determinants in whole Drosophila embryos.

    abstract::Procedures are described for removal of the vitelline membrane from gently fixed Drosophila embryos en masse. The resulting embryos retain excellent structural integrity and are now suitable for a variety of immunocytochemical and biochemical characterizations. ...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/0012-1606(83)90275-0

    authors: Mitchison TJ,Sedat J

    更新日期:1983-09-01 00:00:00

  • Integration of vascular systems between the brain and spinal cord in zebrafish.

    abstract::Cerebral and spinal vascular systems are organized individually, and they then conjugate at their border, through the integration of basilar artery and vertebral arteries. Zebrafish (Danio rerio) is an ideal organism for studying early vascular development, and the precise procedure of cranial and truncal vascular for...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2015.07.015

    authors: Kimura E,Isogai S,Hitomi J

    更新日期:2015-10-01 00:00:00

  • Involvement of K(Ca) channels and stretch-activated channels in calcium influx, triggering membrane fusion of chick embryonic myoblasts.

    abstract::Calcium influx is known to be prerequisite for membrane fusion of myoblasts. However, little is known about the channels that are responsible for the entry of calcium into the cells. Here we show that K(Ca) channels and stretch-activated channels are involved in the calcium influx. Upon analysis of single-channel reco...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1006/dbio.1996.0091

    authors: Shin KS,Park JY,Ha DB,Chung CH,Kang MS

    更新日期:1996-04-10 00:00:00

  • Control of the cell cycle.

    abstract::Cell division is arguably the most fundamental developmental process for single-celled and multicellular organisms alike. The pathway from one cell division to the next is known as the cell cycle. A conserved biochemical regulatory network controls progress along this pathway in plants, animals, and yeasts. This revie...

    journal_title:Developmental biology

    pub_type: 杂志文章,评审

    doi:10.1016/0012-1606(92)90087-w

    authors: Jacobs T

    更新日期:1992-09-01 00:00:00

  • Binding of both acrosome-intact and acrosome-reacted guinea pig sperm to the zona pellucida during in vitro fertilization.

    abstract::Mammalian sperm-egg adhesion occurs when sperm bind to the zona pellucida of the egg. In this study with guinea pig gametes, we have asked if sperm can initiate binding to the zona before and after the acrosome reaction and if the sperm surface protein PH-20 is involved in the binding at these two stages. Sperm bindin...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/0012-1606(87)90191-6

    authors: Myles DG,Hyatt H,Primakoff P

    更新日期:1987-06-01 00:00:00

  • Regional differences in troponin I isoform switching during rat heart development.

    abstract::Expression of cardiac troponin I (TnIcardiac) and slow skeletal troponin I (TnIslow) genes was analyzed at the mRNA and protein level in the developing rat heart. TnIslow mRNA was detectable by in situ hybridization in the embryonic cardiac tube as early as the 13-somite stage (Embryonic Day 10). In contrast, TnIcardi...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1006/dbio.1993.1074

    authors: Gorza L,Ausoni S,Merciai N,Hastings KE,Schiaffino S

    更新日期:1993-03-01 00:00:00

  • Myf5 and MyoD activation define independent myogenic compartments during embryonic development.

    abstract::Gene targeting has indicated that Myf5 and MyoD are required for myogenic determination because skeletal myoblasts and myofibers are missing in mouse embryos lacking both Myf5 and MyoD. To investigate the fate of Myf5:MyoD-deficient myogenic precursor cells during embryogenesis, we examined the sites of epaxial, hypax...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/s0012-1606(03)00139-8

    authors: Kablar B,Krastel K,Tajbakhsh S,Rudnicki MA

    更新日期:2003-06-15 00:00:00

  • The bHLH transcription factor Ascl1a is essential for the specification of the intestinal secretory cells and mediates Notch signaling in the zebrafish intestine.

    abstract::Notch signaling has a fundamental role in stem cell maintenance and in cell fate choice in the intestine of different species. Canonically, Notch signaling represses the expression of transcription factors of the achaete-scute like (ASCL) or atonal related protein (ARP) families. Identifying the ARP/ASCL genes express...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2013.01.011

    authors: Flasse LC,Stern DG,Pirson JL,Manfroid I,Peers B,Voz ML

    更新日期:2013-04-15 00:00:00

  • Interplay between Lefty and Nodal signaling is essential for the organizer and axial formation in amphioxus embryos.

    abstract::The organizer is an essential signaling center required for axial formation during vertebrate embryonic development. In the basal chordate amphioxus, the dorsal blastopore lip of the gastrula has been proposed to be homologous to the vertebrate organizer. Lefty is one of the first genes to be expressed in the organize...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2019.08.006

    authors: Zhang H,Chen S,Shang C,Wu X,Wang Y,Li G

    更新日期:2019-12-01 00:00:00

  • Genetic and epigenetic mechanisms regulating hedgehog expression in the Drosophila wing.

    abstract::Stable subdivision of Drosophila limbs into Anterior (A) and Posterior (P) compartments is a consequence of asymmetric signaling by Hedgehog (Hh) from P to A cells. The activity of the homeodomain protein Engrailed (En) in P cells has been reported to help to generate this asymmetry by inducing the expression of hedge...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2009.01.006

    authors: Bejarano F,Milán M

    更新日期:2009-03-15 00:00:00

  • Developmental timing of a sensory-mediated larval surfacing behavior correlates with cessation of feeding and determination of final adult size.

    abstract::Controlled organismal growth to an appropriate adult size requires a regulated balance between nutrient resources, feeding behavior and growth rate. Defects can result in decreased survival and/or reproductive capability. Since Drosophila adults do not grow larger after eclosion, timing of feeding cessation during the...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2010.07.004

    authors: Wegman LJ,Ainsley JA,Johnson WA

    更新日期:2010-09-15 00:00:00

  • Molecular mechanism of mammary gland involution: An update.

    abstract::The mammary gland (MG) is a unique organ responsible for milk synthesis, secretion, and involution to prepare the gland for subsequent lactation. The mammary epithelial cells (MECs), which are the milk synthesizing units of the MG, proliferate, differentiate, undergo apoptosis and regenerate following a cyclic pathway...

    journal_title:Developmental biology

    pub_type: 杂志文章,评审

    doi:10.1016/j.ydbio.2018.11.002

    authors: Jena MK,Jaswal S,Kumar S,Mohanty AK

    更新日期:2019-01-15 00:00:00

  • Analysis of Cyp26b1/Rarg compound-null mice reveals two genetically separable effects of retinoic acid on limb outgrowth.

    abstract::The role of retinoic acid (RA) in limb development is unclear, although it has been suggested to be a proximalizing factor which plays a morphogenetic role in pattern formation. Exogenous RA produces a teratogenic effect on limb morphology; similarly, changes in the endogenous distribution of RA following genetic abla...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2009.12.024

    authors: Pennimpede T,Cameron DA,MacLean GA,Petkovich M

    更新日期:2010-03-01 00:00:00

  • Evidence for functional redundancy between C. elegans ADAM proteins SUP-17/Kuzbanian and ADM-4/TACE.

    abstract::The ectodomain of LIN-12/Notch proteins is cleaved and shed upon ligand binding. In Caenorhabditis elegans, genetic evidence has implicated SUP-17, the ortholog of Drosophila Kuzbanian and mammalian ADAM10, as the protease that mediates this event. In mammals, however, biochemical evidence has implicated TACE, a diffe...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2005.08.014

    authors: Jarriault S,Greenwald I

    更新日期:2005-11-01 00:00:00

  • GRDN-1/Girdin regulates dendrite morphogenesis and cilium position in two specialized sensory neuron types in C. elegans.

    abstract::Primary cilia are located at the dendritic tips of sensory neurons and house the molecular machinery necessary for detection and transduction of sensory stimuli. The mechanisms that coordinate dendrite extension with cilium position during sensory neuron development are not well understood. Here, we show that GRDN-1, ...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2020.12.022

    authors: Nechipurenko I,Lavrentyeva S,Sengupta P

    更新日期:2021-01-16 00:00:00

  • The Drosophila E93 gene from the 93F early puff displays stage- and tissue-specific regulation by 20-hydroxyecdysone.

    abstract::Pulses of ecdysteroids induce dramatic changes in gene expression that direct the early stages of Drosophila metamorphosis. This gene activity is reflected by the appearance of early and late puffs in the salivary gland polytene chromosomes. Curiously, the early puff genes that have been studied to date are induced by...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1006/dbio.1995.1262

    authors: Baehrecke EH,Thummel CS

    更新日期:1995-09-01 00:00:00

  • The pattern of cytokeratin synthesis is a marker of type 2 cell differentiation in adult and maturing fetal lung alveolar cells.

    abstract::During the last stages of fetal life, the immature epithelial cells of the rat lung alveolus develop the properties of mature type 2 cells. Adult type 2 cells rapidly lose these same properties when isolated and maintained in cell culture. We have examined the synthesis of cytokeratin proteins by adult type 2 cells as...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/0012-1606(88)90396-x

    authors: Paine R,Ben-Ze'ev A,Farmer SR,Brody JS

    更新日期:1988-10-01 00:00:00

  • Choroideremia gene product affects trophoblast development and vascularization in mouse extra-embryonic tissues.

    abstract::Choroideremia (CHM) is a hereditary eye disease caused by mutations in the X-linked CHM gene. Disruption of the Chm gene in mice resulted in prenatal death of Chm-/Y males and Chm-/Chm+ females that had inherited the mutation from their mothers. Male chimeras and Chm+/Chm- females with paternal transmission of the mut...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2004.04.016

    authors: Shi W,van den Hurk JA,Alamo-Bethencourt V,Mayer W,Winkens HJ,Ropers HH,Cremers FP,Fundele R

    更新日期:2004-08-01 00:00:00

  • Effects of phlorizin and ouabain on the polarity of mouse 4-cell/16-cell stage blastomere heterokaryons.

    abstract::Cell polarity is thought to be required for the efficient production of nascent blastocoele fluid, which begins at the 16-cell stage of mouse preimplantation development. In this study the 4-cell/16-cell blastomere heterokaryon was used to test the hypothesis that solute transport across the apical membrane domain ind...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/0012-1606(89)90041-9

    authors: Wiley LM,Obasaju MF

    更新日期:1989-06-01 00:00:00

  • XNP-1/ATR-X acts with RB, HP1 and the NuRD complex during larval development in C. elegans.

    abstract::Mutations in the XNP/ATR-X gene cause several X-linked mental retardation syndromes in humans. The XNP/ATR-X gene encodes a DNA-helicase belonging to the SNF2 family. It has been proposed that XNP/ATR-X might be involved in chromatin remodelling. The lack of a mouse model for the ATR-X syndrome has, however, hampered ...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2004.10.014

    authors: Cardoso C,Couillault C,Mignon-Ravix C,Millet A,Ewbank JJ,Fontés M,Pujol N

    更新日期:2005-02-01 00:00:00

  • Role of RB1 in human embryonic stem cell-derived retinal organoids.

    abstract::Three-dimensional (3D) organoid models derived from human pluripotent stem cells provide a platform for studying human development and understanding disease mechanisms. Most studies that examine biallelic inactivation of the cell cycle regulator Retinoblastoma 1 (RB1) and the link to retinoblastoma is in mice, however...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2020.03.011

    authors: Zheng C,Schneider JW,Hsieh J

    更新日期:2020-06-15 00:00:00

  • Overexpression of the CT GalNAc transferase in skeletal muscle alters myofiber growth, neuromuscular structure, and laminin expression.

    abstract::Carbohydrates have been shown to mediate or modulate a number of important events in the development of the nervous system; however, there is little evidence that they participate directly in the development of synapses. One carbohydrate structure that is likely to be important in synaptic development of the neuromusc...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1006/dbio.2001.0530

    authors: Xia B,Hoyte K,Kammesheidt A,Deerinck T,Ellisman M,Martin PT

    更新日期:2002-02-01 00:00:00

  • Neurogenesis in the water flea Daphnia magna (Crustacea, Branchiopoda) suggests different mechanisms of neuroblast formation in insects and crustaceans.

    abstract::Within euarthropods, the morphological and molecular mechanisms of early nervous system development have been analysed in insects and several representatives of chelicerates and myriapods, while data on crustaceans are fragmentary. Neural stem cells (neuroblasts) generate the nervous system in insects and in higher cr...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2011.05.662

    authors: Ungerer P,Eriksson BJ,Stollewerk A

    更新日期:2011-09-01 00:00:00

  • Patterning through differential endoreduplication in epithelial organogenesis of the chordate, Oikopleura dioica.

    abstract::The contributions that control of cell proliferation and cell growth make to developmental regulation of organ and body size remain poorly explored, particularly with respect to endocycles in polyploid tissues. The epithelium of the marine chordate Oikopleura dioica is composed of a fixed number of cells grouped in te...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1006/dbio.2002.0834

    authors: Ganot P,Thompson EM

    更新日期:2002-12-01 00:00:00

  • Neural progenitor genes. Germinal zone expression and analysis of genetic overlap in stem cell populations.

    abstract::The identification of the genes regulating neural progenitor cell (NPC) functions is of great importance to developmental neuroscience and neural repair. Previously, we combined genetic subtraction and microarray analysis to identify genes enriched in neural progenitor cultures. Here, we apply a strategy to further st...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2003.09.003

    authors: Easterday MC,Dougherty JD,Jackson RL,Ou J,Nakano I,Paucar AA,Roobini B,Dianati M,Irvin DK,Weissman IL,Terskikh AV,Geschwind DH,Kornblum HI

    更新日期:2003-12-15 00:00:00

  • Heat shock factor 2-like activity in mouse blastocysts.

    abstract::The expression of heat shock genes is induced in all living cells by a series of proteotoxic treatments. Heat shock genes are also activated spontaneously during different phases of embryonic development. HSP89 alpha and HSC70 are expressed at a high level in the mouse blastocyst. A family of factors, called HSFs, are...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1006/dbio.1994.1361

    authors: Mezger V,Rallu M,Morimoto RI,Morange M,Renard JP

    更新日期:1994-12-01 00:00:00

  • Trophoblast stem cells differentiate in vitro into invasive trophoblast giant cells.

    abstract::Trophoblast cells are characterized by an invasive behavior into the surrounding uterine tissue. In rodents, an early peri-/endovascular type of invasion exerted by trophoblast giant cells can be distinguished from a late interstitial type carried out by glycogen trophoblast cells. Analysis of the molecular mechanisms...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2004.03.040

    authors: Hemberger M,Hughes M,Cross JC

    更新日期:2004-07-15 00:00:00

  • Developmental regulation of glial cell phagocytic function during Drosophila embryogenesis.

    abstract::The proper removal of superfluous neurons through apoptosis and subsequent phagocytosis is essential for normal development of the central nervous system (CNS). During Drosophila embryogenesis, a large number of apoptotic neurons are efficiently engulfed and degraded by phagocytic glia. Here we demonstrate that glial ...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2014.07.005

    authors: Shklyar B,Sellman Y,Shklover J,Mishnaevski K,Levy-Adam F,Kurant E

    更新日期:2014-09-15 00:00:00

  • The brain expressed x-linked gene 1 (Bex1) regulates myoblast fusion.

    abstract::Skeletal muscle development (myogenesis) is a complex but precisely orchestrated process involving spatiotemporal regulation of the proliferation, differentiation and fusion of myogenic progenitor cells (myoblasts). Here we identify brain expressed x-linked gene 1 (Bex1) as a transient, developmentally regulated gene ...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1016/j.ydbio.2015.11.007

    authors: Jiang C,Wang JH,Yue F,Kuang S

    更新日期:2016-01-01 00:00:00

  • Distinct mechanisms triggering glial differentiation in Drosophila thoracic and abdominal neuroblasts 6-4.

    abstract::Neurons and glia are produced in stereotyped patterns after neuroblast cell division during development of the Drosophila central nervous system. The first cell division of thoracic neuroblast 6-4 (NB6-4T) is asymmetric, giving rise to a glial precursor cell and a neuronal precursor cell. In contrast, abdominal NB6-4 ...

    journal_title:Developmental biology

    pub_type: 杂志文章

    doi:10.1006/dbio.2000.9727

    authors: Akiyama-Oda Y,Hotta Y,Tsukita S,Oda H

    更新日期:2000-06-15 00:00:00