当前位置： SCI文献检索 > DEVELOPMENTAL BIOLOGY期刊下所有文献 > Binding of sperm proacrosin/beta-acrosin to zona pellucida glycoproteins is sulfate and stereodependent. Synthesis of a novel fertilization inhibitor.

Binding of sperm proacrosin/beta-acrosin to zona pellucida glycoproteins is sulfate and stereodependent. Synthesis of a novel fertilization inhibitor.

Abstract：

:Specific binding of spermatozoa to the zona pellucida that surrounds mammalian eggs is a key step in the fertilization process. However, the sperm proteins that recognise zona pellucida receptors remain contentious despite longstanding research efforts to identify them. Here we present evidence that proacrosin, a tissue-specific protein found within the acrosomal vesicle of all mammalian spermatozoa, is a multifunctional protein that mediates binding of acrosome-reacted spermatozoa to zona glycoproteins via a stereospecific polysulfate recognition mechanism. Using sulfated versus non-sulfated forms of chemically defined compounds in binding assays employing native proteins in their normal cellular location or conjugated to FluoSpheres, we have attempted to identify the sulfation "code" required for recognition. Results show that protein conformation is important for specificity and that at least 2 sulfate groups are required to cross-link spatially separated docking sites on proacrosin. The consistently most effective inhibitory compounds were suramin and quercetin-3beta-d-glucoside sulfate. The results support our hypothesis that proacrosin is one of several proteins in the acrosomal matrix that retain acrosome reacted spermatozoa on the zona surface prior to penetration. They also establish, as a proof-of-principle, the feasibility of synthesising sulfated compounds of high specificity as antifertility agents for human or animal use.

journal_name

Dev Biol

journal_title

Developmental biology

authors

Gaboriau D,Howes EA,Clark J,Jones R

doi

10.1016/j.ydbio.2007.04.001

subject

Has Abstract

pub_date

2007-06-15 00:00:00

pages

646-57

issue

2

eissn

0012-1606

issn

1095-564X

pii

S0012-1606(07)00738-5

journal_volume

306

pub_type

杂志文章

相关文献

DEVELOPMENTAL BIOLOGY文献大全
  • Integration of comprehensive 3D microCT and signaling analysis reveals differential regulatory mechanisms of craniofacial bone development.

    abstract：:Growth factor signaling regulates tissue-tissue interactions to control organogenesis and tissue homeostasis. Specifically, transforming growth factor beta (TGFβ) signaling plays a crucial role in the development of cranial neural crest (CNC) cell-derived bone, and loss of Tgfbr2 in CNC cells results in craniofacial s...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2015.02.010

    authors： Ho TV,Iwata J,Ho HA,Grimes WC,Park S,Sanchez-Lara PA,Chai Y

    更新日期：2015-04-15 00:00:00

  • The alpha-fetoprotein enhancer region activates the albumin and alpha-fetoprotein promoters during liver development.

    abstract：:The four members of the albumin gene family encode the serum transport proteins albumin, alpha-fetoprotein, alpha-albumin, and vitamin D-binding protein. These genes are transcribed primarily in the liver with each having a different pattern of developmental expression. The tight linkage of these genes, particularly t...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2009.09.026

    authors： Jin L,Long L,Green MA,Spear BT

    更新日期：2009-12-15 00:00:00

  • Positive and negative regulation of epicardial-mesenchymal transformation during avian heart development.

    abstract：:In the developing heart, the epicardium is essential for coronary vasculogenesis as it provides precursor cells that become coronary vascular smooth muscle and perivascular fibroblasts. These precursor cells are derived from the epicardium via epithelial-mesenchymal transformation (EMT). The factors that regulate epic...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.2001.0254

    authors： Morabito CJ,Dettman RW,Kattan J,Collier JM,Bristow J

    更新日期：2001-06-01 00:00:00

  • Patterns of maternal messenger RNA accumulation and adenylation during oogenesis in Urechis caupo.

    abstract：:We have investigated the accumulation and adenylation of the maternal mRNA during oogenesis in the oocytes of the marine worm Urechis caupo. The analysis, using in vitro translation and cDNA probes to assay for specific mRNAs, demonstrates that different maternal mRNAs accumulate with different patterns during oogenes...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(86)90347-7

    authors： Rosenthal ET,Wilt FH

    更新日期：1986-09-01 00:00:00

  • Soma position is correlated with time of development in three types of identified reticulospinal neurons.

    abstract：:The relationship among neuronal type, position, and time course of development of identified neurons was examined in the zebrafish (Brachydanio rerio). The cells studied, the reticulospinal neurons Mauthner, MiM1, and MiV1, are located within the same small region in the hindbrain, differ stereotypically in their posi...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(85)90422-1

    authors： Mendelson B

    更新日期：1985-12-01 00:00:00

  • Ultrastructural studies of the ontogeny of fetal human and porcine endocrine pancreas, with special reference to colocalization of the four major islet hormones.

    abstract：:Most, if not all, endocrine cells seem capable of synthesizing and storing more than one hormone. Such cellular colocalization of hormones can be due either to the presence of two or more specific granules within the cells or to colocalization of the hormones within a single granule. The present study was performed to...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(92)90122-w

    authors： Lukinius A,Ericsson JL,Grimelius L,Korsgren O

    更新日期：1992-10-01 00:00:00

  • Sperm-induced Ca(2+) oscillations in mouse oocytes and eggs can be mimicked by photolysis of caged inositol 1,4,5-trisphosphate: evidence to support a continuous low level production of inositol 1, 4,5-trisphosphate during mammalian fertilization.

    abstract：:During mouse fertilization the spermatozoon induces a series of low-frequency long-lasting Ca(2+) oscillations. It is generally accepted that these oscillations are due to Ca(2+) release through the inositol 1,4,5-trisphosphate (InsP(3)) receptor. However, InsP(3) microinjection does not mimic sperm-induced Ca(2+) osc...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.2000.9826

    authors： Jones KT,Nixon VL

    更新日期：2000-09-01 00:00:00

  • Development of inositol trisphosphate-induced calcium release mechanism during maturation of hamster oocytes.

    abstract：:Mature hamster eggs exhibit repetitive increases in the intracellular Ca2+ concentration ([Ca2+]i) at fertilization, caused by inositol 1,4,5-trisphosphate (InsP3)-induced Ca2+ release (IICR) from stores. Oscillating Ca2+ rises also occurred in inseminated immature oocytes at the germinal vesicle (GV) stage but the pe...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1993.1059

    authors： Fujiwara T,Nakada K,Shirakawa H,Miyazaki S

    更新日期：1993-03-01 00:00:00

  • Evolutionary developmental transition from median to paired morphology of vertebrate fins: Perspectives from twin-tail goldfish.

    abstract：:Vertebrate morphology has been evolutionarily modified by natural and/or artificial selection. The morphological variation of goldfish is a representative example. In particular, the twin-tail strain of ornamental goldfish shows highly diverged anal and caudal fin morphology: bifurcated anal and caudal fins. Recent mo...

    journal_title：Developmental biology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ydbio.2016.11.022

    authors： Abe G,Ota KG

    更新日期：2017-07-15 00:00:00

  • The initial expression and patterned appearance of tenascin in scutate scales is absent from the dermis of the scaleless (sc/sc) chicken.

    abstract：:Morphogenesis of the anterior metatarsal skin (scutate scale region), from 9.5 to 12 days of development, results in the formation of orderly patterned scale ridges. It is after the initial formation of the Definitive Scale Ridge that the characteristic outer and inner epidermal surfaces differentiate. The hard, plate...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/s0012-1606(05)80016-8

    authors： Shames RB,Jennings AG,Sawyer RH

    更新日期：1991-09-01 00:00:00

  • Evo-engineering and the cellular and molecular origins of the vertebrate spinal cord.

    abstract：:The formation of the spinal cord during early embryonic development in vertebrate embryos is a continuous process that begins at gastrulation and continues through to the completion of somitogenesis. Despite the conserved usage of patterning mechanisms and gene regulatory networks that act to generate specific spinal ...

    journal_title：Developmental biology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ydbio.2017.01.021

    authors： Steventon B,Martinez Arias A

    更新日期：2017-12-01 00:00:00

  • Stage-specific increase in cell surface galactosyltransferase activity during spermatogenesis in mice bearing t alleles.

    abstract：:Mouse sperm surface galactosyltransferase (GalTase) mediates fertilization by binding to its appropriate glycoconjugate substrate in the egg zona pellucida. GalTase is present throughout all stages of spermatogenesis, during which time it redistributes within the plasma membrane from a uniform, diffuse distribution on...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(88)90072-3

    authors： Scully NF,Shur BD

    更新日期：1988-01-01 00:00:00

  • Developmental ablation of Id1 and Id3 genes in the vasculature leads to postnatal cardiac phenotypes.

    abstract：:The Id1 and Id3 genes play major roles during cardiac development, despite their expression being confined to non-myocardial layers (endocardium-endothelium-epicardium). We previously described that Id1Id3 double knockout (dKO) mouse embryos die at mid-gestation from multiple cardiac defects, but early lethality precl...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2010.10.004

    authors： Zhao Q,Beck AJ,Vitale JM,Schneider JS,Gao S,Chang C,Elson G,Leibovich SJ,Park JY,Tian B,Nam HS,Fraidenraich D

    更新日期：2011-01-01 00:00:00

  • BMP receptor 1b is required for axon guidance and cell survival in the developing retina.

    abstract：:Previous work has documented the importance of BMPs in eye development. Loss-of-function studies in mice, with targeted deletions in either the Bmp7 or Bmp4 genes, have shown that these molecules are critical for early eye development. On the basis of the asymmetry in the dorsal-ventral expression patterns of several ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/s0012-1606(02)00115-x

    authors： Liu J,Wilson S,Reh T

    更新日期：2003-04-01 00:00:00

  • Prorenin receptor is critical for nephron progenitors.

    abstract：:Deficient nephrogenesis is the major factor contributing to renal hypoplasia defined as abnormally small kidneys. Nephron induction during kidney development is driven by reciprocal interactions between progenitor cells of the cap mesenchyme (CM) and the ureteric bud (UB). The prorenin receptor (PRR) is a receptor for...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2015.11.024

    authors： Song R,Preston G,Kidd L,Bushnell D,Sims-Lucas S,Bates CM,Yosypiv IV

    更新日期：2016-01-15 00:00:00

  • Fluorescent protein expression driven by her4 regulatory elements reveals the spatiotemporal pattern of Notch signaling in the nervous system of zebrafish embryos.

    abstract：:Notch activation inhibits neuronal differentiation during development of the nervous system; however, the dynamic role of Notch signaling in individual cell lineages remains poorly understood. We have characterized 3.4 kb 5'-regulatory sequence of a Notch target gene, her4, and used it to drive fluorescent gene expres...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2006.10.020

    authors： Yeo SY,Kim M,Kim HS,Huh TL,Chitnis AB

    更新日期：2007-01-15 00:00:00

  • Distinct roles for retinoic acid receptors alpha and beta in early lung morphogenesis.

    abstract：:Retinoic acid (RA) signaling is required for normal development of multiple organs. However, little is known about how RA influences the initial stages of lung development. Here, we used a combination of genetic, pharmacological and explant culture approaches to address this issue, and to investigate how signaling by ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2005.10.045

    authors： Desai TJ,Chen F,Lü J,Qian J,Niederreither K,Dollé P,Chambon P,Cardoso WV

    更新日期：2006-03-01 00:00:00

  • Genetic and epigenetic mechanisms regulating hedgehog expression in the Drosophila wing.

    abstract：:Stable subdivision of Drosophila limbs into Anterior (A) and Posterior (P) compartments is a consequence of asymmetric signaling by Hedgehog (Hh) from P to A cells. The activity of the homeodomain protein Engrailed (En) in P cells has been reported to help to generate this asymmetry by inducing the expression of hedge...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2009.01.006

    authors： Bejarano F,Milán M

    更新日期：2009-03-15 00:00:00

  • Delineating metamorphic pathways in the ascidian Ciona intestinalis.

    abstract：:In most ascidians, metamorphosis of tadpole-like swimming larvae is accompanied by dynamic changes in their shape to form sessile adults. The mechanisms underlying ascidian metamorphosis have been debated for a long time. Although recent molecular studies have revealed the presence of various molecules involving in th...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2008.11.026

    authors： Nakayama-Ishimura A,Chambon JP,Horie T,Satoh N,Sasakura Y

    更新日期：2009-02-15 00:00:00

  • EAST and Chromator control the destruction and remodeling of muscles during Drosophila metamorphosis.

    abstract：:Metamorphosis involves the destruction of larval, the formation of adult and the transformation of larval into adult tissues. In this study, we demonstrate the role of the Drosophila nuclear proteins EAST and Chromator in tissue destruction and remodeling. To better understand the function of east, we performed a yeas...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2007.05.001

    authors： Wasser M,Bte Osman Z,Chia W

    更新日期：2007-07-15 00:00:00

  • Inhibition of protein and lipid sulfation in oligodendrocytes blocks biological responses to FGF-2 and retards cytoarchitectural maturation, but not developmental lineage progression.

    abstract：:We have examined the interfaces between protein and lipid sulfation, the response of progenitor cells to specific growth factors, and developmental lineage progression. The experimental system used is the oligodendrocyte (OL), the cell responsible for myelination of axons in the central nervous system. The ability to ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1994.1105

    authors： Bansal R,Pfeiffer SE

    更新日期：1994-04-01 00:00:00

  • EphB2 regulates axonal growth at the midline in the developing auditory brainstem.

    abstract：:Eph receptors play important roles in axon guidance at the midline. In the auditory system, growth of axons across the midline is an important determinant of auditory function. The avian cochlear nucleus, n. magnocellularis (NM), makes bilateral projections to its target, n. laminaris (NL). We examined the time course...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2006.03.010

    authors： Cramer KS,Cerretti DP,Siddiqui SA

    更新日期：2006-07-01 00:00:00

  • Both insulin and calcium channel signaling are required for developmental regulation of serotonin synthesis in the chemosensory ADF neurons of Caenorhabditis elegans.

    abstract：:Proper calcium channel and insulin signaling are essential for normal brain development. Leaner mice with a mutation in the P/Q-type voltage-gated calcium channel, Cacna1a, develop cerebellar atrophy and mutations in the homologous human gene are associated with increased migraine and seizure tendency. Similarly, abno...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2006.06.005

    authors： Estevez AO,Cowie RH,Gardner KL,Estevez M

    更新日期：2006-10-01 00:00:00

  • Groucho homologue Grg5 interacts with the transcription factor Runx2-Cbfa1 and modulates its activity during postnatal growth in mice.

    abstract：:Runx2-Cbfa1, a Runt transcription factor, plays important roles during skeletal development. It is required for differentiation and function of osteoblasts. In its absence, chondrocyte hypertrophy is severely impaired and there is no vascularization of cartilage templates during skeletal development. These tissue-spec...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2004.03.003

    authors： Wang W,Wang YG,Reginato AM,Glotzer DJ,Fukai N,Plotkina S,Karsenty G,Olsen BR

    更新日期：2004-06-15 00:00:00

  • Expression of CSF-1/c-fms and SF/c-kit mRNA during preimplantation mouse development.

    abstract：:c-fms and c-kit are structurally related tyrosine kinase receptors for colony-stimulating factor-1 (CSF-1) and for steel factor (SF), respectively. The level of c-fms mRNA, like c-kit mRNA, increases during the maturation of oocytes and is an abundant maternal message found in the unfertilized oocyte. Following fertil...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(92)90207-w

    authors： Arceci RJ,Pampfer S,Pollard JW

    更新日期：1992-05-01 00:00:00

  • The 82F late puff contains the L82 gene, an essential member of a novel gene family.

    abstract：:Metamorphosis in Drosophila results from a hierarchy of ecdysone-induced gene expression initiated at the end of the third larval instar. A now classical model of this hierarchy was proposed based on observations of the activity of polytene chromosome "puffs" which distinguished "early" puffs as those directly induced...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1999.9358

    authors： Stowers RS,Russell S,Garza D

    更新日期：1999-09-01 00:00:00

  • foxc1 is required for embryonic head vascular smooth muscle differentiation in zebrafish.

    abstract：:Vascular smooth muscle of the head derives from neural crest, but developmental mechanisms and early transcriptional drivers of the vSMC lineage are not well characterized. We find that in early development, the transcription factor foxc1b is expressed in mesenchymal cells that associate with the vascular endothelium....

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2019.06.005

    authors： Whitesell TR,Chrystal PW,Ryu JR,Munsie N,Grosse A,French CR,Workentine ML,Li R,Zhu LJ,Waskiewicz A,Lehmann OJ,Lawson ND,Childs SJ

    更新日期：2019-09-01 00:00:00

  • Mechanisms of mesendoderm internalization in the Xenopus gastrula: lessons from the ventral side.

    abstract：:Two main processes are involved in driving ventral mesendoderm internalization in the Xenopus gastrula. First, vegetal rotation, an active movement of the vegetal cell mass, initiates gastrulation by rolling the peripheral blastocoel floor against the blastocoel roof. In this way, the leading edge of the internalized ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.2001.0459

    authors： Ibrahim H,Winklbauer R

    更新日期：2001-12-01 00:00:00

  • CnNK-2, an NK-2 homeobox gene, has a role in patterning the basal end of the axis in hydra.

    abstract：:NK-2-class homeobox genes have been identified in a variety of metazoans, from sponges to arthropods and vertebrates, and have been shown to play roles in a variety of cell and tissue specifications. Here we describe the characterization of the NK-2 homolog CnNK-2 from Hydra vulgaris, a freshwater cnidarian. CnNK-2 ex...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1996.0321

    authors： Grens A,Gee L,Fisher DA,Bode HR

    更新日期：1996-12-15 00:00:00

  • DM-GRASP/ALCAM/CD166 is required for cardiac morphogenesis and maintenance of cardiac identity in first heart field derived cells.

    abstract：:Vertebrate heart development requires specification of cardiac precursor cells, migration of cardiac progenitors as well as coordinated cell movements during looping and septation. DM-GRASP/ALCAM/CD166 is a member of the neuronal immunoglobulin domain superfamily of cell adhesion molecules and was recently suggested t...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2008.06.013

    authors： Gessert S,Maurus D,Brade T,Walther P,Pandur P,Kühl M

    更新日期：2008-09-01 00:00:00