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Hensen's node provides an endogenous limb-forming signal.

Abstract：

:Acquisition of limb-forming ability by discrete regions of the lateral plate of the chick embryo is thought to depend on a signaling cascade moving sequentially from the area of Hensen's node to the somitic mesoderm, the intermediate mesoderm, and then to the prospective limb-forming regions of the lateral plate (Stephens et al., 1991). In the present study it is demonstrated that grafts of Hensen's node can induce the formation of supernumerary rudimentary limbs from the non-limb-forming flank region of the lateral plate of stage 9-15 chick embryos. The rudimentary limbs that form from the flank in response to Hensen's node grafts often contain elongated, jointed cartilaginous elements arranged in three distinct proximodistal segments resembling the developing stylopod, zeugopod, and autopod and express the limb-characteristic genes Msx-2 and BMP-4. However, the rudimentary limbs are incomplete and nonpolarized in that they do not form girdles or paired skeletal elements and fail to express sonic hedgehog, FGF-4, and FGF-8, signaling molecules that have been implicated in regulating the patterning of the developing limb bud. These results indicate that Hensen's node can provide a limb-forming signal to the lateral mesoderm, but that other signals are necessary to promote the expression of genes required for the complete patterning and morphogenesis of the limb.

journal_name

Dev Biol

journal_title

Developmental biology

authors

Dealy CN

doi

10.1006/dbio.1997.8646

subject

Has Abstract

pub_date

1997-08-15 00:00:00

pages

216-23

issue

2

eissn

0012-1606

issn

1095-564X

pii

S0012-1606(97)98646-2

journal_volume

188

pub_type

杂志文章

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