Abstract:
:The dorsal-ventral axis of the Xenopus embryo is approximately determined by the point of sperm entry, which occurs randomly about the animal-vegetal axis of the egg. Two cytoplasmic components were studied whose spatial arrangements and local concentration patterns appear to reflect the forming dorsal-ventral axis. First, three-dimensional maps depicting the rearrangements of different size classes of yolk platelets were reconstructed from serial sections. These maps provide information on the time when movements occur and the intracellular directions and distances components can travel within the early embryo. Second, local poly(A) concentrations were observed using a [3H]poly(U) in situ hybridization probe. Poly(A) concentrations were observed to change reproducibly from fertilization to late cleavage. Two cytoplasmic areas were found to undergo major, stage-specific increases in poly(A) concentration.
journal_name
Dev Bioljournal_title
Developmental biologyauthors
Phillips CRdoi
10.1016/0012-1606(85)90457-9subject
Has Abstractpub_date
1985-06-01 00:00:00pages
299-310issue
2eissn
0012-1606issn
1095-564Xpii
0012-1606(85)90457-9journal_volume
109pub_type
杂志文章abstract::The Hedgehog (Hh) signal transduction pathway plays a central role in the development of invertebrates and vertebrates. While much is known about the pathway, the role of Suppressor of fused (Su(fu)), a component of the pathway's signaling complex has remained enigmatic. Previous studies have linked Su(fu) to the cyto...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2006.02.050
更新日期:2006-06-01 00:00:00
abstract::We have investigated the regulation of DNA synthesis in the heterokaryons of HL60 human myelomonocytic leukemia cells and NIH3T3 mouse fibroblasts to examine if the differentiated leukemia cells contained a replication inhibiting activity. Cell fusions were performed either by exposing a suspension of mixed cells to a...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(91)90417-2
更新日期:1991-04-01 00:00:00
abstract::In Xenopus, the hatching and cement glands form at important boundaries in the head. We have examined induction of these glands in order to see the basis for this ectodermal patterning. Ectoderm can be induced to form hatching and cement glands by dorsal mesoderm and by the neural plate. Because the neural plate is su...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1993.1183
更新日期:1993-07-01 00:00:00
abstract::The facial primordia in the chick embryo begin as rounded swellings that surround the primitive mouth and these grow out to form the beak. The control of proximodistal outgrowth is not well understood but may involve similar mechanisms to the limb bud. In order to test this hypothesis, combinations were made between e...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(92)90069-s
更新日期:1992-12-01 00:00:00
abstract::Tbx18 has been shown to be essential for ureteral development. However, it remains unclear whether it plays a direct role in kidney development. Here we addressed this by focusing on examining the pattern and contribution of Tbx18+ cells in the kidney and its role in kidney vascular development. Expression studies and...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2014.04.006
更新日期:2014-07-01 00:00:00
abstract::Alkaline phosphatase (AP) activity is expressed in the endodermal cell lineage of ascidian embryos beginning at gastrulation. AP expression is resistant to levels of actinomycin D which completely suppress the appearance of other tissue-specific enzyme and morphological markers including acetylcholinesterase (AchE), a...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(87)90043-1
更新日期:1987-02-01 00:00:00
abstract::The notochord is the defining characteristic of the chordate embryo and plays critical roles as a signaling center and as the primitive skeleton. In this study we show that early notochord development in Xenopus embryos is regulated by apoptosis. We find apoptotic cells in the notochord beginning at the neural groove ...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2007.08.047
更新日期:2007-11-15 00:00:00
abstract::The mechanism by which pluripotent progenitors give rise to distinct classes of mature neurons in vertebrates is not well understood. To address this issue we undertook a genetic screen for mutations which affect the commitment and differentiation of catecholaminergic (CA) [dopaminergic (DA), noradrenergic (NA), and a...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1999.9204
更新日期:1999-04-15 00:00:00
abstract::During epithelial development cells become polarized along their apical-basal axis and some epithelia also exhibit polarity in the plane of the tissue. Mutations in the gene encoding a Drosophila Pak family serine/threonine kinase, dPak, disrupt the follicular epithelium that covers developing egg chambers during ooge...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2007.02.034
更新日期:2007-05-15 00:00:00
abstract::Meckel-Gruber syndrome (MKS) is an embryonic lethal ciliopathy resulting from mutations in genes encoding proteins localising to the primary cilium. Mutations in the basal body protein MKS1 account for 7% of cases of MKS. The condition affects the development of multiple organs, including brain, kidney and skeleton. H...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2013.02.015
更新日期:2013-05-01 00:00:00
abstract::Ooplasmic segregation in the late interphase zygote of the leech Theromyzon trizonare is accomplished by reorganization of an ectoplasmic cytoskeleton formed by polar rings and meridional bands. The dynamic properties of this cytoskeleton were explored by time-lapse confocal and video microscopy. Cytoskeleton assembly...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2004.03.023
更新日期:2004-07-01 00:00:00
abstract::The diaphragm is a mammalian skeletal muscle essential for respiration and for separating the thoracic and abdominal cavities. Development of the diaphragm requires the coordinated development of muscle, muscle connective tissue, tendon, nerves, and vasculature that derive from different embryonic sources. However, de...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2018.04.010
更新日期:2018-08-15 00:00:00
abstract::The engrailed gene is well known from its role in segmentation and central nervous system development in a variety of species. In molluscs, however, engrailed is involved in shell formation. So far, it seemed that engrailed had been co-opted uniquely for this particular process in molluscs. Here, we show that, in the ...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.2002.0653
更新日期:2002-06-15 00:00:00
abstract::Vertebrate Cdx genes encode homeodomain transcription factors related to caudal in Drosophila. The murine Cdx homologues Cdx1, Cdx2 and Cdx4 play important roles in anterior-posterior patterning of the embryonic axis and the intestine, as well as axial elongation. While our understanding of the ontogenic programs requ...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2011.09.034
更新日期:2012-01-01 00:00:00
abstract::The transforming growth factor-beta (TGF-beta) superfamily contains a variety of growth factors which all share common sequence elements and structural motifs. These proteins are known to exert a wide spectrum of biological responses on a large variety of cell types in both vertebrates and invertebrates. Many of them ...
journal_title:Developmental biology
pub_type: 杂志文章,评审
doi:
更新日期:2002-10-15 00:00:00
abstract::It has been posited that animal development evolved from pre-existing mechanisms for regulating cell differentiation in the single celled and colonial ancestors of animals. Although the progenitors of animals cannot be studied directly, insights into their cell biology may be gleaned from comparisons between animals a...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2011.06.003
更新日期:2011-09-01 00:00:00
abstract::We examined the structure, expression, and possible functions of a nanos homologue during gametogenesis and blastogenesis in the colonial ascidian Botryllus primigenus. An approximately 1.3-kb-long cDNA was cloned; it was termed BpNos since the deduced amino acid sequence (288 aa) contained 2 Nanos-like CCHC zinc fing...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2008.08.023
更新日期:2008-12-01 00:00:00
abstract::Paracrine signaling mediated by FGF-10 and the FGF-R2IIIb receptor is required for formation of the lung. To determine the temporal requirements for FGF signaling during pulmonary morphogenesis, Sprouty-4 (Spry-4), an intracellular FGF receptor antagonist, was expressed in epithelial cells of the fetal lung under cont...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/s0012-1606(03)00106-4
更新日期:2003-06-01 00:00:00
abstract::The molting cycle in insects is regulated by the fluctuating levels of ecdysteroids. Twenty-four hours prior to the pupal molt in Manduca sexta steroid titers are relatively high and they fall to very low levels at 4 hr before the molt. Several physiological events accompanying molts have been shown to require the ris...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1994.1115
更新日期:1994-04-01 00:00:00
abstract::Previous work has documented the importance of BMPs in eye development. Loss-of-function studies in mice, with targeted deletions in either the Bmp7 or Bmp4 genes, have shown that these molecules are critical for early eye development. On the basis of the asymmetry in the dorsal-ventral expression patterns of several ...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/s0012-1606(02)00115-x
更新日期:2003-04-01 00:00:00
abstract::The mab-21 gene was first identified because of its requirement for ray identity specification in Caenorhabditis elegans. It is now known to constitute a family of genes that are highly conserved from vertebrates to invertebrates, and two homologues Mab21l1 and Mab21l2 have been identified in many species. Here we des...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2004.07.016
更新日期:2004-10-15 00:00:00
abstract::Electroporation-based assays were used to test whether the myogenic regulatory factor (MRF) of Ciona intestinalis (CiMRF) interferes with endogenous developmental programs, and to evaluate the importance of its unusual N-terminus for muscle development. We found that CiMRF suppresses both notochord and endoderm develo...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2018.10.010
更新日期:2019-04-15 00:00:00
abstract::HP1 proteins are essential components of heterochromatin and contribute to the transcriptional repression of euchromatic genes. Although most species contain more than one HP1 family member which differ in their chromosomal distribution, it is not known to what extent the activity of these different family members is ...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2006.06.039
更新日期:2006-10-01 00:00:00
abstract::We wish to identify genes involved in mediating early lineage decisions in the mouse embryo. F9 teratocarcinoma cells treated with retinoic acid (RA) in suspension culture develop into embryoid bodies (EBs) with an outer layer of visceral endoderm. In order to identify genes that are involved in establishing this extr...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1993.1236
更新日期:1993-09-01 00:00:00
abstract::Hedgehog proteins have been implicated in the control of myogenesis in the medial vertebrate somite. In the mouse, normal epaxial expression of the myogenic transcription factor gene myf5 is dependent on Sonic hedgehog. Here we examine in zebrafish the interaction between Hedgehog signals, the expression of myoD famil...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.2001.0193
更新日期:2001-08-01 00:00:00
abstract::Genome integrity in the developing germ line is strictly required for fecundity. In proliferating somatic cells and in germ cells, there are mitotic checkpoint mechanisms that ensure accurate chromosome segregation and euploidy. There is growing evidence of mitotic cell cycle components that are uniquely required in t...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2015.03.011
更新日期:2015-06-15 00:00:00
abstract::In the present study, we have investigated the role of tyrosine kinase activity during early retinal development in Xenopus laevis. The protein tyrosine kinase (PTK) inhibitors lavendustin A and genistein were used to determine the possible role of tyrosine kinase activity during retinal development in vivo and in vit...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2003.10.006
更新日期:2004-02-01 00:00:00
abstract::Previous experiments have demonstrated that in the septo-hippocampal system choline acetyltransferase (ChAT) is induced by nerve growth factor (NGF) (Gnahn et al. (1983) Dev. Brain Res. 9, 45-52) and that hippocampal NGF and mRNANGF levels are correlated with the density of cholinergic innervation (Korsching et al. (1...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(87)90235-1
更新日期:1987-04-01 00:00:00
abstract::Germ cells provide maternal mRNAs that are stored in the oocyte, and later translated at a specific time of development. In this context, gene regulation depends mainly on post-transcriptional mechanisms that contribute to keep maternal transcripts in a stable and translationally silent state. In recent years, small n...
journal_title:Developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.ydbio.2016.06.007
更新日期:2016-08-01 00:00:00
abstract::Rapidly growing human teratocarcinoma cells (Tera-2) can be induced to differentiate into quiescent, nontumorigenic cells expressing neuronal markers. To more closely mimic the in vivo conditions for tumor growth, we grew Tera-2 cells in three-dimensional collagen gel cultures. The undifferentiated cells proliferated ...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1994.1016
更新日期:1994-01-01 00:00:00