Apoptosis regulates notochord development in Xenopus.

abstract：:FoxC, FoxF, FoxL1 and FoxQ1 genes have been shown to be clustered in some animal genomes, with mesendodermal expression hypothesised as a selective force maintaining cluster integrity. Hypotheses are, however, constrained by a lack of data from the Lophotrochozoa. Here we characterise members of the FoxC, FoxF, FoxL1 ...

journal_title：Developmental biology

authors： Shimeld SM,Boyle MJ,Brunet T,Luke GN,Seaver EC

更新日期：2010-04-15 00:00:00

abstract：:The processes of myelination remain incompletely understood but are of profound biomedical importance owing to the several dysmyelinating and demyelinating disorders known in humans. Here, we analyze the zebrafish puma mutant, isolated originally for pigment pattern defects limited to the adult stage. We show that pum...

journal_title：Developmental biology

authors： Larson TA,Gordon TN,Lau HE,Parichy DM

更新日期：2010-10-15 00:00:00

abstract：:In the development of mammalian organs, a rapid and robust expansion of the parenchymal compartment must occur following allocation of organ primordia. This expansion must be regulated so that sufficient tissue mass is generated for further organization into functional tissues. The discovery that mosaic patches in the...

journal_title：Developmental biology

authors： Khokha MK,Landini G,Iannaccone PM

更新日期：1994-10-01 00:00:00

abstract：:The monoclonal antibody HNK-1 was used to identify neural crest cells in serial sections of avian embryos to provide a detailed description of the distribution of trunk neural crest cells. The results indicate the presence of three migratory routes in the trunk: (1) a ventral pathway through the anterior sclerotome; (...

journal_title：Developmental biology

authors： Bronner-Fraser M

更新日期：1986-05-01 00:00:00

abstract：:Electroporation-based assays were used to test whether the myogenic regulatory factor (MRF) of Ciona intestinalis (CiMRF) interferes with endogenous developmental programs, and to evaluate the importance of its unusual N-terminus for muscle development. We found that CiMRF suppresses both notochord and endoderm develo...

journal_title：Developmental biology

authors： Ratcliffe LE,Asiedu EK,Pickett CJ,Warburton MA,Izzi SA,Meedel TH

更新日期：2019-04-15 00:00:00

abstract：:Mf1, which encodes a winged-helix/forkhead transcription factor, is the murine homolog of human FKHL7, mutated in individuals with autosomal dominant inherited dysgenesis of the anterior segment of the eye (Axenfeld-Reiger anomaly). Mouse embryos homozygous for null mutations in Mf1 (Mf1(lacZ) and Mf1(ch)) show severe...

journal_title：Developmental biology

authors： Kidson SH,Kume T,Deng K,Winfrey V,Hogan BL

更新日期：1999-07-15 00:00:00

abstract：:This work has identified the enzymes involved in the activation and conjugation of the ubiquitin-like protein NED-8 in Caenorhabditis elegans. A C. elegans conjugating enzyme, UBC-12, is highly specific in its ability to utilize NED-8 as a substrate. Immunostaining shows that NED-8 is conjugated in vivo to a major tar...

journal_title：Developmental biology

authors： Jones D,Candido EP

更新日期：2000-10-01 00:00:00

abstract：:nautilus (nau), one member of the myogenic regulatory family of bHLH-encoding genes, is expressed in a subset of muscle precursors and differentiated fibers in the Drosophila embryo. To elucidate the role of nautilus in myogenesis, we have misexpressed it using the GAL4-targeted system. We find that ectopic expression...

journal_title：Developmental biology

authors： Keller CA,Erickson MS,Abmayr SM

更新日期：1997-01-15 00:00:00

abstract：:We have investigated the imprinting status of two insulin genes using an interspecific recombinant congenic mouse strain carrying Ins1 and Ins2 alleles from Mus spretus on a C57BL/6 genetic background. At Days 12.5, 13.5, and 14.5 of gestation, expression of both parental alleles of both Ins1 and Ins2 was detected in ...

journal_title：Developmental biology

authors： Deltour L,Montagutelli X,Guenet JL,Jami J,Páldi A

更新日期：1995-04-01 00:00:00

abstract：:Interstitial cell migration was characterized in Hydra vulgaris (formerly H. attenuata) and the effects of axial position and tissue injury on migration were investigated. Migrating cells were labeled with the thymidine analog, bromodeoxyuridine, and grafted into unlabeled host polyps. Alternatively, cells were labele...

journal_title：Developmental biology

authors： Teragawa CK,Bode HR

更新日期：1990-03-01 00:00:00

abstract：:This work describes unknown aspects of chordotonal organ (ChO) morphogenesis revealed in post-embryonic stages through the use of new fluorescently labeled markers. We show that towards the end of embryogenesis a hitherto unnoticed phase of cell migration commences in which the cap cells of the ventral ChOs elongate a...

journal_title：Developmental biology

authors： Halachmi N,Nachman A,Salzberg A

更新日期：2016-03-01 00:00:00

abstract：:Septins are guanosine triphosphate-binding proteins that are evolutionally conserved in all eukaryotes other than plants. They function as multimeric complexes that interact with membrane lipids, actomyosin, and microtubules. Based on these interactions, septins play essential roles in the morphogenesis and physiologi...

journal_title：Developmental biology

authors： Torii H,Yoshida A,Katsuno T,Nakagawa T,Ito J,Omori K,Kinoshita M,Yamamoto N

更新日期：2016-11-15 00:00:00

abstract：:The survival effects of brain-derived neurotrophic factor (BDNF) on the ganglion cells of the chick retina were studied in vitro at different embryonic ages. We found these effects to be strongly age-dependent: at E5, when the first ganglion cell axons have crossed the optic chiasm, but not yet reached the tectum, gan...

journal_title：Developmental biology

authors： Rodriguez-Tébar A,Jeffrey PL,Thoenen H,Barde YA

更新日期：1989-12-01 00:00:00

abstract：:We have used amphibian gastrulation as a model system to study the action of the extracellular matrix (ECM) glycoprotein tenascin on mesodermal cell migration. Tenascin function was assayed in vitro during spreading of isolated cells from the dorsal marginal zone (DMZ) and during cell migration from DMZ explants. Plas...

journal_title：Developmental biology

authors： Riou JF,Shi DL,Chiquet M,Boucaut JC

更新日期：1990-02-01 00:00:00

abstract：:The developmental events of sporulation and fruiting body formation in the prokaryote Myxococcus xanthus are preceded by a stage of massive cell death. Two phenotypically complementable strains of M. xanthus defective in developmental lysis were identified from a group of conditional sporulation mutants. Mixture of th...

journal_title：Developmental biology

authors： Janssen GR,Dworkin M

更新日期：1985-11-01 00:00:00

abstract：:To determine whether spontaneous release of transmitter from the growth cones of neurons exhibits properties similar to the spontaneous release which occurs from the neurons at the neuromuscular junction, release of transmitter from the growth cones of Xenopus neurons in culture was monitored in salines containing var...

journal_title：Developmental biology

authors： Young SH

更新日期：1986-02-01 00:00:00

abstract：:Vertebrate neural tube formation involves two distinct morphogenetic events--convergent extension (CE) driven by mediolateral cell intercalation, and bending of the neural plate driven largely by cellular apical constriction. However, the cellular and molecular biomechanics of these processes are not understood. Here,...

journal_title：Developmental biology

authors： Rolo A,Skoglund P,Keller R

更新日期：2009-03-15 00:00:00

abstract：:In mouse chimeras with parthenogenetic cell contribution, the skeletal musculature appears to be largely devoid of parthenogenetically derived cells. To analyze the appearance and early distribution of myotomal cells in parthenotes, we determined the expression of the muscle-specific transcription factors myogenin, MY...

journal_title：Developmental biology

authors： Fundele R,Bober E,Arnold HH,Grim M,Bender R,Wilting J,Christ B

更新日期：1994-01-01 00:00:00

abstract：:Proper patterning and growth of oral structures including teeth, tongue, and palate rely on epithelial-mesenchymal interactions involving coordinated regulation of signal transduction. Understanding molecular mechanisms underpinning oral-facial development will provide novel insights into the etiology of common congen...

journal_title：Developmental biology

authors： Lin C,Fisher AV,Yin Y,Maruyama T,Veith GM,Dhandha M,Huang GJ,Hsu W,Ma L

更新日期：2011-08-01 00:00:00

abstract：:We previously demonstrated that male mice deficient in the soluble adenylyl cyclase (sAC) are sterile and produce spermatozoa with deficits in progressive motility and are unable to fertilize zona-intact eggs. Here, analyses of sAC(-/-) spermatozoa provide additional insights into the functions linked to cAMP signalin...

journal_title：Developmental biology

authors： Xie F,Garcia MA,Carlson AE,Schuh SM,Babcock DF,Jaiswal BS,Gossen JA,Esposito G,van Duin M,Conti M

更新日期：2006-08-15 00:00:00

abstract：:The role of angiotensin II (Ang II) in the early embryonic development of the heart has not been examined. We have used RT-PCR to identify mRNA for angiotensinogen, angiotensin-converting enzyme, and the Ang II AT1 and AT2 receptors in embryonic day 10.25 Sprague-Dawley rats, and have used confocal microscopy to local...

journal_title：Developmental biology

authors： Price RL,Carver W,Simpson DG,Fu L,Zhao J,Borg TK,Terracio L

更新日期：1997-12-15 00:00:00

abstract：:Adherent cultures of E10.5 rat neuroepithelial cells (NEP cells) from the caudal neural tube require FGF (fibroblast growth factor) and CEE (chick embryo extract) to proliferate and maintain an undifferentiated phenotype in culture. Epidermal growth factor (EGF) does not support E10.5 NEP cells in adherent culture and...

journal_title：Developmental biology

authors： Kalyani A,Hobson K,Rao MS

更新日期：1997-06-15 00:00:00

abstract：:Normal animal development requires accurate cell divisions, not only in the early stages of rapid embryonic cleavages, but also in later developmental stages. The Caenorhabditis elegans unc-85 gene is implicated only in cell divisions that occur post-embryonically, primarily in terminal neuronal lineages. Variable pos...

journal_title：Developmental biology

authors： Grigsby IF,Finger FP

更新日期：2008-07-01 00:00:00

abstract：:During its development the epidermis of the pf/pf mutant mouse is invaded by cells from the underlying dermis. These invading cells establish a network of cells including fibroblasts, endothelial cells, and nerve fibers, throughout the epidermis. Subsequent to these events the keratohyalin protein, filaggrin, is drast...

journal_title：Developmental biology

authors： Fisher C,Dale BA,Kollar EJ

更新日期：1984-04-01 00:00:00

abstract：:Notch signaling is involved in a large range of developmental processes, and has been functionally implicated in body plan segmentation in two of the three diverse segmented taxa, the vertebrates and arthropods. Here we investigate expression of Notch, Delta, and hes gene homologues during larval and juvenile developm...

journal_title：Developmental biology

authors： Thamm K,Seaver EC

更新日期：2008-08-01 00:00:00

abstract：:The stromal microenvironment regulates mammary gland branching morphogenesis. We have observed that mast cells are present in the mammary gland throughout its postnatal development and, in particular, are found around the terminal end buds and ductal epithelium of the pubertal gland. Mast cells contribute to allergy, ...

journal_title：Developmental biology

authors： Lilla JN,Werb Z

更新日期：2010-01-01 00:00:00

abstract：:Mammalian sperm must acquire their fertilizing ability after a series of biochemical modifications in the female reproductive tract collectively called capacitation to undergo acrosomal exocytosis, a process that is essential for fertilization. Actin dynamics play a central role in controlling the process of exocytosi...

journal_title：Developmental biology

authors： Romarowski A,Battistone MA,La Spina FA,Puga Molina Ldel C,Luque GM,Vitale AM,Cuasnicu PS,Visconti PE,Krapf D,Buffone MG

更新日期：2015-09-15 00:00:00

abstract：:The germinal vesicle (GV) of starfish oocytes contains a factor which is required to drive the cytoplasmic cycle of the meiotic division. Biochemical investigation of this factor has been difficult due to the small quantities of obtainable GV materials. To overcome this, we have developed a mass-isolation procedure fo...

journal_title：Developmental biology

authors： Nemoto S,Yamamoto K,Hashimoto N

更新日期：1992-06-01 00:00:00

abstract：:Primary mesenchyme cell migration in the sea urchin embryo is inhibited by sulfate deprivation and exposure to exogenous beta-D-xylosides, two treatments known to disrupt proteoglycan synthesis. We show that in the developing sea urchin, exogenous xyloside affects the synthesis by the primary mesenchyme cells of a ver...

journal_title：Developmental biology

authors： Lane MC,Solursh M

更新日期：1991-02-01 00:00:00

abstract：:The mammalian kidney consists of an array of tubules connected to a ductal system that collectively function to control water/salt balance and to remove waste from the organisms' circulatory system. During mammalian embryogenesis, three kidney structures form within the intermediate mesoderm. The two most anterior str...

journal_title：Developmental biology

authors： Mugford JW,Sipilä P,Kobayashi A,Behringer RR,McMahon AP

更新日期：2008-07-15 00:00:00