Tissue- and developmental stage-specific imprinting of the mouse proinsulin gene, Ins2.

abstract：:Monoclonal antibodies (mAbs), electrophoresis, immunoblotting, and immunohistochemistry were used to determine the molecular properties of cardiac myosin heavy chain (MHC) isoforms and the regions of the developing chicken heart in which they were expressed. Adult atria expressed three electrophoretically distinct MHC...

journal_title：Developmental biology

authors： Evans D,Miller JB,Stockdale FE

更新日期：1988-06-01 00:00:00

abstract：:The mechanism by which pluripotent progenitors give rise to distinct classes of mature neurons in vertebrates is not well understood. To address this issue we undertook a genetic screen for mutations which affect the commitment and differentiation of catecholaminergic (CA) [dopaminergic (DA), noradrenergic (NA), and a...

journal_title：Developmental biology

authors： Guo S,Wilson SW,Cooke S,Chitnis AB,Driever W,Rosenthal A

更新日期：1999-04-15 00:00:00

abstract：:Fertilized eggs of the leech Helobdella triserialis undergo a cytoplasmic reorganization which generates domains of nonyolky cytoplasm, called teloplasm, at the animal and vegetal poles. The segregation of teloplasm to one cell of the eight-cell embryo is responsible for a unique developmental fate of that cell, i.e.,...

journal_title：Developmental biology

authors： Astrow SH,Holton B,Weisblat DA

更新日期：1989-10-01 00:00:00

abstract：:In many organisms early embryogenesis is characterised by a period refractory to transcription. In Caenorhabditis elegans, the one-cell embryo is transcriptionally inactive, but at around eight-cell stage transcription is activated in the somatic lineage. This model suggests that histone tail modifications associated ...

journal_title：Developmental biology

authors： Wang S,Fisher K,Poulin GB

更新日期：2011-07-15 00:00:00

abstract：:Early spermatids contain roughly 1000-fold more TATA-binding protein (TBP) mRNA than do somatic cells. The appearance of TBP-overexpressing spermatids in the developing testis is accompanied by a large increase in whole-organ levels of total RNA and of poly(A)+ RNA per cell. Whereas somatic cells initiate transcriptio...

journal_title：Developmental biology

authors： Schmidt EE,Schibler U

更新日期：1997-04-01 00:00:00

abstract：:Ephrins and semaphorins regulate a wide variety of developmental processes, including axon guidance and cell migration. We have studied the roles of the ephrin EFN-4 and the semaphorin MAB-20 in patterning cell-cell contacts among the cells that give rise to the ray sensory organs of Caenorhabditis elegans. In wild-ty...

journal_title：Developmental biology

authors： Hahn AC,Emmons SW

更新日期：2003-04-15 00:00:00

abstract：:The myelin of the peripheral nervous system from the shiverer mutant mice is characterized by the absence of myelin basic protein, while the other myelin protein components are present at normal levels. Myelin lamella formation is normal in the shiverer mutant. Therefore, by using antiserum against myelin basic protei...

journal_title：Developmental biology

authors： Mikoshiba K,Yokoyama M,Takamatsu K,Tsukada Y,Nomura T

更新日期：1984-09-01 00:00:00

abstract：:The salivary system in mammals is comprised of three independently developed pairs of organs, the parotid, submaxillar, and sublingual glands. Each gland is composed of various ductal and acinar cell types that fulfill multiple roles. However, the molecular mechanisms regulating their biogenesis and functions are stil...

journal_title：Developmental biology

authors： Yoshida S,Ohbo K,Takakura A,Takebayashi H,Okada T,Abe K,Nabeshima Y

更新日期：2001-12-15 00:00:00

abstract：:The relationship among neuronal type, position, and time course of development of identified neurons was examined in the zebrafish (Brachydanio rerio). The cells studied, the reticulospinal neurons Mauthner, MiM1, and MiV1, are located within the same small region in the hindbrain, differ stereotypically in their posi...

journal_title：Developmental biology

authors： Mendelson B

更新日期：1985-12-01 00:00:00

abstract：:We have compared insulin binding by heart cells at 7 and 14 days of development. Species specificity, optimum pH, temperature relationships, and time to equilibrium for binding of insulin were the same in both 7 and 14-day systems. Curvilinear Scatchard plots for chicken insulin binding were demonstrated. Binding affi...

journal_title：Developmental biology

authors： Serravezza JC,Wheeler FB,DeHaan RL,Elsas LJ

更新日期：1981-06-01 00:00:00

abstract：:Maintaining tissue homeostasis is a critical process during infection and inflammation. Tissues with a high intrinsic turnover, such as the intestinal epithelium, must launch a rapid response to infections while simultaneously coordinating cell proliferation and differentiation decisions. In this study, we searched fo...

journal_title：Developmental biology

authors： Zhou J,Florescu S,Boettcher AL,Luo L,Dutta D,Kerr G,Cai Y,Edgar BA,Boutros M

更新日期：2015-03-15 00:00:00

abstract：:We have analyzed several aspects of the development of flies carrying mutations at the Glued locus. Optic lobe abnormalities in individuals heterozygous for the original Glued allele were previously shown to result from an action of this mutation in the retinula cells. We have estimated when the functioning of this ge...

journal_title：Developmental biology

authors： Harte PJ,Kankel DR

更新日期：1983-09-01 00:00:00

abstract：:The Jonah gene family consists of approximately 20 genes, distributed in small clusters at eight or more widely dispersed chromosomal sites. Gene clusters differ in the number of genes per cluster, ranging up to four, and in the arrangement of genes within clusters, which include direct repeats, inverted repeats, and ...

journal_title：Developmental biology

authors： Carlson JR,Hogness DS

更新日期：1985-04-01 00:00:00

abstract：:We have studied the differentiation of the oocyte vitelline coat (VC) and jelly coat (JC) of the starfish, Astropecten aurantiacus. The precursor material of both envelopes is secreted by the oocyte while the follicle cells do not appear to participate in the secretory process. The first indication of differentiation ...

journal_title：Developmental biology

authors： Santella L,Monroy A,Rosati F

更新日期：1983-10-01 00:00:00

abstract：:In this paper we present a structural and functional characterization of a new sea urchin embryo transcription factor, SpRunt-1. This factor was isolated by means of its specific interaction with a cis-regulatory target site of the CyIIIa gene. Here we show that this target site, the P7I site, is required for normal e...

journal_title：Developmental biology

authors： Coffman JA,Kirchhamer CV,Harrington MG,Davidson EH

更新日期：1996-02-25 00:00:00

abstract：:The segmentation of somites from the paraxial mesoderm is a crucial event in vertebrate embryonic development; however, the mechanisms underlying this process are not well understood. In a yeast two-hybrid screen we have identified the novel basic-helix-loop-helix (bHLH) protein cMeso-1 which is expressed in the preso...

journal_title：Developmental biology

authors： Buchberger A,Seidl K,Klein C,Eberhardt H,Arnold HH

更新日期：1998-07-15 00:00:00

abstract：:The outstanding migration and differentiation capacities of neural crest cells (NCCs) have fascinated scientists since Wilhelm His described this cell population in 1868. Today, after intense research using vertebrate model organisms, we have gained considerable knowledge regarding the origin, migration and differenti...

journal_title：Developmental biology

authors： Betters E,Liu Y,Kjaeldgaard A,Sundström E,García-Castro MI

更新日期：2010-08-15 00:00:00

abstract：:Implantation represents a critical step for embryonic development and pregnancy. Its success depends on the complex interplay between a receptive endometrium and a competent embryo. Implantation-related events remain hardly accessible, making implantation a true "black box" in developmental biology. Improved in vitro ...

journal_title：Developmental biology

authors： Ban Z,Knöspel F,Schneider MR

更新日期：2020-07-01 00:00:00

abstract：:This study was undertaken to determine whether premigratory neural crest cells of the axolotl embryo differentiate autonomously into chromatophores, or whether stimuli from the environment, particularly from the extracellular matrix, are required for this process. Neural crest cells were excised from the dorsal part o...

journal_title：Developmental biology

authors： Perris R,Löfberg J

更新日期：1986-02-01 00:00:00

abstract：:Initiation of transcription mediated by RNA polymerase II requires a number of transcription factors among which TFIID is the major core promoter recognition factor. TFIID is composed of highly conserved factors which include the TATA-binding protein (TBP) and about 14 TBP-associated factors (TAFs). Recently, the comp...

journal_title：Developmental biology

authors： Lago C,Clerici E,Dreni L,Horlow C,Caporali E,Colombo L,Kater MM

更新日期：2005-09-01 00:00:00

abstract：:The origin of resident (noninflammatory) macrophages in vertebrate tissues is still poorly understood. In the zebrafish embryo, we recently described a specific lineage of early macrophages that differentiate in the yolk sac before the onset of blood circulation. We now show that these early macrophages spread in the ...

journal_title：Developmental biology

authors： Herbomel P,Thisse B,Thisse C

更新日期：2001-10-15 00:00:00

abstract：:Cultured cells obtained from developing chick heart valvular and septal primordial tissues (cardiac cushions) and myocardium were tested for their capacity to bind, internalize, and degrade hyaluronate. A presumptive lysosomal hyaluronidase capable of hyaluronate degradation has been previously isolated and partially ...

journal_title：Developmental biology

authors： Bernanke DH,Orkin RW

更新日期：1984-12-01 00:00:00

abstract：:Deficient nephrogenesis is the major factor contributing to renal hypoplasia defined as abnormally small kidneys. Nephron induction during kidney development is driven by reciprocal interactions between progenitor cells of the cap mesenchyme (CM) and the ureteric bud (UB). The prorenin receptor (PRR) is a receptor for...

journal_title：Developmental biology

authors： Song R,Preston G,Kidd L,Bushnell D,Sims-Lucas S,Bates CM,Yosypiv IV

更新日期：2016-01-15 00:00:00

abstract：:The three fibronectin leucine-rich repeat transmembrane (FLRT) proteins contain 10 leucine-rich repeats (LRR), a type III fibronectin (FN) domain, followed by the transmembrane region, and a short cytoplasmic tail. XFLRT3, a Nodal/TGFbeta target, regulates cell adhesion and modulates FGF signalling during Xenopus gast...

journal_title：Developmental biology

authors： Maretto S,Müller PS,Aricescu AR,Cho KW,Bikoff EK,Robertson EJ

更新日期：2008-06-01 00:00:00

abstract：:In the course of embryogenesis multicellular structures and organs are assembled from constituent cells. One structural component common to many organs is the tube, which consists most simply of a luminal space surrounded by a single layer of epithelial cells. The notochord of ascidian Ciona forms a tube consisting of...

journal_title：Developmental biology

authors： Dong B,Horie T,Denker E,Kusakabe T,Tsuda M,Smith WC,Jiang D

更新日期：2009-06-15 00:00:00

abstract：:A population of hematopoietic progenitors becomes committed within the embryo proper in the floor of the aorta (P-Sp/AGM in the mouse). In birds, this first aspect of intraembryonic hematopoiesis is prominent during embryonic day 3 (E3) as endothelium-associated "intra-aortic clusters." Between E6 and E8, diffuse hema...

journal_title：Developmental biology

authors： Jaffredo T,Gautier R,Brajeul V,Dieterlen-Lièvre F

更新日期：2000-08-15 00:00:00

abstract：:The Drosophila Suppressor of Hairy wing [Su(Hw)] insulator protein has an essential role in the development of the female germline. Here we investigate the function of Su(Hw) in the ovary. We show that Su(Hw) is universally expressed in somatic cells, while germ cell expression is dynamic. Robust levels accumulate in ...

journal_title：Developmental biology

authors： Baxley RM,Soshnev AA,Koryakov DE,Zhimulev IF,Geyer PK

更新日期：2011-08-15 00:00:00

abstract：:Drosophila Polycomb Repressive Complex 2 (PRC2) is a lysine methyltransferase that trimethylates histone H3 lysine 27 (H3K27me3), a modification essential for Polycomb silencing. Mutations in its catalytic subunit, E(Z), that abolish its methyltransferase activity disrupt Polycomb silencing, causing derepression of Po...

journal_title：Developmental biology

authors： Stepanik VA,Harte PJ

更新日期：2012-04-15 00:00:00

abstract：:The level of early histone mRNA in Strongylocentrotus purpuratus changes abruptly at 6 hr of development, increasing an average of 10-fold by 9-10.5 hr and then decreasing over 2-fold by 13.5-15 hr. These changes occur when the late embryonic mRNA is still a very minor component of histone gene transcription. The exac...

journal_title：Developmental biology

authors： Weinberg ES,Hendricks MB,Hemminki K,Kuwabara PE,Farrelly LA

更新日期：1983-07-01 00:00:00

abstract：:Full-grown Xenopus oocytes, Stage VI (1200-1300 microns), undergo meiotic maturation when exposed to progesterone. Smaller stage IV (800 microns) and stage V (1000 microns) oocytes remain in prophase arrest when exposed to this steroid. The larger stage VI oocytes undergo an intracellular alkalization from 7.2 to 7.6,...

journal_title：Developmental biology

authors： Wasserman WJ,Houle JG,Samuel D

更新日期：1984-10-01 00:00:00