The Arabidopsis TFIID factor AtTAF6 controls pollen tube growth.


:Initiation of transcription mediated by RNA polymerase II requires a number of transcription factors among which TFIID is the major core promoter recognition factor. TFIID is composed of highly conserved factors which include the TATA-binding protein (TBP) and about 14 TBP-associated factors (TAFs). Recently, the complete Arabidopsis TAF family has been identified. To obtain functional information about Arabidopsis TAFs, we analyzed a T-DNA insertion mutant for AtTAF6. Segregation analysis showed that plants homozygous for the mutant allele were never found, indicating that inhibition of the AtTAF6 function is lethal. Genetic experiments also revealed that the male gametophyte was affected by the attaf6 mutation since significant reduced transmission of the mutant allele through the male gametophyte was observed. Detailed histological and morphological analysis showed that the T-DNA insertion in AtTAF6 specifically affects pollen tube growth, indicating that the transcriptional regulation of only a specific subset of genes is controlled by this basal transcription factor.


Dev Biol


Developmental biology


Lago C,Clerici E,Dreni L,Horlow C,Caporali E,Colombo L,Kater MM




Has Abstract


2005-09-01 00:00:00














  • AMPK regulation of mouse oocyte meiotic resumption in vitro.

    abstract::We have previously shown that the adenosine analog 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranoside (AICAR), an activator of AMP-activated protein kinase (AMPK), stimulates an increase in AMPK activity and induces meiotic resumption in mouse oocytes [Downs, S.M., Hudson, E.R., Hardie, D.G., 2002. A potential rol...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Chen J,Hudson E,Chi MM,Chang AS,Moley KH,Hardie DG,Downs SM

    更新日期:2006-03-15 00:00:00

  • Egfr/Ras signaling regulates DE-cadherin/Shotgun localization to control vein morphogenesis in the Drosophila wing.

    abstract::Egfr/Ras signaling promotes vein cell fate specification in the developing Drosophila wing. While the importance of Ras signaling in vein determination has been extensively documented, the mechanisms linking Ras activity to vein differentiation remain unclear. We found that Ras signaling regulates both the levels and ...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: O'Keefe DD,Prober DA,Moyle PS,Rickoll WL,Edgar BA

    更新日期:2007-11-01 00:00:00

  • Neurogenesis in the water flea Daphnia magna (Crustacea, Branchiopoda) suggests different mechanisms of neuroblast formation in insects and crustaceans.

    abstract::Within euarthropods, the morphological and molecular mechanisms of early nervous system development have been analysed in insects and several representatives of chelicerates and myriapods, while data on crustaceans are fragmentary. Neural stem cells (neuroblasts) generate the nervous system in insects and in higher cr...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Ungerer P,Eriksson BJ,Stollewerk A

    更新日期:2011-09-01 00:00:00

  • Histone lysine trimethylation exhibits a distinct perinuclear distribution in Plzf-expressing spermatogonia.

    abstract::Chromatin structure plays an important role in the regulation of gene expression. Methylation of lysine residues on histone tails is an epigenetic mark that influences chromatin repression when specifically imparted on lysines 9 and 27 of histone H3, and on lysine 20 of H4. Histone lysines can be mono-, di-, and trime...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Payne C,Braun RE

    更新日期:2006-05-15 00:00:00

  • Syd/JIP3 controls tissue size by regulating Diap1 protein turnover downstream of Yorkie/YAP.

    abstract::How organisms control organ size is not fully understood. We found that Syd/JIP3 is required for proper wing size in Drosophila. JIP3 mutations are associated with organ size defects in mammals. The underlying mechanisms are not well understood. We discovered that Syd/JIP3 inhibition results in a downregulation of the...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Ahmad V,Vadla GP,Chabu CY

    更新日期:2021-01-01 00:00:00

  • Unmasking mRNA in clam oocytes: role of phosphorylation of a 3' UTR masking element-binding protein at fertilization.

    abstract::During meiotic maturation or after fertilization of invertebrate and vertebrate oocytes, many of the quiescent stored mRNAs are recruited into polysomes. In the clam, Spisula solidissima, such masked messages include the abundant mRNAs encoding cyclin A and the small subunit of ribonucleotide reductase. We have previo...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Walker J,Dale M,Standart N

    更新日期:1996-01-10 00:00:00

  • Yolk proteins of Caenorhabditis elegans.

    abstract::A group of proteins judged on several criteria to be yolk proteins have been isolated from a homogenate of the nematode Caenorhabditis elegans. Comparison of partial proteolysis fragments indicates that the two bands of a 170,000-dalton doublet (yp170) are closely related; bands observed at 115,000 daltons (yp115) and...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Sharrock WJ

    更新日期:1983-03-01 00:00:00

  • Inhibition of protein tyrosine kinase activity disrupts early retinal development.

    abstract::In the present study, we have investigated the role of tyrosine kinase activity during early retinal development in Xenopus laevis. The protein tyrosine kinase (PTK) inhibitors lavendustin A and genistein were used to determine the possible role of tyrosine kinase activity during retinal development in vivo and in vit...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Li M,Babenko NA,Sakaguchi DS

    更新日期:2004-02-01 00:00:00

  • Molecular characterization of anterior-like cells in Dictyostelium discoideum.

    abstract::Prestalk cells are found in the anterior 15% of slugs of Dictyostelium discoideum and prespore cells are found in the remaining posterior portions. Neutral red staining as well as immunostaining with antisera prepared against spores or a spore-coat protein has indicated that there are cells in the posterior region whi...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Devine KM,Loomis WF

    更新日期:1985-02-01 00:00:00

  • The Wiskott-Aldrich syndrome protein (WASP) is essential for myoblast fusion in Drosophila.

    abstract::In higher organisms, mononucleated myoblasts fuse to form multinucleated myotubes. During this process, myoblasts undergo specific changes in cell morphology and cytoarchitecture. Previously, we have shown that the actin regulator Kette (Hem-2/Nap-1) is essential for myoblast fusion. In this study, we describe the rol...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Schäfer G,Weber S,Holz A,Bogdan S,Schumacher S,Müller A,Renkawitz-Pohl R,Onel SF

    更新日期:2007-04-15 00:00:00

  • In vivo impact of a 4 bp deletion mutation in the DLX3 gene on bone development.

    abstract::Distal-less 3 (DLX3) gene mutations are etiologic for Tricho-Dento-Osseous syndrome. To investigate the in vivo impact of mutant DLX3 on bone development, we established transgenic (TG) mice expressing the c.571_574delGGGG DLX-3 gene mutation (MT-DLX3) driven by a mouse 2.3 Col1A1 promoter. Microcomputed tomographic a...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Choi SJ,Roodman GD,Feng JQ,Song IS,Amin K,Hart PS,Wright JT,Haruyama N,Hart TC

    更新日期:2009-01-01 00:00:00

  • Binding of sperm proacrosin/beta-acrosin to zona pellucida glycoproteins is sulfate and stereodependent. Synthesis of a novel fertilization inhibitor.

    abstract::Specific binding of spermatozoa to the zona pellucida that surrounds mammalian eggs is a key step in the fertilization process. However, the sperm proteins that recognise zona pellucida receptors remain contentious despite longstanding research efforts to identify them. Here we present evidence that proacrosin, a tiss...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Gaboriau D,Howes EA,Clark J,Jones R

    更新日期:2007-06-15 00:00:00

  • Identification of a proliferating marginal zone of retinal progenitors in postnatal chickens.

    abstract::In warm-blooded vertebrates it is generally accepted that after early stages of development new neurons are not added to the retina. Contrary to this belief, we show here that hatched chickens have a zone of proliferating cells at the peripheral margin of the retina, similar to that of fish and amphibians. We found th...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Fischer AJ,Reh TA

    更新日期:2000-04-15 00:00:00

  • Mechanism of skin morphogenesis. I. Analyses with antibodies to adhesion molecules tenascin, N-CAM, and integrin.

    abstract::To understand cell interactions during induction of skin appendages, we studied the roles of adhesion molecules N-CAM, tenascin, integrin, and fibronectin during feather development. Tenascin appeared in a periodic pattern on epithelia and was so far the earliest molecule detected in placodes. Three placode domains we...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Jiang TX,Chuong CM

    更新日期:1992-03-01 00:00:00

  • Co-expression of multiple neurotransmitter enzyme genes in normal and immortalized sympathoadrenal progenitor cells.

    abstract::We have examined the expression of mRNAs encoding five major neurotransmitter-synthesizing enzymes in MAH cells, a clonal cell line derived by retroviral immortalization of a rat embryonic sympathoadrenal progenitor cell. These mRNAs include tyrosine hydroxylase (TH), choline acetyltransferase (ChAT), tryptophan hydro...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Vandenbergh DJ,Mori N,Anderson DJ

    更新日期:1991-11-01 00:00:00

  • Dynamic expression of Lrp2 pathway members reveals progressive epithelial differentiation of primitive endoderm in mouse blastocyst.

    abstract::Mesenchyme to epithelium transitions are crucial to embryonic development. The early mouse embryo offers an excellent model to study epithelium formation as during the first three days of development two epithelia are formed, the trophectoderm (TE) and the primitive endoderm (PrE). We have previously shown that PrE ce...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Gerbe F,Cox B,Rossant J,Chazaud C

    更新日期:2008-01-15 00:00:00

  • Tracing the progeny of the aortic hemangioblast in the avian embryo.

    abstract::A population of hematopoietic progenitors becomes committed within the embryo proper in the floor of the aorta (P-Sp/AGM in the mouse). In birds, this first aspect of intraembryonic hematopoiesis is prominent during embryonic day 3 (E3) as endothelium-associated "intra-aortic clusters." Between E6 and E8, diffuse hema...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Jaffredo T,Gautier R,Brajeul V,Dieterlen-Lièvre F

    更新日期:2000-08-15 00:00:00

  • Enhanced expression of limb malformations and axial skeleton alterations in legless mutants by transplacental exposure to retinoic acid.

    abstract::This manuscript reports on the limb malformations and axial skeleton alterations found in legless fetuses and their heterozygote and wild-type littermates transplacentally exposed to all-trans-retinoic acid via a single intraperitoneal injection on Day 7, 8, 9, 9.5, 10, 10.5, or 11 of gestation. The most surprising as...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Scott WJ,Collins MD,Ernst AN,Supp DM,Potter SS

    更新日期:1994-07-01 00:00:00

  • Polycomb silencing of the Drosophila 4E-BP gene regulates imaginal disc cell growth.

    abstract::Polycomb group (PcG) proteins are best known for their role in maintaining stable, mitotically heritable silencing of the homeotic (HOX) genes during development. In addition to loss of homeotic gene silencing, some PcG mutants also have small imaginal discs. These include mutations in E(z), Su(z)12, esc and escl, whi...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Mason-Suares H,Tie F,Yan CM,Harte PJ

    更新日期:2013-08-01 00:00:00

  • Pax6 is essential for the generation of late-born retinal neurons and for inhibition of photoreceptor-fate during late stages of retinogenesis.

    abstract::In the developing retina, as in other regions of the CNS, neural progenitors give rise to individual cell types during discrete temporal windows. Pax6 is expressed in retinal progenitor cells (RPCs) throughout the course of retinogenesis, and has been shown to be required during early retinogenesis for generation of m...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Remez LA,Onishi A,Menuchin-Lasowski Y,Biran A,Blackshaw S,Wahlin KJ,Zack DJ,Ashery-Padan R

    更新日期:2017-12-01 00:00:00

  • The 3'UTR of nanos2 directs enrichment in the germ cell lineage of the sea urchin.

    abstract::Nanos is a translational regulator required for the survival and maintenance of primordial germ cells during embryogenesis. Three nanos homologs are present in the genome of the sea urchin Strongylocentrotus purpuratus (Sp), and each nanos mRNA accumulates specifically in the small micromere (sMic) lineage. We found t...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Oulhen N,Yoshida T,Yajima M,Song JL,Sakuma T,Sakamoto N,Yamamoto T,Wessel GM

    更新日期:2013-05-01 00:00:00

  • Reexamination of the sequence of the sea urchin egg receptor for sperm: implications with respect to its properties.

    abstract::A reexamination of the cDNA clones of the Strongylocentrotus purpuratus sea urchin egg receptor for sperm resulted in several important changes to the sequence. By using both rapid amplification of cDNA ends (RACE) and Northern blot analysis for confirmation, the corrected deduced amino acid sequence was shown to lack...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Just ML,Lennarz WJ

    更新日期:1997-04-01 00:00:00

  • Natural size variation among embryos leads to the corresponding scaling in gene expression.

    abstract::Xenopus laevis frogs from laboratory stocks normally lay eggs exhibiting extensive size variability. We find that these initial size differences subsequently affect the size of the embryos prior to the onset of growth, and the size of tadpoles during the growth period. Even though these tadpoles differ in size, their ...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Leibovich A,Edri T,Klein SL,Moody SA,Fainsod A

    更新日期:2020-06-15 00:00:00

  • Studies of the developing chick retina using monoclonal antibody 8A2 that recognizes a novel set of gangliosides.

    abstract::A monoclonal antibody, Mab 8A2, that recognizes a novel set of gangliosides was produced by immunizing a mouse with Embryonic Day 14 chick optic nerve. Immunohistochemical studies of the developing chick retina revealed a complex pattern of Mab 8A2 immunoreactivity. Initially, staining is concentrated in the optic fib...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Drazba J,Pierce M,Lemmon V

    更新日期:1991-05-01 00:00:00

  • Reverse engineering liver buds through self-driven condensation and organization towards medical application.

    abstract::The self-organizing tissue-based approach coupled with induced pluripotent stem (iPS) cell technology is evolving as a promising field for designing organoids in culture and is expected to achieve valuable practical outcomes in regenerative medicine and drug development. Organoids show properties of functional organs ...

    journal_title:Developmental biology

    pub_type: 杂志文章,评审


    authors: Shinozawa T,Yoshikawa HY,Takebe T

    更新日期:2016-12-15 00:00:00

  • Cell lineage conversion in the sea urchin embryo.

    abstract::The mesoderm of the sea urchin embryo conventionally is divided into two populations of cells; the primary mesenchyme cells (PMCs), which produce the larval skeleton, and the secondary mesenchyme cells (SMCs), which differentiate into a variety of cell types but do not participate in skeletogenesis. In this study we e...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Ettensohn CA,McClay DR

    更新日期:1988-02-01 00:00:00

  • Fluorescent protein expression driven by her4 regulatory elements reveals the spatiotemporal pattern of Notch signaling in the nervous system of zebrafish embryos.

    abstract::Notch activation inhibits neuronal differentiation during development of the nervous system; however, the dynamic role of Notch signaling in individual cell lineages remains poorly understood. We have characterized 3.4 kb 5'-regulatory sequence of a Notch target gene, her4, and used it to drive fluorescent gene expres...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Yeo SY,Kim M,Kim HS,Huh TL,Chitnis AB

    更新日期:2007-01-15 00:00:00

  • Adenohypophysis formation in the zebrafish and its dependence on sonic hedgehog.

    abstract::Formation of the adenohypophysis in mammalian embryos occurs via an invagination of the oral ectoderm to form Rathke's pouch, which becomes exposed to opposing dorsoventral gradients of signaling proteins governing specification of the different hormone-producing pituitary cell types. One signal promoting pituitary ce...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Herzog W,Zeng X,Lele Z,Sonntag C,Ting JW,Chang CY,Hammerschmidt M

    更新日期:2003-02-01 00:00:00

  • The "beginnings" of the neural crest.

    abstract:FOREWORD:The neural crest has been the main object of my investigations during my career in science, up to now. It is a fascinating topic for an embryologist because of its two unique characteristics: its large degree of multipotency and the fact that its development involves a phase during which its component cells mi...

    journal_title:Developmental biology

    pub_type: 杂志文章,评审


    authors: Le Douarin NM,Dupin E

    更新日期:2018-12-01 00:00:00

  • Expression of Otx homeodomain proteins induces cell aggregation in developing zebrafish embryos.

    abstract::In the zebrafish embryo, cells fated to give rise to the rostral brain move in a concerted fashion and retain tissue coherence during morphogenesis. We demonstrate here that Otx proteins have a dramatic effect on cell-cell interactions when expressed ectopically in the zebrafish embryo. Injection of zebrafish Otx1 or ...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Bellipanni G,Murakami T,Doerre OG,Andermann P,Weinberg ES

    更新日期:2000-07-15 00:00:00