Mutations in the zebrafish unmask shared regulatory pathways controlling the development of catecholaminergic neurons.

abstract：:Mammalian heart development involves complex morphogenetic events which lead to the formation of fully separated left and right atrial and ventricular chambers from a tubular heart. Separation of left and right ventricular chambers is dependent on a single structure, the interventricular septum (IVS), which has both m...

journal_title：Developmental biology

authors： Franco D,Meilhac SM,Christoffels VM,Kispert A,Buckingham M,Kelly RG

更新日期：2006-06-15 00:00:00

abstract：:Genome integrity in the developing germ line is strictly required for fecundity. In proliferating somatic cells and in germ cells, there are mitotic checkpoint mechanisms that ensure accurate chromosome segregation and euploidy. There is growing evidence of mitotic cell cycle components that are uniquely required in t...

journal_title：Developmental biology

authors： Czechanski A,Kim H,Byers C,Greenstein I,Stumpff J,Reinholdt LG

更新日期：2015-06-15 00:00:00

abstract：:Neuronal circuit development and function require proper synapse formation and maintenance. Genetic screens are one powerful method to identify the mechanisms shaping synaptic development and stability. However, genes with essential roles in non-neural tissues may be missed in traditional loss-of-function screens. In ...

journal_title：Developmental biology

authors： Valakh V,Naylor SA,Berns DS,DiAntonio A

更新日期：2012-06-15 00:00:00

abstract：:The prostate gland develops from the urogenital sinus by a testosterone-dependent process of ductal morphogenesis. Sonic hedgehog (Shh) is expressed in the urogenital sinus epithelium and the time course of expression coincides with the formation of the main prostatic ducts. Expression is most abundant in the lumen of...

journal_title：Developmental biology

authors： Podlasek CA,Barnett DH,Clemens JQ,Bak PM,Bushman W

更新日期：1999-05-01 00:00:00

abstract：:The nucleus of eukaryotic cells is organized into functionally specialized compartments that are essential for the control of gene expression, chromosome architecture and cellular differentiation. The mouse oocyte nucleus or germinal vesicle (GV) exhibits a unique chromatin configuration that is subject to dynamic mod...

journal_title：Developmental biology

authors： De La Fuente R

更新日期：2006-04-01 00:00:00

abstract：:To understand cell interactions during induction of skin appendages, we studied the roles of adhesion molecules N-CAM, tenascin, integrin, and fibronectin during feather development. Tenascin appeared in a periodic pattern on epithelia and was so far the earliest molecule detected in placodes. Three placode domains we...

journal_title：Developmental biology

authors： Jiang TX,Chuong CM

更新日期：1992-03-01 00:00:00

abstract：:Using gene-specific probes derived from four mouse gamma-crystallin cDNAs, we have examined the regulation of different members of the mouse gamma-crystallin gene family during lens development. Our analysis revealed that, while the different gamma-crystallin genes appear to be coordinately activated during embryogene...

journal_title：Developmental biology

authors： Murer-Orlando M,Paterson RC,Lok S,Tsui LC,Breitman ML

更新日期：1987-01-01 00:00:00

abstract：:Similar amounts of expression of a luciferase reporter gene that is driven by the SV40 early promoter are detected in G2 of 1-cell mouse embryo following injection of the male pronucleus in either early or mid/late S. No luciferase activity is observed when the male pronucleus is injected in early S and the embryos an...

journal_title：Developmental biology

authors： Ram PT,Schultz RM

更新日期：1993-04-01 00:00:00

abstract：:The molting cycle in insects is regulated by the fluctuating levels of ecdysteroids. Twenty-four hours prior to the pupal molt in Manduca sexta steroid titers are relatively high and they fall to very low levels at 4 hr before the molt. Several physiological events accompanying molts have been shown to require the ris...

journal_title：Developmental biology

authors： Mészáros M,Morton DB

更新日期：1994-04-01 00:00:00

abstract：:The Foxl1 gene, which encodes a winged helix transcriptional regulator, is expressed in the mesenchymal layer of developing and mature gastrointestinal tract. Foxl1-deficient mice exhibit various defects not only in the epithelial layer of the gastrointestinal tract but also in gut-associated lymphoid tissues. In the ...

journal_title：Developmental biology

authors： Fukuda K,Yoshida H,Sato T,Furumoto TA,Mizutani-Koseki Y,Suzuki Y,Saito Y,Takemori T,Kimura M,Sato H,Taniguchi M,Nishikawa S,Nakayama T,Koseki H

更新日期：2003-03-15 00:00:00

abstract：:TGF-beta (TGFβ) family mediated Smad signaling is involved in mesoderm and endoderm specifications, left-right asymmetry formation and neural tube development. The TGFβ1/2/3 and Activin/Nodal signal transduction cascades culminate with activation of SMAD2 and/or SMAD3 transcription factors and their overactivation are...

journal_title：Developmental biology

authors： Casari A,Schiavone M,Facchinello N,Vettori A,Meyer D,Tiso N,Moro E,Argenton F

更新日期：2014-12-01 00:00:00

abstract：:Immunohistochemical analysis of myosin heavy chain (MHC) isoform expression in perinatal and adult rat diaphragm muscles was performed with antibodies which permitted the identification of all known MHC isoforms found in typical rat muscles. Isoform switching, leading to the emergence of the adult phenotype, was more ...

journal_title：Developmental biology

authors： LaFramboise WA,Daood MJ,Guthrie RD,Schiaffino S,Moretti P,Brozanski B,Ontell MP,Butler-Browne GS,Whalen RG,Ontell M

更新日期：1991-03-01 00:00:00

abstract：:Primitive erythropoiesis is regulated in a non cell-autonomous fashion across evolution from frogs to mammals. In Xenopus laevis, signals from the overlying ectoderm are required to induce the mesoderm to adopt an erythroid fate. Previous studies in our lab identified the transcription factor GATA2 as a key regulator ...

journal_title：Developmental biology

authors： Mimoto MS,Kwon S,Green YS,Goldman D,Christian JL

更新日期：2015-11-01 00:00:00

abstract：:The spermatid nucleus and cytoplasm undergo dramatic morphological modifications during spermatid differentiation into mature sperm. Some of the external force causing this nuclear shaping is generated by a microtubular structure termed the manchette, which attaches to the perinuclear ring of the spermatid. Here, we r...

journal_title：Developmental biology

authors： Tarsounas M,Pearlman RE,Moens PB

更新日期：2001-08-15 00:00:00

abstract：:Lysine methylation of histones is associated with both transcriptionally active chromatin and with silent chromatin, depending on what residue is modified. Histone methyltransferases and demethylases ensure that histone methylations are dynamic and can vary depending on cell cycle- or developmental stage. KDM4A demeth...

journal_title：Developmental biology

authors： Crona F,Dahlberg O,Lundberg LE,Larsson J,Mannervik M

更新日期：2013-01-15 00:00:00

abstract：:These studies examined the potential for reorganization and differentiation of dissociated 18-day fetal rat intestine. Cultures of trypsin-dissociated fetal intestine were maintained in vitro for 1 week on a three-dimensional matrix, then transplanted into syngeneic hosts. When harvested after 4 weeks, these transplan...

journal_title：Developmental biology

authors： Montgomery RK,Zinman HM,Smith BT

更新日期：1983-11-01 00:00:00

abstract：:Ovarian germ cell survival is dependent upon the formation of primordial follicles, which occurs during fetal life in the human. Activin contributes to germ cell proliferation and survival at this time. SMADs2 and 3 are central elements in the activin signalling pathway and thus indicate sites of activin action. We ha...

journal_title：Developmental biology

authors： Coutts SM,Childs AJ,Fulton N,Collins C,Bayne RA,McNeilly AS,Anderson RA

更新日期：2008-02-01 00:00:00

abstract：:A group of proteins judged on several criteria to be yolk proteins have been isolated from a homogenate of the nematode Caenorhabditis elegans. Comparison of partial proteolysis fragments indicates that the two bands of a 170,000-dalton doublet (yp170) are closely related; bands observed at 115,000 daltons (yp115) and...

journal_title：Developmental biology

authors： Sharrock WJ

更新日期：1983-03-01 00:00:00

abstract：:BMP signaling responses are refined by distinct secreted and intracellular antagonists in different cellular and temporal contexts. Here, we show that the nuclear LEM-domain protein MAN1 is a tissue-specific antagonist of BMP signaling in Drosophila. MAN1 contains two potential Mad-binding sites. We generated MAN1Delt...

journal_title：Developmental biology

authors： Wagner N,Weyhersmüller A,Blauth A,Schuhmann T,Heckmann M,Krohne G,Samakovlis C

更新日期：2010-03-01 00:00:00

abstract：:Expression of cardiac troponin I (TnIcardiac) and slow skeletal troponin I (TnIslow) genes was analyzed at the mRNA and protein level in the developing rat heart. TnIslow mRNA was detectable by in situ hybridization in the embryonic cardiac tube as early as the 13-somite stage (Embryonic Day 10). In contrast, TnIcardi...

journal_title：Developmental biology

authors： Gorza L,Ausoni S,Merciai N,Hastings KE,Schiaffino S

更新日期：1993-03-01 00:00:00

abstract：:Formation of the adenohypophysis in mammalian embryos occurs via an invagination of the oral ectoderm to form Rathke's pouch, which becomes exposed to opposing dorsoventral gradients of signaling proteins governing specification of the different hormone-producing pituitary cell types. One signal promoting pituitary ce...

journal_title：Developmental biology

authors： Herzog W,Zeng X,Lele Z,Sonntag C,Ting JW,Chang CY,Hammerschmidt M

更新日期：2003-02-01 00:00:00

abstract：:The germinal vesicle (GV) of starfish oocytes stays just beneath the oocyte cortex at the presumptive animal pole during the long period of oogenesis. We subjected oocytes to a centrifugal force field to detach the GV from the cortex. The association between the cortex and the GV persisted and withstood a small amount...

journal_title：Developmental biology

authors： Miyazaki A,Kamitsubo E,Nemoto SI

更新日期：2000-02-15 00:00:00

abstract：:Skeletal muscle fibers express members of the myosin heavy chain (MyHC) gene family in a fiber-type-specific manner. In avian skeletal muscle it is the expression of the slow MyHC isoforms that most clearly distinguishes slow- from fast-contracting fiber types. Two hypotheses have been proposed to explain fiber-type-s...

journal_title：Developmental biology

authors： DiMario JX,Stockdale FE

更新日期：1997-08-01 00:00:00

abstract：:In the developing retina, as in other regions of the CNS, neural progenitors give rise to individual cell types during discrete temporal windows. Pax6 is expressed in retinal progenitor cells (RPCs) throughout the course of retinogenesis, and has been shown to be required during early retinogenesis for generation of m...

journal_title：Developmental biology

authors： Remez LA,Onishi A,Menuchin-Lasowski Y,Biran A,Blackshaw S,Wahlin KJ,Zack DJ,Ashery-Padan R

更新日期：2017-12-01 00:00:00

abstract：:Kidney development is a complex, little understood process based on inductive interactions and intricate epithelial and mesenchymal morphogenesis. Here, we report the use of subtractive hybridization to clone cDNAs expressed in early nephrogenesis. cDNA made from E14.5 mouse kidney was hybridized with adult mouse live...

journal_title：Developmental biology

authors： McConnell JE,Armstrong JF,Hodges PE,Bard JB

更新日期：1995-05-01 00:00:00

abstract：:During digit development, the correct balance of chondrogenic signals ensures the recruitment of undifferentiated cells into the cartilage lineage or the maintenance of cells at the undifferentiated stage. WNT/β catenin maintains the pool of progenitor cells, whereas TGFβ signalling promotes cartilage differentiation ...

journal_title：Developmental biology

authors： Farrera-Hernández A,Marín-Llera JC,Chimal-Monroy J

更新日期：2021-01-01 00:00:00

abstract：:Wnt signaling pathways have been demonstrated to play important roles in controlling tissue patterning and cell proliferation. In the gastrointestinal tract, mutations that lead to activation of the canonical Wnt pathway through beta-catenin result in familial and sporadic colon cancers. The downstream transcription f...

journal_title：Developmental biology

authors： Theodosiou NA,Tabin CJ

更新日期：2003-07-15 00:00:00

abstract：:The dorsal-ventral axis of the Xenopus embryo is approximately determined by the point of sperm entry, which occurs randomly about the animal-vegetal axis of the egg. Two cytoplasmic components were studied whose spatial arrangements and local concentration patterns appear to reflect the forming dorsal-ventral axis. F...

journal_title：Developmental biology

authors： Phillips CR

更新日期：1985-06-01 00:00:00

abstract：:We have identified zebrafish orthologues of glial cell line-derived neurotrophic factor (GDNF) and the ligand-binding component of its receptor GFRalpha1. We examined the mRNA expression pattern of these genes in the developing spinal cord primary motor neurons (PMN), kidney, and enteric nervous systems (ENS) and have...

journal_title：Developmental biology

authors： Shepherd IT,Beattie CE,Raible DW

更新日期：2001-03-15 00:00:00

abstract：:Fertilization-related sperm mitochondrial movement occurs at a rate comparable to other actin-myosin-driven movements and is inhibited by cytochalasin B and N-ethyl maleimide in Ascidia ceratodes sperm. F-actin was demonstrated in the tails and mitochondria using NBD-phallacidin fluorescence. Both actin and myosin wer...

journal_title：Developmental biology

authors： Lambert CC,Lambert G

更新日期：1984-12-01 00:00:00