Abstract：
:To understand cell interactions during induction of skin appendages, we studied the roles of adhesion molecules N-CAM, tenascin, integrin, and fibronectin during feather development. Tenascin appeared in a periodic pattern on epithelia and was so far the earliest molecule detected in placodes. Three placode domains were identified: the anterior was positive for tenascin, the distal positive for N-CAM, and the posterior lacking both. Integrin appeared in dermal-epidermal junctions of placodes. In feather buds, sagittal sections revealed a transient anterior-posterior asymmetry with tenascin and N-CAM enriched in the anterior mesoderm. Tangential sections revealed a lateral-medial asymmetry with tenascin distributed in a ring shape and N-CAM in an "X" shape. Integrin was diffusely distributed within buds. Later tenascin and N-CAM were enriched in dermal papilla, the inducer of skin appendages. Perturbation of embryonic skin explant cultures with antibodies showed that anti-integrin beta 1 and anti-fibronectin blocked epithelial-mesenchymal interaction, anti-N-CAM caused uneven segregation of mesenchymal condensation, and anti-tenascin inhibited feather bud elongation. Dose-response curves showed gradual effects by these antibodies. The results indicated that these adhesion molecules are independently regulated and each contributes in different phases during morphogenesis of skin appendages.
journal_name
Dev Bioljournal_title
Developmental biologyauthors
Jiang TX,Chuong CMdoi
10.1016/0012-1606(92)90009-6subject
Has Abstractpub_date
1992-03-01 00:00:00pages
82-98issue
1eissn
0012-1606issn
1095-564Xpii
0012-1606(92)90009-6journal_volume
150pub_type
杂志文章abstract：:Bone development is dependent on the functionality of three essential cell types: chondrocytes, osteoclasts and osteoblasts. If any of these cell types is dysfunctional, a developmental bone phenotype can result. The bone disease osteopetrosis is caused by osteoclast dysfunction or impaired osteoclastogenesis, leading...
journal_title：Developmental biology
pub_type： 杂志文章
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更新日期：2010-08-15 00:00:00
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journal_title：Developmental biology
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journal_title：Developmental biology
pub_type： 杂志文章
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更新日期：1996-02-25 00:00:00
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pub_type： 杂志文章
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更新日期：2005-07-01 00:00:00
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更新日期：1990-12-01 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Developmental biology
pub_type： 杂志文章
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更新日期：2014-12-15 00:00:00
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pub_type： 杂志文章
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journal_title：Developmental biology
pub_type： 杂志文章
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journal_title：Developmental biology
pub_type： 杂志文章
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更新日期：2004-02-15 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章
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更新日期：1996-01-10 00:00:00
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更新日期：2015-12-01 00:00:00
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pub_type： 杂志文章
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更新日期：1984-02-01 00:00:00
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pub_type： 杂志文章
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journal_title：Developmental biology
pub_type： 杂志文章
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更新日期：2017-09-01 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章
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更新日期：1992-05-01 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章
doi：
更新日期：1996-09-15 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章
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更新日期：1985-03-01 00:00:00
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journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/0012-1606(83)90178-1
更新日期：1983-04-01 00:00:00
abstract：:Primary cilia are located at the dendritic tips of sensory neurons and house the molecular machinery necessary for detection and transduction of sensory stimuli. The mechanisms that coordinate dendrite extension with cilium position during sensory neuron development are not well understood. Here, we show that GRDN-1, ...
journal_title：Developmental biology
pub_type： 杂志文章
doi：10.1016/j.ydbio.2020.12.022
更新日期：2021-01-16 00:00:00
