当前位置： SCI文献检索 > DEVELOPMENTAL BIOLOGY期刊下所有文献 > Mesenchymal expression of Foxl1, a winged helix transcriptional factor, regulates generation and maintenance of gut-associated lymphoid organs.

Mesenchymal expression of Foxl1, a winged helix transcriptional factor, regulates generation and maintenance of gut-associated lymphoid organs.

Abstract：

:The Foxl1 gene, which encodes a winged helix transcriptional regulator, is expressed in the mesenchymal layer of developing and mature gastrointestinal tract. Foxl1-deficient mice exhibit various defects not only in the epithelial layer of the gastrointestinal tract but also in gut-associated lymphoid tissues. In the small intestine of Foxl1-deficient mice, the formation of Peyer's patches is affected, particularly in the caudal region. This alteration is shown to be due to the delayed formation of Peyer's patches organizing centers as revealed by the expressions of VCAM1 and IL-7 receptor alpha-chain at 17.5 days postcoitus. Peyer's patch defects are concordant with the significantly decreased expression of Lymphotoxin beta-receptor in the caudal region of fetal intestine. Foxl1 is suggested to regulate the responsiveness of fetal intestinal mesenchymal cells to inductive signals mediated by Lymphotoxins during Peyer's patch organogenesis. In addition, constitutive outgrowth of colonic patches due to defects in radioresistant stromal components of colonic patches are seen in Foxl1-deficient mice. Because of the functional similarities of hypertrophic colonic patches to those seen in hapten-induced experimental colitis, this hypertrophy is suggested to involve Lymphotoxin beta-receptor signaling. Together, the data suggest that Foxl1 might be involved in cellular responses of gut-associated lymphoid tissues dependent upon the Lymphotoxins/Lymphotoxin beta-receptor axis.

journal_name

Dev Biol

journal_title

Developmental biology

authors

Fukuda K,Yoshida H,Sato T,Furumoto TA,Mizutani-Koseki Y,Suzuki Y,Saito Y,Takemori T,Kimura M,Sato H,Taniguchi M,Nishikawa S,Nakayama T,Koseki H

doi

10.1016/s0012-1606(02)00088-x

subject

Has Abstract

pub_date

2003-03-15 00:00:00

pages

278-89

issue

2

eissn

0012-1606

issn

1095-564X

pii

S001216060200088X

journal_volume

255

pub_type

杂志文章

相关文献

DEVELOPMENTAL BIOLOGY文献大全
  • Comparative transcriptional profiling and evolutionary analysis of the GRAM domain family in eukaryotes.

    abstract：:The GRAM domain was found in glucosyltransferases, myotubularins and other membrane-associated proteins. So far, functions for majority of these proteins are yet to be uncovered. In order to address the evolutionary and functional significance of this family members, we have performed a comprehensive investigation on ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2007.11.031

    authors： Jiang SY,Ramamoorthy R,Ramachandran S

    更新日期：2008-02-15 00:00:00

  • string(cdc25) and cyclin E are required for patterned histone expression at different stages of Drosophila embryonic development.

    abstract：:Metazoan replication-dependent histone mRNAs accumulate to high levels during S phase as a result of an increase in the rate of histone gene transcription, pre-mRNA processing, and mRNA stability at the G1-S transition. However, relatively little is known about the contribution of these processes to histone expression...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2004.06.019

    authors： Lanzotti DJ,Kupsco JM,Marzluff WF,Duronio RJ

    更新日期：2004-10-01 00:00:00

  • Expression of Patella vulgata orthologs of engrailed and dpp-BMP2/4 in adjacent domains during molluscan shell development suggests a conserved compartment boundary mechanism.

    abstract：:The engrailed gene is well known from its role in segmentation and central nervous system development in a variety of species. In molluscs, however, engrailed is involved in shell formation. So far, it seemed that engrailed had been co-opted uniquely for this particular process in molluscs. Here, we show that, in the ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.2002.0653

    authors： Nederbragt AJ,van Loon AE,Dictus WJ

    更新日期：2002-06-15 00:00:00

  • Multi-scale regulation of cell branching: Modeling morphogenesis.

    abstract：:Plant growth and development are driven by extended phases of irreversible cell expansion generating cells that increase in volume from 10- to 100-fold. Some specialized cell types define cortical sites that reinitiate polarized growth and generate branched cell morphology. This structural specialization of individual...

    journal_title：Developmental biology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ydbio.2018.12.004

    authors： Li J,Kim T,Szymanski DB

    更新日期：2019-07-01 00:00:00

  • MEMO1 drives cranial endochondral ossification and palatogenesis.

    abstract：:The cranial base is a component of the neurocranium and has a central role in the structural integration of the face, brain and vertebral column. Consequently, alteration in the shape of the human cranial base has been intimately linked with primate evolution and defective development is associated with numerous human...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2015.12.024

    authors： Van Otterloo E,Feng W,Jones KL,Hynes NE,Clouthier DE,Niswander L,Williams T

    更新日期：2016-07-15 00:00:00

  • Evidence for engrailed-independent wingless autoregulation in Drosophila.

    abstract：:Proper spatial expression of the wingless (wg) gene in the Drosophila embryonic epidermis is crucial to intrasegmental patterning. Single cell wide wg expression is initiated at the blastoderm stage in response to combinatorial regulation by the pair rule genes. Later, during gastrulation, when the epidermal expressio...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1995.1243

    authors： Yoffe KB,Manoukian AS,Wilder EL,Brand AH,Perrimon N

    更新日期：1995-08-01 00:00:00

  • MGL-1 on AIY neurons translates starvation to reproductive plasticity via neuropeptide signaling in Caenorhabditis elegans.

    abstract：:Reproductive plasticity is the ability of an animal to modulate its reproductive functions in response to environmental changes. For example, Caenorhabditis elegans, a free-living nematode, can adjust the onsets of oogenesis and embryogenesis under harsh environmental conditions, including starvation. However, the mol...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2017.08.014

    authors： Jeong H,Paik YK

    更新日期：2017-10-01 00:00:00

  • The competence of Xenopus blastomeres to produce neural and retinal progeny is repressed by two endo-mesoderm promoting pathways.

    abstract：:Only a subset of cleavage stage blastomeres in the Xenopus embryo is competent to contribute cells to the retina; ventral vegetal blastomeres do not form retina even when provided with neuralizing factors or transplanted to the most retinogenic position of the embryo. These results suggest that endogenous maternal fac...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2007.01.040

    authors： Yan B,Moody SA

    更新日期：2007-05-01 00:00:00

  • Developmental ablation of Id1 and Id3 genes in the vasculature leads to postnatal cardiac phenotypes.

    abstract：:The Id1 and Id3 genes play major roles during cardiac development, despite their expression being confined to non-myocardial layers (endocardium-endothelium-epicardium). We previously described that Id1Id3 double knockout (dKO) mouse embryos die at mid-gestation from multiple cardiac defects, but early lethality precl...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2010.10.004

    authors： Zhao Q,Beck AJ,Vitale JM,Schneider JS,Gao S,Chang C,Elson G,Leibovich SJ,Park JY,Tian B,Nam HS,Fraidenraich D

    更新日期：2011-01-01 00:00:00

  • The delayed entry of thoracic neural crest cells into the dorsolateral path is a consequence of the late emigration of melanogenic neural crest cells from the neural tube.

    abstract：:Neural crest cells migrate along two pathways in the trunk: the ventral path, between the neural tube and somite, and the dorsolateral path, between the somite and overlying ectoderm. In avian embryos, ventral migration precedes dorsolateral migration by nearly 24 h, and the onset of dorsolateral migration coincides w...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1998.8963

    authors： Reedy MV,Faraco CD,Erickson CA

    更新日期：1998-08-15 00:00:00

  • Scalloped a member of the Hippo tumor suppressor pathway controls mushroom body size in Drosophila brain by non-canonical regulation of neuroblast proliferation.

    abstract：:Cell proliferation, growth and survival are three different basic processes which converge at determining a fundamental property -the size of an organism. Scalloped (Sd) is the first characterised transcriptional partner to Yorkie (Yki), the downstream effector of the Hippo pathway which is a highly potential and evol...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2017.10.016

    authors： Rohith BN,Shyamala BV

    更新日期：2017-12-15 00:00:00

  • Notch signaling during larval and juvenile development in the polychaete annelid Capitella sp. I.

    abstract：:Notch signaling is involved in a large range of developmental processes, and has been functionally implicated in body plan segmentation in two of the three diverse segmented taxa, the vertebrates and arthropods. Here we investigate expression of Notch, Delta, and hes gene homologues during larval and juvenile developm...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2008.04.015

    authors： Thamm K,Seaver EC

    更新日期：2008-08-01 00:00:00

  • Novel gain-of-function alleles demonstrate a role for the heterochronic gene lin-41 in C. elegans male tail tip morphogenesis.

    abstract：:To gain an understanding of the genes and mechanisms that govern morphogenesis and its evolution, we have analyzed mutations that disrupt this process in a simple model structure, the male tail tip of the rhabditid nematode C. elegans. During the evolution of rhabditid male tails, there have been several independent c...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2006.04.472

    authors： Del Rio-Albrechtsen T,Kiontke K,Chiou SY,Fitch DH

    更新日期：2006-09-01 00:00:00

  • Ascidian notochord elongation.

    abstract：:The elongation of embryo and tissue is a key morphogenetic event in embryogenesis and organogenesis. Notochord, a typical chordate organ, undergoes elongation to perform its regulatory roles and to form the structural support in the embryo. Notochord elongation is morphologically similar across all chordates, but asci...

    journal_title：Developmental biology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ydbio.2018.11.009

    authors： Lu Q,Bhattachan P,Dong B

    更新日期：2019-04-15 00:00:00

  • Defective development of the embryonic liver in N-myc-deficient mice.

    abstract：:The mechanisms involved in the formation and the differentiation of the liver remain unclear despite extensive studies. To investigate these events in mouse hepatic development, we have taken advantage of the N-myc mutant mouse line which exhibits abnormal liver development. N-myc mutant embryos die between 11.5 and 1...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1997.8823

    authors： Giroux S,Charron J

    更新日期：1998-03-01 00:00:00

  • Distinct populations of endoderm cells converge to generate the embryonic liver bud and ventral foregut tissues.

    abstract：:The location and movement of mammalian gut tissue progenitors, prior to the expression of tissue-specific genes, has been unknown, but this knowledge is essential to identify transitions that lead to cell type specification. To address this, we used vital dyes to label exposed anterior endoderm cells of early somite s...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2005.01.003

    authors： Tremblay KD,Zaret KS

    更新日期：2005-04-01 00:00:00

  • Ap-let neurons--a peptidergic circuit potentially controlling ecdysial behavior in Drosophila.

    abstract：:Here we describe a novel set of peptidergic neurons conserved throughout all developmental stages in the Drosophila central nervous system (CNS). We show that a small complement of 28 apterous-expressing cells (Ap-let neurons) in the ventral nerve cord (VNC) of Drosophila larvae co-express numerous gene products. The ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2004.01.015

    authors： Park D,Han M,Kim YC,Han KA,Taghert PH

    更新日期：2004-05-01 00:00:00

  • An overlapping CArG/octamer element is required for regulation of desmin gene transcription in arterial smooth muscle cells.

    abstract：:The desmin gene encodes an intermediate filament protein that is present in skeletal, cardiac, and smooth muscle cells. This study shows that the 4-kb upstream region of the murine desmin promoter directs expression of a lacZ reporter gene throughout the heart from E7.5 and in skeletal muscle and vascular smooth muscl...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.2000.9865

    authors： Mericskay M,Parlakian A,Porteu A,Dandré F,Bonnet J,Paulin D,Li Z

    更新日期：2000-10-15 00:00:00

  • Keratin 10 gene expression during differentiation of mouse epidermis requires transcription factors C/EBP and AP-2.

    abstract：:The epidermis forms a vital barrier composed of stratified keratinocytes and their differentiated products. One of these products, keratin K10, is critical to epidermal integrity, because mutations in k10 lead to abnormal blistering. For the normal expression of k10, differentiation-associated transcription factors C/...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1999.9460

    authors： Maytin EV,Lin JC,Krishnamurthy R,Batchvarova N,Ron D,Mitchell PJ,Habener JF

    更新日期：1999-12-01 00:00:00

  • Essential mesenchymal role of small GTPase Rac1 in interdigital programmed cell death during limb development.

    abstract：:Developing vertebrate limbs are often utilized as a model for studying pattern formation and morphogenetic cell death. Herein, we report that conditional deletion of Rac1, a member of the Rho family of proteins, in mouse limb bud mesenchyme led to skeletal deformities in the autopod and soft tissue syndactyly, with th...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2009.09.014

    authors： Suzuki D,Yamada A,Amano T,Yasuhara R,Kimura A,Sakahara M,Tsumaki N,Takeda S,Tamura M,Nakamura M,Wada N,Nohno T,Shiroishi T,Aiba A,Kamijo R

    更新日期：2009-11-15 00:00:00

  • The development of the pattern of innervation in chicken hindlimb muscles: evidence for specification of nerve-muscle connections.

    abstract：:The pattern of innervation in 13 chicken hindlimb muscles was studied at various stages of development in order to examine the mechanisms which regulate its formation. The pattern of innervation was visualized by examining the distribution of fiber types within each muscle. It was found that the fiber type which a myo...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(83)90080-5

    authors： McLennan IS

    更新日期：1983-05-01 00:00:00

  • Regulatory elements controlling Ci-msxb tissue-specific expression during Ciona intestinalis embryonic development.

    abstract：:The msh/Msx family is a subclass of homeobox-containing genes suggested to perform a conserved function in the patterning of the early embryo. We had already isolated a member of this gene family (Ci-msxb) in Ciona intestinalis, which has a very complex expression pattern during embryogenesis. To identify the regulato...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2003.11.005

    authors： Russo MT,Donizetti A,Locascio A,D'Aniello S,Amoroso A,Aniello F,Fucci L,Branno M

    更新日期：2004-03-15 00:00:00

  • Modulation of AP and DV signaling pathways by the homeotic gene Ultrabithorax during haltere development in Drosophila.

    abstract：:Suppression of wing fate and specification of haltere fate in Drosophila by the homeotic gene Ultrabithorax is a classical example of Hox regulation of serial homology (Lewis, E.B. 1978. Nature 276, 565-570) and has served as a paradigm for understanding homeotic gene function. We have used DNA microarray analyses to ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2005.12.022

    authors： Mohit P,Makhijani K,Madhavi MB,Bharathi V,Lal A,Sirdesai G,Reddy VR,Ramesh P,Kannan R,Dhawan J,Shashidhara LS

    更新日期：2006-03-15 00:00:00

  • Development and tissue origins of the mammalian cranial base.

    abstract：:The vertebrate cranial base is a complex structure composed of bone, cartilage and other connective tissues underlying the brain; it is intimately connected with development of the face and cranial vault. Despite its central importance in craniofacial development, morphogenesis and tissue origins of the cranial base h...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2008.07.016

    authors： McBratney-Owen B,Iseki S,Bamforth SD,Olsen BR,Morriss-Kay GM

    更新日期：2008-10-01 00:00:00

  • Activation of pmar1 controls specification of micromeres in the sea urchin embryo.

    abstract：:pmar1 is a transcription factor in the paired class homeodomain family that was identified and found to be transcribed in micromeres beginning at the fourth cleavage of sea urchin development [Dev. Biol. 246 (2002), 209]. Based on in situ data, molecular perturbation studies, and QPCR data, the recently published gene...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/s0012-1606(03)00108-8

    authors： Oliveri P,Davidson EH,McClay DR

    更新日期：2003-06-01 00:00:00

  • Stimulation of tentacle and bud formation by the neuropeptide head activator in Hydra magnipapillata.

    abstract：:Stimulation of epithelial cell cycling by the neuropeptide head activator was analyzed in Hydra magnipapillata and compared with the action of head activator on bud formation and tentacle formation during head regeneration. The results obtained indicate that head activator treatment stimulates epithelial cell division...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1996.8491

    authors： Hobmayer B,Holstein TW,David CN

    更新日期：1997-03-01 00:00:00

  • GATA4 mediates gene repression in the mature mouse small intestine through interactions with friend of GATA (FOG) cofactors.

    abstract：:GATA4, a transcription factor expressed in the proximal small intestine but not in the distal ileum, maintains proximal-distal distinctions by multiple processes involving gene repression, gene activation, and cell fate determination. Friend of GATA (FOG) is an evolutionarily conserved family of cofactors whose member...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2008.07.022

    authors： Beuling E,Bosse T,aan de Kerk DJ,Piaseckyj CM,Fujiwara Y,Katz SG,Orkin SH,Grand RJ,Krasinski SD

    更新日期：2008-10-01 00:00:00

  • p53-mediated germ cell quality control in spermatogenesis.

    abstract：:Spontaneous germ cell death is a common cellular process in the mammalian testis, although the function of this process during spermatogenesis is unclear. An investigation was undertaken to determine whether p53 serves as a mechanism in germ cell quality control by causing spontaneous germ cell death. Using an annexin...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1998.9074

    authors： Yin Y,Stahl BC,DeWolf WC,Morgentaler A

    更新日期：1998-12-01 00:00:00

  • At the base of colinear Hox gene expression: cis-features and trans-factors orchestrating the initial phase of Hox cluster activation.

    abstract：:Hox genes are crucial players in the generation and pattering of the vertebrate trunk and posterior body during embryogenesis. Their initial expression takes place shortly after the establishment of the primitive streak, in the posterior-most part of the mouse embryo and is a determinant step for setting up the defini...

    journal_title：Developmental biology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ydbio.2017.02.009

    authors： Neijts R,Deschamps J

    更新日期：2017-08-15 00:00:00

  • Targeted disruption of the cardiac troponin T gene causes sarcomere disassembly and defects in heartbeat within the early mouse embryo.

    abstract：:Cardiac troponin T (cTnT) is a component of the troponin (Tn) complex in cardiac myocytes, and plays a regulatory role in cardiac muscle contraction by anchoring two other Tn components, troponin I (TnI) and troponin C, to tropomyosin (Tm) on the thin filaments. In order to determine the in vivo function of cTnT, we c...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2008.07.007

    authors： Nishii K,Morimoto S,Minakami R,Miyano Y,Hashizume K,Ohta M,Zhan DY,Lu QW,Shibata Y

    更新日期：2008-10-01 00:00:00