当前位置： SCI文献检索 > DEVELOPMENTAL BIOLOGY期刊下所有文献 > Scalloped a member of the Hippo tumor suppressor pathway controls mushroom body size in Drosophila brain by non-canonical regulation of neuroblast proliferation.

Scalloped a member of the Hippo tumor suppressor pathway controls mushroom body size in Drosophila brain by non-canonical regulation of neuroblast proliferation.

Abstract：

:Cell proliferation, growth and survival are three different basic processes which converge at determining a fundamental property -the size of an organism. Scalloped (Sd) is the first characterised transcriptional partner to Yorkie (Yki), the downstream effector of the Hippo pathway which is a highly potential and evolutionarily conserved regulator of organ size. Here we have studied the hypomorphic effect of sd on the development of Mushroom Bodies (MBs) in Drosophila brain. We show that, sd non-function results in an increase in the size of MBs. We demonstrate that, sd regulation on MB size operates through multiple routes. Sd expressed in the differentiated MB neurons, imposes non-cell autonomous repression on the proliferation of MB precursor cells, and Sd expression in the MB neuroblasts (NB) cell autonomously represses mushroom body neuroblast (MBNB) proliferation. Further Sd in Kenyon cells (KCs) imparts a cell autonomous restriction on their growth. Our findings are distinctive because, while the classical sd loss of function phenotypes in eye, wing and lymph gland are reported as loss of tissue or reduced organ size, the present study shows that, Sd inactivation in the developing MB, promotes precursor cell proliferation and results in an increase in the organ size.

journal_name

Dev Biol

journal_title

Developmental biology

authors

Rohith BN,Shyamala BV

doi

10.1016/j.ydbio.2017.10.016

subject

Has Abstract

pub_date

2017-12-15 00:00:00

pages

203-214

issue

2

eissn

0012-1606

issn

1095-564X

pii

S0012-1606(17)30266-X

journal_volume

432

pub_type

杂志文章

相关文献

DEVELOPMENTAL BIOLOGY文献大全
  • MEMO1 drives cranial endochondral ossification and palatogenesis.

    abstract：:The cranial base is a component of the neurocranium and has a central role in the structural integration of the face, brain and vertebral column. Consequently, alteration in the shape of the human cranial base has been intimately linked with primate evolution and defective development is associated with numerous human...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2015.12.024

    authors： Van Otterloo E,Feng W,Jones KL,Hynes NE,Clouthier DE,Niswander L,Williams T

    更新日期：2016-07-15 00:00:00

  • Cell migration and activated PI3K/AKT-directed elongation in the developing rat Müllerian duct.

    abstract：:In vertebrates, the Müllerian duct elongates along the Wolffian duct, a mesonephric structure that is required for Müllerian duct formation. Recently, several genes required for initial Müllerian duct formation have been identified. However, the precise mechanism of Müllerian duct elongation remains to be elucidated. ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2008.10.027

    authors： Fujino A,Arango NA,Zhan Y,Manganaro TF,Li X,MacLaughlin DT,Donahoe PK

    更新日期：2009-01-15 00:00:00

  • Developmental timing of a sensory-mediated larval surfacing behavior correlates with cessation of feeding and determination of final adult size.

    abstract：:Controlled organismal growth to an appropriate adult size requires a regulated balance between nutrient resources, feeding behavior and growth rate. Defects can result in decreased survival and/or reproductive capability. Since Drosophila adults do not grow larger after eclosion, timing of feeding cessation during the...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2010.07.004

    authors： Wegman LJ,Ainsley JA,Johnson WA

    更新日期：2010-09-15 00:00:00

  • Signal transduction pathways leading to spore differentiation in Dictyostelium discoideum.

    abstract：:Cells that overexpress PKA as a consequence of carrying multiple copies of the gene encoding the catalytic subunit can be induced to sporulate when developing as single cells. A peptide phosphorylated by PKA, termed SDF-1, has recently been shown to stimulate this process (Anjard et al., 1997). Several genes have been...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1997.8804

    authors： Anjard C,Zeng C,Loomis WF,Nellen W

    更新日期：1998-01-15 00:00:00

  • The effect of back-transplants of the embryonic gut wall on growth of the neural tube.

    abstract：:Experiments in which the developing gut of avian embryos was back-transplanted to permit the bowel to interact with the developing neural tube were undertaken. Segments of intestine from 4-day quail embryos were implanted between the somites and neural tubes of chick embryos of 7 to 24 somites. The spinal cord respond...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(87)90486-6

    authors： Rothman TP,Gershon MD,Fontaine-Pérus JC,Chanconie M,Le Douarin NM

    更新日期：1987-12-01 00:00:00

  • Molecular patterning of the embryonic cranial mesenchyme revealed by genome-wide transcriptional profiling.

    abstract：:In the head of an embryo, a layer of mesenchyme surrounds the brain underneath the surface ectoderm. This cranial mesenchyme gives rise to the meninges, the calvaria (top part of the skull), and the dermis of the scalp. Abnormal development of these structures, especially the meninges and the calvaria, is linked to si...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2019.07.015

    authors： Dasgupta K,Chung JU,Asam K,Jeong J

    更新日期：2019-11-15 00:00:00

  • Cell division in the ciliary ganglion of quail embryos in situ and after back-transplantation into the neural crest migration pathways of chick embryos.

    abstract：:Embryonic 4- to 15-day-old quail ciliary ganglia (CG) were grafted into the neural crest migration pathway of 2-day-old chick embryos at the adrenomedullary level of the neural axis. This back-transplantation results in dispersion of cells of the implanted ganglion, their migration in the host embryo, and subsequent p...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(84)90286-0

    authors： Dupin E

    更新日期：1984-10-01 00:00:00

  • Cloning and characterization of chicken Paraxis: a regulator of paraxial mesoderm development and somite formation.

    abstract：:To investigate the molecular regulation of embryonic somite formation and development, we have cloned the full-length cDNA and characterized the embryonic expression profile of chicken Paraxis, a member of a novel family of basic helix-loop-helix (bHLH) proteins, which has been suggested to play a role in paraxial mes...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1997.8663

    authors： Barnes GL,Alexander PG,Hsu CW,Mariani BD,Tuan RS

    更新日期：1997-09-01 00:00:00

  • Epithelial-mesenchymal interactions in the outgrowth of limb buds and facial primordia in chick embryos.

    abstract：:The facial primordia in the chick embryo begin as rounded swellings that surround the primitive mouth and these grow out to form the beak. The control of proximodistal outgrowth is not well understood but may involve similar mechanisms to the limb bud. In order to test this hypothesis, combinations were made between e...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(92)90069-s

    authors： Richman JM,Tickle C

    更新日期：1992-12-01 00:00:00

  • Increase in intracellular cAMP is a prerequisite signal for initiation of physiological oocyte meiotic maturation in the hydrozoan Cytaeis uchidae.

    abstract：:In medusae of the hydrozoan Cytaeis uchidae, oocyte meiotic maturation and spawning occur as a consequence of dark-light transition. In this study, we investigated the mechanism underlying the initiation of meiotic maturation using in vitro (isolated oocytes from ovaries) and in vivo (ovarian oocytes in medusae) syste...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2006.06.034

    authors： Takeda N,Kyozuka K,Deguchi R

    更新日期：2006-10-01 00:00:00

  • Differential actions of VEGF-A isoforms on perichondrial angiogenesis during endochondral bone formation.

    abstract：:During endochondral bone formation, vascular invasion initiates the replacement of avascular cartilage by bone. We demonstrate herein that the cartilage-specific overexpression of VEGF-A(164) in mice results in the hypervascularization of soft connective tissues away from cartilage. Unexpectedly, perichondrial tissue ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2009.05.552

    authors： Takimoto A,Nishizaki Y,Hiraki Y,Shukunami C

    更新日期：2009-08-15 00:00:00

  • Distinct functions of the leucine-rich repeat transmembrane proteins capricious and tartan in the Drosophila tracheal morphogenesis.

    abstract：:A key step in organogenesis of the Drosophila tracheal system is the integration of isolated tracheal metameres into a connected tubular network. The interaction of tracheal cells with surrounding mesodermal cells is crucial in this process. In particular, single mesodermal cells called bridge-cells are essential for ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2006.04.462

    authors： Krause C,Wolf C,Hemphälä J,Samakovlis C,Schuh R

    更新日期：2006-08-01 00:00:00

  • The anterior visceral endoderm of the mouse embryo is established from both preimplantation precursor cells and by de novo gene expression after implantation.

    abstract：:Initiation of the development of the anterior-posterior axis in the mouse embryo has been thought to take place only when the anterior visceral endoderm (AVE) emerges and starts its asymmetric migration. However, expression of Lefty1, a marker of the AVE, was recently found to initiate before embryo implantation. This...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2007.06.020

    authors： Torres-Padilla ME,Richardson L,Kolasinska P,Meilhac SM,Luetke-Eversloh MV,Zernicka-Goetz M

    更新日期：2007-09-01 00:00:00

  • Trophoblast stem cells differentiate in vitro into invasive trophoblast giant cells.

    abstract：:Trophoblast cells are characterized by an invasive behavior into the surrounding uterine tissue. In rodents, an early peri-/endovascular type of invasion exerted by trophoblast giant cells can be distinguished from a late interstitial type carried out by glycogen trophoblast cells. Analysis of the molecular mechanisms...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2004.03.040

    authors： Hemberger M,Hughes M,Cross JC

    更新日期：2004-07-15 00:00:00

  • Spermatogonia-dependent expression of testicular genes in mice.

    abstract：:Spermatogenesis is initiated by the interaction of germ cells and somatic cells in seminiferous tubules. We used cDNA microarrays and representational difference analysis to identify genes that are expressed in the testis of the jsd/jsd mutant mouse, which contains only type A spermatogonial germ cells and Sertoli cel...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.2002.0671

    authors： Tanaka K,Tamura H,Tanaka H,Katoh M,Futamata Y,Seki N,Nishimune Y,Hara T

    更新日期：2002-06-15 00:00:00

  • Emergence of the mature myosin phenotype in the rat diaphragm muscle.

    abstract：:Immunohistochemical analysis of myosin heavy chain (MHC) isoform expression in perinatal and adult rat diaphragm muscles was performed with antibodies which permitted the identification of all known MHC isoforms found in typical rat muscles. Isoform switching, leading to the emergence of the adult phenotype, was more ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(91)90473-g

    authors： LaFramboise WA,Daood MJ,Guthrie RD,Schiaffino S,Moretti P,Brozanski B,Ontell MP,Butler-Browne GS,Whalen RG,Ontell M

    更新日期：1991-03-01 00:00:00

  • The nucleolar GTP-binding proteins Gnl2 and nucleostemin are required for retinal neurogenesis in developing zebrafish.

    abstract：:Nucleostemin (NS), a member of a family of nucleolar GTP-binding proteins, is highly expressed in proliferating cells such as stem and cancer cells and is involved in the control of cell cycle progression. Both depletion and overexpression of NS result in stabilization of the tumor suppressor p53 protein in vitro. Alt...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2011.04.028

    authors： Paridaen JT,Janson E,Utami KH,Pereboom TC,Essers PB,van Rooijen C,Zivkovic D,MacInnes AW

    更新日期：2011-07-15 00:00:00

  • Roles of growth hormone and insulin-like growth factor 1 in mouse postnatal growth.

    abstract：:To examine the relationship between growth hormone (GH) and insulin-like growth factor 1 (IGF1) in controlling postnatal growth, we performed a comparative analysis of dwarfing phenotypes manifested in mouse mutants lacking GH receptor, IGF1, or both. This genetic study has provided conclusive evidence demonstrating t...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.2000.9975

    authors： Lupu F,Terwilliger JD,Lee K,Segre GV,Efstratiadis A

    更新日期：2001-01-01 00:00:00

  • Yes-associated protein 1 translocation through actin cytoskeleton organization in trophectoderm cells.

    abstract：:A mammalian embryo experiences the first cell segregation at the blastocyst stage, in which cells giving form to the embryo are sorted into two lineages; trophectoderm (TE) and inner cell mass (ICM). This first cell segregation process is governed by cell position-dependent Hippo signaling, which is a phosphorylation ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2020.09.004

    authors： Yamamura S,Goda N,Akizawa H,Kohri N,Balboula AZ,Kobayashi K,Bai H,Takahashi M,Kawahara M

    更新日期：2020-12-01 00:00:00

  • Binding of both acrosome-intact and acrosome-reacted guinea pig sperm to the zona pellucida during in vitro fertilization.

    abstract：:Mammalian sperm-egg adhesion occurs when sperm bind to the zona pellucida of the egg. In this study with guinea pig gametes, we have asked if sperm can initiate binding to the zona before and after the acrosome reaction and if the sperm surface protein PH-20 is involved in the binding at these two stages. Sperm bindin...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(87)90191-6

    authors： Myles DG,Hyatt H,Primakoff P

    更新日期：1987-06-01 00:00:00

  • The Drosophila Wilms׳ Tumor 1-Associating Protein (WTAP) homolog is required for eye development.

    abstract：:Sine Oculis (So), the founding member of the SIX family of homeobox transcription factors, binds to sequence specific DNA elements and regulates transcription of downstream target genes. It does so, in part, through the formation of distinct biochemical complexes with Eyes Absent (Eya) and Groucho (Gro). While these c...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2014.03.012

    authors： Anderson AM,Weasner BP,Weasner BM,Kumar JP

    更新日期：2014-06-15 00:00:00

  • Expression of DjY1, a protein containing a cold shock domain and RG repeat motifs, is targeted to sites of regeneration in planarians.

    abstract：:Planarians are well-known for their exceptional regenerative abilities. This investigation focuses on the involvement of a Y-box protein, defined by the presence of a cold-shock domain, in regeneration-specific processes. Previous studies have shown that developmentally expressed Y-box proteins bind to mRNA molecules ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1998.8996

    authors： Salvetti A,Batistoni R,Deri P,Rossi L,Sommerville J

    更新日期：1998-09-15 00:00:00

  • Morphogenetic movements driving neural tube closure in Xenopus require myosin IIB.

    abstract：:Vertebrate neural tube formation involves two distinct morphogenetic events--convergent extension (CE) driven by mediolateral cell intercalation, and bending of the neural plate driven largely by cellular apical constriction. However, the cellular and molecular biomechanics of these processes are not understood. Here,...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2008.12.009

    authors： Rolo A,Skoglund P,Keller R

    更新日期：2009-03-15 00:00:00

  • Ancestral Myf5 gene activity in periocular connective tissue identifies a subset of fibro/adipogenic progenitors but does not connote a myogenic origin.

    abstract：:Extraocular muscles (EOM) represent a unique muscle group that controls eye movements and originates from head mesoderm, while the more typically studied body and limb muscles are somite-derived. Aiming to investigate myogenic progenitors (satellite cells) in EOM versus limb and diaphragm of adult mice, we have been u...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2013.08.010

    authors： Stuelsatz P,Shearer A,Yablonka-Reuveni Z

    更新日期：2014-01-15 00:00:00

  • Myosin heavy chain mutations that cause Freeman-Sheldon syndrome lead to muscle structural and functional defects in Drosophila.

    abstract：:Missense mutations in the MYH3 gene encoding myosin heavy chain-embryonic (MyHC-embryonic) have been reported to cause two skeletal muscle contracture syndromes, Freeman Sheldon Syndrome (FSS) and Sheldon Hall Syndrome (SHS). Two residues in MyHC-embryonic that are most frequently mutated, leading to FSS, R672 and T17...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2019.02.017

    authors： Das S,Kumar P,Verma A,Maiti TK,Mathew SJ

    更新日期：2019-05-15 00:00:00

  • Identification of a major polypeptide component of the sea urchin fertilization envelope.

    abstract：:A monoclonal antibody (MAb No. 25-16), raised against purified cortical secretory vesicles (CVs) from the eggs of Strongylocentrotus purpuratus, has been used to identify a previously uncharacterized CV-derived polypeptide component of the sea urchin fertilization envelope (FE). MAb No. 25-16, an IgG1, bound to a grou...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(89)90210-8

    authors： Vater CA,Jackson RC

    更新日期：1989-03-01 00:00:00

  • Identification of a dopaminergic enhancer indicates complexity in vertebrate dopamine neuron phenotype specification.

    abstract：:The dopaminergic neurons of the basal ganglia play critical roles in CNS function and human disease, but specification of dopamine neuron phenotype is poorly understood in vertebrates. We performed an in vivo screen in zebrafish to identify dopaminergic neuron enhancers, in order to facilitate studies on the specifica...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2011.01.023

    authors： Fujimoto E,Stevenson TJ,Chien CB,Bonkowsky JL

    更新日期：2011-04-15 00:00:00

  • A newly identified type of attachment cell is critical for normal patterning of chordotonal neurons.

    abstract：:This work describes unknown aspects of chordotonal organ (ChO) morphogenesis revealed in post-embryonic stages through the use of new fluorescently labeled markers. We show that towards the end of embryogenesis a hitherto unnoticed phase of cell migration commences in which the cap cells of the ventral ChOs elongate a...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2016.01.009

    authors： Halachmi N,Nachman A,Salzberg A

    更新日期：2016-03-01 00:00:00

  • Dynamin-mediated endocytosis is required for tube closure, cell intercalation, and biased apical expansion during epithelial tubulogenesis in the Drosophila ovary.

    abstract：:Most metazoans are able to grow beyond a few hundred cells and to support differentiated tissues because they elaborate multicellular, epithelial tubes that are indispensable for nutrient and gas exchange. To identify and characterize the cellular behaviors and molecular mechanisms required for the morphogenesis of ep...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2015.10.034

    authors： Peters NC,Berg CA

    更新日期：2016-01-01 00:00:00

  • Evolutionary view of pluripotency seen from early development of non-mammalian amniotes.

    abstract：:Early embryonic cells are capable of acquiring numerous developmental fates until they become irreversibly committed to specific lineages depending on intrinsic determinants and/or regional interactions. From fertilization to gastrulation, such pluripotent cells first increase in number and then turn to undergoing dif...

    journal_title：Developmental biology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ydbio.2019.04.014

    authors： Nakanoh S,Agata K

    更新日期：2019-08-15 00:00:00