Comparative transcriptional profiling and evolutionary analysis of the GRAM domain family in eukaryotes.


:The GRAM domain was found in glucosyltransferases, myotubularins and other membrane-associated proteins. So far, functions for majority of these proteins are yet to be uncovered. In order to address the evolutionary and functional significance of this family members, we have performed a comprehensive investigation on their genome-wide identification, phylogenetic relationship and expression divergence in five different organisms representing monocot/dicot plants, vertebrate/invertebrate animals and yeast, namely, Oryza sativa, Arabidopsis thaliana, Mus musculus, Drosophila melanogaster and Saccharomyces cerevisiae, respectively. We have identified 65 members of GRAM domain family from these organisms. Our data revealed that this family was an ancient group and various organisms had evolved into different family sizes. Large-scale genome duplication and divergence in both expression patterns and functions were significantly contributed to the expansion and retention of this family. Mouse and Drosophila members showed higher divergences in their proteins as indicated by higher Ka/Ks ratios and possessed multiple domains in various combinations. However, in plants, their protein functions were possibly retained with a relatively low divergence as signified by lower Ka/Ks ratios and only one additional domain was combined during evolution. On the other hand, this family in all five organisms exhibited high divergence in their expression patterns both at tissue level and under various biotic and abiotic stresses. These highly divergent expression patterns unraveled the complexity of functions of GRAM domain family. Each member may play specialized roles in a specific tissue or stress condition and may function as regulators of environmental and hormonal signaling.


Dev Biol


Developmental biology


Jiang SY,Ramamoorthy R,Ramachandran S




Has Abstract


2008-02-15 00:00:00














  • Epithelial sheet movement requires the cooperation of c-Jun and MAP3K1.

    abstract::Epithelial sheet movement is an essential morphogenetic process during mouse embryonic eyelid closure in which Mitogen-Activated Protein 3 Kinase 1 (MAP3K1) and c-Jun play a critical role. Here we show that MAP3K1 associates with the cytoskeleton, activates Jun N-terminal kinase (JNK) and actin polymerization, and pro...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Meng Q,Mongan M,Wang J,Tang X,Zhang J,Kao W,Xia Y

    更新日期:2014-11-01 00:00:00

  • Accumulation kinetics of cotton late embryogenesis-abundant mRNAs and storage protein mRNAs: coordinate regulation during embryogenesis and the role of abscisic acid.

    abstract::The accumulation of total RNA transcripts of 18 late embryo-abundant (Lea) gene families, each encoding two closely related Lea mRNAs, was measured in cotyledon total RNA during embryogenesis and germination of Gossypium hirsutum L. by RNA dot hybridization. Transcript abundance of the three storage protein families w...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Galau GA,Bijaisoradat N,Hughes DW

    更新日期:1987-09-01 00:00:00

  • The alphaBbetaC integrin is expressed on the surface of the sea urchin egg and removed at fertilization.

    abstract::Integrins are expressed on the surface of some vertebrate eggs where they are thought to have a role in fertilization. The objective of this study is to determine if integrins are expressed on sea urchin eggs. The alphaB and betaC subunits were cloned using the homology polymerase chain reaction. Monoclonal and polycl...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Murray G,Reed C,Marsden M,Rise M,Wang D,Burke RD

    更新日期:2000-11-15 00:00:00

  • Spermiogenesis is impaired in mice bearing a targeted mutation in the protein phosphatase 1cgamma gene.

    abstract::Type 1 protein phosphatases (PP1) are involved in diverse cellular activities, ranging from glycogen metabolism to chromatin structure modification, mitosis, and meiosis. The holoenzymes are composed of two or more subunits, including a catalytic subunit (PP1c) and one or more regulatory subunits. Many eukaryotes poss...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Varmuza S,Jurisicova A,Okano K,Hudson J,Boekelheide K,Shipp EB

    更新日期:1999-01-01 00:00:00

  • The brain expressed x-linked gene 1 (Bex1) regulates myoblast fusion.

    abstract::Skeletal muscle development (myogenesis) is a complex but precisely orchestrated process involving spatiotemporal regulation of the proliferation, differentiation and fusion of myogenic progenitor cells (myoblasts). Here we identify brain expressed x-linked gene 1 (Bex1) as a transient, developmentally regulated gene ...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Jiang C,Wang JH,Yue F,Kuang S

    更新日期:2016-01-01 00:00:00

  • Analysis of early human neural crest development.

    abstract::The outstanding migration and differentiation capacities of neural crest cells (NCCs) have fascinated scientists since Wilhelm His described this cell population in 1868. Today, after intense research using vertebrate model organisms, we have gained considerable knowledge regarding the origin, migration and differenti...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Betters E,Liu Y,Kjaeldgaard A,Sundström E,García-Castro MI

    更新日期:2010-08-15 00:00:00

  • Severe developmental bone phenotype in ClC-7 deficient mice.

    abstract::Bone development is dependent on the functionality of three essential cell types: chondrocytes, osteoclasts and osteoblasts. If any of these cell types is dysfunctional, a developmental bone phenotype can result. The bone disease osteopetrosis is caused by osteoclast dysfunction or impaired osteoclastogenesis, leading...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Neutzsky-Wulff AV,Sims NA,Supanchart C,Kornak U,Felsenberg D,Poulton IJ,Martin TJ,Karsdal MA,Henriksen K

    更新日期:2010-08-15 00:00:00

  • Rac1 deficiency in the forebrain results in neural progenitor reduction and microcephaly.

    abstract::The Rho family of small GTPases has been implicated in many neurological disorders including mental retardation, but whether they are involved in primary microcephaly (microcephalia vera) is unknown. Here, we examine the role of Rac1 in mammalian neural progenitors and forebrain development by a conditional gene-targe...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Chen L,Melendez J,Campbell K,Kuan CY,Zheng Y

    更新日期:2009-01-01 00:00:00

  • Derepression of sonic hedgehog signaling upon Gpr161 deletion unravels forebrain and ventricular abnormalities.

    abstract::Inverse gradients of transcriptional repressors antagonize the transcriptional effector response to morphogens. However, the role of such inverse regulation might not manifest solely from lack of repressors. Sonic hedgehog (Shh) patterns the forebrain by being expressed ventrally; however, absence of antagonizing Gli3...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Shimada IS,Somatilaka BN,Hwang SH,Anderson AG,Shelton JM,Rajaram V,Konopka G,Mukhopadhyay S

    更新日期:2019-06-01 00:00:00

  • Histone methylation controls telomerase-independent telomere lengthening in cells undergoing dedifferentiation.

    abstract::Cellular dedifferentiation underlies topical issues in biology such as regeneration and nuclear cloning and has common features in plants and animals. In plants, this process characterizes the transition of differentiated leaf cells to protoplasts (plant cells devoid of cell walls) and is accompanied by global chromat...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Grafi G,Ben-Meir H,Avivi Y,Moshe M,Dahan Y,Zemach A

    更新日期:2007-06-15 00:00:00

  • Secondary heart field contributes myocardium and smooth muscle to the arterial pole of the developing heart.

    abstract::The arterial pole of the heart is the region where the ventricular myocardium continues as the vascular smooth muscle tunics of the aorta and pulmonary trunk. It has been shown that the arterial pole myocardium derives from the secondary heart field and the smooth muscle tunic of the aorta and pulmonary trunk derives ...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Waldo KL,Hutson MR,Ward CC,Zdanowicz M,Stadt HA,Kumiski D,Abu-Issa R,Kirby ML

    更新日期:2005-05-01 00:00:00

  • Epicardial GATA factors regulate early coronary vascular plexus formation.

    abstract::During early development, GATA factors have been shown to be important for key events of coronary vasculogenesis, including formation of the epicardium. Myocardial GATA factors are required for coronary vascular (CV) formation; however, the role of epicardial localized GATAs in this process has not been addressed. The...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Kolander KD,Holtz ML,Cossette SM,Duncan SA,Misra RP

    更新日期:2014-02-01 00:00:00

  • Dissection of cis-regulatory elements in the C. elegans Hox gene egl-5 promoter.

    abstract::Hox genes are highly conserved segmental identity genes well known for their complex expression patterns and divergent targets. Here we present an analysis of cis-regulatory elements in the Caenorhabditis elegans Hox gene egl-5, which is expressed in multiple tissues in the posterior region of the nematode. We have ut...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Teng Y,Girard L,Ferreira HB,Sternberg PW,Emmons SW

    更新日期:2004-12-15 00:00:00

  • Direct interaction between Teashirt and Sex combs reduced proteins, via Tsh's acidic domain, is essential for specifying the identity of the prothorax in Drosophila.

    abstract::teashirt (tsh) encodes a zinc-finger protein that is thought to be part of a network that contributes to regionalization of the Drosophila embryo and establishes the domains of Hox protein function. tsh and the Hox gene Sex combs reduced (Scr) are essential to establish the identity of the first thoracic segment. We u...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Taghli-Lamallem O,Gallet A,Leroy F,Malapert P,Vola C,Kerridge S,Fasano L

    更新日期:2007-07-01 00:00:00

  • Wnt4 is essential to normal mammalian lung development.

    abstract::Wnt signaling is essential to many events during organogenesis, including the development of the mammalian lung. The Wnt family member Wnt4 has been shown to be required for the development of kidney, gonads, thymus, mammary and pituitary glands. Here, we show that Wnt4 is critical for proper morphogenesis and growth ...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Caprioli A,Villasenor A,Wylie LA,Braitsch C,Marty-Santos L,Barry D,Karner CM,Fu S,Meadows SM,Carroll TJ,Cleaver O

    更新日期:2015-10-15 00:00:00

  • Lineage analysis of early neural plate cells: cells with purely neuronal fate coexist with bipotential neuroglial progenitors.

    abstract::To investigate the lineage relationships of neurons and astroglial cells early in central nervous system development, we have analyzed the progeny of neural plate cells in an amphibian embryo (Pleurodeles waltl). A fluorescent tracer, lysinated rhodamine-dextran, was iontophoretically injected into individual precurso...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Soula C,Foulquier F,Duprat AM,Cochard P

    更新日期:1993-09-01 00:00:00

  • Regulation of cyclin A localization downstream of Par-1 function is critical for the centrosome orientation checkpoint in Drosophila male germline stem cells.

    abstract::Male germline stem cells (GSCs) in Drosophila melanogaster divide asymmetrically by orienting the mitotic spindle with respect to the niche, a microenvironment that specifies stem cell identity. The spindle orientation is prepared during interphase through stereotypical positioning of the centrosomes. We recently demo...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Yuan H,Chiang CY,Cheng J,Salzmann V,Yamashita YM

    更新日期:2012-01-01 00:00:00

  • The Drosophila larval visual system: high-resolution analysis of a simple visual neuropil.

    abstract::The task of the visual system is to translate light into neuronal encoded information. This translation of photons into neuronal signals is achieved by photoreceptor neurons (PRs), specialized sensory neurons, located in the eye. Upon perception of light the PRs will send a signal to target neurons, which represent a ...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Sprecher SG,Cardona A,Hartenstein V

    更新日期:2011-10-01 00:00:00

  • Protein tyrosine kinase activity following fertilization is required to complete gastrulation, but not for initial differentiation of endoderm and mesoderm in the sea urchin embryo.

    abstract::The egg activation process functions to implement developmental programs that act much later in embryogenesis. One example of this is the fact that application of protein tyrosine kinase inhibitors to the fertilized sea urchin egg for a 15-min period results in a defect in the gastrulation process occurring over 24 h ...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Livingston BT,VanWinkle CE,Kinsey WH

    更新日期:1998-01-01 00:00:00

  • Pabp binds to the osk 3'UTR and specifically contributes to osk mRNA stability and oocyte accumulation.

    abstract::RNA localization is tightly coordinated with RNA stability and translation control. Bicaudal-D (Bic-D), Egalitarian (Egl), microtubules and their motors are part of a Drosophila transport machinery that localizes mRNAs to specific cellular regions during oogenesis and embryogenesis. We identified the Poly(A)-binding p...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Vazquez-Pianzola P,Urlaub H,Suter B

    更新日期:2011-09-15 00:00:00

  • Desert hedgehog-primary cilia cross talk shapes mitral valve tissue by organizing smooth muscle actin.

    abstract::Non-syndromic mitral valve prolapse (MVP) is the most common heart valve disease affecting 2.4% of the population. Recent studies have identified genetic defects in primary cilia as causative to MVP, although the mechanism of their action is currently unknown. Using a series of gene inactivation approaches, we define ...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Fulmer D,Toomer KA,Glover J,Guo L,Moore K,Moore R,Stairley R,Gensemer C,Abrol S,Rumph MK,Emetu F,Lipschutz JH,McDowell C,Bian J,Wang C,Beck T,Wessels A,Renault MA,Norris RA

    更新日期:2020-07-01 00:00:00

  • Widespread distribution of type II collagen during embryonic chick development.

    abstract::Type II collagen is a major component of hyaline cartilage, and has been suggested to be causally involved in promoting chondrogenesis during embryonic development. In the present study we have performed an immunohistochemical analysis of the distribution of type II collagen during several early stages of embryonic ch...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Kosher RA,Solursh M

    更新日期:1989-02-01 00:00:00

  • Position-specific growth of mouse limb bud cells in vitro.

    abstract::The relationship between cellular position and growth control has been studied in cultures of dissociated fragments of mouse limb bud cells. Using cells derived from various positions along the anterior-posterior axis of the limb bud we have developed culture conditions that optimize growth of positionally isolated ce...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Shi C,Muneoka K

    更新日期:1992-05-01 00:00:00

  • Hedgehog signaling patterns mesoderm in the sea urchin.

    abstract::The Hedgehog (Hh) signaling pathway is essential for patterning many structures in vertebrates including the nervous system, chordamesoderm, limb and endodermal organs. In the sea urchin, a basal deuterostome, Hh signaling is shown to participate in organizing the mesoderm. At gastrulation the Hh ligand is expressed b...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Walton KD,Warner J,Hertzler PH,McClay DR

    更新日期:2009-07-01 00:00:00

  • In vivo impact of a 4 bp deletion mutation in the DLX3 gene on bone development.

    abstract::Distal-less 3 (DLX3) gene mutations are etiologic for Tricho-Dento-Osseous syndrome. To investigate the in vivo impact of mutant DLX3 on bone development, we established transgenic (TG) mice expressing the c.571_574delGGGG DLX-3 gene mutation (MT-DLX3) driven by a mouse 2.3 Col1A1 promoter. Microcomputed tomographic a...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Choi SJ,Roodman GD,Feng JQ,Song IS,Amin K,Hart PS,Wright JT,Haruyama N,Hart TC

    更新日期:2009-01-01 00:00:00

  • bves: A novel gene expressed during coronary blood vessel development.

    abstract::We have used a subtractive method to clone novel messages enriched in the heart. Here we show that one such message, bves (blood vessel/epicardial substance) is a novel protein that is highly conserved between chicken and mouse. The bves message is detected at high levels in early chick hearts. Using anti-Bves antibod...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Reese DE,Zavaljevski M,Streiff NL,Bader D

    更新日期:1999-05-01 00:00:00

  • Dynamic localization and functional implications of Aurora-C kinase during male mouse meiosis.

    abstract::Aurora-C was first identified during screening for kinases expressed in mouse sperm and eggs. Herein, we report for the first time the precise subcellular localization of endogenous Aurora-C during male meiotic division. The localization of Aurora-C was analyzed by immunofluorescence staining on chromosome spreads of ...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Tang CJ,Lin CY,Tang TK

    更新日期:2006-02-15 00:00:00

  • Glial progenitors of the neonatal subventricular zone differentiate asynchronously, leading to spatial dispersion of glial clones and to the persistence of immature glia in the adult mammalian CNS.

    abstract::The subventricular zone (SVZ) of the developing mammalian forebrain gives rise to astrocytes and oligodendrocytes in the neocortex and white matter, and neurons in the olfactory bulb in perinatal life. We have examined the developmental fates and spatial distributions of the descendants of single SVZ cells by infectin...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Zerlin M,Milosevic A,Goldman JE

    更新日期:2004-06-01 00:00:00

  • A switch from MafB to MafA expression accompanies differentiation to pancreatic beta-cells.

    abstract::Major insulin gene transcription factors, such as PDX-1 or NeuroD1, have equally important roles in pancreatic development and the differentiation of pancreatic endocrine cells. Previously, we identified and cloned another critical insulin gene transcription factor MafA (RIPE3b1) and reported that other Maf factors we...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Nishimura W,Kondo T,Salameh T,El Khattabi I,Dodge R,Bonner-Weir S,Sharma A

    更新日期:2006-05-15 00:00:00

  • Cranial neural crest cells contribute to connective tissue in cranial muscles in the anuran amphibian, Bombina orientalis.

    abstract::The contribution of cranial neural crest cells to the development and patterning of cranial muscles in amphibians was investigated in the phylogenetically basal and morphologically generalized frog, Bombina orientalis. Experimental methods included fluorescent marking of premigratory cranial neural crest and extirpati...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Olsson L,Falck P,Lopez K,Cobb J,Hanken J

    更新日期:2001-09-15 00:00:00