Abstract:
:The GRAM domain was found in glucosyltransferases, myotubularins and other membrane-associated proteins. So far, functions for majority of these proteins are yet to be uncovered. In order to address the evolutionary and functional significance of this family members, we have performed a comprehensive investigation on their genome-wide identification, phylogenetic relationship and expression divergence in five different organisms representing monocot/dicot plants, vertebrate/invertebrate animals and yeast, namely, Oryza sativa, Arabidopsis thaliana, Mus musculus, Drosophila melanogaster and Saccharomyces cerevisiae, respectively. We have identified 65 members of GRAM domain family from these organisms. Our data revealed that this family was an ancient group and various organisms had evolved into different family sizes. Large-scale genome duplication and divergence in both expression patterns and functions were significantly contributed to the expansion and retention of this family. Mouse and Drosophila members showed higher divergences in their proteins as indicated by higher Ka/Ks ratios and possessed multiple domains in various combinations. However, in plants, their protein functions were possibly retained with a relatively low divergence as signified by lower Ka/Ks ratios and only one additional domain was combined during evolution. On the other hand, this family in all five organisms exhibited high divergence in their expression patterns both at tissue level and under various biotic and abiotic stresses. These highly divergent expression patterns unraveled the complexity of functions of GRAM domain family. Each member may play specialized roles in a specific tissue or stress condition and may function as regulators of environmental and hormonal signaling.
journal_name
Dev Bioljournal_title
Developmental biologyauthors
Jiang SY,Ramamoorthy R,Ramachandran Sdoi
10.1016/j.ydbio.2007.11.031subject
Has Abstractpub_date
2008-02-15 00:00:00pages
418-32issue
2eissn
0012-1606issn
1095-564Xpii
S0012-1606(07)01552-7journal_volume
314pub_type
杂志文章abstract::The engrailed gene is well known from its role in segmentation and central nervous system development in a variety of species. In molluscs, however, engrailed is involved in shell formation. So far, it seemed that engrailed had been co-opted uniquely for this particular process in molluscs. Here, we show that, in the ...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.2002.0653
更新日期:2002-06-15 00:00:00
abstract::The migration and fate of cranial and vagal neural crest-derived progenitor cells (NCPCs) have been extensively studied; however, much less is known about sacral NCPCs particularly in regard to their distribution in the urogenital system. To construct a spatiotemporal map of NCPC migration pathways into the developing...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2017.04.011
更新日期:2017-09-01 00:00:00
abstract::The segmental origin and migratory pattern of neural crest cells at the trunk level of avian embryos was studied, with special emphasis on the formation of the dorsal root ganglia (DRG) which organize in the anterior half of each somite. Neural crest cells were visualized using the quail-chick marker and HNK-1 immunof...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(87)90236-3
更新日期:1987-04-01 00:00:00
abstract::Organismal growth and body size are influenced by both genetic and environmental factors. We have utilized the strong molecular genetic techniques available in the nematode Caenorhabditis elegans to identify genetic determinants of body size. In C. elegans, DBL-1, a member of the conserved family of secreted growth fa...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2011.01.016
更新日期:2011-04-01 00:00:00
abstract::Alkaline phosphatase (AP) activity is expressed in the endodermal cell lineage of ascidian embryos beginning at gastrulation. AP expression is resistant to levels of actinomycin D which completely suppress the appearance of other tissue-specific enzyme and morphological markers including acetylcholinesterase (AchE), a...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(87)90043-1
更新日期:1987-02-01 00:00:00
abstract::Using lineage tracers, we recently showed dorsal and ventral ectodermal compartments along the sides of the body in chick embryos. The compartments are formed both in presumptive limb-forming regions where they position the apical ridge and also in presumptive interlimb (flank). Here we show, using a novel technique c...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.2000.9659
更新日期:2000-06-15 00:00:00
abstract::We have investigated the accumulation and adenylation of the maternal mRNA during oogenesis in the oocytes of the marine worm Urechis caupo. The analysis, using in vitro translation and cDNA probes to assay for specific mRNAs, demonstrates that different maternal mRNAs accumulate with different patterns during oogenes...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(86)90347-7
更新日期:1986-09-01 00:00:00
abstract::During limb development, Sonic hedgehog (SHH) and HOX proteins are considered among the most important factors regulating digit number and identity. SHH signaling prevents the processing of GLI3 into a short form that functions as a strong transcriptional repressor. Gli3 mutant limbs are characterized by a severe poly...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2007.07.023
更新日期:2007-10-15 00:00:00
abstract::This work describes unknown aspects of chordotonal organ (ChO) morphogenesis revealed in post-embryonic stages through the use of new fluorescently labeled markers. We show that towards the end of embryogenesis a hitherto unnoticed phase of cell migration commences in which the cap cells of the ventral ChOs elongate a...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2016.01.009
更新日期:2016-03-01 00:00:00
abstract::Endogenous patterns of retinoic acid (RA) signaling in avian cardiac morphogenesis were characterized by localized expression of a key RA-synthetic enzyme, RALDH2, which displayed a biphasic pattern during heart development. RALDH2 immunoreactivity was initially apparent posterior to Hensen's node of stage 5-6 embryos...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1999.9588
更新日期:2000-03-01 00:00:00
abstract::The vertebrate liver and heart arise from adjacent cell layers in the anterior lateral (AL) endoderm and mesoderm of late gastrula embryos, and the earliest stages of liver and heart development are interrelated through reciprocal tissue interactions. Although classical embryological studies performed several decades ...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2004.01.019
更新日期:2004-04-15 00:00:00
abstract::Two populations of blastomeres become positionally distinct during fourth cleavage in the mouse embryo; the inner cells become enclosed within the embryo and the outer cells form the enclosing layer. The segregation of these two cell populations is important for later development, because it represents the initial ste...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(90)90003-2
更新日期:1990-01-01 00:00:00
abstract::Developing vertebrate limbs are often utilized as a model for studying pattern formation and morphogenetic cell death. Herein, we report that conditional deletion of Rac1, a member of the Rho family of proteins, in mouse limb bud mesenchyme led to skeletal deformities in the autopod and soft tissue syndactyly, with th...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2009.09.014
更新日期:2009-11-15 00:00:00
abstract::Integrins are expressed on the surface of some vertebrate eggs where they are thought to have a role in fertilization. The objective of this study is to determine if integrins are expressed on sea urchin eggs. The alphaB and betaC subunits were cloned using the homology polymerase chain reaction. Monoclonal and polycl...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.2000.9910
更新日期:2000-11-15 00:00:00
abstract::Myoblast fusion (a critical process by which muscles grow) occurs in a multi-step fashion that requires actin and membrane remodeling; but important questions remain regarding the spatial/temporal regulation of and interrelationship between these processes. We recently reported that the Rho-GAP, GRAF1, was particularl...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2014.06.025
更新日期:2014-09-15 00:00:00
abstract::The proper removal of superfluous neurons through apoptosis and subsequent phagocytosis is essential for normal development of the central nervous system (CNS). During Drosophila embryogenesis, a large number of apoptotic neurons are efficiently engulfed and degraded by phagocytic glia. Here we demonstrate that glial ...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2014.07.005
更新日期:2014-09-15 00:00:00
abstract::Although round spermatid injection can be used to create progeny for males who do not produce mature sperm, the rate of successful embryogenesis after such procedures is significantly lower than that for similar procedures using mature spermatozoa. The mechanisms underlying this difference are unknown. In this study, ...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2005.10.026
更新日期:2006-01-01 00:00:00
abstract::The ectoderm of early Xenopus gastrula is competent to become induced to neural tissue, but dorsal ectoderm is more neural competent than ventral ectoderm. It is a tenable, but as yet untested possibility that the higher neural competence of dorsal gastrula ectoderm is dependent on the presence of the dorsal mesoderm....
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(92)90168-g
更新日期:1992-07-01 00:00:00
abstract::The relative sizes of the various structures in Hydra attenuata were compared over a broad range of animal sizes to determine in detail the ability to regulate proportions during regeneration. The three components of the head, namely hypostome, tentacles, and tentacle zone from which the tentacles emerge, the body col...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(84)90318-x
更新日期:1984-06-01 00:00:00
abstract::Bicaudal-D (Bic-D) is required for the transport of determinant mRNAs and proteins to the presumptive oocyte, an essential step in the differentiation of the oocyte. Bic-D protein contains four well-defined heptad repeat domains characteristic of intermediate filament proteins. We characterized the ovarian phenotypes ...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.2001.0170
更新日期:2001-04-01 00:00:00
abstract::Many organisms both undergo dramatic morphological changes during post-embryonic development and also regenerate lost structures, but the roles of epigenetic regulators in such processes are only beginning to be understood. In the present study, the functions of two histone modifiers were examined during metamorphosis...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2019.03.002
更新日期:2019-06-01 00:00:00
abstract::mid and H15 encode Tbx20 transcription factors that specify ventral pattern in the Drosophila leg. We find that there are at least two pathways for mid and H15 specification of ventral fate. In the first pathway, mid and H15 negatively regulate Dpp, the dorsal signal in leg development. mid and H15 block the dorsalizi...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2019.05.012
更新日期:2019-11-01 00:00:00
abstract::Pericellular proteolysis by ADAM family metalloproteinases has been widely implicated in cell signaling and development. We recently found that Xenopus ADAM13, an ADAM metalloproteinase, is required for activation of canonical Wnt signaling during cranial neural crest (CNC) induction by regulating a novel crosstalk be...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2011.12.031
更新日期:2012-03-01 00:00:00
abstract::Gap junctions are intercellular channels made of connexins (Cxs) that allow direct communication between adjacent cells. Modulation of Cxs has been associated with abnormal development and function of the mammary gland and breast cancer. However, the mechanisms underlying their expression during normal mammary gland a...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2016.06.011
更新日期:2016-08-01 00:00:00
abstract::The definitive feature of the many thousand cis-regulatory control modules in an animal genome is their information processing capability. These modules are "wired" together in large networks that control major processes such as development; they constitute "genomic computers." Each control module receives multiple in...
journal_title:Developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.ydbio.2007.08.009
更新日期:2007-10-15 00:00:00
abstract::Eye cups from stage 14-28 (E2 to E5) chick and quail embryos consisting of neural retina, lens, and vitreous body were cultured for 1 or 2 days. These eyes expanded by proliferation of the retinal cells and the surface areas of the retinae increased several-fold. The area covered by ganglion cells and axons also expan...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(86)90194-6
更新日期:1986-04-01 00:00:00
abstract::Chick embryonic heart cell isolates and monolayer cultures were prepared from atria and ventricles at selected stages of cardiac development. The cardiac myocytes were assayed for myosin heavy chain (MHC) content using monoclonal antibodies (McAbs) specific in the heart for atrial (B-1), ventricular (ALD-19), or condu...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(86)90241-1
更新日期:1986-05-01 00:00:00
abstract::Immature, Stage VI oocytes of Xenopus laevis fail to activate (i.e., to propagate a cortical reaction and elevate a fertilization envelope) when pricked or exposed to A23187. We determined the times during maturation when immature oocytes treated with progesterone in vitro developed the capacity to respond to pricking...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(84)90177-5
更新日期:1984-03-01 00:00:00
abstract::Specific binding of spermatozoa to the zona pellucida that surrounds mammalian eggs is a key step in the fertilization process. However, the sperm proteins that recognise zona pellucida receptors remain contentious despite longstanding research efforts to identify them. Here we present evidence that proacrosin, a tiss...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2007.04.001
更新日期:2007-06-15 00:00:00
abstract::Gr16 (chromosome 2, 6.9 cM) is a dominant, grey egg mutation of the domestic silkmoth, Bombyx mori, which produces an opaque instead of a translucent chorion. To determine the underlying cause of this defect, we examined the effects of the mutation on chorion ultrastructure, protein accumulation, and biosynthesis patt...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1993.1112
更新日期:1993-05-01 00:00:00