Abstract:
:Many organisms both undergo dramatic morphological changes during post-embryonic development and also regenerate lost structures, but the roles of epigenetic regulators in such processes are only beginning to be understood. In the present study, the functions of two histone modifiers were examined during metamorphosis and larval limb regeneration in the red flour beetle Tribolium castaneum. Polycomb (Pc), a member of Polycomb repressive complex 1 (PRC1), and Enhancer of zeste (E(z)), a member of Polycomb repressive complex 2 (PRC2), were silenced in larvae using RNA interference. In the absence of Pc, the head appendages of adults transformed into a leg-like morphology, and the legs and wings assumed a metathoracic identity, indicating that Pc acts to specify proper segmental identity. Similarly, silencing of E(z) led to homeotic transformation of legs and wings. Additional defects were also observed in limb patterning as well as eye morphogenesis, indicating that PcG proteins play critical roles in imaginal precursor cells. In addition, larval legs and antennae failed to re-differentiate when either Pc or E(z) was knocked down, indicating that histone modification is necessary for proper blastema growth and differentiation. These findings indicate that PcG proteins play extensive roles in postembryonic plasticity of imaginal precursor cells.
journal_name
Dev Bioljournal_title
Developmental biologyauthors
Chou J,Ferris AC,Chen T,Seok R,Yoon D,Suzuki Ydoi
10.1016/j.ydbio.2019.03.002subject
Has Abstractpub_date
2019-06-01 00:00:00pages
34-46issue
1eissn
0012-1606issn
1095-564Xpii
S0012-1606(18)30836-4journal_volume
450pub_type
杂志文章abstract::The unfertilized oocyte contains various granules which serve as storage sites for proteins, the majority which are yolk granules or platelets. Yolk granules are thought to provide the developing embryo with nutrients essential for its survival, while other granules contain proteins such as enzymes and extracellular m...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1995.1040
更新日期:1995-02-01 00:00:00
abstract::Leaf primordia, first visible as small bumps, are produced in a cyclical pattern at the edges of the shoot apex, a smooth region at the top of the stem. Their formation is a biomechanical process. This review first considers hypothetical construction mechanisms and then summarizes research that provides information ab...
journal_title:Developmental biology
pub_type: 杂志文章,评审
doi:10.1016/0012-1606(92)90089-y
更新日期:1992-09-01 00:00:00
abstract::G protein Galpha subunits contribute to the specificity of different signal transduction pathways in Dictyostelium discoideum but Galpha subunit-effector interactions have not been previously identified. The requirement of the Dictyostelium Galpha4 subunit for MAP kinase (MAPK) activation and the identification of a p...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2009.09.011
更新日期:2009-11-15 00:00:00
abstract::The mammalian kidney consists of an array of tubules connected to a ductal system that collectively function to control water/salt balance and to remove waste from the organisms' circulatory system. During mammalian embryogenesis, three kidney structures form within the intermediate mesoderm. The two most anterior str...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2008.03.044
更新日期:2008-07-15 00:00:00
abstract::We have investigated sensillum development in Drosophila embryos homozygous for mutations in the locus string (stg). In these embryos, cell division is blocked following blastoderm formation. This permits a study of the differentiative fate of undivided precursor cells, in particular those giving rise to the larval se...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(90)90184-k
更新日期:1990-03-01 00:00:00
abstract::We have used a subtractive method to clone novel messages enriched in the heart. Here we show that one such message, bves (blood vessel/epicardial substance) is a novel protein that is highly conserved between chicken and mouse. The bves message is detected at high levels in early chick hearts. Using anti-Bves antibod...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1999.9246
更新日期:1999-05-01 00:00:00
abstract::Specification of the primordial germ cells (PGCs) is essential for sexually reproducing animals. Although the mechanisms of PGC specification are diverse between organisms, the RNA binding protein Nanos is consistently required in the germ line in all species tested. How Nanos is selectively expressed in the germ line...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2019.04.010
更新日期:2019-08-01 00:00:00
abstract::Wnt signaling pathways have been demonstrated to play important roles in controlling tissue patterning and cell proliferation. In the gastrointestinal tract, mutations that lead to activation of the canonical Wnt pathway through beta-catenin result in familial and sporadic colon cancers. The downstream transcription f...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/s0012-1606(03)00185-4
更新日期:2003-07-15 00:00:00
abstract::The nuclear lamina is an extensive protein network that underlies the inner nuclear envelope. This network includes the LAP2-emerin-MAN1-domain (LEM-D) protein family, proteins that share an association with the chromatin binding protein Barrier-to-autointegration factor (BAF). Loss of individual LEM-D proteins causes...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2016.05.001
更新日期:2016-07-01 00:00:00
abstract::Skeletal muscle fibers express members of the myosin heavy chain (MyHC) gene family in a fiber-type-specific manner. In avian skeletal muscle it is the expression of the slow MyHC isoforms that most clearly distinguishes slow- from fast-contracting fiber types. Two hypotheses have been proposed to explain fiber-type-s...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1997.8619
更新日期:1997-08-01 00:00:00
abstract::We demonstrate that interspecific sequence conservation can provide a systematic guide to the identification of functional cis-regulatory elements within a large expanse of genomic DNA. The test was carried out on the otx gene of Strongylocentrotus purpuratus. This gene plays a major role in the gene regulatory networ...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.2002.0618
更新日期:2002-06-01 00:00:00
abstract::To examine whether the 200-kDa neurofilament protein (200K NFP) is involved in mechanically stabilizing axons, we studied the developmental appearance of immunoreactivity to nonphosphorylated and phosphorylated 200K NFP at the neuromuscular junction. Polyinnervated rat muscle fibers become singly innervated during the...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(88)90422-8
更新日期:1988-11-01 00:00:00
abstract::c-fms and c-kit are structurally related tyrosine kinase receptors for colony-stimulating factor-1 (CSF-1) and for steel factor (SF), respectively. The level of c-fms mRNA, like c-kit mRNA, increases during the maturation of oocytes and is an abundant maternal message found in the unfertilized oocyte. Following fertil...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(92)90207-w
更新日期:1992-05-01 00:00:00
abstract::Epigenetic gene control is involved in mechanisms of development. Little is known about the cooperation of nuclear and chromatin events in programmed differentiation from mouse embryonic stem cells (ESC). To address this, Oct3/4-positive ESC and differentiated progenies, Sox1-positive neural precursor cells (NPC) and ...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2006.04.450
更新日期:2006-10-15 00:00:00
abstract::The rabbit sperm membrane autoantigen RSA-1 is a sialoglycoprotein of 13,000 daltons which first appears on the surface of pachytene spermatocytes. Using specific antiserum to RSA-1 the antigen has been localized by immunofluorescence and immunoperoxidase staining. On testicular cells labeled at 37 degrees C, RSA-1 is...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(81)90400-0
更新日期:1981-06-01 00:00:00
abstract::Three dominant second-chromosome rearrangement mutations in Drosophila melanogaster, Aristapedioid1 (Arp), vestigial-Depilate (vgD), and vestigial62 (vg62), result in developmental abnormalities of the bristle sense organs on the notum, abdomen, legs, and wing margin. The bristle abnormalities are associated with over...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1994.1039
更新日期:1994-02-01 00:00:00
abstract::We present evidence to show that differentiation in wing cells to produce hairs is synchronous over the distal 90% of the wing surface (approximately 28,000 cells). In spite of this synchrony within such a large area a temporal gradient exists between zones (in general anterior to posterior) on the animal surface with...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(83)90047-7
更新日期:1983-02-01 00:00:00
abstract::Continuous communication between cells is necessary for development of any multicellular organism and depends on the recognition of secreted signals. A wide range of molecules including proteins, peptides, amino acids, nucleic acids, steroids and polylketides are used as intercellular signals in plants and animals. Th...
journal_title:Developmental biology
pub_type: 杂志文章,评审
doi:10.1016/j.ydbio.2014.04.001
更新日期:2014-07-01 00:00:00
abstract::We investigated the potential role of rostral-caudal and dorsal-ventral subdivisions of the early rostral brain by relating these subdivisions to the early patterning of neuron cell bodies and their axon projections. The earliest neurons were mapped using the lipophilic axon tracers diI and diO on embryos fixed on emb...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1006/dbio.1996.0008
更新日期:1996-01-10 00:00:00
abstract::Spermatogenesis is a complex process that requires coordinated proliferation and differentiation of male germ cells. The molecular events that dictate this process are largely unknown, but are likely to involve highly regulated transcriptional control. In this study, we investigate the contribution of chromatin associ...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2012.07.006
更新日期:2012-09-15 00:00:00
abstract::Pericytes heterogeneity is based on their morphology, distribution, and markers. It is well known that pericytes from different organs may have distinct embryonic sources. Yamazaki et al. (2017) using several transgenic mouse model reveal by cell-lineage tracing that pericytes are even more heterogeneous than previous...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2017.05.001
更新日期:2017-07-01 00:00:00
abstract::During animal fertilizations, each oocyte or egg must produce a proper intracellular calcium signal for development to proceed normally. As a supplement to recent synopses of fertilization-induced calcium responses in mammals, this paper reviews the spatiotemporal properties of calcium signaling during fertilization a...
journal_title:Developmental biology
pub_type: 杂志文章,评审
doi:10.1006/dbio.1999.9340
更新日期:1999-07-15 00:00:00
abstract::The cardiac neural crest contains ectomesenchymal and neural anlagen that are necessary for normal heart development. It is not known whether other regions of the neural crest are capable of supporting normal heart development. In the experiments reported herein, quail donor embryos provided cardiac, trunk, or mesence...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/0012-1606(89)90112-7
更新日期:1989-08-01 00:00:00
abstract::Integrin α5-null embryos die in mid-gestation from severe defects in cardiovascular morphogenesis, which stem from defective development of the neural crest, heart and vasculature. To investigate the role of integrin α5β1 in cardiovascular development, we used the Mesp1(Cre) knock-in strain of mice to ablate integrin ...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2014.09.014
更新日期:2014-11-15 00:00:00
abstract::Hoxa2 gene is a primary player in regulation of craniofacial programs of head development in vertebrates. Here we investigate the evolution of a Hoxa2 neural crest enhancer identified originally in mouse by comparing and contrasting the fugu hoxa2a and hoxa2b genes with their orthologous teleost and mammalian sequence...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2015.11.006
更新日期:2016-01-15 00:00:00
abstract::The development of the Drosophila leg is a good model to study processes of pattern formation, cell death and segmentation. Such processes require the coordinate activity of different genes and signaling pathways that progressively subdivide the leg territory into smaller domains. One of the main pathways needed for l...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2013.10.011
更新日期:2014-01-15 00:00:00
abstract::The current picture of embryonic development in nematodes is essentially shaped by Caenorhabditis elegans and its close relatives. As their pattern of embryogenesis is rather similar, it is often considered to be representative for the taxon Nematoda as a whole. Here we give for the first time a comprehensive descript...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2009.06.009
更新日期:2009-10-01 00:00:00
abstract::FOG-2 is a multi-zinc finger protein that binds the transcriptional activator GATA4 and modulates GATA4-mediated regulation of target genes during heart development. Our previous work has demonstrated that the Nucleosome Remodeling and Deacetylase (NuRD) complex physically interacts with FOG-2 and is necessary for FOG...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2014.08.030
更新日期:2014-11-01 00:00:00
abstract::Drosophila N-cadherin (CadN) is an evolutionarily conserved, atypical classical cadherin, which has a large complex extracellular domain and a catenin-binding cytoplasmic domain. We have previously shown that CadN regulates target selection of R7 photoreceptor axons. To determine the functional domains of CadN, we con...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2007.01.030
更新日期:2007-04-15 00:00:00
abstract::Thrombospondin type 1 repeat (TSR) superfamily members regulate diverse biological activities ranging from cell motility to inhibition of angiogenesis. In this study, we verified that mouse protein O-fucosyltransferase-2 (POFUT2) specifically adds O-fucose to TSRs. Using two Pofut2 gene-trap lines, we demonstrated tha...
journal_title:Developmental biology
pub_type: 杂志文章
doi:10.1016/j.ydbio.2010.07.008
更新日期:2010-10-01 00:00:00