当前位置： SCI文献检索 > DEVELOPMENTAL BIOLOGY期刊下所有文献 > Hoxd and Gli3 interactions modulate digit number in the amniote limb.

Hoxd and Gli3 interactions modulate digit number in the amniote limb.

Abstract：

:During limb development, Sonic hedgehog (SHH) and HOX proteins are considered among the most important factors regulating digit number and identity. SHH signaling prevents the processing of GLI3 into a short form that functions as a strong transcriptional repressor. Gli3 mutant limbs are characterized by a severe polydactyly and associated ectopic anterior expression of 5'Hoxd genes. To genetically determine the involvement of 5'Hoxd genes in the polydactyly of Gli3 mutants, we have generated a compound mutant that simultaneously removes the three most 5'-located Hoxd genes and Gli3. Remarkably, the limbs that form in the absence of all four of these genes show the most severe polydactyly so far reported in the mouse. The analysis of gene expression performed in compound mutants allows us to propose that the increase in the number of digits is mediated by the gain in function of Hoxd10 and Hoxd9. Our results also support the notion that an adequate balance between positive and negative effects of different Hoxd genes is required for pentadactyly.

journal_name

Dev Biol

journal_title

Developmental biology

authors

Sheth R,Bastida MF,Ros M

doi

10.1016/j.ydbio.2007.07.023

subject

Has Abstract

pub_date

2007-10-15 00:00:00

pages

430-41

issue

2

eissn

0012-1606

issn

1095-564X

pii

S0012-1606(07)01220-1

journal_volume

310

pub_type

杂志文章

相关文献

DEVELOPMENTAL BIOLOGY文献大全
  • EphB2 regulates axonal growth at the midline in the developing auditory brainstem.

    abstract：:Eph receptors play important roles in axon guidance at the midline. In the auditory system, growth of axons across the midline is an important determinant of auditory function. The avian cochlear nucleus, n. magnocellularis (NM), makes bilateral projections to its target, n. laminaris (NL). We examined the time course...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2006.03.010

    authors： Cramer KS,Cerretti DP,Siddiqui SA

    更新日期：2006-07-01 00:00:00

  • The 5' UTR and 3' UTR of the sperm mitochondria-associated cysteine-rich protein mRNA regulate translation in spermatids by multiple mechanisms in transgenic mice.

    abstract：:The Smcp mRNA encoding the sperm mitochondria-associated cysteine-rich protein is translationally repressed in round spermatids and translationally active in elongated spermatids. The patterns of transcription and translation of fusions of the Smcp promoter, the green fluorescent protein coding region (Gfp) and variou...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2006.04.468

    authors： Hawthorne SK,Busanelli RR,Kleene KC

    更新日期：2006-09-01 00:00:00

  • Arabidopsis actin-related protein ARP5 in multicellular development and DNA repair.

    abstract：:Actin-related protein 5 (ARP5) is a conserved subunit of the INO80 chromatin-remodeling complex in yeast and mammals. We have characterized the expression and subcellular distribution of Arabidopsis thaliana ARP5 and explored its role in the epigenetic control of multicellular development and DNA repair. ARP5-specific...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2009.08.006

    authors： Kandasamy MK,McKinney EC,Deal RB,Smith AP,Meagher RB

    更新日期：2009-11-01 00:00:00

  • A role for fibronectin in the migration of avian precardiac cells. I. Dose-dependent effects of fibronectin antibody.

    abstract：:An anterior-posterior concentration difference of fibronectin associated with the endoderm in early chick embryos has been implicated in the directional migration of precardiac mesoderm cells. We have examined the effect of increasing concentrations of an antibody to fibronectin (FN) to test the essentiality of FN to ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(88)90378-8

    authors： Linask KK,Lash JW

    更新日期：1988-10-01 00:00:00

  • WIND1 induces dynamic metabolomic reprogramming during regeneration in Brassica napus.

    abstract：:Plants often display a high competence for regeneration under stress conditions. Signals produced in response to various types of stress serve as critical triggers for de novo organogenesis, but the identity of these signaling molecules underlying cellular reprogramming are largely unknown. We previously identified an...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2018.07.006

    authors： Iwase A,Mita K,Favero DS,Mitsuda N,Sasaki R,Kobayshi M,Takebayashi Y,Kojima M,Kusano M,Oikawa A,Sakakibara H,Saito K,Imamura J,Sugimoto K

    更新日期：2018-10-01 00:00:00

  • Distinct functions of the leucine-rich repeat transmembrane proteins capricious and tartan in the Drosophila tracheal morphogenesis.

    abstract：:A key step in organogenesis of the Drosophila tracheal system is the integration of isolated tracheal metameres into a connected tubular network. The interaction of tracheal cells with surrounding mesodermal cells is crucial in this process. In particular, single mesodermal cells called bridge-cells are essential for ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2006.04.462

    authors： Krause C,Wolf C,Hemphälä J,Samakovlis C,Schuh R

    更新日期：2006-08-01 00:00:00

  • Cytokines modulate preimplantation development and pregnancy.

    abstract：:Using two different models of pregnancy failure in mice, we show in this communication that preimplantation embryonic development can be controlled, in vivo, with cytokines. In one model, described by us previously, CSF-1 is shown to block gestations in plugged females due to its induction of defective early developme...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(91)90236-v

    authors： Tartakovsky B,Ben-Yair E

    更新日期：1991-08-01 00:00:00

  • Identification of satellite cells from anole lizard skeletal muscle and demonstration of expanded musculoskeletal potential.

    abstract：:The lizards are evolutionarily the closest vertebrates to humans that demonstrate the ability to regenerate entire appendages containing cartilage, muscle, skin, and nervous tissue. We previously isolated PAX7-positive cells from muscle of the green anole lizard, Anolis carolinensis, that can differentiate into multin...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2017.08.037

    authors： Palade J,Djordjevic D,Hutchins ED,George RM,Cornelius JA,Rawls A,Ho JWK,Kusumi K,Wilson-Rawls J

    更新日期：2018-01-15 00:00:00

  • Forkhead transcription factor Foxf2 (LUN)-deficient mice exhibit abnormal development of secondary palate.

    abstract：:The forkhead genes encode a transcription factor involved in embryogenesis and pattern formation in multicellular organisms. They are mammalian transcriptional regulators that bind DNA as a monomer through their forkhead domain. The Foxf2 (LUN) mRNA is expressed in the mesenchyme directly adjacent to the ectoderm-deri...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/s0012-1606(03)00176-3

    authors： Wang T,Tamakoshi T,Uezato T,Shu F,Kanzaki-Kato N,Fu Y,Koseki H,Yoshida N,Sugiyama T,Miura N

    更新日期：2003-07-01 00:00:00

  • Genetic interactions of eyes absent, twin of eyeless and orthodenticle regulate sine oculis expression during ocellar development in Drosophila.

    abstract：:The homeobox gene sine oculis (so) is required for the development of the entire visual system in Drosophila, which includes the compound eyes, the ocelli, the optic lobe of the brain and the Bolwig's organ. During ocelli development, so expression labels, together with eyes absent (eya), the emergence of the ocellar ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2010.05.494

    authors： Blanco J,Pauli T,Seimiya M,Udolph G,Gehring WJ

    更新日期：2010-08-15 00:00:00

  • Expression of Patella vulgata orthologs of engrailed and dpp-BMP2/4 in adjacent domains during molluscan shell development suggests a conserved compartment boundary mechanism.

    abstract：:The engrailed gene is well known from its role in segmentation and central nervous system development in a variety of species. In molluscs, however, engrailed is involved in shell formation. So far, it seemed that engrailed had been co-opted uniquely for this particular process in molluscs. Here, we show that, in the ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.2002.0653

    authors： Nederbragt AJ,van Loon AE,Dictus WJ

    更新日期：2002-06-15 00:00:00

  • Cyclical generation and degeneration of organs in a colonial urochordate involves crosstalk between old and new: a model for development and regeneration.

    abstract：:Botryllus schlosseri is a colonial marine urochordate in which all adult organisms (called zooids) in a colony die synchronously by apoptosis (programmed cell death) in cyclical fashion. During this death phase called takeover, cell corpses within the dying organism are engulfed by circulating phagocytic cells. The "o...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.2002.0772

    authors： Lauzon RJ,Ishizuka KJ,Weissman IL

    更新日期：2002-09-15 00:00:00

  • Notch signaling during larval and juvenile development in the polychaete annelid Capitella sp. I.

    abstract：:Notch signaling is involved in a large range of developmental processes, and has been functionally implicated in body plan segmentation in two of the three diverse segmented taxa, the vertebrates and arthropods. Here we investigate expression of Notch, Delta, and hes gene homologues during larval and juvenile developm...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2008.04.015

    authors： Thamm K,Seaver EC

    更新日期：2008-08-01 00:00:00

  • Transcriptional repressor and activator activities of SMA-9 contribute differentially to BMP-related signaling outputs.

    abstract：:In the nematode Caenorhabditis elegans, the BMP-related growth factor DBL-1 regulates body size and male tail morphogenesis via a conserved receptor/Smad signaling pathway. Smads are transcription factors, but rely on transcription cofactors for appropriate regulation of target genes in response to TGF-beta- and BMP-r...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2007.02.038

    authors： Liang J,Yu L,Yin J,Savage-Dunn C

    更新日期：2007-05-15 00:00:00

  • Cell specific loss of polarity-inducing ability by later stage mouse preimplantation embryos.

    abstract：:The individual blastomeres of the preimplantation mouse embryo become polarized during the 8-cell stage. Microvilli become restricted to the free surface of the embryo and this region of the membrane shows increased labeling with FITC-Con A and trinitrobenzenesulfonate (TNBS). Previous studies have shown that this pol...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(86)90204-6

    authors： Adler RR,Ziomek CA

    更新日期：1986-04-01 00:00:00

  • The TATA binding protein in the sea urchin embryo is maternally derived.

    abstract：:The cDNA encoding the TATA binding protein was isolated from 8- to 16-cell and morula-stage embryonic libraries of two distantly related species of sea urchin, Strongylocentrotus purpuratus and Lytechinus variegatus, respectively. The two proteins are 96% identical over both the N- and C-terminal domains, suggesting a...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1998.9052

    authors： Edelmann L,Zheng L,Wang ZF,Marzluff W,Wessel GM,Childs G

    更新日期：1998-12-01 00:00:00

  • Functional genomics identifies regulators of the phototransduction machinery in the Drosophila larval eye and adult ocelli.

    abstract：:Sensory perception of light is mediated by specialized Photoreceptor neurons (PRs) in the eye. During development all PRs are genetically determined to express a specific Rhodopsin (Rh) gene and genes mediating a functional phototransduction pathway. While the genetic and molecular mechanisms of PR development is well...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2015.12.026

    authors： Mishra AK,Bargmann BOR,Tsachaki M,Fritsch C,Sprecher SG

    更新日期：2016-02-15 00:00:00

  • Cellular heterogeneity during vertebrate skeletal muscle development.

    abstract：:Although skeletal muscles appear superficially alike at different anatomical locations, in reality there is considerably more diversity than previously anticipated. Heterogeneity is not only restricted to completely developed fibers, but is clearly apparent during development at the molecular, cellular and anatomical ...

    journal_title：Developmental biology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ydbio.2007.06.006

    authors： Biressi S,Molinaro M,Cossu G

    更新日期：2007-08-15 00:00:00

  • Primitive and definitive blood share a common origin in Xenopus: a comparison of lineage techniques used to construct fate maps.

    abstract：:Primitive blood constitutes the ventralmost mesoderm in amphibians, and its cleavage-stage origin reveals important clues about the orientation of the dorsal/ventral axis in the embryo. In recent years, investigators employing various lineage-labeling strategies have reported disparate results for the origin of primit...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.2002.0717

    authors： Lane MC,Sheets MD

    更新日期：2002-08-01 00:00:00

  • Induction of early transcription in one-cell mouse embryos by microinjection of the nonhistone chromosomal protein HMG-I.

    abstract：:In the mouse embryo, the onset of zygotic transcription occurs at the end of the first cell cycle, upon completion of DNA replication. We show that the nonhistone chromosomal protein HMG-I, whose translocation into the pronuclei of one-cell embryos is linked to this first round of DNA synthesis, plays a critical role ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.2000.9668

    authors： Beaujean N,Bouniol-Baly C,Monod C,Kissa K,Jullien D,Aulner N,Amirand C,Debey P,Käs E

    更新日期：2000-05-15 00:00:00

  • Constitutive activation of hedgehog signaling adversely affects epithelial cell fate during palatal fusion.

    abstract：:Cleft palate is one of the most common craniofacial congenital defects in humans. It is associated with multiple genetic and environmental risk factors, including mutations in the genes encoding signaling molecules in the sonic hedgehog (Shh) pathway, which are risk factors for cleft palate in both humans and mice. Ho...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2018.07.003

    authors： Li J,Yuan Y,He J,Feng J,Han X,Jing J,Ho TV,Xu J,Chai Y

    更新日期：2018-09-01 00:00:00

  • A novel Cripto-related protein reveals an essential role for EGF-CFCs in Nodal signalling in Xenopus embryos.

    abstract：:The location, timing and intensity of Nodal signalling are all critical for proper patterning of the vertebrate embryo. Genetic evidence from mouse and zebrafish indicates that EGF-CFC family members are essential for Nodal ligands to signal. However, the Xenopus EGF-CFC, FRL1, has been implicated in Wnt signalling an...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2006.01.006

    authors： Dorey K,Hill CS

    更新日期：2006-04-15 00:00:00

  • An intrinsic timer that controls cell-cycle withdrawal in cultured cardiac myocytes.

    abstract：:Developing cardiac myocytes divide a limited number of times before they stop and terminally differentiate, but the mechanism that stops their division is unknown. To help study the stopping mechanism, we defined conditions under which embryonic rat cardiac myocytes cultured in serum-free medium proliferate and exit t...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1999.9524

    authors： Burton PB,Raff MC,Kerr P,Yacoub MH,Barton PJ

    更新日期：1999-12-15 00:00:00

  • Alignment of centrosomal and growth axes is a late event during polarization of Pelvetia compressa zygotes.

    abstract：:Zygotes and embryos of the fucoid brown alga Pelvetia compressa undergo a series of asymmetric cleavages. We are interested in the developmental role of these cleavages and the mechanism controlling their alignment. To assess the importance of division plane alignment, the orientation of the first asymmetric division ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1997.8832

    authors： Bisgrove SR,Kropf DL

    更新日期：1998-02-15 00:00:00

  • Altered proteoglycan synthesis disrupts feather pattern formation in chick embryonic skin.

    abstract：:We have tested the role of proteoglycans in the development of feather pattern by culturing 7-day-old embryonic chick skins on medium containing para-nitrophenyl-beta-D-xyloside (2 mM). Xylosides compete with core proteins of proteoglycans by acting as exogenous acceptors for the synthesis of glycosaminoglycans leadin...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(88)90199-6

    authors： Goetinck PF,Carlone DL

    更新日期：1988-05-01 00:00:00

  • Identification of a dopaminergic enhancer indicates complexity in vertebrate dopamine neuron phenotype specification.

    abstract：:The dopaminergic neurons of the basal ganglia play critical roles in CNS function and human disease, but specification of dopamine neuron phenotype is poorly understood in vertebrates. We performed an in vivo screen in zebrafish to identify dopaminergic neuron enhancers, in order to facilitate studies on the specifica...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2011.01.023

    authors： Fujimoto E,Stevenson TJ,Chien CB,Bonkowsky JL

    更新日期：2011-04-15 00:00:00

  • Molecular integration of inductive and mesoderm-intrinsic inputs governs even-skipped enhancer activity in a subset of pericardial and dorsal muscle progenitors.

    abstract：:Individual somatic muscles and heart progenitors are specified at defined positions within the mesodermal layer of Drosophila. The expression of the homeobox gene even-skipped (eve) identifies one specific subset of cells in the dorsal mesoderm, which give rise to particular pericardial cells and dorsal body wall musc...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.2001.0397

    authors： Knirr S,Frasch M

    更新日期：2001-10-01 00:00:00

  • In vivo impact of a 4 bp deletion mutation in the DLX3 gene on bone development.

    abstract：:Distal-less 3 (DLX3) gene mutations are etiologic for Tricho-Dento-Osseous syndrome. To investigate the in vivo impact of mutant DLX3 on bone development, we established transgenic (TG) mice expressing the c.571_574delGGGG DLX-3 gene mutation (MT-DLX3) driven by a mouse 2.3 Col1A1 promoter. Microcomputed tomographic a...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2008.10.014

    authors： Choi SJ,Roodman GD,Feng JQ,Song IS,Amin K,Hart PS,Wright JT,Haruyama N,Hart TC

    更新日期：2009-01-01 00:00:00

  • Pax6 is regulated by Meis and Pbx homeoproteins during pancreatic development.

    abstract：:Pancreatic development depends on the transcription factor Pax6, which controls islet cell differentiation and hormone production. To understand the regulation of Pax6 pancreatic expression, we have identified a minimal Pax6 pancreatic enhancer and show that it contains a composite binding site for Meis and Pbx homeop...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2006.06.030

    authors： Zhang X,Rowan S,Yue Y,Heaney S,Pan Y,Brendolan A,Selleri L,Maas RL

    更新日期：2006-12-15 00:00:00

  • Developmental origin and morphogenesis of the diaphragm, an essential mammalian muscle.

    abstract：:The diaphragm is a mammalian skeletal muscle essential for respiration and for separating the thoracic and abdominal cavities. Development of the diaphragm requires the coordinated development of muscle, muscle connective tissue, tendon, nerves, and vasculature that derive from different embryonic sources. However, de...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2018.04.010

    authors： Sefton EM,Gallardo M,Kardon G

    更新日期：2018-08-15 00:00:00