当前位置： SCI文献检索 > DEVELOPMENTAL BIOLOGY期刊下所有文献 > Constitutive activation of hedgehog signaling adversely affects epithelial cell fate during palatal fusion.

Constitutive activation of hedgehog signaling adversely affects epithelial cell fate during palatal fusion.

Abstract：

:Cleft palate is one of the most common craniofacial congenital defects in humans. It is associated with multiple genetic and environmental risk factors, including mutations in the genes encoding signaling molecules in the sonic hedgehog (Shh) pathway, which are risk factors for cleft palate in both humans and mice. However, the function of Shh signaling in the palatal epithelium during palatal fusion remains largely unknown. Although components of the Shh pathway are localized in the palatal epithelium, specific inhibition of Shh signaling in palatal epithelium does not affect palatogenesis. We therefore utilized a hedgehog (Hh) signaling gain-of-function mouse model, K14-Cre;R26SmoM2, to uncover the role of Shh signaling in the palatal epithelium during palatal fusion. In this study, we discovered that constitutive activation of Hh signaling in the palatal epithelium results in submucous cleft palate and persistence of the medial edge epithelium (MEE). Further investigation revealed that precise downregulation of Shh signaling is required at a specific time point in the MEE during palatal fusion. Upregulation of Hh signaling in the palatal epithelium maintains the proliferation of MEE cells. This may be due to a dysfunctional p63/Irf6 regulatory loop. The resistance of MEE cells to apoptosis is likely conferred by enhancement of a cell adhesion network through the maintenance of p63 expression. Collectively, our data illustrate that persistent Hh signaling in the palatal epithelium contributes to the etiology and pathogenesis of submucous cleft palate through its interaction with a p63/Irf6-dependent biological regulatory loop and through a p63-induced cell adhesion network.

journal_name

Dev Biol

journal_title

Developmental biology

authors

Li J,Yuan Y,He J,Feng J,Han X,Jing J,Ho TV,Xu J,Chai Y

doi

10.1016/j.ydbio.2018.07.003

subject

Has Abstract

pub_date

2018-09-01 00:00:00

pages

191-203

issue

1

eissn

0012-1606

issn

1095-564X

pii

S0012-1606(18)30306-3

journal_volume

441

pub_type

杂志文章

相关文献

DEVELOPMENTAL BIOLOGY文献大全
  • The apical disposition of the Caenorhabditis elegans intestinal terminal web is maintained by LET-413.

    abstract：:We wish to understand how organ-specific structures assemble during embryonic development. In the present paper, we consider what determines the subapical position of the terminal web in the intestinal cells of the nematode Caenorhabditis elegans. The terminal web refers to the organelle-depleted, intermediate filamen...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2004.01.003

    authors： Bossinger O,Fukushige T,Claeys M,Borgonie G,McGhee JD

    更新日期：2004-04-15 00:00:00

  • Notch signaling is required for normal prostatic epithelial cell proliferation and differentiation.

    abstract：:Notch pathway is crucial for stem/progenitor cell maintenance, growth and differentiation in a variety of tissues. Using a transgenic cell ablation approach, we found in our previous study that cells expressing Notch1 are crucial for prostate early development and re-growth. Here, we further define the role of Notch s...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2005.11.009

    authors： Wang XD,Leow CC,Zha J,Tang Z,Modrusan Z,Radtke F,Aguet M,de Sauvage FJ,Gao WQ

    更新日期：2006-02-01 00:00:00

  • Synthesis and distribution of carbohydrate chains in cleavage-stage mouse embryos carrying the t12 lethal mutation.

    abstract：:Carbohydrate chains on the t12 mutant embryos were analyzed. No abnormalities of the synthesis of the carbohydrate chains were observed in the t12 homozygotes until the late morula stage, when radiolabeled carbohydrate chains were analyzed by Sephadex G-50 column chromatography. Furthermore, polarization of the Con A ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(88)90309-0

    authors： Iwakura Y,Nozaki M

    更新日期：1988-08-01 00:00:00

  • Characterization and regulation of insulin binding by embryonic chick heart cells.

    abstract：:We have compared insulin binding by heart cells at 7 and 14 days of development. Species specificity, optimum pH, temperature relationships, and time to equilibrium for binding of insulin were the same in both 7 and 14-day systems. Curvilinear Scatchard plots for chicken insulin binding were demonstrated. Binding affi...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(81)90410-3

    authors： Serravezza JC,Wheeler FB,DeHaan RL,Elsas LJ

    更新日期：1981-06-01 00:00:00

  • Enhancer activity sensitive to the orientation of the gene it regulates in the chordate genome.

    abstract：:Enhancers are flexible in terms of their location and orientation relative to the genes they regulate. However, little is known about whether the flexibility can be applied in every combination of enhancers and genes. Enhancer detection with transposable elements is a powerful method to identify enhancers in the genom...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2012.12.012

    authors： Hozumi A,Yoshida R,Horie T,Sakuma T,Yamamoto T,Sasakura Y

    更新日期：2013-03-01 00:00:00

  • Epicardial GATA factors regulate early coronary vascular plexus formation.

    abstract：:During early development, GATA factors have been shown to be important for key events of coronary vasculogenesis, including formation of the epicardium. Myocardial GATA factors are required for coronary vascular (CV) formation; however, the role of epicardial localized GATAs in this process has not been addressed. The...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2013.12.033

    authors： Kolander KD,Holtz ML,Cossette SM,Duncan SA,Misra RP

    更新日期：2014-02-01 00:00:00

  • Localization of chemoattractant receptors on Dictyostelium discoideum cells during aggregation and down-regulation.

    abstract：:cAMP chemoattractant receptors on the surface of Dictyostelium discoideum cells are visualized by means of immunocytochemistry. Receptor antigen is virtually absent from growing cells and begins to accumulate after about 6 hr of starvation, concomitant with the increase in surface cAMP binding activity. In aggregating...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(88)90268-0

    authors： Wang M,Van Haastert PJ,Devreotes PN,Schaap P

    更新日期：1988-07-01 00:00:00

  • Ectodermal-derived Endothelin1 is required for patterning the distal and intermediate domains of the mouse mandibular arch.

    abstract：:Morphogenesis of the vertebrate head relies on proper dorsal-ventral (D-V) patterning of neural crest cells (NCC) within the pharyngeal arches. Endothelin-1 (Edn1)-induced signaling through the endothelin-A receptor (Ednra) is crucial for cranial NCC patterning within the mandibular portion of the first pharyngeal arc...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2012.08.003

    authors： Tavares AL,Garcia EL,Kuhn K,Woods CM,Williams T,Clouthier DE

    更新日期：2012-11-01 00:00:00

  • Developmental sequence of expression of voltage-dependent currents in embryonic Xenopus laevis myocytes.

    abstract：:Although the development of several of the voltage-dependent currents in embryonic amphibian myocytes has been described, the overall muscle electrical development, particularly the relative times of expression of different voltage-dependent currents, has not been addressed in a single study under one set of condition...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(92)90043-g

    authors： Spruce AE,Moody WJ

    更新日期：1992-11-01 00:00:00

  • N-cadherin-catenin interaction: necessary component of cardiac cell compartmentalization during early vertebrate heart development.

    abstract：:During early heart development the expression pattern of N-cadherin, a calcium-dependent cell adhesion molecule, suggests its involvement in morphoregulation and the stabilization of cardiomyocyte differentiation. N-cadherin's adhesive activity is dependent upon its interaction with the intracellular catenins. An asso...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1997.8570

    authors： Linask KK,Knudsen KA,Gui YH

    更新日期：1997-05-15 00:00:00

  • zipper Nonmuscle myosin-II functions downstream of PS2 integrin in Drosophila myogenesis and is necessary for myofibril formation.

    abstract：:Nonmuscle myosin-II is a key motor protein that drives cell shape change and cell movement. Here, we analyze the function of nonmuscle myosin-II during Drosophila embryonic myogenesis. We find that nonmuscle myosin-II and the adhesion molecule, PS2 integrin, colocalize at the developing muscle termini. In the paradigm...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.2001.0452

    authors： Bloor JW,Kiehart DP

    更新日期：2001-11-15 00:00:00

  • Alkaline phosphatase expression in ascidian egg fragments and andromerogons.

    abstract：:Alkaline phosphatase (AP) activity is expressed in the endodermal cell lineage of ascidian embryos beginning at gastrulation. AP expression is resistant to levels of actinomycin D which completely suppress the appearance of other tissue-specific enzyme and morphological markers including acetylcholinesterase (AchE), a...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(87)90043-1

    authors： Bates WR,Jeffery WR

    更新日期：1987-02-01 00:00:00

  • fucosyltransferase1 and H-type complex carbohydrates modulate epithelial cell proliferation during prostatic branching morphogenesis.

    abstract：:The prostate undergoes branching morphogenesis dependent on paracrine interactions between the prostatic epithelium and the urogenital mesenchyme. To identify cell-surface molecules that function in this process, monoclonal antibodies raised against epithelial cell-surface antigens were screened for antigen expression...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.2001.0223

    authors： Marker PC,Stephan JP,Lee J,Bald L,Mather JP,Cunha GR

    更新日期：2001-05-01 00:00:00

  • A switch from MafB to MafA expression accompanies differentiation to pancreatic beta-cells.

    abstract：:Major insulin gene transcription factors, such as PDX-1 or NeuroD1, have equally important roles in pancreatic development and the differentiation of pancreatic endocrine cells. Previously, we identified and cloned another critical insulin gene transcription factor MafA (RIPE3b1) and reported that other Maf factors we...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2006.02.028

    authors： Nishimura W,Kondo T,Salameh T,El Khattabi I,Dodge R,Bonner-Weir S,Sharma A

    更新日期：2006-05-15 00:00:00

  • Functional connections with foreign muscles made by a target-deprived insect motorneuron.

    abstract：:Metathoracic limb buds were removed unilaterally from Locusta migratoria embryos at 30% of embryonic development, thereby depriving limb-innervating neurons of the opportunity of innervating their normal target muscles. The operated embryos were allowed to hatch and develop to adulthood, and then the connections betwe...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(85)90335-5

    authors： Whitington PM

    更新日期：1985-02-01 00:00:00

  • SMAD4 is essential for generating subtypes of neurons during cerebellar development.

    abstract：:Cerebellum development involves the coordinated production of multiple neuronal cell types. The cerebellar primordium contains two germinative zones, the rhombic lip (RL) and the ventricular zone (VZ), which generate different types of glutamatergic and GABAergic neurons, respectively. What regulates the specification...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2012.02.017

    authors： Fernandes M,Antoine M,Hébert JM

    更新日期：2012-05-01 00:00:00

  • Dpp/Gbb signaling is required for normal intestinal regeneration during infection.

    abstract：:Maintaining tissue homeostasis is a critical process during infection and inflammation. Tissues with a high intrinsic turnover, such as the intestinal epithelium, must launch a rapid response to infections while simultaneously coordinating cell proliferation and differentiation decisions. In this study, we searched fo...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2014.12.017

    authors： Zhou J,Florescu S,Boettcher AL,Luo L,Dutta D,Kerr G,Cai Y,Edgar BA,Boutros M

    更新日期：2015-03-15 00:00:00

  • Organoid technology for retinal repair.

    abstract：:A major cause for vision impairment and blindness in industrialized countries is the loss of the light-sensing retinal tissue in the eye. Photoreceptor damage is one of the main characteristics found in retinal degeneration diseases, such as Retinitis Pigmentosa or age-related macular degeneration. The lack of effecti...

    journal_title：Developmental biology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ydbio.2017.09.028

    authors： Llonch S,Carido M,Ader M

    更新日期：2018-01-15 00:00:00

  • Actin is a major structural and functional element of the egg cortex of giant silkmoths during oogenesis.

    abstract：:The cortex and subcortical regions of the developing follicles and eggs of silkmoths are rich in cytoskeletal elements, particularly actin. In situ analysis using [3H]-polyuridylic acid and biotinylated oligo d(T) reveals a pattern of changes in poly(A)+ RNA distribution during oogenesis. The developing pattern of dis...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1993.1031

    authors： Watson CA,Sauman I,Berry SJ

    更新日期：1993-02-01 00:00:00

  • Directed overexpression of suppressor 2 of zeste and Posterior Sex Combs results in bristle abnormalities in Drosophila melanogaster.

    abstract：:Three dominant second-chromosome rearrangement mutations in Drosophila melanogaster, Aristapedioid1 (Arp), vestigial-Depilate (vgD), and vestigial62 (vg62), result in developmental abnormalities of the bristle sense organs on the notum, abdomen, legs, and wing margin. The bristle abnormalities are associated with over...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1994.1039

    authors： Sharp EJ,Martin EC,Adler PN

    更新日期：1994-02-01 00:00:00

  • Serotonin-induced meiosis reinitiation from the first prophase and from the first metaphase in oocytes of the marine bivalve Hiatella flaccida: respective changes in intracellular Ca2+ and pH.

    abstract：:In the marine bivalve Hiatella flaccida, full-grown oocytes in ovaries are arrested at the first prophase (prophase-I) of meiosis, whereas spawned oocytes have reinitiated meiosis from prophase-I and are again arrested at the first metaphase (metaphase-I). The neurohormone serotonin (5-hydroxytryptamine, 5-HT) was abl...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.1995.1298

    authors： Deguchi R,Osanai K

    更新日期：1995-10-01 00:00:00

  • Different molecular mechanisms for cAMP regulation of gene expression during Dictyostelium development.

    abstract：:Alterations in cAMP concentrations have been implicated in developmentally regulated gene expression in Dictyostelium. Using a variety of culture conditions to control the metabolism of cAMP during cytodifferentiation, I have examined the role of the cyclic nucleotide in development. Conditions which allow intracellul...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(87)90342-3

    authors： Kimmel AR

    更新日期：1987-07-01 00:00:00

  • Distinct roles of Fgf8, Foxi1, Dlx3b and Pax8/2 during otic vesicle induction and maintenance in medaka.

    abstract：:The development of the vertebrate inner ear is a complex process that has been investigated in several model organisms. In this work, we examined genetic interactions regulating early development of otic structures in medaka. We demonstrate that misexpression of Fgf8, Dlx3b and Foxi1 during early gastrulation is suffi...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2007.04.022

    authors： Aghaallaei N,Bajoghli B,Czerny T

    更新日期：2007-07-15 00:00:00

  • Growth cone interactions with a glial cell line from embryonic Xenopus retina.

    abstract：:We have isolated a nonneuronal cell line from Xenopus retinal neuroepithelium (XR1 cell line). On the basis of immunocytochemical characterization using monoclonal antibodies generated in our laboratory as well as several other glial-specific antibodies, we have established that the XR1 cells are derived from embryoni...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(89)90086-9

    authors： Sakaguchi DS,Moeller JF,Coffman CR,Gallenson N,Harris WA

    更新日期：1989-07-01 00:00:00

  • Chromatin modifications in the germinal vesicle (GV) of mammalian oocytes.

    abstract：:The nucleus of eukaryotic cells is organized into functionally specialized compartments that are essential for the control of gene expression, chromosome architecture and cellular differentiation. The mouse oocyte nucleus or germinal vesicle (GV) exhibits a unique chromatin configuration that is subject to dynamic mod...

    journal_title：Developmental biology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ydbio.2006.01.008

    authors： De La Fuente R

    更新日期：2006-04-01 00:00:00

  • Osteogenic cell lineage analysis is facilitated by organ cultures of embryonic chick periosteum.

    abstract：:Monoclonal antibodies against the surface of embryonic osteogenic cells (SB-1, SB-2, SB-3, and SB-5) have been used to characterize the sequence of transitions involved in the osteogenic cell lineage. In the present study, immunohistochemical analyses of the expression of osteogenic cell surface antigens in organ cult...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/0012-1606(90)90388-y

    authors： Bruder SP,Caplan AI

    更新日期：1990-10-01 00:00:00

  • Development of the enteric nervous system in the moth. I. Diversity of cell types and the embryonic expression of FMRFamide-related neuropeptides.

    abstract：:The enteric nervous system (ENS) of the larval moth Manduca sexta consists of two small ganglia and several nerve networks that lie superficially along the alimentary tract. Within this system are approximately 600 neurons that exhibit a spectrum of biochemical and morphological characteristics and that express these ...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/s0012-1606(89)80039-9

    authors： Copenhaver PF,Taghert PH

    更新日期：1989-01-01 00:00:00

  • Molecular patterning of the embryonic cranial mesenchyme revealed by genome-wide transcriptional profiling.

    abstract：:In the head of an embryo, a layer of mesenchyme surrounds the brain underneath the surface ectoderm. This cranial mesenchyme gives rise to the meninges, the calvaria (top part of the skull), and the dermis of the scalp. Abnormal development of these structures, especially the meninges and the calvaria, is linked to si...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2019.07.015

    authors： Dasgupta K,Chung JU,Asam K,Jeong J

    更新日期：2019-11-15 00:00:00

  • Sp5, a new member of the Sp1 family, is dynamically expressed during development and genetically interacts with Brachyury.

    abstract：:We describe the identification, biochemical characterisation, and mutation of a novel mouse gene: Sp5. Sp5 encodes a protein having a C-terminal C(2)H(2) zinc finger domain closely related to that of the transcription factor Sp1. In vitro, DNA binding studies show that it binds to the GC box, a DNA motif present in th...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1006/dbio.2000.9878

    authors： Harrison SM,Houzelstein D,Dunwoodie SL,Beddington RS

    更新日期：2000-11-15 00:00:00

  • A novel Cripto-related protein reveals an essential role for EGF-CFCs in Nodal signalling in Xenopus embryos.

    abstract：:The location, timing and intensity of Nodal signalling are all critical for proper patterning of the vertebrate embryo. Genetic evidence from mouse and zebrafish indicates that EGF-CFC family members are essential for Nodal ligands to signal. However, the Xenopus EGF-CFC, FRL1, has been implicated in Wnt signalling an...

    journal_title：Developmental biology

    pub_type： 杂志文章

    doi：10.1016/j.ydbio.2006.01.006

    authors： Dorey K,Hill CS

    更新日期：2006-04-15 00:00:00