Distinct functions of the leucine-rich repeat transmembrane proteins capricious and tartan in the Drosophila tracheal morphogenesis.


:A key step in organogenesis of the Drosophila tracheal system is the integration of isolated tracheal metameres into a connected tubular network. The interaction of tracheal cells with surrounding mesodermal cells is crucial in this process. In particular, single mesodermal cells called bridge-cells are essential for the guided outgrowth of dorsal trunk branches to direct formation of the main airway, the dorsal trunk. Here, we present evidence that the two leucine-rich repeat transmembrane proteins Capricious and Tartan contribute differently to the formation of branch interconnections during tracheal development. Capricious is specifically localized on the surface of bridge-cells and facilitates the outgrowing dorsal trunk cells of adjacent metameres toward each other. We show that Capricious requires both extracellular and intracellular domains during tracheal branch outgrowth. In contrast, Tartan is expressed broadly in mesodermal cells and exerts its role in tracheal branch outgrowth through its extracellular domain. We propose that Capricious contributes to the instructive role of bridge-cells whereas Tartan provides permissive substrate for the migrating tracheal cells during the network formation.


Dev Biol


Developmental biology


Krause C,Wolf C,Hemphälä J,Samakovlis C,Schuh R




Has Abstract


2006-08-01 00:00:00














  • Ontogeny of the mouse vocal fold epithelium.

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    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Lungova V,Verheyden JM,Herriges J,Sun X,Thibeault SL

    更新日期:2015-03-15 00:00:00

  • Quantitative analysis of cyclic AMP waves mediating aggregation in Dictyostelium discoideum.

    abstract::We have previously reported the detection of cAMP waves within monolayers of aggregating Dictyostelium discoideum cells (K. J. Tomchik and P.N. Devreotes, 1981, Science 212, 443-446). The computer-assisted analysis presented here of the fluorographic images of the cAMP waves reveals (1) all the waves have a consistent...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Devreotes PN,Potel MJ,MacKay SA

    更新日期:1983-04-01 00:00:00

  • Position-specific growth of mouse limb bud cells in vitro.

    abstract::The relationship between cellular position and growth control has been studied in cultures of dissociated fragments of mouse limb bud cells. Using cells derived from various positions along the anterior-posterior axis of the limb bud we have developed culture conditions that optimize growth of positionally isolated ce...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Shi C,Muneoka K

    更新日期:1992-05-01 00:00:00

  • Cdc42 protein acts upstream of IQGAP1 and regulates cytokinesis in mouse oocytes and embryos.

    abstract::Cdc42 and Rac1 Rho family GTPases, and their interacting protein IQGAP1 are the key regulators of cell polarity. We examined the role of Cdc42 and IQGAP1 in establishing the polarity of mouse oocyte and regulation of meiotic and mitotic divisions. We showed that Cdc42 was localized on the microtubules of meiotic and m...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Bielak-Zmijewska A,Kolano A,Szczepanska K,Maleszewski M,Borsuk E

    更新日期:2008-10-01 00:00:00

  • Two novel type II receptors mediate BMP signalling and are required to establish left-right asymmetry in zebrafish.

    abstract::Ligands of the transforming growth factor beta (TGFbeta) superfamily, like Nodal and bone morphogenetic protein (BMP), are pivotal to establish left-right (LR) asymmetry in vertebrates. However, the receptors mediating this process are unknown. Here we identified two new type II receptors for BMPs in zebrafish termed ...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Monteiro R,van Dinther M,Bakkers J,Wilkinson R,Patient R,ten Dijke P,Mummery C

    更新日期:2008-03-01 00:00:00

  • The nucleolar GTP-binding proteins Gnl2 and nucleostemin are required for retinal neurogenesis in developing zebrafish.

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    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Paridaen JT,Janson E,Utami KH,Pereboom TC,Essers PB,van Rooijen C,Zivkovic D,MacInnes AW

    更新日期:2011-07-15 00:00:00

  • Characterization of a sperm factor for egg activation at fertilization of the newt Cynops pyrrhogaster.

    abstract::Eggs of the newt, Cynops pyrrhogaster, arrested at the second meiotic metaphase are activated by sperm at fertilization and then complete meiosis to initiate development. We highly purified a sperm factor for egg activation from a sperm extract with several chromatographies. The purified fraction containing only a 45 ...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Harada Y,Matsumoto T,Hirahara S,Nakashima A,Ueno S,Oda S,Miyazaki S,Iwao Y

    更新日期:2007-06-15 00:00:00

  • Heparan sulfate proteoglycans regulate BMP signalling during neural crest induction.

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    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Pegge J,Tatsinkam AJ,Rider CC,Bell E

    更新日期:2020-04-15 00:00:00

  • The regulatory mechanisms that underlie inappropriate transcription of the myogenic determination gene Myf5 in the central nervous system.

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    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Daubas P,Crist CG,Bajard L,Relaix F,Pecnard E,Rocancourt D,Buckingham M

    更新日期:2009-03-01 00:00:00

  • Cell lineage analysis of maize bundle sheath and mesophyll cells.

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    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Langdale JA,Lane B,Freeling M,Nelson T

    更新日期:1989-05-01 00:00:00

  • Radial leaves of the maize mutant ragged seedling2 retain dorsiventral anatomy.

    abstract::ragged seedling2 (rgd2) is a novel, recessive mutation affecting lateral organ development in maize. The mutant phenotype of homozygous rgd2-R leaves is variable. Mild leaf phenotypes have a reduced midrib and may be moderately narrow and furcated; severe Rgd2-R(-) leaves are filamentous or even radial. Despite their ...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Henderson DC,Muehlbauer GJ,Scanlon MJ

    更新日期:2005-06-15 00:00:00

  • Precocious retinal neurons: Pax6 controls timing of differentiation and determination of cell type.

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    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Philips GT,Stair CN,Young Lee H,Wroblewski E,Berberoglu MA,Brown NL,Mastick GS

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  • A growth-promoting influence from the mesonephros during limb outgrowth.

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    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Geduspan JS,Solursh M

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    abstract::It has been difficult to examine the role of TGF-ß in post-natal tooth development due to perinatal lethality in many of the signaling deficient mouse models. To address the role of Tgfbr2 in postnatal tooth development, we generated a mouse in which Tgfbr2 was deleted in odontoblast- and bone-producing mesenchyme. Os...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Wang Y,Cox MK,Coricor G,MacDougall M,Serra R

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  • Intracellular calcium release channel expression during embryogenesis.

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    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Rosemblit N,Moschella MC,Ondriašová E,Gutstein DE,Ondriaš K,Marks AR

    更新日期:1999-02-15 00:00:00

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    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Vlahou A,Flytzanis CN

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    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Ostrom L,Tang MJ,Gruss P,Dressler GR

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    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Bell J,Char BR,Maxson R

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  • Functional genomics identifies neural stem cell sub-type expression profiles and genes regulating neuroblast homeostasis.

    abstract::The Drosophila larval central brain contains about 10,000 differentiated neurons and 200 scattered neural progenitors (neuroblasts), which can be further subdivided into ~95 type I neuroblasts and eight type II neuroblasts per brain lobe. Only type II neuroblasts generate self-renewing intermediate neural progenitors ...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Carney TD,Miller MR,Robinson KJ,Bayraktar OA,Osterhout JA,Doe CQ

    更新日期:2012-01-01 00:00:00

  • Loss of Fgfr2 leads to partial XY sex reversal.

    abstract::In mammals, sex is determined in the bipotential embryonic gonad by a balanced network of gene actions which when altered causes disorders of sexual development (DSD, formerly known as intersex). In the XY gonad, presumptive Sertoli cells begin to differentiate when SRY up-regulates SOX9, which in turn activates FGF9 ...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Bagheri-Fam S,Sim H,Bernard P,Jayakody I,Taketo MM,Scherer G,Harley VR

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    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Shepherd I,Luo Y,Raper JA,Chang S

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  • Immunofluorescent studies for myosin, actin, tropomyosin and alpha-actinin in cultured cardiomyopathic hamster heart cells.

    abstract::Primary cultures of cardiac myocytes from newborn normal and genetically cardiomyopathic (strain UM-X7.1) hamsters were analyzed by electron microscopy and immunofluorescent staining for myosin, actin, tropomyosin, and alpha-actinin. Antibody staining of these contractile proteins demonstrates that both normal and car...

    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Lemanski LF,Tu ZH

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    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Lallier TE,DeSimone DW

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    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Grana TM,Cox EA,Lynch AM,Hardin J

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    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Korzh S,Winata CL,Zheng W,Yang S,Yin A,Ingham P,Korzh V,Gong Z

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    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Niakan KK,Eggan K

    更新日期:2013-03-01 00:00:00

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    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Bloor JW,Kiehart DP

    更新日期:2001-11-15 00:00:00

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    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Satoh A,Bryant SV,Gardiner DM

    更新日期:2012-06-15 00:00:00

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    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Godsave S,Dekker EJ,Holling T,Pannese M,Boncinelli E,Durston A

    更新日期:1994-12-01 00:00:00

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    journal_title:Developmental biology

    pub_type: 杂志文章


    authors: Brisken C,Kaur S,Chavarria TE,Binart N,Sutherland RL,Weinberg RA,Kelly PA,Ormandy CJ

    更新日期:1999-06-01 00:00:00