At the base of colinear Hox gene expression: cis-features and trans-factors orchestrating the initial phase of Hox cluster activation.

abstract：:To analyze the molecular mechanism of the limb pattern formation, we have tried to make monoclonal antibodies against antigens from chick limb buds. We obtained one antibody named AV-1 which recognized a specific region of chick limb buds. AV-1 reacted with the distal portion of the anteroventral mesoderm of only deve...

journal_title：Developmental biology

authors： Ohsugi K,Ide H

更新日期：1986-10-01 00:00:00

abstract：:Septins are guanosine triphosphate-binding proteins that are evolutionally conserved in all eukaryotes other than plants. They function as multimeric complexes that interact with membrane lipids, actomyosin, and microtubules. Based on these interactions, septins play essential roles in the morphogenesis and physiologi...

journal_title：Developmental biology

authors： Torii H,Yoshida A,Katsuno T,Nakagawa T,Ito J,Omori K,Kinoshita M,Yamamoto N

更新日期：2016-11-15 00:00:00

abstract：:Developing cardiac myocytes divide a limited number of times before they stop and terminally differentiate, but the mechanism that stops their division is unknown. To help study the stopping mechanism, we defined conditions under which embryonic rat cardiac myocytes cultured in serum-free medium proliferate and exit t...

journal_title：Developmental biology

authors： Burton PB,Raff MC,Kerr P,Yacoub MH,Barton PJ

更新日期：1999-12-15 00:00:00

abstract：:We have examined the expression of mRNAs encoding five major neurotransmitter-synthesizing enzymes in MAH cells, a clonal cell line derived by retroviral immortalization of a rat embryonic sympathoadrenal progenitor cell. These mRNAs include tyrosine hydroxylase (TH), choline acetyltransferase (ChAT), tryptophan hydro...

journal_title：Developmental biology

authors： Vandenbergh DJ,Mori N,Anderson DJ

更新日期：1991-11-01 00:00:00

abstract：:Major insulin gene transcription factors, such as PDX-1 or NeuroD1, have equally important roles in pancreatic development and the differentiation of pancreatic endocrine cells. Previously, we identified and cloned another critical insulin gene transcription factor MafA (RIPE3b1) and reported that other Maf factors we...

journal_title：Developmental biology

authors： Nishimura W,Kondo T,Salameh T,El Khattabi I,Dodge R,Bonner-Weir S,Sharma A

更新日期：2006-05-15 00:00:00

abstract：:Neuronal differentiation requires a coordinated intracellular response to diverse extracellular stimuli, but the role of specific signaling mechanisms in regulating this process is still poorly understood. Soluble guanylate cyclases (sGCs), which can be stimulated by diffusible free radical gasses such as nitric oxide...

journal_title：Developmental biology

authors： Wright JW,Schwinof KM,Snyder MA,Copenhaver PF

更新日期：1998-12-01 00:00:00

abstract：:Distinct groups of dopaminergic neurons develop at defined anatomical sites in the brain to modulate function of a large diversity of local and far-ranging circuits. However, the molecular identity as judged from transcription factor expression has not been determined for all dopaminergic groups. Here, we analyze regi...

journal_title：Developmental biology

authors： Filippi A,Jainok C,Driever W

更新日期：2012-09-01 00:00:00

abstract：:We investigated the potential role of rostral-caudal and dorsal-ventral subdivisions of the early rostral brain by relating these subdivisions to the early patterning of neuron cell bodies and their axon projections. The earliest neurons were mapped using the lipophilic axon tracers diI and diO on embryos fixed on emb...

journal_title：Developmental biology

authors： Mastick GS,Easter SS Jr

更新日期：1996-01-10 00:00:00

abstract：:Botryllus schlosseri is a colonial marine urochordate in which all adult organisms (called zooids) in a colony die synchronously by apoptosis (programmed cell death) in cyclical fashion. During this death phase called takeover, cell corpses within the dying organism are engulfed by circulating phagocytic cells. The "o...

journal_title：Developmental biology

authors： Lauzon RJ,Ishizuka KJ,Weissman IL

更新日期：2002-09-15 00:00:00

abstract：:The outstanding migration and differentiation capacities of neural crest cells (NCCs) have fascinated scientists since Wilhelm His described this cell population in 1868. Today, after intense research using vertebrate model organisms, we have gained considerable knowledge regarding the origin, migration and differenti...

journal_title：Developmental biology

authors： Betters E,Liu Y,Kjaeldgaard A,Sundström E,García-Castro MI

更新日期：2010-08-15 00:00:00

abstract：:Immunocytochemical studies were performed to determine if denervated rodent iris produces nerve growth factor (NGF) in a form chemically similar to that of the 7S NGF complex in mouse submandibular glands. Antisera to the alpha, beta, and gamma subunits of 7S NGF were raised in rabbits and characterized on immunoblots...

journal_title：Developmental biology

authors： Murphy RA,Landis SC,Bernanke J,Siminoski K

更新日期：1986-04-01 00:00:00

abstract：:Cdc42 and Rac1 Rho family GTPases, and their interacting protein IQGAP1 are the key regulators of cell polarity. We examined the role of Cdc42 and IQGAP1 in establishing the polarity of mouse oocyte and regulation of meiotic and mitotic divisions. We showed that Cdc42 was localized on the microtubules of meiotic and m...

journal_title：Developmental biology

authors： Bielak-Zmijewska A,Kolano A,Szczepanska K,Maleszewski M,Borsuk E

更新日期：2008-10-01 00:00:00

abstract：:The distribution and ontogeny of four neuropeptides in developing chick lumbosacral sensory and sympathetic ganglia were studied using immunohistochemical techniques. Antibodies to two of these peptides, substance P (SP) and calcitonin gene-related peptide (CGRP), stained small neurons in the medial part of the dorsal...

journal_title：Developmental biology

authors： New HV,Mudge AW

更新日期：1986-08-01 00:00:00

abstract：:The ubiquitin ligase Smurf1 can target a handful of signaling proteins for ubiquitin-mediated proteasomal destruction or functional modification, including TGF-beta receptors, Smads, transcription factors, RhoA and MEKK2. Smurf1 was initially implicated in BMP pathway regulation in embryonic development, but its poten...

journal_title：Developmental biology

authors： Alexandrova EM,Thomsen GH

更新日期：2006-11-15 00:00:00

abstract：:Following their birth in olfactory placode, luteinizing hormone-releasing hormone (LHRH)-containing neurons migrate across the developing cribriform plate and form a dispersed population in the mammalian basal forebrain. The present study reveals the colocalization of unique glycoconjugate antigens (detected with mono...

journal_title：Developmental biology

authors： Tobet SA,Crandall JE,Schwarting GA

更新日期：1993-02-01 00:00:00

abstract：:During development of the central nervous system (CNS), commissural axons grow toward the ventral midline. After crossing the floor plate, they abruptly change their trajectory from the circumferential to the longitudinal axis. The contacts between the commissural axons and the floor plate cells are involved in this a...

journal_title：Developmental biology

authors： Okabe N,Shimizu K,Ozaki-Kuroda K,Nakanishi H,Morimoto K,Takeuchi M,Katsumaru H,Murakami F,Takai Y

更新日期：2004-09-15 00:00:00

abstract：:A cDNA library was used to measure changes in many individual mRNAs during muscle differentiation in culture. A library of 1000 clones was constructed from total myofiber poly(A) RNA. About 23% of these clones gave a detectable colony hybridization signal using end-labeled myofiber mRNA, the remainder containing muscl...

journal_title：Developmental biology

authors： Devlin RB,Haskell SG

更新日期：1983-02-01 00:00:00

abstract：:Integrins are alphabeta transmembrane receptors that function in key cellular processes, including cell adhesion, differentiation, and extracellular matrix deposition through interactions with extracellular, membrane, and cytoplasmic proteins. We previously identified and cloned a muscle beta1 integrin cytoplasmic bin...

journal_title：Developmental biology

authors： Li J,Rao H,Burkin D,Kaufman SJ,Wu C

更新日期：2003-09-01 00:00:00

abstract：:The organization of the embryonic neural plate requires coordination of multiple signal transduction pathways, including fibroblast growth factors (FGFs), bone morphogenetic proteins (BMPs), and WNTs. Many studies have suggested that a critical component of this process is the patterning of posterior neural tissues by...

journal_title：Developmental biology

authors： Roche DD,Liu KJ,Harland RM,Monsoro-Burq AH

更新日期：2009-09-01 00:00:00

abstract：:In this paper I sought to determine how the expression of differentiated traits of chick retinal pigmented epithelial (RPE) cells in vitro can be modulated by varying both the biochemical and the spatial complexity, and the mechanical properties, of the growth substratum. I have used glass derivatized with proteins of...

journal_title：Developmental biology

authors： Opas M

更新日期：1989-02-01 00:00:00

abstract：:Neural crest cells originate in the dorsal neural tube but subsequently undergo an epithelial-to-mesenchymal transition (EMT), delaminate, and migrate to diverse locations in the embryo where they contribute to a variety of derivatives. Cadherins are a family of cell-cell adhesion molecules expressed in a broad range ...

journal_title：Developmental biology

authors： Coles EG,Taneyhill LA,Bronner-Fraser M

更新日期：2007-12-15 00:00:00

abstract：:In mammals, two spatially and temporally distinct waves of fiber cell differentiation are crucial steps for normal lens development. In between these phases, an anterior growth zone forms in which progenitor cells migrate circumferentially, terminally exit the cell cycle and initiate differentiation at the lens equato...

journal_title：Developmental biology

authors： Le TT,Conley KW,Brown NL

更新日期：2009-04-01 00:00:00

abstract：:Zygotic gene activation is essential for development beyond the 2-cell stage in the preimplantation mouse embryo. Based on alpha-amanitin-sensitive BrUTP incorporation, transcription initiates in the 1-cell embryo and a major reprogramming of gene expression driven by newly expressed genes is prominently observed duri...

journal_title：Developmental biology

authors： Zeng F,Schultz RM

更新日期：2005-07-01 00:00:00

abstract：:Bullous pemphigoid antisera and monoclonal antibodies to type VII collagen were used to localize hemidesmosomes and anchoring fibrils, respectively, in tissues of developing eyes and healing corneal wounds of New Zealand white rabbits. In the 17-day fetal rabbit eye, both antibodies colocalize to the epithelial-stroma...

journal_title：Developmental biology

authors： Gipson IK,Spurr-Michaud SJ,Tisdale AS

更新日期：1988-04-01 00:00:00

abstract：:Full-grown Xenopus oocytes, Stage VI (1200-1300 microns), undergo meiotic maturation when exposed to progesterone. Smaller stage IV (800 microns) and stage V (1000 microns) oocytes remain in prophase arrest when exposed to this steroid. The larger stage VI oocytes undergo an intracellular alkalization from 7.2 to 7.6,...

journal_title：Developmental biology

authors： Wasserman WJ,Houle JG,Samuel D

更新日期：1984-10-01 00:00:00

abstract：:The formation of the spinal cord during early embryonic development in vertebrate embryos is a continuous process that begins at gastrulation and continues through to the completion of somitogenesis. Despite the conserved usage of patterning mechanisms and gene regulatory networks that act to generate specific spinal ...

journal_title：Developmental biology

authors： Steventon B,Martinez Arias A

更新日期：2017-12-01 00:00:00

abstract：:It is well established that the notochord influences the development of adjacent neural and mesodermal tissue. Involvement of the notochord in the differentiation of the dorsal pancreas has been demonstrated. However, our knowledge of the signals involved in pancreatic development is still incomplete. In order to iden...

journal_title：Developmental biology

authors： Stephan JP,Bald L,Roberts PE,Lee J,Gu Q,Mather JP

更新日期：1999-08-15 00:00:00

abstract：:A new monoclonal antibody, specific to an epitope in the carboxyl terminus of the Drosophila collagen IV molecule (basement membrane collagen) was identified. The distributions of collagen IV, laminin, and an additional extracellular molecule, the 2G2 antigen (2G2-Ag), were followed immunocytochemically during early w...

journal_title：Developmental biology

authors： Murray MA,Fessler LI,Palka J

更新日期：1995-03-01 00:00:00

abstract：:We recently demonstrated a critical role for two-pore channel type 2 (TPC2)-mediated Ca2+ release during the differentiation of slow (skeletal) muscle cells (SMC) in intact zebrafish embryos, via the introduction of a translational-blocking morpholino antisense oligonucleotide (MO). Here, we extend our study and demon...

journal_title：Developmental biology

authors： Kelu JJ,Webb SE,Parrington J,Galione A,Miller AL

更新日期：2017-05-15 00:00:00

abstract：:Through the course of evolution, the gastrointestinal (GI) tract has been modified to maximize nutrient absorption, forming specialized segments that are morphologically and functionally distinct. Here we show that the GI tract of the Mexican tetra, Astyanax mexicanus, has distinct regions, exhibiting differences in m...

journal_title：Developmental biology

authors： Riddle MR,Boesmans W,Caballero O,Kazwiny Y,Tabin CJ

更新日期：2018-09-15 00:00:00