Position specific binding of a monoclonal antibody in chick limb buds.

abstract：:The Drosophila homeobox gene tinman and its vertebrate homologs Nkx-2.5 and Nkx-2.3 are critical determinants of cardiac development. We report here the identification of a new tinman-related gene, nkx2.7, as well as orthologs of Nkx-2.5 and Nkx-2.3 in the zebrafish. Analysis of their expression in the developing zebr...

journal_title：Developmental biology

authors： Lee KH,Xu Q,Breitbart RE

更新日期：1996-12-15 00:00:00

abstract：:We report here the identification and characterization of a novel gene, T1 alpha, expressed in high abundance in adult rat lung, fetal lung, and early fetal brain. T1 alpha was identified by a monoclonal antibody previously shown to be specific for an antigen expressed by alveolar epithelial type I cells. The cDNA for...

journal_title：Developmental biology

authors： Rishi AK,Joyce-Brady M,Fisher J,Dobbs LG,Floros J,VanderSpek J,Brody JS,Williams MC

更新日期：1995-01-01 00:00:00

abstract：:Nociceptive neurons innervate the skin with complex dendritic arbors that respond to pain-evoking stimuli such as harsh mechanical force or extreme temperatures. Here we describe the structure and development of a model nociceptor, the PVD neuron of C. elegans, and identify transcription factors that control morphogen...

journal_title：Developmental biology

authors： Smith CJ,Watson JD,Spencer WC,O'Brien T,Cha B,Albeg A,Treinin M,Miller DM 3rd

更新日期：2010-09-01 00:00:00

abstract：:Modulation of reactive oxygen species (ROS) plays a key role in signal transduction pathways. Selenoproteins act controlling the redox balance of the cell. We have studied how the alteration of the redox balance caused by patufet (selD(ptuf)), a null mutation in the Drosophila melanogaster selenophosphate synthetase 1...

journal_title：Developmental biology

authors： Morey M,Serras F,Baguñà J,Hafen E,Corominas M

更新日期：2001-10-01 00:00:00

abstract：:In the zebrafish embryo, cells fated to give rise to the rostral brain move in a concerted fashion and retain tissue coherence during morphogenesis. We demonstrate here that Otx proteins have a dramatic effect on cell-cell interactions when expressed ectopically in the zebrafish embryo. Injection of zebrafish Otx1 or ...

journal_title：Developmental biology

authors： Bellipanni G,Murakami T,Doerre OG,Andermann P,Weinberg ES

更新日期：2000-07-15 00:00:00

abstract：:AKT signaling is an essential intracellular pathway controlling cell homeostasis, cell proliferation and survival, as well as cell migration and differentiation in adults. Alterations impacting the AKT pathway are involved in many pathological conditions in human disease. Similarly, during development, multiple transm...

journal_title：Developmental biology

authors： Sittewelle M,Monsoro-Burq AH

更新日期：2018-12-01 00:00:00

abstract：:The Mesp bHLH genes play a conserved role during segmental patterning of the mesoderm in the vertebrate embryo by specifying segmental boundaries and anteroposterior (A-P) segmental polarity. Here we use a xenotransgenic approach to compare the transcriptional enhancers that drive expression of the Mesp genes within s...

journal_title：Developmental biology

authors： Moreno TA,Jappelli R,Izpisúa Belmonte JC,Kintner C

更新日期：2008-03-15 00:00:00

abstract：:Metazoan development involves a myriad of dynamic cellular processes that require cytoskeletal function. Nonmuscle myosin II plays essential roles in embryonic development; however, knowledge of its role in post-embryonic development, even in model organisms such as Drosophila melanogaster, is only recently being reve...

journal_title：Developmental biology

authors： Franke JD,Montague RA,Kiehart DP

更新日期：2010-09-15 00:00:00

abstract：:BMP signaling responses are refined by distinct secreted and intracellular antagonists in different cellular and temporal contexts. Here, we show that the nuclear LEM-domain protein MAN1 is a tissue-specific antagonist of BMP signaling in Drosophila. MAN1 contains two potential Mad-binding sites. We generated MAN1Delt...

journal_title：Developmental biology

authors： Wagner N,Weyhersmüller A,Blauth A,Schuhmann T,Heckmann M,Krohne G,Samakovlis C

更新日期：2010-03-01 00:00:00

abstract：:The contributions that control of cell proliferation and cell growth make to developmental regulation of organ and body size remain poorly explored, particularly with respect to endocycles in polyploid tissues. The epithelium of the marine chordate Oikopleura dioica is composed of a fixed number of cells grouped in te...

journal_title：Developmental biology

authors： Ganot P,Thompson EM

更新日期：2002-12-01 00:00:00

abstract：:Projection neurons of the developing cerebral cortex are generated in the cerebral ventricular zone and subsequently move to the developing cortical plate via radial migration. Conversely, most inhibitory interneurons originate in the ganglionic eminences and enter the developing cortical plate by tangential migration...

journal_title：Developmental biology

authors： Britanova O,Alifragis P,Junek S,Jones K,Gruss P,Tarabykin V

更新日期：2006-10-01 00:00:00

abstract：:Oct-4 is the earliest expressed gene known to encode a transcription factor which is developmentally regulated during mammalian embryogenesis. In order to understand the role of Oct-4 in early murine embryogenesis, we carried out an analysis of the temporal and spatial pattern of protein expression. We report the pres...

journal_title：Developmental biology

authors： Palmieri SL,Peter W,Hess H,Schöler HR

更新日期：1994-11-01 00:00:00

abstract：:Myogenesis in the embryo and the adult mammal consists of a highly organized and regulated sequence of cellular processes to form or repair muscle tissue that include cell proliferation, migration, and differentiation. Data from cell culture and in vivo experiments implicate both FGFs and HGF as critical regulators of...

journal_title：Developmental biology

authors： Cornelison DD,Filla MS,Stanley HM,Rapraeger AC,Olwin BB

更新日期：2001-11-01 00:00:00

abstract：:Prestalk cells are found in the anterior 15% of slugs of Dictyostelium discoideum and prespore cells are found in the remaining posterior portions. Neutral red staining as well as immunostaining with antisera prepared against spores or a spore-coat protein has indicated that there are cells in the posterior region whi...

journal_title：Developmental biology

authors： Devine KM,Loomis WF

更新日期：1985-02-01 00:00:00

abstract：:Progression of germ cells through meiosis is regulated by phosphorylation events. We previously showed the key role of cyclin dependent kinases in meiotic divisions of rat spermatocytes co-cultured with Sertoli cells (SC). In the present study, we used the same culture system to address the role of mitogen-activated p...

journal_title：Developmental biology

authors： Godet M,Sabido O,Gilleron J,Durand P

更新日期：2008-03-01 00:00:00

abstract：:Stable subdivision of Drosophila limbs into Anterior (A) and Posterior (P) compartments is a consequence of asymmetric signaling by Hedgehog (Hh) from P to A cells. The activity of the homeodomain protein Engrailed (En) in P cells has been reported to help to generate this asymmetry by inducing the expression of hedge...

journal_title：Developmental biology

authors： Bejarano F,Milán M

更新日期：2009-03-15 00:00:00

abstract：:In medusae of the hydrozoan Cytaeis uchidae, oocyte meiotic maturation and spawning occur as a consequence of dark-light transition. In this study, we investigated the mechanism underlying the initiation of meiotic maturation using in vitro (isolated oocytes from ovaries) and in vivo (ovarian oocytes in medusae) syste...

journal_title：Developmental biology

authors： Takeda N,Kyozuka K,Deguchi R

更新日期：2006-10-01 00:00:00

abstract：:The vertebrate pituitary gland is a key endocrine control organ that contains six distinct hormone secreting cell types. In this study, we analyzed the role of direct cell-to-cell Delta-Notch signaling in zebrafish anterior pituitary cell type specification. We demonstrate that initial formation of the anterior pituit...

journal_title：Developmental biology

authors： Dutta S,Dietrich JE,Westerfield M,Varga ZM

更新日期：2008-07-15 00:00:00

abstract：:I report on the synthesis of fibronectin in the developing chick Müllerian duct mesenchymal cells. Before the differentiation of female chick Müllerian duct, the amount of fibronectin in the cells of the right duct is 44% lower than in the left duct. While after differentiation, the amount of fibronectin in the right ...

journal_title：Developmental biology

authors： Teng CS

更新日期：1990-07-01 00:00:00

abstract：:Effective transgenesis methods have been successfully employed in many organisms including zebrafish. However, accurate spatiotemporal control of transgene expression is still difficult to achieve. Here we describe a system for chemical-inducible gene expression and demonstrate its feasibility for generating transgeni...

journal_title：Developmental biology

authors： Emelyanov A,Parinov S

更新日期：2008-08-01 00:00:00

abstract：:The specification of the five individual hormone-secreting cell types in the anterior pituitary requires a series of sequential cell fate decisions. We have immortalized cells at several stages along this pathway of pituitary differentiation. Here, we present analysis of differences in gene expression between an anter...

journal_title：Developmental biology

authors： Holley SJ,Hall SB,Mellon PL

更新日期：2002-04-15 00:00:00

abstract：:Cellular dedifferentiation underlies topical issues in biology such as regeneration and nuclear cloning and has common features in plants and animals. In plants, this process characterizes the transition of differentiated leaf cells to protoplasts (plant cells devoid of cell walls) and is accompanied by global chromat...

journal_title：Developmental biology

authors： Grafi G,Ben-Meir H,Avivi Y,Moshe M,Dahan Y,Zemach A

更新日期：2007-06-15 00:00:00

abstract：:The lateral line system comprises an array of mechanosensory organs, the neuromasts, distributed over the body surface. Each neuromast consists of a patch of mechanosensory hair cells surrounded by support cells. We show that, in the zebrafish, two proneural genes are essential for differentiation of the hair cells, n...

journal_title：Developmental biology

authors： Sarrazin AF,Villablanca EJ,Nuñez VA,Sandoval PC,Ghysen A,Allende ML

更新日期：2006-07-15 00:00:00

abstract：:The hox genes play a central role in organogenesis and are implicated in the formation of hematopoietic stem cells (HSCs). The cdx genes encode homeodomain transcription factors that act as master regulators of the hox genes. In zebrafish, mutations in cdx4 cause a severe, but not complete, deficit in embryonic blood ...

journal_title：Developmental biology

authors： Davidson AJ,Zon LI

更新日期：2006-04-15 00:00:00

abstract：:The cellular control of the switch from embryonic to fetal globin formation in man was investigated with studies of globin expression in erythroid cells of 35- to 56-day-old embryos. Analyses of globins synthesized in vivo and in cultures of erythroid progenitors (burst-forming units, BFUe) showed that cells of the yo...

journal_title：Developmental biology

authors： Stamatoyannopoulos G,Constantoulakis P,Brice M,Kurachi S,Papayannopoulou T

更新日期：1987-09-01 00:00:00

abstract：:Nicastrin is a recently identified member of high-molecular weight complexes containing presenilin. The Caenorhabditis elegans homolog of nicastrin, aph-2, was shown to be required for GLP-1/Notch signaling in the early embryo. In addition to the maternal-effect embryonic lethal phenotype, aph-2 mutant animals also di...

journal_title：Developmental biology

authors： Levitan D,Yu G,St George Hyslop P,Goutte C

更新日期：2001-12-15 00:00:00

abstract：:The transforming growth factor-beta (TGF-beta) superfamily contains a variety of growth factors which all share common sequence elements and structural motifs. These proteins are known to exert a wide spectrum of biological responses on a large variety of cell types in both vertebrates and invertebrates. Many of them ...

journal_title：Developmental biology

authors： Balemans W,Van Hul W

更新日期：2002-10-15 00:00:00

abstract：:Urodeles begin gastrulation with much of their presumptive mesoderm in the superficial cell layer, all of which must move into the deep layers during development. We studied the morphogenesis of superficial mesoderm in the urodeles Ambystoma maculatum, Ambystoma mexicanum, and Taricha granulosa. In all three species, ...

journal_title：Developmental biology

authors： Shook DR,Majer C,Keller R

更新日期：2002-08-15 00:00:00

abstract：:We have analyzed several aspects of the development of flies carrying mutations at the Glued locus. Optic lobe abnormalities in individuals heterozygous for the original Glued allele were previously shown to result from an action of this mutation in the retinula cells. We have estimated when the functioning of this ge...

journal_title：Developmental biology

authors： Harte PJ,Kankel DR

更新日期：1983-09-01 00:00:00

abstract：:In higher organisms, mononucleated myoblasts fuse to form multinucleated myotubes. During this process, myoblasts undergo specific changes in cell morphology and cytoarchitecture. Previously, we have shown that the actin regulator Kette (Hem-2/Nap-1) is essential for myoblast fusion. In this study, we describe the rol...

journal_title：Developmental biology

authors： Schäfer G,Weber S,Holz A,Bogdan S,Schumacher S,Müller A,Renkawitz-Pohl R,Onel SF

更新日期：2007-04-15 00:00:00