APH-2/nicastrin functions in LIN-12/Notch signaling in the Caenorhabditis elegans somatic gonad.

abstract：:Lumenogenesis of small seamless tubes occurs through intracellular membrane growth and directed vesicle fusion events. Within the Caenorhabditis elegans excretory cell, which forms seamless intracellular tubes (canals) that mediate osmoregulation, lumens grow in length and diameter when vesicles fuse with the expandin...

journal_title：Developmental biology

authors： Armenti ST,Chan E,Nance J

更新日期：2014-10-01 00:00:00

abstract：:Cranial placodes are specialized ectodermal regions in the developing vertebrate head that give rise to both neural and non-neural cell types of the neuroendocrine system and the sense organs of the visual, olfactory and acoustic systems. The cranial placodes develop from a panplacodal region which is specifically mar...

journal_title：Developmental biology

authors： Posnien N,Koniszewski N,Bucher G

更新日期：2011-02-01 00:00:00

abstract：:Epithelial-mesenchymal interactions are of major importance during development to direct correct differentiation and morphogenesis of embryonic tissues. One subset of lateral mesoderm-derived mesenchymal cells will form the smooth muscle (SM) layer of the primary epithelial lining of hollow internal organs. It has bee...

journal_title：Developmental biology

authors： Saint-Jeannet JP,Thiery JP,Koteliansky VE

更新日期：1994-08-01 00:00:00

abstract：:The regeneration of lost body parts is a fascinating phenomenon exhibited by some multicellular organisms. In social amoebae, such as Dictyostelium discoideum, the pseudoplasmodium is a temporary migratory multicellular structure with high regeneration ability. It consists of future stalk cells (prestalk cells) at the...

journal_title：Developmental biology

authors： Mohri K,Tanaka R,Nagano S

更新日期：2020-01-01 00:00:00

abstract：:The endoderm of C. elegans arises entirely from a single progenitor cell, the E blastomere, whose identity is specified by GATA type transcription factors, including END-1. In response to an inductive interaction mediated through Wnt/MAP kinase signaling pathways, POP-1, a Lef/Tcf-type transcription factor, restricts ...

journal_title：Developmental biology

authors： Witze ES,Field ED,Hunt DF,Rothman JH

更新日期：2009-03-01 00:00:00

abstract：:Many insects undergo katatrepsis, essential reorganization by the extraembryonic membranes that repositions the embryo. Knockdown of the zen gene by RNA interference (RNAi) prevents katatrepsis in the milkweed bug Oncopeltus fasciatus. However, the precise morphogenetic defect has been uncertain, and katatrepsis itsel...

journal_title：Developmental biology

authors： Panfilio KA

更新日期：2009-09-15 00:00:00

abstract：:The organizer is an essential signaling center required for axial formation during vertebrate embryonic development. In the basal chordate amphioxus, the dorsal blastopore lip of the gastrula has been proposed to be homologous to the vertebrate organizer. Lefty is one of the first genes to be expressed in the organize...

journal_title：Developmental biology

authors： Zhang H,Chen S,Shang C,Wu X,Wang Y,Li G

更新日期：2019-12-01 00:00:00

abstract：:The mouse Otlx2 gene is a new member of the paired-like family of homeobox genes whose human homologue, RIEG, is involved in Rieger syndrome, an autosomal-dominant disorder. One of the cardinal features of Rieger syndrome is dental hypoplasia, indicating that Otlx2/RIEG activity is essential for normal tooth developme...

journal_title：Developmental biology

authors： Mucchielli ML,Mitsiadis TA,Raffo S,Brunet JF,Proust JP,Goridis C

更新日期：1997-09-15 00:00:00

abstract：:Metathoracic limb buds were removed unilaterally from Locusta migratoria embryos at 30% of embryonic development, thereby depriving limb-innervating neurons of the opportunity of innervating their normal target muscles. The operated embryos were allowed to hatch and develop to adulthood, and then the connections betwe...

journal_title：Developmental biology

authors： Whitington PM

更新日期：1985-02-01 00:00:00

abstract：:BMP-2 and BMP-4 are known to be involved in the early events which specify the cardiac lineage. Their later patterns of expression in the developing mouse and chick heart, in the myocardium overlying the atrioventricular canal (AV) and outflow tract (OFT) cushions, also suggest that they may play a role in valvoseptal...

journal_title：Developmental biology

authors： Allen SP,Bogardi JP,Barlow AJ,Mir SA,Qayyum SR,Verbeek FJ,Anderson RH,Francis-West PH,Brown NA,Richardson MK

更新日期：2001-07-01 00:00:00

abstract：:We have investigated the function of the neurogenic gene Notch (N) during development of the adult sensilla of Drosophila. Heat pulses were applied to flies carrying the temperature-sensitive Notch allele Nts1 at different larval and pupal stages. We can show that the reduction of Notch+ function during a short interv...

journal_title：Developmental biology

authors： Hartenstein V,Posakony JW

更新日期：1990-11-01 00:00:00

abstract：:Septins are guanosine triphosphate-binding proteins that are evolutionally conserved in all eukaryotes other than plants. They function as multimeric complexes that interact with membrane lipids, actomyosin, and microtubules. Based on these interactions, septins play essential roles in the morphogenesis and physiologi...

journal_title：Developmental biology

authors： Torii H,Yoshida A,Katsuno T,Nakagawa T,Ito J,Omori K,Kinoshita M,Yamamoto N

更新日期：2016-11-15 00:00:00

abstract：:Cellular dedifferentiation underlies topical issues in biology such as regeneration and nuclear cloning and has common features in plants and animals. In plants, this process characterizes the transition of differentiated leaf cells to protoplasts (plant cells devoid of cell walls) and is accompanied by global chromat...

journal_title：Developmental biology

authors： Grafi G,Ben-Meir H,Avivi Y,Moshe M,Dahan Y,Zemach A

更新日期：2007-06-15 00:00:00

abstract：:In normal development the veg1 tier of the sixth cleavage Strongylocentrotus purpuratus embryo contributes progeny to both ectodermal lineages and portions of the archenteron. Treatment with 18 mM LiCl specifically affects this lineage allocation, reducing or eliminating the veg1 contribution to ectoderm. Less frequen...

journal_title：Developmental biology

authors： Cameron RA,Davidson EH

更新日期：1997-07-15 00:00:00

abstract：:To examine the possible role of homeo box genes in murine development we have studied the structure and expression pattern of Hox-2.5, a newly isolated homeo box gene that maps to the left end of the mouse Hox-2 locus on chromosome 11. The sequence of the Hox-2.5 homeo box has been determined. It is highly homologous ...

journal_title：Developmental biology

authors： Bogarad LD,Utset MF,Awgulewitsch A,Miki T,Hart CP,Ruddle FH

更新日期：1989-06-01 00:00:00

abstract：:The unc-52 gene of Claenorhabditis elegans encodes a homologue of the basement membrane heparan sulfate proteoglycan perlecan. Viable alleles reduce the abundance of UNC-52 in late larval stages and increase the frequency of distal tip cell (DTC) migration defects caused by mutations disrupting the UNC-6/netrin guidan...

journal_title：Developmental biology

authors： Merz DC,Alves G,Kawano T,Zheng H,Culotti JG

更新日期：2003-04-01 00:00:00

abstract：:During chick limb development the gap junction protein Connexin-43 (Cx43) is expressed in discrete spatially restricted domains in the apical ectodermal ridge (AER) and mesenchyme of the zone of polarising activity. Antisense oligonucleotides (ODNs) were used to investigate the role of Connexin-43 (Cx43) in the develo...

journal_title：Developmental biology

authors： Makarenkova H,Patel K

更新日期：1999-03-15 00:00:00

abstract：:We have isolated two related Xenopus homologues of the homeotic zinc finger protein Teashirt1 (Tsh1), XTsh1a and XTsh1b. While Drosophila teashirt specifies trunk identity in the fly, the developmental relevance of vertebrate Tsh homologues is unknown. XTsh1a/b are expressed in prospective trunk CNS throughout early n...

journal_title：Developmental biology

authors： Koebernick K,Kashef J,Pieler T,Wedlich D

更新日期：2006-10-01 00:00:00

abstract：:Experiments in which the developing gut of avian embryos was back-transplanted to permit the bowel to interact with the developing neural tube were undertaken. Segments of intestine from 4-day quail embryos were implanted between the somites and neural tubes of chick embryos of 7 to 24 somites. The spinal cord respond...

journal_title：Developmental biology

authors： Rothman TP,Gershon MD,Fontaine-Pérus JC,Chanconie M,Le Douarin NM

更新日期：1987-12-01 00:00:00

abstract：:Mammalian sperm-egg adhesion occurs when sperm bind to the zona pellucida of the egg. In this study with guinea pig gametes, we have asked if sperm can initiate binding to the zona before and after the acrosome reaction and if the sperm surface protein PH-20 is involved in the binding at these two stages. Sperm bindin...

journal_title：Developmental biology

authors： Myles DG,Hyatt H,Primakoff P

更新日期：1987-06-01 00:00:00

abstract：:Drosophila melanogaster mature oocytes in ovaries are arrested at metaphase I of meiosis. Eggs that have reached the uterus have released this arrest. It was not known where in the female reproductive tract egg activation occurs and what triggers it. We investigated when and where the egg is activated in Drosophila in...

journal_title：Developmental biology

authors： Heifetz Y,Yu J,Wolfner MF

更新日期：2001-06-15 00:00:00

abstract：:Multipotent, self-renewing neural stem cells reside in the embryonic mouse telencephalic germinal zone. Using an in vitro neurosphere assay for neural stem cell proliferation, we demonstrate that FGF-responsive neural stem cells are present as early as E8.5 in the anterior neural plate, but EGF-responsive neural stem ...

journal_title：Developmental biology

authors： Tropepe V,Sibilia M,Ciruna BG,Rossant J,Wagner EF,van der Kooy D

更新日期：1999-04-01 00:00:00

abstract：:The embryonic cell lineage of Caenorhabditis elegans has been traced from zygote to newly hatched larva, with the result that the entire cell lineage of this organism is now known. During embryogenesis 671 cells are generated; in the hermaphrodite 113 of these (in the male 111) undergo programmed death and the remaind...

journal_title：Developmental biology

authors： Sulston JE,Schierenberg E,White JG,Thomson JN

更新日期：1983-11-01 00:00:00

abstract：:The development of the vertebrate inner ear is a complex process that has been investigated in several model organisms. In this work, we examined genetic interactions regulating early development of otic structures in medaka. We demonstrate that misexpression of Fgf8, Dlx3b and Foxi1 during early gastrulation is suffi...

journal_title：Developmental biology

authors： Aghaallaei N,Bajoghli B,Czerny T

更新日期：2007-07-15 00:00:00

abstract：:Type II collagen is a major component of hyaline cartilage, and has been suggested to be causally involved in promoting chondrogenesis during embryonic development. In the present study we have performed an immunohistochemical analysis of the distribution of type II collagen during several early stages of embryonic ch...

journal_title：Developmental biology

authors： Kosher RA,Solursh M

更新日期：1989-02-01 00:00:00

abstract：:Primitive blood constitutes the ventralmost mesoderm in amphibians, and its cleavage-stage origin reveals important clues about the orientation of the dorsal/ventral axis in the embryo. In recent years, investigators employing various lineage-labeling strategies have reported disparate results for the origin of primit...

journal_title：Developmental biology

authors： Lane MC,Sheets MD

更新日期：2002-08-01 00:00:00

abstract：:Mechanisms coupling growth and metabolism are conserved in Drosophila and mammals. In metazoans, such coupling is achieved across tissue scales through the regulated secretion of chemical messengers such as insulin that control the metabolism and growth of cells. Although the regulated secretion of Insulin like peptid...

journal_title：Developmental biology

authors： Ashe S,Malhotra V,Raghu P

更新日期：2018-02-01 00:00:00

abstract：:Ca2+-sensitive microelectrodes were used to study changes in cytoplasmic free calcium during progesterone-induced meiotic maturation in Xenopus laevis oocytes. In contrast to previous reports, no changes were detected during the maturation process, although a large activation pulse of Ca2+ was seen when in vitro matur...

journal_title：Developmental biology

authors： Robinson KR

更新日期：1985-06-01 00:00:00

abstract：:The genetic and developmental bases for trait expression and variation in adults are largely unknown. One system in which genes and cell behaviors underlying adult traits can be elucidated is the larval-to-adult transformation of zebrafish, Danio rerio. Metamorphosis in this and many other teleost fishes resembles amp...

journal_title：Developmental biology

authors： Parichy DM,Turner JM

更新日期：2003-04-15 00:00:00

abstract：:The rabbit ovum seldom becomes polyspermic despite the presence of supernumerary sperm with easy access to the ovum plasma membrane. The purpose of this study was to characterize the role of ovum investments in blocking polyspermy. Ova were inseminated with capacitated sperm in vitro and were fertilized. Early stages ...

journal_title：Developmental biology

authors： McCulloh DH,Wall RJ,Levitan H

更新日期：1987-04-01 00:00:00